RGD Reference Report - Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix. - Rat Genome Database

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Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix.

Authors: Cheung, TH  Yu, MM  Lo, KW  Yim, SF  Chung, TK  Wong, YF 
Citation: Cheung TH, etal., Cancer Lett. 2001 May 26;166(2):199-206.
RGD ID: 2299057
Pubmed: PMID:11311493   (View Abstract at PubMed)

Amplification and overexpression of cyclin D1 and CDK4 genes in cervical carcinoma were studied by semi-quantitative differential polymerase chain reaction assay and an immunostaining technique, respectively. Amplifications of cyclin D1 and CDK4 genes were found in 24% (27/113) and 26% (29/112) of tumors, respectively. Overexpression of cyclin D1 and CDK4 was demonstrated in 32% (21/66) and 73% (45/62) of tumors, respectively. No tumor showed CDK4 gene mutation on single strand conformational polymorphism. Sixteen percent (8/49) of the tumor specimens showed neither amplification nor overexpression. Disease stage, tumor grade and overexpression of cyclin D1 were found to be independent poor prognostic factors in cervical carcinoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Uterine Cervical Neoplasms  IDA 2299057DNA:amplificationRGD 
Uterine Cervical Neoplasms  ISOCDK4 (Homo sapiens)2299057; 2299057DNA:amplificationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdk4  (cyclin-dependent kinase 4)

Genes (Mus musculus)
Cdk4  (cyclin dependent kinase 4)

Genes (Homo sapiens)
CDK4  (cyclin dependent kinase 4)


Additional Information