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Gene: CDK4 (cyclin dependent kinase 4) Homo sapiens
Symbol: CDK4
Name: cyclin dependent kinase 4
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of cell cycle; and positive regulation of fibroblast proliferation. Localizes to several cellular components, including the chromatin; cyclin-dependent protein kinase holoenzyme complex; and nucleus. Implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma multiforme; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including breast cancer; carcinoma (multiple); cervix uteri carcinoma in situ; nephroblastoma; and pancreatic cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell division kinase 4; cell division protein kinase 4; CMM3; cyclin-dependent kinase 4; melanoma cutaneous malignant, 3; MGC14458; PSK-J3
Mus musculus (house mouse) : Cdk4 (cyclin-dependent kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdk4 (cyclin-dependent kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk4 (cyclin dependent kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK4 (cyclin dependent kinase 4)
Canis lupus familiaris (dog) : CDK4 (cyclin dependent kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk4 (cyclin dependent kinase 4)
Sus scrofa (pig) : CDK4 (cyclin dependent kinase 4)
Chlorocebus sabaeus (green monkey) : CDK4 (cyclin dependent kinase 4)
Heterocephalus glaber (naked mole-rat) : Cdk4 (cyclin dependent kinase 4)
more info ...
Related Pseudogenes: CDK4P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1257,747,727 - 57,756,013 (-)Ensembl
GRCh381257,747,727 - 57,752,310 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371258,141,510 - 58,146,304 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,428,270 - 56,432,431 (-)NCBINCBI36hg18NCBI36
Build 341256,428,271 - 56,432,431NCBI
Celera1257,799,597 - 57,803,758 (-)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,178,350 - 55,183,070 (-)NCBIHuRef
CHM1_11258,109,315 - 58,114,035 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

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