Mir30b (microRNA 30b) - Rat Genome Database

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Gene: Mir30b (microRNA 30b) Rattus norvegicus
Symbol: Mir30b
Name: microRNA 30b
RGD ID: 2325392
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of angiogenesis. Predicted to act upstream of or within several processes, including cellular hyperosmotic salinity response; cellular response to lipopolysaccharide; and long-term synaptic potentiation. Predicted to be located in extracellular space. Orthologous to human MIR30B (microRNA 30b); INTERACTS WITH bisphenol A; bleomycin A2; cisplatin.
Type: ncrna (Ensembl: miRNA)
Previously known as: rno-mir-30b
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27100,132,589 - 100,132,675 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7100,132,589 - 100,132,675 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7101,904,807 - 101,904,893 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07104,106,484 - 104,106,570 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07104,025,792 - 104,025,878 (-)NCBIRnor_WKY
Rnor_6.07109,282,662 - 109,282,747 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7109,282,658 - 109,282,752 (-)EnsemblRnor6.0rn6Rnor6.0
Celera796,643,845 - 96,643,931 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)


References - curated
# Reference Title Reference Citation
1. MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. Liao WT, etal., J Pathol. 2014 Mar;232(4):415-27. doi: 10.1002/path.4309.
2. MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. Pan W, etal., PLoS One. 2013;8(1):e53950. doi: 10.1371/journal.pone.0053950. Epub 2013 Jan 9.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Teng Y, etal., Nat Commun. 2017 Feb 17;8:14448. doi: 10.1038/ncomms14448.
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17028171   PMID:17604727   PMID:18762567   PMID:19188439   PMID:20403161   PMID:20708584   PMID:23646144   PMID:24178239  
PMID:24205035   PMID:24898602   PMID:25701595   PMID:25791621   PMID:25858512   PMID:27765894   PMID:28578340   PMID:30701530   PMID:30721562   PMID:31054938   PMID:31814697   PMID:32329883  
PMID:32794050   PMID:32976819   PMID:33930933   PMID:35256590   PMID:36282532  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27100,132,589 - 100,132,675 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7100,132,589 - 100,132,675 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7101,904,807 - 101,904,893 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07104,106,484 - 104,106,570 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07104,025,792 - 104,025,878 (-)NCBIRnor_WKY
Rnor_6.07109,282,662 - 109,282,747 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7109,282,658 - 109,282,752 (-)EnsemblRnor6.0rn6Rnor6.0
Celera796,643,845 - 96,643,931 (-)NCBICelera
Cytogenetic Map7q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh388134,800,520 - 134,800,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8134,800,520 - 134,800,607 (-)EnsemblGRCh38hg38GRCh38
GRCh378135,812,763 - 135,812,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368135,881,944 - 135,882,031 (-)NCBINCBI36Build 36hg18NCBI36
Celera8131,985,504 - 131,985,591 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8131,128,460 - 131,128,547 (-)NCBIHuRef
CHM1_18135,854,881 - 135,854,968 (-)NCBICHM1_1
T2T-CHM13v2.08135,918,411 - 135,918,498 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391568,209,264 - 68,209,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1568,209,264 - 68,209,359 (-)EnsemblGRCm39 Ensembl
GRCm381568,337,415 - 68,337,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1568,337,415 - 68,337,510 (-)EnsemblGRCm38mm10GRCm38
MGSCv371568,168,977 - 68,169,072 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1569,853,459 - 69,853,554 (-)NCBICelera
Cytogenetic Map15D2NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11330,906,038 - 30,906,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1330,906,038 - 30,906,097 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1330,881,273 - 30,881,332 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01331,271,855 - 31,271,914 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11330,991,393 - 30,991,452 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01331,090,357 - 31,090,416 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01331,440,586 - 31,440,645 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl46,952,794 - 6,952,869 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.146,952,794 - 6,952,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.246,717,643 - 6,717,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)799736187103146217Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27100,132,762 - 100,133,039 (+)MAPPERmRatBN7.2
Rnor_6.07109,282,835 - 109,283,111NCBIRnor6.0
Rnor_5.07109,225,013 - 109,225,289UniSTSRnor5.0
Celera796,644,019 - 96,644,295UniSTS
Cytogenetic Map7 RGD


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 6
Low 2 8 25 9 16 9 8 9 9 8 11 3 8
Below cutoff 1


Nucleotide Sequences
RefSeq Transcripts NR_031841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000079419
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7100,132,589 - 100,132,675 (-)Ensembl
Rnor_6.0 Ensembl7109,282,658 - 109,282,752 (-)Ensembl
RefSeq Acc Id: NR_031841
Rat AssemblyChrPosition (strand)Source
mRatBN7.27100,132,589 - 100,132,675 (-)NCBI
Rnor_6.07109,282,662 - 109,282,747 (-)NCBI
Celera796,643,845 - 96,643,931 (-)NCBI

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325392 AgrOrtholog
BioCyc Gene G2FUF-33099 BioCyc
Ensembl Genes ENSRNOG00000053467 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000079419 ENTREZGENE
miRBase MI0000868 ENTREZGENE
NCBI Gene 100314231 ENTREZGENE
PhenoGen Mir30b PhenoGen
RNAcentral URS00005165DA RNACentral
  URS00005E5FB5 RNACentral
  URS000075BCFE RNACentral
  URS0000CCFFD9 RNACentral

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir30b  microRNA 30b  Mir30b  microRNA mir-30b  Name updated 61478 APPROVED
2010-06-02 Mir30b  microRNA mir-30b      Symbol and Name status set to provisional 70820 PROVISIONAL