Cdk4 (cyclin-dependent kinase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cdk4 (cyclin-dependent kinase 4) Rattus norvegicus
Analyze
Symbol: Cdk4
Name: cyclin-dependent kinase 4
RGD ID: 621120
Description: Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to polyamine macromolecule; positive regulation of cell size; and response to hyperoxia. Located in nucleus and perinuclear region of cytoplasm. Biomarker of hepatocellular carcinoma; pancreatic cancer; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division protein kinase 4; LOC100362034; PSK-J3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Ept7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,771,453 - 64,774,891 (+)NCBIGRCr8
mRatBN7.2762,886,124 - 62,889,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,883,105 - 62,942,403 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,775,434 - 64,778,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,977,836 - 66,981,274 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,778,880 - 66,782,325 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,345,971 - 70,352,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,349,863 - 70,352,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,527,545 - 70,530,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1767,037,674 - 67,039,905 (+)NCBI
Celera760,029,956 - 60,032,798 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 40 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Ratbreast cancer disease_progressionISOCDK4 (Homo sapiens)2293576 RGD 
Cdk4Ratbreast carcinoma  ISOCDK4 (Homo sapiens)2293583DNA:amplificationRGD 
Cdk4Ratcervix uteri carcinoma in situ disease_progressionISOCDK4 (Homo sapiens)2293574associated with Papillomavirus Infections and protein:increased expression:cervix epitheliumRGD 
Cdk4RatEndometrial Neoplasms disease_progressionISOCDK4 (Homo sapiens)2299055protein:increased expression:endometriumRGD 
Cdk4RatExperimental Liver Cirrhosis  IEP 2289284 RGD 
Cdk4RatExperimental Mammary Neoplasms  IEP 2293581protein:increased expression:mammary glandRGD 
Cdk4RatExperimental Mammary Neoplasms susceptibilityISOCdk4 (Mus musculus)2293577 RGD 
Cdk4RatGerm Cell and Embryonal Neoplasms  ISOCDK4 (Homo sapiens)2296041protein:increased expression:testisRGD 
Cdk4Ratglioblastoma  ISOCDK4 (Homo sapiens)13702089DNA:amplicationRGD 
Cdk4Rathepatocellular carcinoma treatmentIEP 152998960 RGD 
Cdk4Rathigh grade glioma  ISOCdk4 (Mus musculus)13702091 RGD 
Cdk4Rathigh grade glioma disease_progressionISOCDK4 (Homo sapiens)13702090 RGD 
Cdk4RatHyperoxia  IEP 2289663mRNA:increased expression:lungRGD 
Cdk4Ratislet cell tumor  ISOCDK4 (Homo sapiens)13452384protein:increased expression:pancreas and islet of Langerhans (human)RGD 
Cdk4RatLeydig cell tumor  ISOCdk4 (Mus musculus)2293582associated with Multiple Endocrine Neoplasia Type 1 and protein:increased expression:testesRGD 
Cdk4Ratlung adenocarcinoma  ISOCDK4 (Homo sapiens)13464277protein:increased expression:lungRGD 
Cdk4Ratlung non-small cell carcinoma treatmentISOCDK4 (Homo sapiens)13464276 RGD 
Cdk4Ratlung non-small cell carcinoma disease_progressionISOCDK4 (Homo sapiens)13464275 RGD 
Cdk4Ratlung squamous cell carcinoma  ISOCDK4 (Homo sapiens)13464277protein:increased expression:lungRGD 
Cdk4Ratnephroblastoma disease_progressionISOCDK4 (Homo sapiens)2289153 RGD 
1 to 20 of 40 rows
1 to 20 of 29 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Ratcataract 15 multiple types  ISOCDK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 15 multiple typesClinVarPMID:28492532
Cdk4RatCharcot-Marie-Tooth disease axonal type 2U  ISOCDK4 (Homo sapiens)8554872ClinVar Annotator: match by term: CHARCOT-MARIE-TOOTH DISEASE more ...ClinVarPMID:28492532
Cdk4Ratdiffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  ISOCDK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Diffuse pediatric-type high-grade glioma and H3-wildtype and IDH-wildtypeClinVarPMID:25741868 and PMID:28492532
Cdk4RatEwing sarcoma  ISOCDK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Ewing sarcomaClinVarPMID:24755471 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4RatHereditary Neoplastic Syndromes  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4RatHereditary Neoplastic Syndromes  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4RatHereditary Neoplastic Syndromes  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4RatHereditary Neoplastic Syndromes  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
Cdk4RatHereditary Neoplastic Syndromes  ISOCDK4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10398427 more ...
1 to 20 of 29 rows
1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4RatAnimal Mammary Neoplasms  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:14522882
Cdk4RatBrain Neoplasms  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20932960
Cdk4RatBrain Stem Neoplasms  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24098593
Cdk4Ratcarcinoma  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:14522882
Cdk4RatExperimental Mammary Neoplasms  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 more ...
Cdk4RatExperimental Neoplasms  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20932960
Cdk4Rathead and neck squamous cell carcinoma  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29464035
Cdk4Rathepatocellular carcinoma  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26189965
Cdk4Ratliposarcoma  ISOCDK4 (Homo sapiens)11554173CTD more ...CTDPMID:20601955 and PMID:23569312
Cdk4Ratskin melanoma  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cdk4RatStomach Neoplasms  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21628965
Cdk4RatTriple Negative Breast Neoplasms  ISOCDK4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33727089
1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Rattype 1 diabetes mellitus  ISSCdk4 (Mus musculus)13592920OMIM:222100MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Ratfamilial melanoma  ISOCDK4 (Homo sapiens)7240710 OMIM 

1 to 20 of 496 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Rat(-)-epigallocatechin 3-gallate decreases expressionISOCDK4 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of CDK4 proteinCTDPMID:15142168
Cdk4Rat(1->4)-beta-D-glucan multiple interactionsISOCdk4 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CDK4 mRNACTDPMID:36331819
Cdk4Rat(20R)-protopanaxadiol increases expressionISOCDK4 (Homo sapiens)6480464protopanaxadiol results in increased expression of CDK4 mRNA and protopanaxadiol results in increased expression of CDK4 proteinCTDPMID:31805304
Cdk4Rat(S)-naringenin multiple interactionsISOCDK4 (Homo sapiens)6480464[naringenin co-treated with bisphenol A] results in increased expression of CDK4 mRNACTDPMID:36235125
Cdk4Rat(S)-nicotine decreases expressionISOCDK4 (Homo sapiens)6480464Nicotine results in decreased expression of CDK4 proteinCTDPMID:15231866
Cdk4Rat(S)-nicotine decreases expressionISOCdk4 (Mus musculus)6480464Nicotine results in decreased expression of CDK4 mRNA and Nicotine results in decreased expression of CDK4 proteinCTDPMID:17135361
Cdk4Rat(S)-nicotine multiple interactionsISOCDK4 (Homo sapiens)6480464Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] more ...CTDPMID:15231866 and PMID:18805435
Cdk4Rat(Z)-3-butylidenephthalide decreases expressionEXP 6480464butylidenephthalide results in decreased expression of CDK4 proteinCTDPMID:16987298
Cdk4Rat(Z)-3-butylidenephthalide decreases expressionISOCDK4 (Homo sapiens)6480464butylidenephthalide results in decreased expression of CDK4 proteinCTDPMID:16987298
Cdk4Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expressionISOCdk4 (Mus musculus)64804642 more ...CTDPMID:15525693
Cdk4Rat1,2-dichloroethane increases expressionISOCdk4 (Mus musculus)6480464ethylene dichloride results in increased expression of CDK4 mRNACTDPMID:28960355
Cdk4Rat1,2-dimethylhydrazine multiple interactionsISOCdk4 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of CDK4 mRNACTDPMID:22206623
Cdk4Rat1,2-dimethylhydrazine increases expressionISOCdk4 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of CDK4 mRNACTDPMID:22206623
Cdk4Rat1,3-dinitrobenzene increases expressionEXP 64804643-dinitrobenzene results in increased expression of CDK4 mRNACTDPMID:22841810
Cdk4Rat1,3-thiazolidine-2,4-dione decreases expressionISOCDK4 (Homo sapiens)64804642 and 4-thiazolidinedione results in decreased expression of CDK4 proteinCTDPMID:15916743
Cdk4Rat1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea multiple interactionsISOCDK4 (Homo sapiens)6480464[N-(4-methoxybenzyl)-N'-(5-nitro-1 and 3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CDK4 protein]CTDPMID:20540935
Cdk4Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of CDK4 mRNACTDPMID:16174780
Cdk4Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of CDK4 mRNACTDPMID:12655037 more ...
Cdk4Rat17beta-estradiol multiple interactionsISOCDK4 (Homo sapiens)6480464[Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK4 protein more ...CTDPMID:19361625 more ...
Cdk4Rat17beta-estradiol multiple interactionsISOCdk4 (Mus musculus)6480464Estradiol inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CDK4 mRNA] and Estradiol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA]CTDPMID:19874833

1 to 20 of 496 rows

Biological Process
1 to 20 of 34 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Ratanimal organ regeneration  IEP 2289284 RGD 
Cdk4Ratcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Cdk4Ratcellular response to interleukin-4 acts_upstream_of_or_withinISOCdk4 (Mus musculus)1624291 PMID:8543804RGDPMID:8543804
Cdk4Ratcellular response to ionomycin acts_upstream_of_or_withinISOCdk4 (Mus musculus)1624291 PMID:8543804RGDPMID:8543804
Cdk4Ratcellular response to lipopolysaccharide acts_upstream_of_or_withinISOCdk4 (Mus musculus)1624291 PMID:8543804RGDPMID:8543804
Cdk4Ratcellular response to phorbol 13-acetate 12-myristate acts_upstream_of_or_withinISOCdk4 (Mus musculus)1624291 PMID:8543804RGDPMID:8543804
Cdk4Ratcellular response to polyamine macromolecule  IEP 151893503 RGD 
Cdk4Ratcircadian rhythm  IEP 70761 RGD 
Cdk4RatG1/S transition of mitotic cell cycle involved_inIBACGD:CAL0000191263 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdk4RatG1/S transition of mitotic cell cycle involved_inISOCDK4 (Homo sapiens)1624291 PMID:19237565 and PMID:7603984RGDPMID:19237565 and PMID:7603984
Cdk4RatG1/S transition of mitotic cell cycle involved_inNAS 151356636PMID:7603984ComplexPortal 
Cdk4Ratlens development in camera-type eye  IEP 724665 RGD 
Cdk4Ratpositive regulation of apoptotic process  IMP 2293585 RGD 
Cdk4Ratpositive regulation of cell population proliferation  IMP 1642396 RGD 
Cdk4Ratpositive regulation of cell population proliferation involved_inISOCDK4 (Homo sapiens)1624291 PMID:7603984RGDPMID:7603984
Cdk4Ratpositive regulation of cell size  IMP 704385 RGD 
Cdk4Ratpositive regulation of epithelial cell proliferation  IMP 151893503 RGD 
Cdk4Ratpositive regulation of fibroblast proliferation involved_inISOCDK4 (Homo sapiens)1624291 PMID:17420273RGDPMID:17420273
Cdk4Ratpositive regulation of G2/M transition of mitotic cell cycle involved_inISOCDK4 (Homo sapiens)1624291 PMID:19124461RGDPMID:19124461
Cdk4Ratpositive regulation of G2/M transition of mitotic cell cycle involved_inISSUniProtKB:P118021600115GO_REF:0000024UniProtGO_REF:0000024
1 to 20 of 34 rows

Cellular Component
1 to 20 of 35 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Ratbicellular tight junction located_inISOCdk4 (Mus musculus)1624291 PMID:21411630RGDPMID:21411630
Cdk4Ratchromatin located_inISOCDK4 (Homo sapiens)1624291 PMID:18827403RGDPMID:18827403
Cdk4Ratcyclin D1-CDK4 complex part_ofISOCdk4 (Mus musculus)1624291 PMID:17948060RGDPMID:17948060
Cdk4Ratcyclin D1-CDK4 complex part_ofISOCDK4 (Homo sapiens)1624291 PMID:19237565RGDPMID:19237565
Cdk4Ratcyclin D1-CDK4 complex part_ofISOComplexPortal:CPX-20101600115GO_REF:0000114ComplexPortalGO_REF:0000114
Cdk4Ratcyclin D2-CDK4 complex part_ofISOComplexPortal:CPX-20111600115GO_REF:0000114ComplexPortalGO_REF:0000114
Cdk4Ratcyclin D2-CDK4 complex part_ofISOCdk4 (Mus musculus)1624291 PMID:7739547 and PMID:8543804RGDPMID:7739547 and PMID:8543804
Cdk4Ratcyclin D2-CDK4 complex part_ofISOCDK4 (Homo sapiens)1624291 PMID:11896535RGDPMID:11896535
Cdk4Ratcyclin D3-CDK4 complex part_ofISOCDK4 (Homo sapiens)1624291 PMID:19237555RGDPMID:19237555
Cdk4Ratcyclin-dependent protein kinase holoenzyme complex part_ofISOCDK4 (Homo sapiens)1624291 PMID:17420273 and PMID:18827403RGDPMID:17420273 and PMID:18827403
Cdk4Ratcyclin-dependent protein kinase holoenzyme complex part_ofISOCdk4 (Mus musculus)1624291PR:P17918 more ...RGDPMID:12970760
Cdk4Ratcyclin-dependent protein kinase holoenzyme complex part_ofIBAMGI:104772 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdk4Ratcytoplasm  IDA 2293585 RGD 
Cdk4Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cdk4Ratcytoplasm is_active_inIBAPANTHER:PTN000623979 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdk4Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cdk4Ratcytoplasm located_inISOCDK4 (Sus scrofa)1624291 PMID:23827822RGDPMID:23827822
Cdk4Ratcytosol located_inISOCDK4 (Homo sapiens) and UniProtKB:P11802-11624291 RGDGO_REF:0000052
Cdk4Ratcytosol located_inISOCDK4 (Homo sapiens)1624291 PMID:18827403RGDPMID:18827403
Cdk4Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
1 to 20 of 35 rows

Molecular Function
1 to 20 of 28 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Cdk4RatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Cdk4RatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Cdk4RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Cdk4Ratcyclin binding  IPICcnd3 (Rattus norvegicus)1582338 RGD 
Cdk4Ratcyclin binding enablesIBAFB:FBgn0016131 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdk4Ratcyclin binding enablesISOCdk4 (Mus musculus)1624291PR:P30282 PMID:23109711RGDPMID:23109711
Cdk4Ratcyclin binding enablesISOCDK4 (Homo sapiens)1624291UniProtKB:P24385 and PMID:19124461RGDPMID:19124461
Cdk4Ratcyclin binding  IPICcnd1 (Rattus norvegicus)1582338 RGD 
Cdk4Ratcyclin binding  IPICcnd2 (Rattus norvegicus)1582338 RGD 
Cdk4Ratcyclin-dependent protein serine/threonine kinase activity  IDA 704385 RGD 
Cdk4Ratcyclin-dependent protein serine/threonine kinase activity enablesIEAEC:2.7.11.221600115GO_REF:0000003UniProtGO_REF:0000003
Cdk4Ratcyclin-dependent protein serine/threonine kinase activity enablesISOCdk4 (Mus musculus)1624291 PMID:12970171 and PMID:12970760RGDPMID:12970171 and PMID:12970760
Cdk4Ratcyclin-dependent protein serine/threonine kinase activity enablesIBACGD:CAL0000191263 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdk4Ratcyclin-dependent protein serine/threonine kinase activity enablesISOCDK4 (Homo sapiens)1624291 PMID:19237565 and PMID:8114739RGDPMID:19237565 and PMID:8114739
Cdk4Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Cdk4Ratkinase activity enablesISOCdk4 (Mus musculus)1624291 PMID:12124778RGDPMID:12124778
Cdk4Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Cdk4Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Cdk4Ratprotein binding enablesISOCdk4 (Mus musculus)1624291PR:P39689 more ...RGDPMID:12124778 more ...
1 to 20 of 28 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4RatG1 phase pathway  IEA 1358139 RGD 
Cdk4RatG1/S transition pathway  ISOCDK4 (Homo sapiens)8694143 RGD 
Cdk4RatG1/S transition pathway  ISOCDK4 (Homo sapiens)8694150 RGD 
Cdk4RatS phase pathway  IEA 1358139 RGD 

Imported Annotations - KEGG (archival)

1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Ratcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
Cdk4Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Cdk4Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Cdk4Ratglioma pathway  IEA 6907045 KEGGrno:05214
Cdk4Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Cdk4Ratmelanoma pathway  IEA 6907045 KEGGrno:05218
Cdk4Ratnon-small cell lung carcinoma pathway   IEA 6907045 KEGGrno:05223
Cdk4Ratp53 signaling pathway   IEA 6907045 KEGGrno:04115
Cdk4Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Cdk4Ratsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222
Cdk4RatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660
Cdk4Raturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219
1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdk4Ratneoplasm  IDA 625485 RGD 

1 to 20 of 67 rows
#
Reference Title
Reference Citation
1. Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons. Alvira D, etal., Neuroscience. 2007 Apr 25;146(1):350-65. Epub 2007 Mar 7.
2. Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation. An HX, etal., Am J Pathol. 1999 Jan;154(1):113-8.
3. Concomitant deregulation of HIF1alpha and cell cycle proteins in VHL-mutated renal cell carcinomas. Atkins DJ, etal., Virchows Arch. 2005 Sep;447(3):634-42. Epub 2005 Jul 1.
4. The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma. Bahnassy AA, etal., J Egypt Natl Canc Inst. 2006 Dec;18(4):292-302.
5. Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Beauchamp RD, etal., Ann Surg. 1996 May;223(5):620-7; discussion 627-8.
6. [A rare type of bone involvement in scleroderma (author's transl)] Bem Z and Birecka A, Pol Przegl Radiol Med Nukl 1978 Mar-Apr;42(2):115-7.
7. Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri- and post-menopausal breast cancer. Bonin S, etal., Virchows Arch. 2006 May;448(5):539-44. Epub 2006 Jan 27.
8. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
9. Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix. Cheung TH, etal., Cancer Lett. 2001 May 26;166(2):199-206.
10. Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues. Cho FS, etal., Biochem Biophys Res Commun 1993 Mar 31;191(3):860-5.
11. Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma. Ciznadija D, etal., Cancer Res. 2011 Oct 1;71(19):6174-83. doi: 10.1158/0008-5472.CAN-11-1031. Epub 2011 Aug 15.
12. Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi. Cui L, etal., Urol Res. 2006 Oct;34(5):321-8. Epub 2006 Jul 29.
13. miR-124 radiosensitizes human glioma cells by targeting CDK4. Deng X, etal., J Neurooncol. 2013 Sep;114(3):263-74. doi: 10.1007/s11060-013-1179-2. Epub 2013 Jun 13.
14. Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor. Faussillon M, etal., Cancer Lett. 2005 Apr 18;221(1):67-75.
15. Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation. Gao CY, etal., Exp Eye Res 1999 Dec;69(6):695-703.
16. [Expression and roles of CDK4 and p21 in lung tissues of premature rats with hyperoxia-induced chronic lung disease.] Gao Y, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Dec;9(6):595-600.
17. [Retrospective study of one year of family therapy in a neurological practice (author's transl)] Gattringer B Nervenarzt 1977 Jun;48(6):326-30.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2. Gillam MP, etal., Oncogene. 2015 Feb 12;34(7):932-8. doi: 10.1038/onc.2014.3. Epub 2014 Feb 17.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
1 to 20 of 67 rows
PMID:7739547   PMID:8114739   PMID:8543804   PMID:8988060   PMID:9190208   PMID:10082561   PMID:11384971   PMID:12124778   PMID:12130539   PMID:12588994   PMID:12917627   PMID:12970171  
PMID:12970760   PMID:15489334   PMID:15645444   PMID:15958724   PMID:15975997   PMID:16109376   PMID:17253961   PMID:17420273   PMID:17556661   PMID:17996899   PMID:18291362   PMID:18700867  
PMID:18775106   PMID:18827403   PMID:19124461   PMID:19306950   PMID:19351720   PMID:19533683   PMID:20181929   PMID:20399237   PMID:20466002   PMID:21179739   PMID:21411630   PMID:21508411  
PMID:21628965   PMID:22258892   PMID:22322893   PMID:23109711   PMID:23827822   PMID:24244372   PMID:25241353   PMID:26975029   PMID:27894668   PMID:28983608   PMID:29024678   PMID:30701428  
PMID:32666227   PMID:33336721   PMID:37684532  



Cdk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,771,453 - 64,774,891 (+)NCBIGRCr8
mRatBN7.2762,886,124 - 62,889,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,883,105 - 62,942,403 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,775,434 - 64,778,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,977,836 - 66,981,274 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,778,880 - 66,782,325 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,345,971 - 70,352,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,349,863 - 70,352,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,527,545 - 70,530,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1767,037,674 - 67,039,905 (+)NCBI
Celera760,029,956 - 60,032,798 (+)NCBICelera
Cytogenetic Map7q22NCBI
CDK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,747,727 - 57,752,310 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,747,727 - 57,756,013 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,141,510 - 58,146,093 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,428,270 - 56,432,431 (-)NCBINCBI36Build 36hg18NCBI36
Build 341256,428,271 - 56,432,431NCBI
Celera1257,799,597 - 57,803,758 (-)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1255,178,350 - 55,183,070 (-)NCBIHuRef
CHM1_11258,109,315 - 58,114,035 (-)NCBICHM1_1
T2T-CHM13v2.01257,716,081 - 57,720,660 (-)NCBIT2T-CHM13v2.0
Cdk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,899,404 - 126,903,157 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10126,899,403 - 126,903,789 (+)EnsemblGRCm39 Ensembl
GRCm3810127,063,535 - 127,067,288 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,063,534 - 127,067,920 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,500,659 - 126,504,339 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,466,564 - 126,470,344 (+)NCBIMGSCv36mm8
Celera10129,456,113 - 129,459,793 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Cdk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,453,732 - 5,460,718 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,457,927 - 5,460,718 (-)NCBIChiLan1.0ChiLan1.0
CDK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,588,715 - 36,592,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,585,486 - 36,589,570 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,174,446 - 31,178,597 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,434,594 - 31,438,876 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,434,594 - 31,438,876 (+)Ensemblpanpan1.1panPan2
CDK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,812,864 - 1,815,815 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,812,886 - 1,815,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,875,926 - 1,878,880 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,822,137 - 1,825,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,822,136 - 1,825,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,799,847 - 1,802,800 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0102,041,940 - 2,044,865 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0102,166,806 - 2,169,759 (-)NCBIUU_Cfam_GSD_1.0
Cdk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494556,980,973 - 56,983,964 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366461,886,262 - 1,889,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,038,891 - 23,042,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,039,206 - 23,041,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,661,877 - 53,665,688 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,659,336 - 53,664,861 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,295,806 - 192,300,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,191,014 - 10,194,275 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,191,679 - 10,194,585 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Cdk4
16 total Variants

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:151
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000031796
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

1 to 10 of 36 rows
PMC212738P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8764,772,249 - 64,772,451 (+)Marker Load Pipeline
mRatBN7.2762,886,920 - 62,887,122 (+)MAPPERmRatBN7.2
Rnor_6.0770,350,048 - 70,350,249NCBIRnor6.0
Rnor_5.0770,527,750 - 70,527,951UniSTSRnor5.0
Celera760,030,157 - 60,030,358UniSTS
Cytogenetic Map7q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000031796   ⟹   ENSRNOP00000034754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,886,150 - 62,889,544 (+)Ensembl
Rnor_6.0 Ensembl770,349,863 - 70,352,418 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096017   ⟹   ENSRNOP00000092678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,883,308 - 62,889,547 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097940   ⟹   ENSRNOP00000087160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,883,105 - 62,889,544 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102408   ⟹   ENSRNOP00000079772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,886,086 - 62,942,403 (+)Ensembl
RefSeq Acc Id: NM_001402395   ⟹   NP_001389324
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8764,771,453 - 64,774,891 (+)NCBI
mRatBN7.2762,886,124 - 62,889,562 (+)NCBI
RefSeq Acc Id: NM_053593   ⟹   NP_446045
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8764,771,453 - 64,774,891 (+)NCBI
mRatBN7.2762,886,124 - 62,889,562 (+)NCBI
Rnor_6.0770,345,971 - 70,352,689 (+)NCBI
Rnor_5.0770,527,545 - 70,530,391 (+)NCBI
Celera760,029,956 - 60,032,798 (+)RGD
Sequence:
Protein RefSeqs NP_001389324 (Get FASTA)   NCBI Sequence Viewer  
  NP_446045 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40903 (Get FASTA)   NCBI Sequence Viewer  
  AAB68843 (Get FASTA)   NCBI Sequence Viewer  
  AAH70956 (Get FASTA)   NCBI Sequence Viewer  
  EDM16502 (Get FASTA)   NCBI Sequence Viewer  
  P35426 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446045   ⟸   NM_053593
- Peptide Label: isoform 1
- UniProtKB: P35426 (UniProtKB/Swiss-Prot),   A6HQS0 (UniProtKB/TrEMBL),   A0A8L2QI74 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034754   ⟸   ENSRNOT00000031796
Ensembl Acc Id: ENSRNOP00000092678   ⟸   ENSRNOT00000096017
Ensembl Acc Id: ENSRNOP00000087160   ⟸   ENSRNOT00000097940
Ensembl Acc Id: ENSRNOP00000079772   ⟸   ENSRNOT00000102408
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P35426-F1-model_v2 AlphaFold P35426 1-303 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33776 BioCyc
Ensembl Genes ENSRNOG00000025602 Ensembl
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921199 IMAGE-MGC_LOAD
  IMAGE:7104124 IMAGE-MGC_LOAD
InterPro CDK UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:94201 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72728 IMAGE-MGC_LOAD
  MGC:91543 IMAGE-MGC_LOAD
NCBI Gene 94201 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot
  CYCLIN-DEPENDENT KINASE 4 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Cdk4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025602 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZNF8_RAT UniProtKB/TrEMBL
  A0A8I6A6S0_RAT UniProtKB/TrEMBL
  A0A8I6AI03_RAT UniProtKB/TrEMBL
  A0A8L2QI74 ENTREZGENE, UniProtKB/TrEMBL
  A6HQS0 ENTREZGENE, UniProtKB/TrEMBL
  CDK4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q71VC8_RAT UniProtKB/TrEMBL
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Cdk4  cyclin-dependent kinase 4  LOC100362034  cyclin-dependent kinase 4  Data merged from RGD:2318946 737654 PROVISIONAL
2010-05-05 LOC100362034  cyclin-dependent kinase 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cdk4  cyclin-dependent kinase 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cdk4  cyclin-dependent kinase 4      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_disease may mediate hypertrophic growth of cardiomyocytes in cardiac hypertrophy 704385
gene_physical_interaction interacts with Ccnd3 70761
gene_process plays a key role in the G1/S transition in cell cycle 70761