(-)-epigallocatechin 3-gallate decreases expression ISO RGD:732061 6480464 epigallocatechin gallate results in decreased expression of CDK4 protein CTD PMID:15142168 (20R)-protopanaxadiol increases expression ISO RGD:732061 6480464 protopanaxadiol results in increased expression of CDK4 mRNA, protopanaxadiol results in increased expression of CDK4 protein CTD PMID:31805304 (S)-nicotine decreases expression ISO RGD:732061 6480464 Nicotine results in decreased expression of CDK4 protein CTD PMID:15231866 (S)-nicotine decreases expression ISO RGD:732062 6480464 Nicotine results in decreased expression of CDK4 mRNA, Nicotine results in decreased expression of CDK4 protein CTD PMID:17135361 (S)-nicotine multiple interactions ISO RGD:732061 6480464 Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] more ... CTD PMID:15231866 , PMID:18805435 (Z)-3-butylidenephthalide decreases expression EXP 6480464 butylidenephthalide results in decreased expression of CDK4 protein CTD PMID:16987298 (Z)-3-butylidenephthalide decreases expression ISO RGD:732061 6480464 butylidenephthalide results in decreased expression of CDK4 protein CTD PMID:16987298 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expression ISO RGD:732062 6480464 2 more ... CTD PMID:15525693 1,2-dichloroethane increases expression ISO RGD:732062 6480464 ethylene dichloride results in increased expression of CDK4 mRNA CTD PMID:28960355 1,2-dimethylhydrazine multiple interactions ISO RGD:732062 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of CDK4 mRNA CTD PMID:22206623 1,2-dimethylhydrazine increases expression ISO RGD:732062 6480464 1, 2-Dimethylhydrazine results in increased expression of CDK4 mRNA CTD PMID:22206623 1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of CDK4 mRNA CTD PMID:22841810 1,3-thiazolidine-2,4-dione decreases expression ISO RGD:732061 6480464 2, 4-thiazolidinedione results in decreased expression of CDK4 protein CTD PMID:15916743 1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea multiple interactions ISO RGD:732061 6480464 [N-(4-methoxybenzyl)-N'-(5-nitro-1, 3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CDK4 protein] CTD PMID:20540935 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CDK4 mRNA CTD PMID:16174780 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of CDK4 mRNA CTD PMID:12655037 more ... 17beta-estradiol multiple interactions ISO RGD:732061 6480464 [Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK4 protein more ... CTD PMID:19361625 more ... 17beta-estradiol multiple interactions ISO RGD:732062 6480464 Estradiol inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CDK4 mRNA], Estradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA] CTD PMID:19874833 17beta-estradiol increases expression ISO RGD:732061 6480464 Estradiol results in increased expression of CDK4 mRNA, Estradiol results in increased expression of CDK4 protein CTD PMID:19361625 more ... 17beta-estradiol increases activity ISO RGD:732061 6480464 Estradiol results in increased activity of CDK4 protein CTD PMID:9705214 19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol decreases expression EXP 6480464 17alpha-ethynylestr-5(10)-ene-3alpha, 17beta-diol results in decreased expression of CDK4 protein CTD PMID:16019103 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:732061 6480464 2 more ... CTD PMID:26988655 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:732062 6480464 2 more ... CTD PMID:30294300 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:732062 6480464 Tetrachlorodibenzodioxin results in decreased expression of CDK4 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732061 6480464 Tetrachlorodibenzodioxin results in increased expression of CDK4 protein CTD PMID:27312872 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin promotes the reaction [CCND2 protein binds to CDK4 protein] CTD PMID:12387751 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732062 6480464 Tetrachlorodibenzodioxin promotes the reaction [1 more ... CTD PMID:20637255 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732061 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDK4 protein] more ... CTD PMID:19917880 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CDK4 mRNA CTD PMID:16960034 , PMID:24136580 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of CDK4 mRNA CTD PMID:21346803 2-acetamidofluorene increases activity EXP 6480464 2-Acetylaminofluorene results in increased activity of CDK4 protein CTD PMID:15158336 2-methoxy-17beta-estradiol decreases expression ISO RGD:732061 6480464 2-Methoxyestradiol results in decreased expression of CDK4 protein CTD PMID:23967052 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of CDK4 mRNA CTD PMID:15890375 2-tert-butylhydroquinone multiple interactions ISO RGD:732061 6480464 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased expression of CDK4 protein] CTD PMID:26878773 2-tert-butylhydroquinone increases expression ISO RGD:732061 6480464 2-tert-butylhydroquinone results in increased expression of CDK4 protein CTD PMID:26878773 3,3',5,5'-tetrabromobisphenol A affects expression EXP 6480464 tetrabromobisphenol A affects the expression of CDK4 mRNA CTD PMID:26988606 3,3'-diindolylmethane decreases expression ISO RGD:732061 6480464 3, 3'-diindolylmethane results in decreased expression of CDK4 protein CTD PMID:22514694 3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 mRNA, [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 protein CTD PMID:12616621 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732062 6480464 5 more ... CTD PMID:24646949 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732061 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDK4 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDK4 mRNA CTD PMID:28628672 3-nitropropanoic acid increases expression EXP 6480464 3-nitropropionic acid results in increased expression of CDK4 protein CTD PMID:21827787 4,4'-sulfonyldiphenol multiple interactions ISO RGD:732061 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDK4 mRNA CTD PMID:28628672 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO RGD:732061 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [CDK4 protein binds to CCND1 protein] CTD PMID:18805435 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDK4 mRNA CTD PMID:15890375 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of CDK4 mRNA CTD PMID:21346803 4-hydroxyphenyl retinamide increases expression ISO RGD:732062 6480464 Fenretinide results in increased expression of CDK4 mRNA CTD PMID:28973697 5-azacytidine decreases expression ISO RGD:732061 6480464 Azacitidine analog results in decreased expression of CDK4 protein CTD PMID:18324645 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CDK4 mRNA CTD PMID:24780913 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:12376462 acetaldehyde multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased expression of CDK4 mRNA] CTD PMID:14636436 , PMID:18234639 acetaldehyde increases expression EXP 6480464 Acetaldehyde results in increased expression of CDK4 mRNA CTD PMID:14636436 , PMID:18234639 acetylsalicylic acid decreases expression ISO RGD:732061 6480464 Aspirin results in decreased expression of CDK4 mRNA CTD PMID:20457246 acridine-9(10H)-thione decreases activity ISO RGD:732061 6480464 thioacridone results in decreased activity of CDK4 protein CTD PMID:15724842 acrylamide decreases expression ISO RGD:732062 6480464 Acrylamide analog results in decreased expression of CDK4 protein CTD PMID:17317719 Actein decreases expression ISO RGD:732061 6480464 actein results in decreased expression of CDK4 protein CTD PMID:14758092 acteoside multiple interactions ISO RGD:732061 6480464 acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein], acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein] CTD PMID:17634406 acteoside decreases activity ISO RGD:732061 6480464 acteoside results in decreased activity of CDK4 protein CTD PMID:17634406 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CDK4 mRNA CTD PMID:15890375 aflatoxin B1 decreases expression ISO RGD:732062 6480464 Aflatoxin B1 results in decreased expression of CDK4 mRNA CTD PMID:29274131 aflatoxin B1 increases expression ISO RGD:732061 6480464 Aflatoxin B1 results in increased expression of CDK4 mRNA CTD PMID:27153756 albuterol increases expression ISO RGD:732061 6480464 Albuterol results in increased expression of CDK4 protein CTD PMID:18362475 all-trans-retinoic acid increases activity ISO RGD:732061 6480464 Tretinoin results in increased activity of CDK4 protein CTD PMID:15695403 all-trans-retinoic acid decreases expression ISO RGD:732061 6480464 Tretinoin results in decreased expression of CDK4 mRNA CTD PMID:33167477 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of CDK4 protein CTD PMID:11675954 all-trans-retinoic acid multiple interactions EXP 6480464 Tretinoin inhibits the reaction [FGF2 protein results in increased expression of CDK4 mRNA], Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of CDK4 mRNA] CTD PMID:11675954 , PMID:21964460 alpha-Zearalanol decreases expression ISO RGD:732062 6480464 Zeranol results in decreased expression of CDK4 protein CTD PMID:24120472 alvocidib multiple interactions ISO RGD:732061 6480464 alvocidib binds to and results in decreased activity of CDK4 protein CTD PMID:24102143 alvocidib decreases expression ISO RGD:732062 6480464 alvocidib results in decreased expression of CDK4 protein CTD PMID:12734434 alvocidib decreases activity ISO RGD:732061 6480464 alvocidib results in decreased activity of CDK4 protein CTD PMID:12517783 amlodipine multiple interactions ISO RGD:732061 6480464 Amlodipine results in decreased activity of and results in decreased expression of CDK4 protein CTD PMID:17217918 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CDK4 mRNA, Ammonium Chloride affects the expression of CDK4 protein CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of CDK4 mRNA CTD PMID:12420312 andrographolide multiple interactions ISO RGD:732061 6480464 andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein] CTD PMID:18619950 andrographolide decreases expression ISO RGD:732061 6480464 andrographolide results in decreased expression of CDK4 protein CTD PMID:18619950 aniline increases expression EXP 6480464 aniline results in increased expression of CDK4 protein CTD PMID:21070798 antroquinonol multiple interactions ISO RGD:732061 6480464 antroquinonol results in decreased expression of and results in decreased localization of CDK4 protein CTD PMID:19723512 arecoline increases expression EXP 6480464 Arecoline results in increased expression of CDK4 mRNA, Arecoline results in increased expression of CDK4 protein CTD PMID:21741983 arsane increases expression ISO RGD:732061 6480464 Arsenic results in increased expression of CDK4 mRNA CTD PMID:20654705 arsane affects methylation ISO RGD:732061 6480464 Arsenic affects the methylation of CDK4 gene CTD PMID:25304211 arsane multiple interactions ISO RGD:732061 6480464 [silybin co-treated with Arsenic] results in decreased expression of CDK4 protein CTD PMID:25868784 arsenic atom increases expression ISO RGD:732061 6480464 Arsenic results in increased expression of CDK4 mRNA CTD PMID:20654705 arsenic atom affects methylation ISO RGD:732061 6480464 Arsenic affects the methylation of CDK4 gene CTD PMID:25304211 arsenic atom multiple interactions ISO RGD:732061 6480464 [silybin co-treated with Arsenic] results in decreased expression of CDK4 protein CTD PMID:25868784 arsenous acid increases expression ISO RGD:732061 6480464 Arsenic Trioxide results in increased expression of CDK4 mRNA CTD PMID:17530438 more ... arsenous acid multiple interactions ISO RGD:732061 6480464 Arsenic Trioxide inhibits the reaction [PDGFB protein results in increased expression of CDK4 protein] CTD PMID:35276128 atrazine decreases expression ISO RGD:732061 6480464 Atrazine results in decreased expression of CDK4 mRNA CTD PMID:22378314 , PMID:34146662 baicalein increases expression ISO RGD:732061 6480464 baicalein results in increased expression of CDK4 protein CTD PMID:22820424 belinostat decreases expression ISO RGD:732061 6480464 belinostat results in decreased expression of CDK4 mRNA CTD PMID:19606018 benzo[a]pyrene increases expression ISO RGD:732061 6480464 Benzo(a)pyrene results in increased expression of CDK4 mRNA, Benzo(a)pyrene results in increased expression of CDK4 protein CTD PMID:19027820 , PMID:30020114 benzo[a]pyrene increases methylation ISO RGD:732061 6480464 Benzo(a)pyrene results in increased methylation of CDK4 promoter CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:732061 6480464 Benzo(a)pyrene affects the methylation of CDK4 exon CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:732062 6480464 Benzo(a)pyrene results in decreased expression of CDK4 mRNA CTD PMID:19770486 benzo[a]pyrene multiple interactions ISO RGD:732061 6480464 CDK4 protein promotes the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein], Folic Acid affects the reaction [Benzo(a)pyrene results in increased expression of CDK4 protein] CTD PMID:16406622 , PMID:30020114 benzoic acid multiple interactions ISO RGD:732061 6480464 Benzoic Acid analog results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:10403840 berberine decreases expression ISO RGD:732061 6480464 Berberine results in decreased expression of CDK4 protein CTD PMID:16505103 beta-ionone decreases expression ISO RGD:732061 6480464 beta-ionone results in decreased expression of CDK4 protein CTD PMID:15450939 , PMID:31506784 bezafibrate increases expression ISO RGD:732062 6480464 Bezafibrate results in increased expression of CDK4 mRNA CTD PMID:15447978 biotin increases expression ISO RGD:732062 6480464 Biotin results in increased expression of CDK4 mRNA CTD PMID:34699867 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:732062 6480464 Diethylhexyl Phthalate results in decreased expression of CDK4 mRNA CTD PMID:19874833 , PMID:31211961 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of CDK4 mRNA CTD PMID:35762964 bis(2-ethylhexyl) phthalate increases expression ISO RGD:732062 6480464 Diethylhexyl Phthalate results in increased expression of CDK4 mRNA CTD PMID:25701202 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:732062 6480464 Estradiol inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CDK4 mRNA] CTD PMID:19874833 bisphenol A increases expression ISO RGD:732061 6480464 bisphenol A results in increased expression of CDK4 mRNA, bisphenol A results in increased expression of CDK4 protein CTD PMID:19361625 more ... bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CDK4 mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:732061 6480464 fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDK4 protein] CTD PMID:19361625 Bisphenol B increases expression EXP 6480464 bisphenol B results in increased expression of CDK4 mRNA, bisphenol B results in increased expression of CDK4 protein CTD PMID:33940105 bisphenol F multiple interactions ISO RGD:732061 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDK4 mRNA CTD PMID:28628672 BMS-754807 multiple interactions ISO RGD:732061 6480464 [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein, [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 brassinolide decreases expression ISO RGD:732061 6480464 brassinolide results in decreased expression of CDK4 protein CTD PMID:20833159 busulfan decreases expression ISO RGD:732062 6480464 Busulfan results in decreased expression of CDK4 mRNA CTD PMID:15388331 Butylbenzyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of CDK4 mRNA CTD PMID:35762964 Butylparaben increases expression ISO RGD:732061 6480464 butylparaben results in increased expression of CDK4 mRNA CTD PMID:24481588 butyric acid decreases expression EXP 6480464 Butyric Acid results in decreased expression of CDK4 mRNA CTD PMID:12800193 cadmium dichloride multiple interactions ISO RGD:732062 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CDK4 protein CTD PMID:12135628 cadmium dichloride decreases expression ISO RGD:732061 6480464 Cadmium Chloride results in decreased expression of CDK4 mRNA CTD PMID:25851441 cadmium dichloride increases expression ISO RGD:732061 6480464 Cadmium Chloride results in increased expression of CDK4 mRNA CTD PMID:20219890 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of CDK4 mRNA CTD PMID:18636176 caffeine multiple interactions ISO RGD:732062 6480464 Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:15126379 caffeine decreases expression ISO RGD:732061 6480464 Caffeine results in decreased expression of CDK4 mRNA CTD PMID:11793227 calcitriol multiple interactions ISO RGD:732061 6480464 Calcitriol promotes the reaction [CDKN1B protein binds to CDK4 protein] CTD PMID:16322758 calix[6]arene decreases expression ISO RGD:732061 6480464 calix(6)arene results in decreased expression of CDK4 protein CTD PMID:23872419 canertinib multiple interactions ISO RGD:732062 6480464 Canertinib inhibits the reaction [Acetaminophen promotes the reaction [[CCND1 protein binds to and results in increased activity of CDK4 protein] which results in increased phosphorylation of RB1 protein]], Canertinib inhibits the reaction [Acetaminophen results in increased expression of CDK4 protein] CTD PMID:28123000 cannabidiol decreases expression ISO RGD:732062 6480464 Cannabidiol results in decreased expression of CDK4 protein CTD PMID:34871667 cannabidiol multiple interactions ISO RGD:732061 6480464 [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of CDK4 mRNA CTD PMID:32992648 cannabidiol decreases expression ISO RGD:732061 6480464 Cannabidiol results in decreased expression of CDK4 protein CTD PMID:34871667 capsaicin decreases expression EXP 6480464 Capsaicin results in decreased expression of CDK4 mRNA CTD PMID:16278290 captan decreases expression ISO RGD:732062 6480464 Captan results in decreased expression of CDK4 mRNA CTD PMID:31558096 carbon nanotube multiple interactions ISO RGD:732061 6480464 [Nanotubes, Carbon co-treated with Nitrogen] results in increased expression of CDK4 protein CTD PMID:25797581 carbon nanotube increases expression ISO RGD:732062 6480464 Nanotubes more ... CTD PMID:25554681 carbon nanotube increases expression ISO RGD:732061 6480464 Nanotubes, Carbon results in increased expression of CDK4 mRNA CTD PMID:25511174 carbon nanotube decreases expression ISO RGD:732061 6480464 Nanotubes more ... CTD PMID:15585362 , PMID:28673683 carbonyl cyanide p-trifluoromethoxyphenylhydrazone multiple interactions ISO RGD:732061 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [CDKN1B protein binds to CDK4 protein] CTD PMID:19819288 Cardanol decreases expression ISO RGD:732061 6480464 cardanol results in decreased expression of CDK4 mRNA CTD PMID:26694491 celecoxib decreases expression ISO RGD:732061 6480464 Celecoxib results in decreased expression of CDK4 protein CTD PMID:16136956 CGP 52608 multiple interactions ISO RGD:732061 6480464 CGP 52608 promotes the reaction [RORA protein binds to CDK4 gene] CTD PMID:28238834 chalcones decreases expression ISO RGD:732061 6480464 Chalcones analog results in decreased expression of CDK4 mRNA CTD PMID:32856275 cholesterol multiple interactions ISO RGD:732061 6480464 Cholesterol inhibits the reaction [arachidonyl dopamine results in decreased expression of CDK4 mRNA] CTD PMID:33393692 chromium(6+) decreases expression EXP 6480464 chromium hexavalent ion results in decreased expression of CDK4 protein CTD PMID:21621607 chromium(6+) decreases expression ISO RGD:732061 6480464 chromium hexavalent ion results in decreased expression of CDK4 mRNA CTD PMID:23940686 chromium(6+) multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CDK4 protein] CTD PMID:21621607 ciglitazone decreases expression ISO RGD:732061 6480464 ciglitazone results in decreased expression of CDK4 protein CTD PMID:21080969 ciglitazone decreases expression EXP 6480464 ciglitazone results in decreased expression of CDK4 mRNA CTD PMID:20578043 ciglitazone multiple interactions ISO RGD:732061 6480464 CREBBP protein inhibits the reaction [ciglitazone results in decreased expression of CDK4 protein], NCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of CDK4 protein] CTD PMID:21080969 Cirsimarin decreases expression ISO RGD:732061 6480464 cirsimarin results in decreased expression of CDK4 mRNA CTD PMID:35710092 cisplatin increases expression ISO RGD:732061 6480464 Cisplatin results in increased expression of CDK4 mRNA, Cisplatin results in increased expression of CDK4 protein CTD PMID:27594783 , PMID:32562082 cisplatin decreases expression ISO RGD:732061 6480464 Cisplatin results in decreased expression of CDK4 protein CTD PMID:20195699 cisplatin decreases expression ISO RGD:732062 6480464 Cisplatin results in decreased expression of CDK4 mRNA CTD PMID:21151649 cisplatin multiple interactions ISO RGD:732061 6480464 (1 more ... CTD PMID:20195699 more ... clofibrate decreases expression ISO RGD:732061 6480464 Clofibrate results in decreased expression of CDK4 protein CTD PMID:21080969 clofibrate multiple interactions ISO RGD:732061 6480464 CREBBP protein inhibits the reaction [Clofibrate results in decreased expression of CDK4 protein], NCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of CDK4 protein] CTD PMID:21080969 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CDK4 mRNA CTD PMID:17602206 clotrimazole decreases expression ISO RGD:732061 6480464 Clotrimazole results in decreased expression of CDK4 CTD PMID:20724915 clozapine increases expression EXP 6480464 Clozapine results in increased expression of CDK4 mRNA CTD PMID:15860345 cobalt dichloride decreases expression ISO RGD:732061 6480464 cobaltous chloride results in decreased expression of CDK4 mRNA CTD PMID:19376846 cocaine affects expression ISO RGD:732062 6480464 Cocaine affects the expression of CDK4 mRNA CTD PMID:18355967 copper atom multiple interactions ISO RGD:732061 6480464 [Chelating Agents binds to Copper] which results in decreased expression of CDK4 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:732061 6480464 [Chelating Agents binds to Copper] which results in decreased expression of CDK4 mRNA CTD PMID:30911355 coptisine decreases expression ISO RGD:732061 6480464 coptisine analog results in decreased expression of CDK4 protein CTD PMID:30472432 corticosterone multiple interactions EXP 6480464 Corticosterone inhibits the reaction [CDKN1A protein binds to CDK4 protein], Corticosterone promotes the reaction [CDKN1B protein binds to CDK4 protein] CTD PMID:12807724 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of CDK4 protein CTD PMID:12807724 corticosterone decreases activity EXP 6480464 Corticosterone results in decreased activity of CDK4 protein CTD PMID:12807724 coumarin decreases expression ISO RGD:732061 6480464 coumarin analog results in decreased expression of CDK4 mRNA CTD PMID:32578917 Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of CDK4 mRNA CTD PMID:26577399 curcumin decreases expression ISO RGD:732061 6480464 Curcumin analog results in decreased expression of CDK4 mRNA, Curcumin results in decreased expression of CDK4 protein CTD PMID:18156803 more ... cyclosporin A increases expression ISO RGD:732061 6480464 Cyclosporine results in increased expression of CDK4 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:732061 6480464 Cyclosporine results in decreased expression of CDK4 mRNA CTD PMID:25562108 cyclosporin A decreases expression ISO RGD:732062 6480464 Cyclosporine results in decreased expression of CDK4 mRNA CTD PMID:19770486 daidzein decreases activity ISO RGD:732061 6480464 daidzein results in decreased activity of CDK4 protein CTD PMID:21161820 DDT increases expression ISO RGD:732062 6480464 DDT results in increased expression of CDK4 protein CTD PMID:23684557 deguelin decreases expression ISO RGD:732061 6480464 deguelin metabolite results in decreased expression of CDK4 protein, deguelin results in decreased expression of CDK4 protein CTD PMID:19139008 , PMID:19336726 demethoxycurcumin decreases expression ISO RGD:732061 6480464 demethoxycurcumin results in decreased expression of CDK4 protein CTD PMID:34291863 dexamethasone decreases expression ISO RGD:732062 6480464 Dexamethasone results in decreased expression of CDK4 mRNA CTD PMID:21041162 dexamethasone multiple interactions ISO RGD:732061 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDK4 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDK4 mRNA CTD PMID:28628672 dexamethasone multiple interactions ISO RGD:732062 6480464 5 more ... CTD PMID:24646949 Diacetoxyscirpenol decreases expression ISO RGD:732062 6480464 diacetoxyscirpenol results in decreased expression of CDK4 mRNA CTD PMID:31836554 diarsenic trioxide increases expression ISO RGD:732061 6480464 Arsenic Trioxide results in increased expression of CDK4 mRNA CTD PMID:17530438 more ... diarsenic trioxide multiple interactions ISO RGD:732061 6480464 Arsenic Trioxide inhibits the reaction [PDGFB protein results in increased expression of CDK4 protein] CTD PMID:35276128 diazinon increases methylation ISO RGD:732061 6480464 Diazinon results in increased methylation of CDK4 gene CTD PMID:22964155 dibutyl phthalate decreases expression ISO RGD:732062 6480464 Dibutyl Phthalate results in decreased expression of CDK4 mRNA CTD PMID:17361019 , PMID:21266533 dibutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of CDK4 mRNA CTD PMID:35762964 dibutyl phthalate increases expression ISO RGD:732061 6480464 Dibutyl Phthalate results in increased expression of CDK4 mRNA CTD PMID:22179484 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of CDK4 mRNA CTD PMID:18636392 Didymin decreases expression ISO RGD:732061 6480464 didymin results in decreased expression of CDK4 protein CTD PMID:27899290 Didymin multiple interactions ISO RGD:732061 6480464 locostatin inhibits the reaction [didymin results in decreased expression of CDK4 protein] CTD PMID:27899290 diethyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of CDK4 mRNA CTD PMID:35762964 diethyl sulfate affects expression ISO RGD:732061 6480464 diethyl sulfate affects the expression of CDK4 protein CTD PMID:23887207 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of CDK4 mRNA CTD PMID:15890375 diethylstilbestrol decreases expression ISO RGD:732062 6480464 Diethylstilbestrol results in decreased expression of CDK4 mRNA CTD PMID:21041162 dihydro-beta-erythroidine multiple interactions ISO RGD:732061 6480464 Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 diisobutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of CDK4 mRNA CTD PMID:35762964 diisononyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of CDK4 mRNA CTD PMID:35762964 dimethylarsinous acid decreases expression ISO RGD:732061 6480464 dimethylarsinous acid results in decreased expression of CDK4 mRNA CTD PMID:20886546 Dinitramine decreases expression ISO RGD:732062 6480464 dinitramine results in decreased expression of CDK4 mRNA CTD PMID:33288293 dinitrogen multiple interactions ISO RGD:732061 6480464 [Nanotubes, Carbon co-treated with Nitrogen] results in increased expression of CDK4 protein CTD PMID:25797581 dioscin decreases expression ISO RGD:732061 6480464 dioscin results in decreased expression of CDK4 mRNA CTD PMID:33359023 dioxygen multiple interactions ISO RGD:732061 6480464 [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of CDK4 mRNA, [Oxygen co-treated with Ozone] results in decreased expression of CDK4 mRNA CTD PMID:32992648 disodium selenite increases expression ISO RGD:732061 6480464 Sodium Selenite results in increased expression of CDK4 mRNA CTD PMID:16705456 doxorubicin multiple interactions ISO RGD:732062 6480464 [zoledronic acid co-treated with Doxorubicin] results in decreased expression of CDK4 protein, Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of CDK4 protein] CTD PMID:17876044 , PMID:19789217 doxorubicin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of CDK4 protein] CTD PMID:33484087 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of CDK4 protein CTD PMID:33484087 dronedarone decreases expression ISO RGD:732061 6480464 dronedarone results in decreased expression of CDK4 protein CTD PMID:29616291 elemental selenium decreases expression ISO RGD:732061 6480464 Selenium deficiency results in decreased expression of CDK4 mRNA CTD PMID:11925459 elemental selenium increases expression ISO RGD:732061 6480464 Selenium results in increased expression of CDK4 mRNA CTD PMID:19244175 emodin decreases expression ISO RGD:732061 6480464 Emodin results in decreased expression of CDK4 mRNA CTD PMID:16045814 enzyme inhibitor multiple interactions ISO RGD:732061 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CDK4 protein CTD PMID:23301498 erlotinib hydrochloride decreases phosphorylation ISO RGD:732062 6480464 Erlotinib Hydrochloride results in decreased phosphorylation of CDK4 protein CTD PMID:21195724 esculetin decreases expression EXP 6480464 esculetin results in decreased expression of CDK4 protein CTD PMID:21600278 esculetin multiple interactions EXP 6480464 esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein], SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein] CTD PMID:21600278 ethyl trans-caffeate affects expression ISO RGD:732061 6480464 ethyl caffeate affects the expression of CDK4 protein CTD PMID:24892518 farrerol decreases expression ISO RGD:732061 6480464 farrerol results in decreased expression of CDK4 mRNA, farrerol results in decreased expression of CDK4 protein CTD PMID:35833306 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of CDK4 mRNA CTD PMID:18035473 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CDK4 mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:732061 6480464 Folic Acid affects the reaction [Benzo(a)pyrene results in increased expression of CDK4 protein] CTD PMID:30020114 folic acid multiple interactions ISO RGD:732062 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of CDK4 mRNA CTD PMID:22206623 folpet decreases expression ISO RGD:732062 6480464 folpet results in decreased expression of CDK4 mRNA CTD PMID:31558096 fulvestrant multiple interactions ISO RGD:732061 6480464 fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDK4 protein], fulvestrant inhibits the reaction [Estradiol results in increased expression of CDK4 protein] CTD PMID:19361625 furan increases methylation EXP 6480464 furan results in increased methylation of CDK4 gene CTD PMID:22079235 galangin decreases expression ISO RGD:732061 6480464 galangin results in decreased expression of CDK4 protein CTD PMID:25450235 gamma-tocopherol multiple interactions ISO RGD:732061 6480464 Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein CTD PMID:12504091 geldanamycin decreases expression ISO RGD:732061 6480464 geldanamycin results in decreased expression of CDK4 protein CTD PMID:28673683 genistein decreases activity ISO RGD:732061 6480464 Genistein results in decreased activity of CDK4 protein CTD PMID:21161820 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of CDK4 mRNA CTD PMID:22061828 geraniol decreases expression ISO RGD:732061 6480464 geraniol results in decreased expression of CDK4 protein CTD PMID:15450939 , PMID:21371438 gingerol decreases expression ISO RGD:732061 6480464 gingerol results in decreased expression of CDK4 protein CTD PMID:18058799 glafenine increases expression EXP 6480464 Glafenine results in increased expression of CDK4 mRNA CTD PMID:24136188 glutathione increases expression EXP 6480464 Glutathione deficiency results in increased expression of CDK4 mRNA CTD PMID:15345336 glycitein decreases activity ISO RGD:732061 6480464 glycitein results in decreased activity of CDK4 protein CTD PMID:21161820 glyphosate increases expression ISO RGD:732061 6480464 glyphosate results in increased expression of CDK4 protein CTD PMID:24073338 glyphosate decreases expression ISO RGD:732061 6480464 glyphosate results in decreased expression of CDK4 mRNA CTD PMID:31295307 haloperidol increases expression EXP 6480464 Haloperidol results in increased expression of CDK4 mRNA CTD PMID:15860345 hesperetin multiple interactions ISO RGD:732061 6480464 hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein] CTD PMID:17927510 hesperetin decreases expression ISO RGD:732061 6480464 hesperetin results in decreased expression of CDK4 CTD PMID:17927510 hesperidin multiple interactions ISO RGD:732061 6480464 BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 mRNA] more ... CTD PMID:34984768 hesperidin decreases expression ISO RGD:732061 6480464 Hesperidin results in decreased expression of CDK4 mRNA, Hesperidin results in decreased expression of CDK4 protein CTD PMID:34984768 Hexamethonium multiple interactions ISO RGD:732061 6480464 Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 hydralazine multiple interactions ISO RGD:732061 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CDK4 mRNA CTD PMID:17183730 hydroxyurea decreases expression ISO RGD:732062 6480464 Hydroxyurea results in decreased expression of CDK4 protein CTD PMID:16356682 indole-3-methanol increases expression ISO RGD:732061 6480464 indole-3-carbinol analog results in increased expression of CDK4 protein CTD PMID:20570586 indole-3-methanol decreases expression ISO RGD:732061 6480464 indole-3-carbinol results in decreased expression of CDK4 CTD PMID:16082211 indole-3-methanol decreases activity ISO RGD:732061 6480464 indole-3-carbinol analog results in decreased activity of CDK4 protein CTD PMID:20570586 indolin-2-one decreases activity ISO RGD:732061 6480464 2-oxindole results in decreased activity of CDK4 protein CTD PMID:15724842 indolin-2-one multiple interactions ISO RGD:732061 6480464 2-oxindole analog results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:10403840 indometacin decreases expression ISO RGD:732061 6480464 Indomethacin results in decreased expression of CDK4 protein CTD PMID:15786552 indometacin multiple interactions ISO RGD:732061 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDK4 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDK4 mRNA CTD PMID:28628672 iodoacetic acid increases expression ISO RGD:732062 6480464 Iodoacetic Acid results in increased expression of CDK4 mRNA CTD PMID:31693920 Isoangustone A decreases expression ISO RGD:732061 6480464 isoangustone A results in decreased expression of CDK4 protein CTD PMID:21429724 Isoangustone A decreases expression ISO RGD:732062 6480464 isoangustone A results in decreased expression of CDK4 protein CTD PMID:21429724 juglone multiple interactions ISO RGD:732061 6480464 [juglone co-treated with Ascorbic Acid] results in decreased expression of CDK4 protein CTD PMID:29992683 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CDK4 protein] CTD PMID:21621607 L-ascorbic acid multiple interactions ISO RGD:732061 6480464 [juglone co-treated with Ascorbic Acid] results in decreased expression of CDK4 protein CTD PMID:29992683 lead(0) increases expression ISO RGD:732061 6480464 Lead results in increased expression of CDK4 mRNA CTD PMID:19921347 lead(0) affects expression ISO RGD:732061 6480464 Lead affects the expression of CDK4 mRNA CTD PMID:28903495 lead(2+) increases expression ISO RGD:732061 6480464 Lead results in increased expression of CDK4 mRNA CTD PMID:19921347 lead(2+) affects expression ISO RGD:732061 6480464 Lead affects the expression of CDK4 mRNA CTD PMID:28903495 lidocaine affects expression ISO RGD:732062 6480464 Lidocaine affects the expression of CDK4 mRNA CTD PMID:18931217 lovastatin decreases expression EXP 6480464 Lovastatin results in decreased expression of CDK4 mRNA, Lovastatin results in decreased expression of CDK4 protein CTD PMID:20578043 LY294002 multiple interactions ISO RGD:732061 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDK4 protein] CTD PMID:27312872 lycopene decreases expression ISO RGD:732061 6480464 lycopene results in decreased expression of CDK4 protein CTD PMID:17337101 malachite green cation multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA, [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein CTD PMID:12616621 melatonin decreases expression ISO RGD:732061 6480464 Melatonin results in decreased expression of CDK4 mRNA, Melatonin results in decreased expression of CDK4 protein CTD PMID:21108658 melittin decreases expression ISO RGD:732061 6480464 Melitten results in decreased expression of CDK4 protein CTD PMID:26189965 memantine increases expression ISO RGD:732061 6480464 Memantine results in increased expression of CDK4 protein CTD PMID:29226720 menadione decreases expression ISO RGD:732061 6480464 Vitamin K 3 results in decreased expression of CDK4 mRNA CTD PMID:16010434 menaquinone decreases expression ISO RGD:732061 6480464 Vitamin K 2 results in decreased expression of CDK4 mRNA CTD PMID:16010434 metformin multiple interactions ISO RGD:732061 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA CTD PMID:29309887 metformin increases expression ISO RGD:732061 6480464 Metformin results in increased expression of CDK4 protein CTD PMID:29226720 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of CDK4 mRNA CTD PMID:15890375 methidathion increases expression ISO RGD:732062 6480464 methidathion results in increased expression of CDK4 mRNA CTD PMID:34813904 methotrexate decreases expression ISO RGD:732061 6480464 Methotrexate results in decreased expression of CDK4 mRNA CTD PMID:21678067 methoxychlor increases expression ISO RGD:732062 6480464 Methoxychlor metabolite results in increased expression of CDK4 protein, Methoxychlor results in increased expression of CDK4 protein CTD PMID:15525693 methoxychlor multiple interactions ISO RGD:732062 6480464 Acetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CDK4 mRNA] CTD PMID:19615393 methoxychlor decreases expression ISO RGD:732062 6480464 Methoxychlor results in decreased expression of CDK4 mRNA, Methoxychlor results in decreased expression of CDK4 protein CTD PMID:19615393 methylparaben increases expression ISO RGD:732061 6480464 methylparaben results in increased expression of CDK4 mRNA CTD PMID:24481588 methylseleninic acid multiple interactions ISO RGD:732061 6480464 methylselenic acid promotes the reaction [CDKN2A protein binds to CDK4 protein binds to CCND1 protein], methylselenic acid results in decreased activity of [CDKN2A protein binds to CDK4 protein binds to CCND1 protein] CTD PMID:17847021 methylseleninic acid decreases expression ISO RGD:732061 6480464 methylselenic acid results in decreased expression of CDK4 mRNA CTD PMID:11830524 more ... miconazole increases expression ISO RGD:732062 6480464 Miconazole results in increased expression of CDK4 mRNA CTD PMID:27462272 microcystin RR decreases expression ISO RGD:732061 6480464 microcystin RR results in decreased expression of CDK4 protein CTD PMID:19111056 microcystin-LR decreases expression ISO RGD:732062 6480464 cyanoginosin LR results in decreased expression of CDK4 mRNA, cyanoginosin LR results in decreased expression of CDK4 protein CTD PMID:28414124 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:732062 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA CTD PMID:19874833 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:732062 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDK4 mRNA, Estradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA] CTD PMID:19874833 , PMID:31884101 monobenzyl phthalate multiple interactions ISO RGD:732062 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDK4 mRNA CTD PMID:31884101 monoethyl phthalate multiple interactions ISO RGD:732062 6480464 [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CDK4 mRNA CTD PMID:31884101 N-acetyl-L-cysteine multiple interactions ISO RGD:732062 6480464 Acetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CDK4 mRNA] CTD PMID:19615393 N-methyl-4-phenylpyridinium decreases expression ISO RGD:732062 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of CDK4 protein CTD PMID:26558463 N-methyl-4-phenylpyridinium decreases expression ISO RGD:732061 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of CDK4 protein CTD PMID:26768367 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of CDK4 protein CTD PMID:21628965 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:732062 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CDK4 protein CTD PMID:12135628 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CDK4 mRNA more ... CTD PMID:12616621 more ... N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of CDK4 protein CTD PMID:11831363 more ... N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of CDK4 mRNA CTD PMID:15890375 naringin multiple interactions ISO RGD:732061 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK4 protein] more ... CTD PMID:18296682 naringin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK4 protein] more ... CTD PMID:18951945 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of CDK4 mRNA CTD PMID:24136188 nickel atom decreases expression ISO RGD:732061 6480464 Nickel results in decreased expression of CDK4 mRNA CTD PMID:23195993 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of CDK4 mRNA CTD PMID:22546817 niclosamide decreases expression ISO RGD:732061 6480464 Niclosamide results in decreased expression of CDK4 protein CTD PMID:29031202 nicotine decreases expression ISO RGD:732061 6480464 Nicotine results in decreased expression of CDK4 protein CTD PMID:15231866 nicotine multiple interactions ISO RGD:732061 6480464 Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] more ... CTD PMID:15231866 , PMID:18805435 nicotine decreases expression ISO RGD:732062 6480464 Nicotine results in decreased expression of CDK4 mRNA, Nicotine results in decreased expression of CDK4 protein CTD PMID:17135361 ochratoxin A decreases expression ISO RGD:732061 6480464 ochratoxin A results in decreased expression of CDK4 mRNA CTD PMID:31154016 orlistat decreases expression ISO RGD:732061 6480464 Orlistat results in decreased expression of CDK4 protein CTD PMID:30667213 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of CDK4 mRNA CTD PMID:18636392 ozone multiple interactions ISO RGD:732061 6480464 [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of CDK4 mRNA, [Oxygen co-treated with Ozone] results in decreased expression of CDK4 mRNA CTD PMID:32992648 paclitaxel multiple interactions ISO RGD:732061 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA CTD PMID:29309887 palbociclib multiple interactions ISO RGD:732061 6480464 palbociclib inhibits the reaction [[CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of SHOX2 protein] more ... CTD PMID:20473330 more ... palbociclib decreases activity ISO RGD:732061 6480464 palbociclib results in decreased activity of CDK4 protein CTD PMID:24795392 palbociclib multiple interactions ISO RGD:732062 6480464 [CDKN2A gene mutant form results in increased expression of CDK4 protein] which results in increased susceptibility to palbociclib CTD PMID:24098593 palbociclib increases expression ISO RGD:732061 6480464 palbociclib results in increased expression of CDK4 protein CTD PMID:22869556 palbociclib increases response to substance ISO RGD:732061 6480464 CDK4 protein results in increased susceptibility to palbociclib CTD PMID:22761470 palbociclib decreases response to substance ISO RGD:732061 6480464 CDK4 protein results in decreased susceptibility to palbociclib CTD PMID:22711607 Panduratin A decreases expression ISO RGD:732061 6480464 panduratin A results in decreased expression of CDK4 protein CTD PMID:16497706 paracetamol decreases expression ISO RGD:732061 6480464 Acetaminophen results in decreased expression of CDK4 mRNA CTD PMID:11793227 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of CDK4 mRNA CTD PMID:33387578 paracetamol increases expression ISO RGD:732062 6480464 Acetaminophen results in increased expression of CDK4 protein CTD PMID:28123000 paracetamol multiple interactions ISO RGD:732062 6480464 Acetaminophen promotes the reaction [[CCND1 protein binds to and results in increased activity of CDK4 protein] which results in increased phosphorylation of RB1 protein] more ... CTD PMID:28123000 , PMID:34546377 paracetamol decreases expression ISO RGD:732062 6480464 Acetaminophen results in decreased expression of CDK4 protein CTD PMID:25319358 , PMID:25956474 paracetamol affects expression ISO RGD:732062 6480464 Acetaminophen affects the expression of CDK4 mRNA CTD PMID:17562736 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of CDK4 mRNA, Pentachlorophenol results in increased expression of CDK4 protein CTD PMID:19442831 perfluorooctane-1-sulfonic acid increases expression ISO RGD:732061 6480464 perfluorooctane sulfonic acid results in increased expression of CDK4 protein CTD PMID:29063134 perfluorooctanoic acid increases expression ISO RGD:732061 6480464 perfluorooctanoic acid results in increased expression of CDK4 mRNA, perfluorooctanoic acid results in increased expression of CDK4 protein CTD PMID:29502166 , PMID:32068100 phenobarbital affects expression ISO RGD:732062 6480464 Phenobarbital affects the expression of CDK4 mRNA CTD PMID:23091169 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of CDK4 protein CTD PMID:15603588 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:12376462 , PMID:14522882 phorbol 13-acetate 12-myristate decreases expression ISO RGD:732061 6480464 Tetradecanoylphorbol Acetate results in decreased expression of CDK4 mRNA CTD PMID:15978937 phorbol 13-acetate 12-myristate increases expression ISO RGD:732061 6480464 Tetradecanoylphorbol Acetate results in increased expression of CDK4 protein CTD PMID:24073338 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:732062 6480464 PPARD protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDK4 mRNA] CTD PMID:10866668 phorbol 13-acetate 12-myristate increases expression ISO RGD:732062 6480464 Tetradecanoylphorbol Acetate results in increased expression of CDK4 mRNA CTD PMID:10866668 picoxystrobin decreases expression ISO RGD:732061 6480464 picoxystrobin results in decreased expression of CDK4 mRNA CTD PMID:33512557 pinosylvin decreases expression ISO RGD:732061 6480464 pinosylvin results in decreased expression of CDK4 protein CTD PMID:23333577 piperine multiple interactions ISO RGD:732062 6480464 piperine inhibits the reaction [IL2 protein results in increased expression of CDK4 protein] CTD PMID:25655587 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of CDK4 mRNA CTD PMID:15890375 pirinixic acid decreases expression ISO RGD:732062 6480464 pirinixic acid results in decreased expression of CDK4 mRNA CTD PMID:18445702 pirinixic acid multiple interactions ISO RGD:732062 6480464 PPARA protein affects the reaction [pirinixic acid results in increased expression of CDK4 protein] CTD PMID:17483499 pirinixic acid increases expression ISO RGD:732062 6480464 pirinixic acid results in increased expression of CDK4 mRNA, pirinixic acid results in increased expression of CDK4 protein CTD PMID:16377806 more ... pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of CDK4 mRNA CTD PMID:15890375 poly(propylene imine) macromolecule increases expression ISO RGD:732061 6480464 poly(propyleneimine) analog results in increased expression of CDK4 mRNA CTD PMID:16308212 ponatinib multiple interactions ISO RGD:732061 6480464 (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK4 protein], ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 ponatinib decreases expression ISO RGD:732061 6480464 ponatinib results in decreased expression of CDK4 protein CTD PMID:25053825 potassium iodide decreases expression EXP 6480464 Potassium Iodide results in decreased expression of CDK4 protein CTD PMID:32593569 proanthocyanidin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of CDK4 protein] CTD PMID:33484087 proanthocyanidin increases expression EXP 6480464 Proanthocyanidins results in increased expression of CDK4 protein CTD PMID:33484087 progesterone increases expression ISO RGD:732062 6480464 Progesterone results in increased expression of CDK4 mRNA CTD PMID:19847363 propylparaben increases expression ISO RGD:732062 6480464 propylparaben results in increased expression of CDK4 mRNA CTD PMID:31306770 propylparaben increases expression ISO RGD:732061 6480464 propylparaben results in increased expression of CDK4 mRNA CTD PMID:24481588 pterostilbene decreases expression EXP 6480464 pterostilbene results in decreased expression of CDK4 protein CTD PMID:20398797 pyrazinecarboxamide increases expression EXP 6480464 Pyrazinamide results in increased expression of CDK4 mRNA CTD PMID:22431067 pyrogallol decreases expression ISO RGD:732062 6480464 Pyrogallol results in decreased expression of CDK4 mRNA CTD PMID:20362636 pyrogallol multiple interactions ISO RGD:732062 6480464 Silymarin inhibits the reaction [Pyrogallol results in decreased expression of CDK4 mRNA] CTD PMID:20362636 pyrrolidine dithiocarbamate decreases expression EXP 6480464 pyrrolidine dithiocarbamic acid results in decreased expression of CDK4 protein CTD PMID:14603533 quercetin multiple interactions ISO RGD:732061 6480464 Quercetin inhibits the reaction [TNF protein results in increased activity of CDK4 protein], Quercetin inhibits the reaction [TNF protein results in increased expression of CDK4 protein] CTD PMID:12589822 quercetin decreases expression ISO RGD:732061 6480464 Quercetin results in decreased expression of CDK4 mRNA CTD PMID:14715546 , PMID:15309432 quizartinib multiple interactions ISO RGD:732061 6480464 (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK4 protein], quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 quizartinib decreases expression ISO RGD:732061 6480464 quizartinib results in decreased expression of CDK4 protein CTD PMID:25053825 resveratrol multiple interactions ISO RGD:732061 6480464 resveratrol affects the activity of [CCND1 protein co-treated with CDK4 protein] more ... CTD PMID:11481417 more ... resveratrol decreases expression ISO RGD:732062 6480464 resveratrol results in decreased expression of CDK4 mRNA, resveratrol results in decreased expression of CDK4 protein CTD PMID:15122319 , PMID:25338179 resveratrol affects expression ISO RGD:732061 6480464 resveratrol affects the expression of CDK4 protein CTD PMID:12392819 resveratrol decreases expression ISO RGD:732061 6480464 resveratrol results in decreased expression of CDK4 mRNA, resveratrol results in decreased expression of CDK4 protein CTD PMID:11481417 more ... ritonavir decreases expression ISO RGD:732061 6480464 Ritonavir results in decreased expression of CDK4 mRNA, Ritonavir results in decreased expression of CDK4 protein CTD PMID:16551874 , PMID:19386116 rotenone decreases expression ISO RGD:732061 6480464 Rotenone results in decreased expression of CDK4 mRNA CTD PMID:33512557 rottlerin multiple interactions ISO RGD:732061 6480464 [sorafenib co-treated with rottlerin] results in decreased expression of CDK4 protein CTD PMID:16959960 S-(1,2-dichlorovinyl)-L-cysteine increases expression ISO RGD:732062 6480464 S-(1, 2-dichlorovinyl)cysteine results in increased expression of CDK4 protein CTD PMID:16495211 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein] CTD PMID:21600278 selenium atom decreases expression ISO RGD:732061 6480464 Selenium deficiency results in decreased expression of CDK4 mRNA CTD PMID:11925459 selenium atom increases expression ISO RGD:732061 6480464 Selenium results in increased expression of CDK4 mRNA CTD PMID:19244175 selumetinib decreases expression ISO RGD:732062 6480464 AZD 6244 results in decreased expression of CDK4 protein CTD PMID:17876044 selumetinib multiple interactions ISO RGD:732062 6480464 Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of CDK4 protein] CTD PMID:17876044 silibinin multiple interactions ISO RGD:732061 6480464 [Silybin co-treated with Arsenic] results in decreased expression of CDK4 protein CTD PMID:25868784 simvastatin decreases expression ISO RGD:732061 6480464 Simvastatin results in decreased expression of CDK4 protein CTD PMID:20878096 simvastatin decreases activity EXP 6480464 Simvastatin results in decreased activity of CDK4 protein CTD PMID:18804536 sirolimus decreases expression ISO RGD:732061 6480464 Sirolimus results in decreased expression of CDK4 protein CTD PMID:22761470 sodium arsenite decreases activity ISO RGD:732062 6480464 sodium arsenite results in decreased activity of CDK4 protein CTD PMID:11807808 sodium arsenite multiple interactions ISO RGD:732062 6480464 Plant Extracts inhibits the reaction [sodium arsenite results in decreased expression of CDK4 protein] CTD PMID:27723467 sodium arsenite affects expression ISO RGD:732062 6480464 sodium arsenite affects the expression of CDK4 mRNA CTD PMID:16507464 sodium arsenite increases expression ISO RGD:732062 6480464 sodium arsenite results in increased expression of CDK4 protein CTD PMID:16507464 sodium arsenite increases expression ISO RGD:732061 6480464 sodium arsenite results in increased expression of CDK4 protein CTD PMID:21726611 sodium arsenite decreases expression ISO RGD:732061 6480464 sodium arsenite results in decreased expression of CDK4 mRNA, sodium arsenite results in decreased expression of CDK4 protein CTD PMID:20886546 , PMID:26878773 sodium arsenite multiple interactions ISO RGD:732061 6480464 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased expression of CDK4 protein] more ... CTD PMID:21726611 more ... sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CDK4 mRNA, sodium arsenite results in decreased expression of CDK4 protein CTD PMID:20598115 , PMID:21964460 sodium arsenite decreases expression ISO RGD:732062 6480464 sodium arsenite results in decreased expression of CDK4 protein CTD PMID:20336670 , PMID:27723467 sodium arsenite multiple interactions EXP 6480464 Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of CDK4 mRNA] CTD PMID:21964460 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of CDK4 mRNA CTD PMID:22561333 sodium dichromate decreases expression ISO RGD:732062 6480464 sodium bichromate results in decreased expression of CDK4 mRNA CTD PMID:31558096 sodium fluoride increases expression ISO RGD:732061 6480464 Sodium Fluoride results in increased expression of CDK4 mRNA, Sodium Fluoride results in increased expression of CDK4 protein CTD PMID:31669217 sorafenib multiple interactions ISO RGD:732061 6480464 [sorafenib co-treated with rottlerin] results in decreased expression of CDK4 protein CTD PMID:16959960 sorafenib decreases expression ISO RGD:732061 6480464 sorafenib results in decreased expression of CDK4 protein CTD PMID:16959960 sulindac multiple interactions ISO RGD:732061 6480464 CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CDK4 protein] CTD PMID:18291362 sulindac multiple interactions EXP 6480464 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CDK4 mRNA CTD PMID:20371263 sulindac decreases expression ISO RGD:732061 6480464 Sulindac results in decreased expression of CDK4 protein CTD PMID:17292881 , PMID:18291362 sunitinib increases expression ISO RGD:732061 6480464 Sunitinib results in increased expression of CDK4 mRNA CTD PMID:31533062 syringic acid decreases expression ISO RGD:732061 6480464 syringic acid results in decreased expression of CDK4 mRNA CTD PMID:33759321 T-2 toxin decreases expression EXP 6480464 T-2 Toxin results in decreased expression of CDK4 mRNA, T-2 Toxin results in decreased expression of CDK4 protein CTD PMID:29567467 tamoxifen decreases expression ISO RGD:732061 6480464 Tamoxifen results in decreased expression of CDK4 mRNA CTD PMID:34821461 tanespimycin decreases expression ISO RGD:732061 6480464 tanespimycin results in decreased expression of CDK4 protein CTD PMID:17157164 more ... terephthalic acid increases expression EXP 6480464 terephthalic acid results in increased expression of CDK4 protein CTD PMID:16896691 tetracaine decreases phosphorylation ISO RGD:732062 6480464 Tetracaine results in decreased phosphorylation of CDK4 protein CTD PMID:34822839 tetracaine decreases phosphorylation ISO RGD:732061 6480464 Tetracaine results in decreased phosphorylation of CDK4 protein CTD PMID:34822839 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CDK4 protein CTD PMID:17298859 tetrachloromethane increases expression ISO RGD:732062 6480464 Carbon Tetrachloride results in increased expression of CDK4 mRNA CTD PMID:31919559 thimerosal decreases expression ISO RGD:732061 6480464 Thimerosal results in decreased expression of CDK4 protein CTD PMID:16649253 thioacetamide decreases expression ISO RGD:732061 6480464 Thioacetamide results in decreased expression of CDK4 mRNA CTD PMID:11793227 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of CDK4 mRNA CTD PMID:34492290 thioridazine decreases expression ISO RGD:732061 6480464 Thioridazine results in decreased expression of CDK4 protein CTD PMID:21035837 thymoquinone multiple interactions EXP 6480464 thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CDK4 protein] CTD PMID:24012840 tocopherol multiple interactions ISO RGD:732061 6480464 Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein CTD PMID:12504091 trans-pinosylvin decreases expression ISO RGD:732061 6480464 pinosylvin results in decreased expression of CDK4 protein CTD PMID:23333577 trichloroethene increases expression ISO RGD:732061 6480464 Trichloroethylene results in increased expression of CDK4 protein CTD PMID:34896440 trichostatin A decreases expression ISO RGD:732061 6480464 trichostatin A results in decreased expression of CDK4 mRNA CTD PMID:19606018 , PMID:23770000 trimellitic anhydride increases expression ISO RGD:732062 6480464 trimellitic anhydride results in increased expression of CDK4 mRNA CTD PMID:19042947 Triptolide increases expression ISO RGD:732062 6480464 triptolide results in increased expression of CDK4 protein CTD PMID:26990902 triptonide increases expression ISO RGD:732062 6480464 triptonide results in increased expression of CDK4 mRNA CTD PMID:33045310 troglitazone multiple interactions ISO RGD:732061 6480464 [N-(4-methoxybenzyl)-N'-(5-nitro-1 more ... CTD PMID:20540935 troglitazone decreases expression ISO RGD:732062 6480464 troglitazone results in decreased expression of CDK4 protein CTD PMID:15610522 troglitazone decreases expression ISO RGD:732061 6480464 troglitazone results in decreased expression of CDK4 mRNA, troglitazone results in decreased expression of CDK4 protein CTD PMID:19140230 , PMID:20540935 Tryptanthrine decreases expression ISO RGD:732061 6480464 tryptanthrine results in decreased expression of CDK4 protein CTD PMID:23500671 tubocurarine multiple interactions ISO RGD:732061 6480464 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 tungsten increases expression ISO RGD:732062 6480464 Tungsten results in increased expression of CDK4 mRNA CTD PMID:30912803 urea multiple interactions ISO RGD:732061 6480464 Urea analog results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:10403840 urethane increases expression ISO RGD:732062 6480464 Urethane results in increased expression of CDK4 mRNA, Urethane results in increased expression of CDK4 protein CTD PMID:12117781 urethane decreases expression ISO RGD:732061 6480464 Urethane results in decreased expression of CDK4 mRNA CTD PMID:28818685 ursolic acid decreases expression ISO RGD:732061 6480464 ursolic acid results in decreased expression of CDK4 protein CTD PMID:24802810 usnic acid decreases expression ISO RGD:732061 6480464 usnic acid results in decreased expression of CDK4 protein CTD PMID:27369375 valproic acid multiple interactions ISO RGD:732061 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CDK4 mRNA CTD PMID:17183730 valproic acid decreases expression ISO RGD:732061 6480464 Valproic Acid results in decreased expression of CDK4 mRNA CTD PMID:29154799 vemurafenib decreases expression ISO RGD:732061 6480464 vemurafenib results in decreased expression of CDK4 protein CTD PMID:27087167 vinyl carbamate decreases expression ISO RGD:732062 6480464 vinyl carbamate results in decreased expression of CDK4 mRNA CTD PMID:17849452 vitamin E increases expression ISO RGD:732061 6480464 Vitamin E results in increased expression of CDK4 mRNA CTD PMID:19244175 vorinostat decreases expression ISO RGD:732061 6480464 vorinostat results in decreased expression of CDK4 protein CTD PMID:19440035 vorinostat multiple interactions ISO RGD:732061 6480464 [17-(dimethylaminoethylamino)-17-demethoxygeldanamycin co-treated with vorinostat] results in decreased expression of CDK4 protein CTD PMID:19440035 wogonin decreases expression ISO RGD:732061 6480464 wogonin results in decreased expression of CDK4 protein CTD PMID:23872260 wogonin decreases expression EXP 6480464 wogonin results in decreased expression of CDK4 protein CTD PMID:23872260 Y-27632 decreases expression EXP 6480464 Y 27632 results in decreased expression of CDK4 mRNA CTD PMID:20578043 zidovudine multiple interactions ISO RGD:732061 6480464 [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA CTD PMID:20370541 zoledronic acid multiple interactions ISO RGD:732062 6480464 [zoledronic acid co-treated with Doxorubicin] results in decreased expression of CDK4 protein CTD PMID:19789217
