Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cdk4 (cyclin-dependent kinase 4) Rattus norvegicus
Analyze
Symbol: Cdk4
Name: cyclin-dependent kinase 4
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell size; response to hyperoxia; and response to testosterone. Localizes to the nucleus and perinuclear region of cytoplasm. Predicted to colocalize with the bicellular tight junction. Biomarker of pancreatic cancer; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma multiforme; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cell division protein kinase 4; LOC100362034; PSK-J3
Orthologs:
Homo sapiens (human) : CDK4 (cyclin dependent kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Cdk4 (cyclin-dependent kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk4 (cyclin dependent kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK4 (cyclin dependent kinase 4)
Canis lupus familiaris (dog) : CDK4 (cyclin dependent kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk4 (cyclin dependent kinase 4)
Sus scrofa (pig) : CDK4 (cyclin dependent kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0770,345,971 - 70,352,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0770,527,545 - 70,530,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1767,037,674 - 67,039,905 (+)NCBI
Celera760,029,956 - 60,032,798 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cdk4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621120
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.