Ccnd1 (cyclin D1) - Rat Genome Database

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Gene: Ccnd1 (cyclin D1) Rattus norvegicus
Symbol: Ccnd1
Name: cyclin D1
RGD ID: 68384
Description: Enables protein kinase binding activity. Involved in several processes, including animal organ development; response to corticosterone; and response to vitamin E. Located in cytoplasm and nucleus. Used to study prostate cancer and status epilepticus. Biomarker of impotence; transitional cell carcinoma; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1); PARTICIPATES IN E-cadherin signaling pathway; G1/S transition pathway; Notch signaling pathway; INTERACTS WITH (R)-adrenaline; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G1/S-specific cyclin-D1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21200,089,002 - 200,098,524 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1200,089,002 - 200,098,602 (-)Ensembl
Rnor_6.01218,090,750 - 218,100,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,090,750 - 218,100,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,960,136 - 224,969,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,357,235 - 205,366,757 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,510,735 - 205,520,201 (-)NCBI
Celera1197,647,068 - 197,656,590 (-)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Bowen's Disease  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Burns  (IEP)
carcinoma  (ISO)
Cecal Neoplasms  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chronic Hepatitis C  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (IEP,ISO)
Experimental Neoplasms  (ISO)
Genomic Instability  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hyperparathyroidism  (ISO)
Hyperplasia  (ISO)
impotence  (IEP)
intellectual disability  (ISO)
Intestinal Polyps  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Neoplasms  (ISO)
leukemia  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (IEP,ISO)
mantle cell lymphoma  (ISO)
medulloblastoma  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
non-Hodgkin lymphoma  (ISO)
ovarian carcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
pancreatic solid pseudopapillary carcinoma  (ISO)
papilloma  (ISO)
penile benign neoplasm  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (IMP)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
Salivary Gland Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (IDA)
Stomach Neoplasms  (ISO)
thyroid gland papillary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (IEP,ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
visual epilepsy  (IEP)
von Hippel-Lindau disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1,4-dithiothreitol  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-Dihydroxybenzophenone  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxy-17beta-estradiol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyidazoxan  (EXP)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-bromoindirubin-3'-oxime  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9,10-anthraquinone  (ISO)
acetaldehyde  (EXP)
acetamide  (EXP)
acetone  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP,ISO)
Actein  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (ISO)
Aeroplysinin 1  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allose  (ISO)
alpha-Zearalanol  (ISO)
alternariol  (ISO)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
andrographolide  (ISO)
androstane  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene  (ISO)
antroquinonol  (ISO)
arecoline  (EXP,ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asiatic acid  (EXP)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
bacitracin  (EXP)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzamides  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
benzophenanthridine  (ISO)
Berbamine  (ISO)
berberine  (ISO)
Besigomsin  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP)
betulinic acid  (ISO)
bexarotene  (EXP,ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BMS-754807  (ISO)
boric acid  (ISO)
boron atom  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
brassinolide  (ISO)
brazilein  (ISO)
brilliant green  (ISO)
bromobenzene  (EXP)
bromodichloromethane  (EXP)
bucladesine  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calyculin a  (ISO)
camostat  (ISO)
camptothecin  (ISO)
canertinib  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (ISO)