Cdk4 (cyclin-dependent kinase 4) - Rat Genome Database

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Gene: Cdk4 (cyclin-dependent kinase 4) Rattus norvegicus
Symbol: Cdk4
Name: cyclin-dependent kinase 4
RGD ID: 621120
Description: Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to polyamine macromolecule; positive regulation of cell size; and response to testosterone. Located in perinuclear region of cytoplasm. Biomarker of hepatocellular carcinoma; pancreatic cancer; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division protein kinase 4; LOC100362034; PSK-J3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Ept7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8764,771,453 - 64,774,891 (+)NCBIGRCr8
mRatBN7.2762,886,124 - 62,889,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,883,105 - 62,942,403 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,775,434 - 64,778,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,977,836 - 66,981,274 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,778,880 - 66,782,325 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,345,971 - 70,352,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,349,863 - 70,352,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,527,545 - 70,530,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1767,037,674 - 67,039,905 (+)NCBI
Celera760,029,956 - 60,032,798 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,3-thiazolidine-2,4-dione  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-methoxy-17beta-estradiol  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
acridine-9(10H)-thione  (ISO)
acrylamide  (ISO)
Actein  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP,ISO)
albuterol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
aniline  (EXP)
Antrocin  (ISO)
antroquinonol  (ISO)
arecoline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
berberine  (ISO)
beta-ionone  (ISO)
bezafibrate  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
BMS-754807  (ISO)
brassinolide  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
butyric acid  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
canertinib  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
Cardanol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chalcones  (ISO)
cholesterol  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (EXP,ISO)
Cirsimarin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corticosterone  (EXP)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
daidzein  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
dexamethasone  (ISO)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
Didymin  (ISO)
dieckol  (ISO)
diethyl phthalate  (EXP)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydro-beta-erythroidine  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
Dinitramine  (ISO)
dinitrogen  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
enzyme inhibitor  (ISO)
erlotinib hydrochloride  (ISO)
esculetin  (EXP)
ethyl trans-caffeate  (ISO)
farrerol  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galangin  (ISO)
gamma-tocopherol  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
gingerol  (ISO)
glafenine  (EXP)
glutathione  (EXP)
glycitein  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
hesperetin  (ISO)
hesperidin  (ISO)
Hexamethonium  (ISO)
hydralazine  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (ISO)
indolin-2-one  (ISO)
indometacin  (ISO)
inulin  (ISO)
iodoacetic acid  (ISO)
Isoangustone A  (ISO)
isopimaric acid  (ISO)
isosilybin A  (ISO)
juglone  (ISO)
kaempferol  (EXP)
L-ascorbic acid  (EXP,ISO)
lead(0)  (ISO)
lidocaine  (ISO)
Liensinine  (ISO)
lovastatin  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
malachite green cation  (EXP)
melatonin  (ISO)
melittin  (ISO)
memantine  (ISO)
menadione  (ISO)
menaquinone  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin RR  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
orlistat  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(propylene imine) macromolecule  (ISO)
ponatinib  (ISO)
potassium iodide  (EXP)
proanthocyanidin  (EXP)
progesterone  (ISO)
propylparaben  (ISO)
pterostilbene  (EXP)
pyrazinecarboxamide  (EXP)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quizartinib  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Sanggenon C  (ISO)
SB 203580  (EXP)
selenium atom  (ISO)
selumetinib  (ISO)
silibinin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
sulindac  (EXP,ISO)
sunitinib  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
terephthalic acid  (EXP)
tetracaine  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thioridazine  (ISO)
thymoquinone  (EXP)
tocopherol  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
Tryptanthrine  (ISO)
tubocurarine  (ISO)
tungsten  (ISO)
urea  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinyl carbamate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wogonin  (EXP,ISO)
wortmannin  (ISO)
Y-27632  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
neoplasm  (IDA)

References - curated
# Reference Title Reference Citation
1. Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons. Alvira D, etal., Neuroscience. 2007 Apr 25;146(1):350-65. Epub 2007 Mar 7.
2. Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation. An HX, etal., Am J Pathol. 1999 Jan;154(1):113-8.
3. Concomitant deregulation of HIF1alpha and cell cycle proteins in VHL-mutated renal cell carcinomas. Atkins DJ, etal., Virchows Arch. 2005 Sep;447(3):634-42. Epub 2005 Jul 1.
4. The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma. Bahnassy AA, etal., J Egypt Natl Canc Inst. 2006 Dec;18(4):292-302.
5. Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Beauchamp RD, etal., Ann Surg. 1996 May;223(5):620-7; discussion 627-8.
6. [A rare type of bone involvement in scleroderma (author's transl)] Bem Z and Birecka A, Pol Przegl Radiol Med Nukl 1978 Mar-Apr;42(2):115-7.
7. Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri- and post-menopausal breast cancer. Bonin S, etal., Virchows Arch. 2006 May;448(5):539-44. Epub 2006 Jan 27.
8. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
9. Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix. Cheung TH, etal., Cancer Lett. 2001 May 26;166(2):199-206.
10. Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues. Cho FS, etal., Biochem Biophys Res Commun 1993 Mar 31;191(3):860-5.
11. Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma. Ciznadija D, etal., Cancer Res. 2011 Oct 1;71(19):6174-83. doi: 10.1158/0008-5472.CAN-11-1031. Epub 2011 Aug 15.
12. Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi. Cui L, etal., Urol Res. 2006 Oct;34(5):321-8. Epub 2006 Jul 29.
13. miR-124 radiosensitizes human glioma cells by targeting CDK4. Deng X, etal., J Neurooncol. 2013 Sep;114(3):263-74. doi: 10.1007/s11060-013-1179-2. Epub 2013 Jun 13.
14. Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor. Faussillon M, etal., Cancer Lett. 2005 Apr 18;221(1):67-75.
15. Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation. Gao CY, etal., Exp Eye Res 1999 Dec;69(6):695-703.
16. [Expression and roles of CDK4 and p21 in lung tissues of premature rats with hyperoxia-induced chronic lung disease.] Gao Y, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Dec;9(6):595-600.
17. [Retrospective study of one year of family therapy in a neurological practice (author's transl)] Gattringer B Nervenarzt 1977 Jun;48(6):326-30.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2. Gillam MP, etal., Oncogene. 2015 Feb 12;34(7):932-8. doi: 10.1038/onc.2014.3. Epub 2014 Feb 17.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Circadian regulation of diverse gene products revealed by mRNA expression profiling of synchronized fibroblasts. Grundschober C, etal., J Biol Chem 2001 Dec 14;276(50):46751-8.
22. Deregulation of anti-Mullerian hormone/BMP and transforming growth factor-beta pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice. Hussein N, etal., Endocr Relat Cancer. 2008 Mar;15(1):217-27.
23. Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma. Isohookana J, etal., Pathol Res Pract. 2018 Jun;214(6):840-847. doi: 10.1016/j.prp.2018.04.016. Epub 2018 May 1.
24. Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype. Keutgen XM, etal., Cancer. 2018 Feb 1;124(3):636-647. doi: 10.1002/cncr.31057. Epub 2017 Nov 17.
25. p27kip1 Antisense-induced proliferative activity of rat corneal endothelial cells. Kikuchi M, etal., Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1763-70.
26. Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies. Koivisto C, etal., Toxicol Pathol. 2012 Jul;40(5):751-63. doi: 10.1177/0192623312441407. Epub 2012 Apr 3.
27. RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer. Leake K, etal., PLoS One. 2012;7(4):e34582. doi: 10.1371/journal.pone.0034582. Epub 2012 Apr 3.
28. Involvement of cyclin D1/CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb(2+)-induced neuronal death in cultured hippocampal neurons. Li C, etal., Toxicol Appl Pharmacol. 2008 Jun 15;229(3):351-61. Epub 2008 Feb 16.
29. A study on p16, pRb, cdk4 and cyclinD1 expression in non-small cell lung cancers. Lingfei K, etal., Cancer Lett. 1998 Aug 14;130(1-2):93-101.
30. Protein signature for non-small cell lung cancer prognosis. Liu W, etal., Am J Cancer Res. 2014 May 26;4(3):256-69. eCollection 2014.
31. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
32. Synthetic lethal therapy for KRAS mutant non-small-cell lung carcinoma with nanoparticle-mediated CDK4 siRNA delivery. Mao CQ, etal., Mol Ther. 2014 May;22(5):964-73. doi: 10.1038/mt.2014.18. Epub 2014 Feb 5.
33. Growth suppression by p16ink4 requires functional retinoblastoma protein. Medema RH, etal., Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6289-93. doi: 10.1073/pnas.92.14.6289.
34. CDK4 IVS4-nt40G-->A and T2D-associated obesity in Italians. Meenakshisundaram R and Gragnoli C, J Cell Physiol. 2009 Nov;221(2):273-5.
35. CDK4 IVS4-nt40G-->A SNP and type 2 diabetes in Italians. Meenakshisundaram R, etal., Diabetes Res Clin Pract. 2009 Nov;86(2):e28-30. Epub 2009 Aug 19.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Transgenic expression of a mutated cyclin-dependent kinase 4 (CDK4/R24C) in pancreatic beta-cells prevents progression of diabetes in db/db mice. Miyawaki K, etal., Diabetes Res Clin Pract. 2008 Oct;82(1):33-41. Epub 2008 Aug 3.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. The Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 to Facilitate the Activation of Cdk4/6 and Early G1 Phase Progression. Obaya AJ, etal., J Biol Chem 2002 Aug 23;277(34):31263-9.
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Qiu C, etal., Cancer Res. 2003 Sep 15;63(18):5674-8.
44. Altered mRNA expression of the Rb and p16 tumor suppressor genes and of CDK4 in transitional cell carcinomas of the urinary bladder associated with tumor progression. Quentin T, etal., Anticancer Res. 2004 Mar-Apr;24(2B):1011-23.
45. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Rane SG, etal., Nat Genet. 1999 May;22(1):44-52.
46. Reactome: A Knowledgebase of Biological Processes Reactome
47. GOA pipeline RGD automated data pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control. Sadek K, etal., Iran J Pharm Res. 2020 Fall;19(4):372-386. doi: 10.22037/ijpr.2020.1101292.
51. Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. Schmidt BA, etal., Cancer Res. 2001 May 15;61(10):4214-21.
52. Expression of the cell-cycle regulatory proteins (pRb, cyclin D1, p16INK4A and cdk4) in human endometrial cancer: correlation with clinicopathological features. Semczuk A, etal., Arch Gynecol Obstet. 2004 Jan;269(2):104-10. Epub 2002 Nov 22.
53. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
54. Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Shukla S and Gupta S, Mol Cancer Ther. 2006 Apr;5(4):843-52.
55. Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer. Simon R, etal., Oncogene. 2002 Apr 11;21(16):2476-83.
56. Expression of cell cycle regulatory factors in differentiating osteoblasts: postproliferative up-regulation of cyclins B and E. Smith E, etal., Cancer Res. 1995 Nov 1;55(21):5019-24.
57. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
58. Significance of E2F-1 overexpression in epithelial ovarian cancer. Suh DS, etal., Int J Gynecol Cancer. 2008 May-Jun;18(3):492-8. Epub 2007 Aug 10.
59. Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy. Tamamori-Adachi M, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):274-80.
60. Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. Tang LH, etal., Clin Cancer Res. 2012 Sep 1;18(17):4612-20. doi: 10.1158/1078-0432.CCR-11-3264. Epub 2012 Jul 3.
61. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Wagner M, etal., Genes Dev. 2001 Feb 1;15(3):286-93.
62. CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes. Wierod L, etal., Cell Prolif. 2007 Aug;40(4):475-87.
63. Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines. Xiao L, etal., Mol Biol Cell. 2011 Sep;22(17):3055-69. doi: 10.1091/mbc.E11-01-0069. Epub 2011 Jul 7.
64. Cell Proliferation and Expression of Cell Cycle Regulatory Proteins that Control the G1/S Transition Are Age Dependent and Lobe Specific in the Brown Norway Rat Model of Prostatic Hyperplasia. Yan J and Brown TR, Endocrinology. 2008 Jan;149(1):193-207. Epub 2007 Oct 25.
65. Expression patterns of cytokine, growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis. Yang S, etal., World J Gastroenterol. 2006 Feb 21;12(7):1063-70.
66. Requirement for CDK4 kinase function in breast cancer. Yu Q, etal., Cancer Cell. 2006 Jan;9(1):23-32.
67. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Zheng S, etal., Genes Dev. 2013 Jul 1;27(13):1462-72. doi: 10.1101/gad.213686.113. Epub 2013 Jun 24.
Additional References at PubMed
PMID:7739547   PMID:8114739   PMID:8543804   PMID:8988060   PMID:9190208   PMID:10082561   PMID:11384971   PMID:12124778   PMID:12130539   PMID:12588994   PMID:12917627   PMID:12970171  
PMID:12970760   PMID:15489334   PMID:15645444   PMID:15958724   PMID:15975997   PMID:16109376   PMID:17253961   PMID:17420273   PMID:17556661   PMID:17996899   PMID:18291362   PMID:18700867  
PMID:18775106   PMID:18827403   PMID:19124461   PMID:19306950   PMID:19351720   PMID:19533683   PMID:20181929   PMID:20399237   PMID:20466002   PMID:21179739   PMID:21411630   PMID:21508411  
PMID:21628965   PMID:22258892   PMID:22322893   PMID:23109711   PMID:23827822   PMID:24244372   PMID:25241353   PMID:26657864   PMID:26975029   PMID:27894668   PMID:28983608   PMID:29024678  
PMID:30701428   PMID:32666227   PMID:33336721   PMID:37684532  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8764,771,453 - 64,774,891 (+)NCBIGRCr8
mRatBN7.2762,886,124 - 62,889,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,883,105 - 62,942,403 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,775,434 - 64,778,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,977,836 - 66,981,274 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,778,880 - 66,782,325 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,345,971 - 70,352,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,349,863 - 70,352,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,527,545 - 70,530,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1767,037,674 - 67,039,905 (+)NCBI
Celera760,029,956 - 60,032,798 (+)NCBICelera
Cytogenetic Map7q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381257,747,727 - 57,752,310 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,747,727 - 57,756,013 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,141,510 - 58,146,093 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,428,270 - 56,432,431 (-)NCBINCBI36Build 36hg18NCBI36
Build 341256,428,271 - 56,432,431NCBI
Celera1257,799,597 - 57,803,758 (-)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1255,178,350 - 55,183,070 (-)NCBIHuRef
CHM1_11258,109,315 - 58,114,035 (-)NCBICHM1_1
T2T-CHM13v2.01257,716,081 - 57,720,660 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910126,899,404 - 126,903,157 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10126,899,403 - 126,903,789 (+)EnsemblGRCm39 Ensembl
GRCm3810127,063,535 - 127,067,288 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,063,534 - 127,067,920 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,500,659 - 126,504,339 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,466,564 - 126,470,344 (+)NCBIMGSCv36mm8
Celera10129,456,113 - 129,459,793 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554585,453,732 - 5,460,718 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,457,927 - 5,460,718 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21036,588,715 - 36,592,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,585,486 - 36,589,570 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,174,446 - 31,178,597 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,434,594 - 31,438,876 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,434,594 - 31,438,876 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1101,812,864 - 1,815,815 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,812,886 - 1,815,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,875,926 - 1,878,880 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,822,137 - 1,825,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,822,136 - 1,825,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,799,847 - 1,802,800 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0102,041,940 - 2,044,865 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0102,166,806 - 2,169,759 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494556,980,973 - 56,983,964 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366461,886,262 - 1,889,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl523,038,891 - 23,042,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,039,206 - 23,041,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11153,661,877 - 53,665,688 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,659,336 - 53,664,861 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,295,806 - 192,300,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480210,191,014 - 10,194,275 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,191,679 - 10,194,585 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cdk4
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:151
Interacting mature miRNAs:165
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2762,886,920 - 62,887,122 (+)MAPPERmRatBN7.2
Rnor_6.0770,350,048 - 70,350,249NCBIRnor6.0
Rnor_5.0770,527,750 - 70,527,951UniSTSRnor5.0
Celera760,030,157 - 60,030,358UniSTS
Cytogenetic Map7q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 2 2 22 10 9
Medium 3 43 55 39 19 39 8 11 52 25 32 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000031796   ⟹   ENSRNOP00000034754
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,886,150 - 62,889,544 (+)Ensembl
Rnor_6.0 Ensembl770,349,863 - 70,352,418 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096017   ⟹   ENSRNOP00000092678
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,883,308 - 62,889,547 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097940   ⟹   ENSRNOP00000087160
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,883,105 - 62,889,544 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102408   ⟹   ENSRNOP00000079772
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,886,086 - 62,942,403 (+)Ensembl
RefSeq Acc Id: NM_001402395   ⟹   NP_001389324
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8764,771,453 - 64,774,891 (+)NCBI
mRatBN7.2762,886,124 - 62,889,562 (+)NCBI
RefSeq Acc Id: NM_053593   ⟹   NP_446045
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8764,771,453 - 64,774,891 (+)NCBI
mRatBN7.2762,886,124 - 62,889,562 (+)NCBI
Rnor_6.0770,345,971 - 70,352,689 (+)NCBI
Rnor_5.0770,527,545 - 70,530,391 (+)NCBI
Celera760,029,956 - 60,032,798 (+)RGD
RefSeq Acc Id: NP_446045   ⟸   NM_053593
- Peptide Label: isoform 1
- UniProtKB: P35426 (UniProtKB/Swiss-Prot),   A6HQS0 (UniProtKB/TrEMBL),   A0A8L2QI74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034754   ⟸   ENSRNOT00000031796
RefSeq Acc Id: ENSRNOP00000092678   ⟸   ENSRNOT00000096017
RefSeq Acc Id: ENSRNOP00000087160   ⟸   ENSRNOT00000097940
RefSeq Acc Id: ENSRNOP00000079772   ⟸   ENSRNOT00000102408
RefSeq Acc Id: NP_001389324   ⟸   NM_001402395
- Peptide Label: isoform 2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35426-F1-model_v2 AlphaFold P35426 1-303 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621120 AgrOrtholog
BioCyc Gene G2FUF-33776 BioCyc
Ensembl Genes ENSRNOG00000025602 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031796 ENTREZGENE
  ENSRNOT00000031796.5 UniProtKB/TrEMBL
  ENSRNOT00000096017.1 UniProtKB/TrEMBL
  ENSRNOT00000097940.1 UniProtKB/TrEMBL
  ENSRNOT00000102408.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94201 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk4 PhenoGen
RatGTEx ENSRNOG00000025602 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Cdk4  cyclin-dependent kinase 4  LOC100362034  cyclin-dependent kinase 4  Data merged from RGD:2318946 737654 PROVISIONAL
2010-05-05 LOC100362034  cyclin-dependent kinase 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cdk4  cyclin-dependent kinase 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cdk4  cyclin-dependent kinase 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may mediate hypertrophic growth of cardiomyocytes in cardiac hypertrophy 704385
gene_physical_interaction interacts with Ccnd3 70761
gene_process plays a key role in the G1/S transition in cell cycle 70761