Ccnd1 (cyclin D1) - Rat Genome Database

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Gene: Ccnd1 (cyclin D1) Rattus norvegicus
Analyze
Symbol: Ccnd1
Name: cyclin D1
RGD ID: 68384
Description: Enables protein kinase binding activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and response to vitamin E. Predicted to be located in bicellular tight junction and nucleoplasm. Predicted to be part of cyclin D1-CDK4 complex; cyclin D1-CDK6 complex; and transcription repressor complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Used to study prostate cancer and status epilepticus. Biomarker of atherosclerosis; impotence; interstitial cystitis; liver cancer; and transitional cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1); PARTICIPATES IN E-cadherin signaling pathway; G1/S transition pathway; Notch signaling pathway; INTERACTS WITH (R)-adrenaline; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G1/S-specific cyclin-D1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,518,288 - 209,527,986 (-)NCBIGRCr8
mRatBN7.21200,089,002 - 200,098,524 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,089,002 - 200,098,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,470,197 - 208,479,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,556,434 - 215,565,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,230,641 - 208,240,163 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,090,750 - 218,100,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,090,750 - 218,100,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,960,136 - 224,969,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,357,235 - 205,366,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,510,735 - 205,520,201 (-)NCBI
Celera1197,647,068 - 197,656,590 (-)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 74 rows

  
Object Symbol
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Source
Original Reference(s)
Ccnd1Ratacute lymphoblastic leukemia  ISOCCND1 (Homo sapiens)11352824mRNA:increased expression:bone marrow (human)RGD 
Ccnd1Ratacute myeloid leukemia  ISOCCND1 (Homo sapiens)11352824mRNA:increased expression:bone marrow (human)RGD 
Ccnd1Ratacute myeloid leukemia treatmentISOCCND1 (Homo sapiens)11353789human tumor in a mouse modelRGD 
Ccnd1Ratatherosclerosis  IEP 329849122associated with type 2 diabetes mellitus more ...RGD 
Ccnd1RatB-lymphoblastic leukemia/lymphoma  ISOCcnd1 (Mus musculus)11353783mRNA:increased expression:B cell (mouse)RGD 
Ccnd1RatBreast Neoplasms susceptibilityISOCCND1 (Homo sapiens)2289126DNA:polymorphismRGD 
Ccnd1RatBreast Neoplasms disease_progressionISOCCND1 (Homo sapiens)2289131protein:increased expression:breastRGD 
Ccnd1Ratbronchiolo-alveolar adenocarcinoma  ISOCCND1 (Homo sapiens)13434930protein:increased expression:lungRGD 
Ccnd1RatBurns  IEP 2289134 RGD 
Ccnd1Ratcervix uteri carcinoma in situ  ISOCCND1 (Homo sapiens)2293574protein:increased expression:uterine cervixRGD 
Ccnd1RatChronic Hepatitis C  ISOCCND1 (Homo sapiens)32716380mRNA:increased expression:CD19+Bcell:RGD 
Ccnd1Ratcolon adenoma severityISOCCND1 (Homo sapiens)151665121 RGD 
Ccnd1Ratductal carcinoma in situ  ISOCCND1 (Homo sapiens)2289132protein:decreased expression:breastRGD 
Ccnd1RatEndometrial Neoplasms  ISOCCND1 (Homo sapiens)2296034protein:increased expression:endometriumRGD 
Ccnd1RatExperimental Liver Neoplasms  IEP 2289139 RGD 
Ccnd1RatExperimental Mammary Neoplasms  IEP 2289336protein:decreased expression:mammary glandRGD 
Ccnd1RatExperimental Mammary Neoplasms  IEP 2306898mRNA:increased expression:mammary gland (rat)RGD 
Ccnd1RatExperimental Mammary Neoplasms  IEP 2292404mRNA and protein:increased expression:mammary gland (rat)RGD 
Ccnd1RatExperimental Mammary Neoplasms  IEP 2289337 RGD 
Ccnd1RatExperimental Mammary Neoplasms  ISOCcnd1 (Mus musculus)2296037 RGD 
1 to 20 of 74 rows
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Original Reference(s)
Ccnd1RatAicardi-Goutieres Syndrome 3  ISOCCND1 (Homo sapiens)8554872ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 3ClinVarPMID:28492532
Ccnd1Ratcolorectal cancer  ISOCCND1 (Homo sapiens)8554872ClinVar Annotator: match by term: Colorectal cancer and susceptibility toClinVarPMID:10667569 more ...
Ccnd1Ratimmunodeficiency 90  ISOCCND1 (Homo sapiens)8554872ClinVar Annotator: match by term: Infections more ...ClinVarPMID:28492532
Ccnd1Ratintellectual disability  ISOCCND1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Ccnd1Ratlong QT syndrome  ISOCCND1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital long QT syndromeClinVar 
Ccnd1Ratmultiple myeloma  ISOCCND1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10667569 more ...
Ccnd1Ratvon Hippel-Lindau disease  ISOCCND1 (Homo sapiens)8554872ClinVar Annotator: match by term: VON HIPPEL-LINDAU SYNDROME and MODIFIER OFClinVarPMID:10667569 more ...
1 to 20 of 44 rows
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Original Reference(s)
Ccnd1Ratadenocarcinoma  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26432044
Ccnd1Ratadenoid cystic carcinoma  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16762588
Ccnd1Ratangiosarcoma  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17569031
Ccnd1RatAnimal Mammary Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 more ...
Ccnd1RatBowen's Disease  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29103775
Ccnd1RatBrain Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20932960 and PMID:27935819
Ccnd1RatBreast Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12839951 more ...
Ccnd1Ratcarcinoma  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 more ...
Ccnd1RatCecal Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14688030
Ccnd1RatColonic Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18283038 more ...
Ccnd1RatColorectal Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ccnd1RatDisease Progression  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29103775
Ccnd1RatEndometrial Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29232554
Ccnd1RatEsophageal Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12235107
Ccnd1Ratesophagus squamous cell carcinoma  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25151357
Ccnd1RatExperimental Liver Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28100771
Ccnd1RatExperimental Mammary Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 more ...
Ccnd1RatExperimental Neoplasms  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20932960
Ccnd1RatGenomic Instability  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8548770
Ccnd1Rathead and neck squamous cell carcinoma  ISOCCND1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26909611 and PMID:29464035
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Original Reference(s)
Ccnd1Ratcolorectal cancer susceptibilityISOCCND1 (Homo sapiens)7240710 OMIM 
Ccnd1Ratmultiple myeloma susceptibilityISOCCND1 (Homo sapiens)7240710 OMIM 
Ccnd1Ratvon Hippel-Lindau disease susceptibilityISOCCND1 (Homo sapiens)7240710 OMIM 

1 to 20 of 1620 rows

  
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Original Reference(s)
Ccnd1Rat(+)-catechin decreases expressionISOCCND1 (Homo sapiens)6480464Catechin analog results in decreased expression of CCND1 proteinCTDPMID:16413414
Ccnd1Rat(+)-schisandrin B decreases expressionISOCCND1 (Homo sapiens)6480464schizandrin B results in decreased expression of CCND1 mRNACTDPMID:18161920
Ccnd1Rat(+)-Tetrandrine decreases expressionISOCCND1 (Homo sapiens)6480464tetrandrine results in decreased expression of CCND1 proteinCTDPMID:30123091 and PMID:31255635
Ccnd1Rat(+)-Tetrandrine affects expressionISOCCND1 (Homo sapiens)6480464tetrandrine affects the expression of CCND1 proteinCTDPMID:30123091
Ccnd1Rat(+)-Tetrandrine multiple interactionsISOCCND1 (Homo sapiens)6480464[sodium arsenite co-treated with tetrandrine] affects the expression of CCND1 protein and [sodium arsenite co-treated with tetrandrine] results in decreased expression of CCND1 proteinCTDPMID:30123091
Ccnd1Rat(-)-Arctigenin decreases expressionISOCCND1 (Homo sapiens)6480464arctigenin results in decreased expression of CCND1 mRNA and arctigenin results in decreased expression of CCND1 proteinCTDPMID:20510325
Ccnd1Rat(-)-cotinine increases expressionISOCCND1 (Homo sapiens)6480464Cotinine results in increased expression of CCND1 proteinCTDPMID:31678612
Ccnd1Rat(-)-epigallocatechin 3-gallate decreases expressionISOCCND1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of CCND1 proteinCTDPMID:15142168 and PMID:32512070
Ccnd1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCcnd1 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]CTDPMID:27058323
Ccnd1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCCND1 (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]CTDPMID:24508477
Ccnd1Rat(20R)-protopanaxadiol increases expressionISOCCND1 (Homo sapiens)6480464protopanaxadiol results in increased expression of CCND1 mRNACTDPMID:31805304
Ccnd1Rat(20S)-ginsenoside Rh2 decreases expressionISOCCND1 (Homo sapiens)6480464ginsenoside Rh2 results in decreased expression of CCND1 proteinCTDPMID:26482938
Ccnd1Rat(R)-adrenaline increases expressionEXP 6480464Epinephrine results in increased expression of CCND1 mRNA and Epinephrine results in increased expression of CCND1 proteinCTDPMID:17680988 and PMID:26964897
Ccnd1Rat(R)-adrenaline multiple interactionsISOCCND1 (Homo sapiens)6480464ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein] more ...CTDPMID:17680988
Ccnd1Rat(R)-adrenaline multiple interactionsEXP 64804642-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Epinephrine results in increased expression of CCND1 protein] more ...CTDPMID:17680988 and PMID:26964897
Ccnd1Rat(R)-lipoic acid multiple interactionsISOCCND1 (Homo sapiens)6480464Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]CTDPMID:21600978
Ccnd1Rat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]CTDPMID:26332274
Ccnd1Rat(S)-colchicine increases expressionISOCcnd1 (Mus musculus)6480464Colchicine results in increased expression of CCND1 proteinCTDPMID:16495211
Ccnd1Rat(S)-colchicine increases expressionEXP 6480464Colchicine results in increased expression of CCND1 mRNACTDPMID:18255150
Ccnd1Rat(S)-naringenin multiple interactionsISOCCND1 (Homo sapiens)6480464[Tamoxifen co-treated with naringenin] results in decreased expression of CCND1 mRNACTDPMID:30153467

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Biological Process
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Object Symbol
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Original Reference(s)
Ccnd1Ratanimal organ regeneration  IEP 2289142 RGD 
Ccnd1Ratcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Ccnd1Ratcell population proliferation acts_upstream_of_or_withinIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcell population proliferation acts_upstream_of_or_withinISOCcnd1 (Mus musculus)1624291MGI:1857280 PMID:26876175RGDPMID:26876175
Ccnd1RatDNA damage response involved_inISOCCND1 (Homo sapiens)1624291 PMID:19412162RGDPMID:19412162
Ccnd1RatDNA damage response involved_inIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1RatDNA damage response involved_inISSUniProtKB:P243851600115GO_REF:0000024UniProtGO_REF:0000024
Ccnd1Ratendoplasmic reticulum unfolded protein response acts_upstream_of_or_withinIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratendoplasmic reticulum unfolded protein response acts_upstream_of_or_withinISOCcnd1 (Mus musculus)1624291 PMID:16176978RGDPMID:16176978
Ccnd1Ratfat cell differentiation acts_upstream_of_or_withinIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratfat cell differentiation acts_upstream_of_or_withinISOCcnd1 (Mus musculus)1624291 PMID:12502791RGDPMID:12502791
Ccnd1RatG1/S transition of mitotic cell cycle involved_inISSUniProtKB:P243851600115GO_REF:0000024UniProtGO_REF:0000024
Ccnd1RatG1/S transition of mitotic cell cycle acts_upstream_of_or_withinIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1RatG1/S transition of mitotic cell cycle involved_inIBACGD:CAL0000185532 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccnd1RatG1/S transition of mitotic cell cycle acts_upstream_of_or_withinISOCcnd1 (Mus musculus)1624291 PMID:16176978RGDPMID:16176978
Ccnd1RatG1/S transition of mitotic cell cycle involved_inNAS 151356636PMID:7603984ComplexPortal 
Ccnd1RatG1/S transition of mitotic cell cycle involved_inISOCCND1 (Homo sapiens)1624291 PMID:19412162 more ...RGDPMID:19412162 more ...
Ccnd1RatG1/S transition of mitotic cell cycle involved_inIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratlactation acts_upstream_of_or_withinIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratlactation acts_upstream_of_or_withinISOCcnd1 (Mus musculus)1624291MGI:2180640 more ...RGDPMID:10419681 and PMID:11747812
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Cellular Component
1 to 20 of 39 rows

  
Object Symbol
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Original Reference(s)
Ccnd1Ratbicellular tight junction located_inIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratbicellular tight junction located_inISOCcnd1 (Mus musculus)1624291 PMID:21411630RGDPMID:21411630
Ccnd1Ratcyclin D1-CDK4 complex part_ofISOComplexPortal:CPX-20101600115GO_REF:0000114ComplexPortalGO_REF:0000114
Ccnd1Ratcyclin D1-CDK4 complex part_ofISOCcnd1 (Mus musculus)1624291 PMID:17948060RGDPMID:17948060
Ccnd1Ratcyclin D1-CDK4 complex part_ofIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcyclin D1-CDK4 complex part_ofIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcyclin D1-CDK4 complex part_ofISOCCND1 (Homo sapiens)1624291 PMID:19237565RGDPMID:19237565
Ccnd1Ratcyclin D1-CDK6 complex part_ofISOCCND1 (Homo sapiens)1624291 PMID:15232106RGDPMID:15232106
Ccnd1Ratcyclin D1-CDK6 complex part_ofIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcyclin-dependent protein kinase holoenzyme complex part_ofISSUniProtKB:P243851600115GO_REF:0000024UniProtGO_REF:0000024
Ccnd1Ratcyclin-dependent protein kinase holoenzyme complex part_ofISOCcnd1 (Mus musculus)1624291PR:P30285 more ...RGDPMID:12970760 and PMID:19767775
Ccnd1Ratcyclin-dependent protein kinase holoenzyme complex part_ofIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcyclin-dependent protein kinase holoenzyme complex part_ofIBAMGI:108042 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccnd1Ratcyclin-dependent protein kinase holoenzyme complex part_ofIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcyclin-dependent protein kinase holoenzyme complex part_ofISOCCND1 (Homo sapiens)1624291 PMID:17420273 and PMID:8114739RGDPMID:17420273 and PMID:8114739
Ccnd1Ratcytoplasm located_inIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcytoplasm located_inISOCCND1 (Homo sapiens)1624291 PMID:29279382RGDPMID:29279382
Ccnd1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Ccnd1Ratcytoplasm located_inISOCcnd1 (Mus musculus)1624291 PMID:19531352 and PMID:21911473RGDPMID:19531352 and PMID:21911473
Ccnd1Ratcytoplasm located_inIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Ccnd1Ratcyclin-dependent protein serine/threonine kinase activator activity enablesIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcyclin-dependent protein serine/threonine kinase activator activity enablesISOCCND1 (Homo sapiens)1624291 PMID:19237565RGDPMID:19237565
Ccnd1Ratcyclin-dependent protein serine/threonine kinase regulator activity enablesIBACGD:CAL0000175354 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccnd1Ratcyclin-dependent protein serine/threonine kinase regulator activity enablesIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratcyclin-dependent protein serine/threonine kinase regulator activity enablesISOCcnd1 (Mus musculus)1624291 PMID:12502791RGDPMID:12502791
Ccnd1Ratenzyme binding enablesISOCCND1 (Homo sapiens)1624291UniProtKB:O75604 and PMID:19412162RGDPMID:19412162
Ccnd1Ratenzyme binding enablesIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Rathistone deacetylase binding enablesISOCCND1 (Homo sapiens)1624291UniProtKB:O15379 and PMID:18417529RGDPMID:18417529
Ccnd1Rathistone deacetylase binding enablesIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratkinase activity enablesISOCcnd1 (Mus musculus)1624291 PMID:12124778RGDPMID:12124778
Ccnd1Ratkinase activity enablesIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratproline-rich region binding enablesIEAUniProtKB:P24385 and ensembl:ENSP000002275071600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratproline-rich region binding enablesISOCCND1 (Homo sapiens)1624291 PMID:19124461RGDPMID:19124461
Ccnd1Ratprotein binding enablesISOCCND1 (Homo sapiens)1624291UniProtKB:O15379 more ...RGDPMID:15232106 more ...
Ccnd1Ratprotein binding enablesISOCcnd1 (Mus musculus)1624291MGI:1351650 more ...RGDPMID:11980909 more ...
Ccnd1Ratprotein kinase activity enablesIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratprotein kinase activity enablesISOCcnd1 (Mus musculus)1624291 PMID:12588994RGDPMID:12588994
Ccnd1Ratprotein kinase binding  IPICdk4 (Rattus norvegicus)1582338 RGD 
Ccnd1Ratprotein kinase binding enablesIEAUniProtKB:P25322 and ensembl:ENSMUSP000000914951600115GO_REF:0000107EnsemblGO_REF:0000107
Ccnd1Ratprotein kinase binding enablesISOCcnd1 (Mus musculus)1624291UniProtKB:P30285 and PMID:19767775RGDPMID:19767775
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RGD Manual Annotations


  
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Original Reference(s)
Ccnd1RatG1 phase pathway  IEA 1358139 RGD 
Ccnd1RatG1/S transition pathway  ISOCCND1 (Homo sapiens)8694143 RGD 
Ccnd1RatS phase pathway  IEA 1358139 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Ccnd1Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
Ccnd1Ratcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
Ccnd1Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Ccnd1Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Ccnd1Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Ccnd1Ratendometrial cancer pathway   IEA 6907045 KEGGrno:05213
Ccnd1Ratglioma pathway  IEA 6907045 KEGGrno:05214
Ccnd1RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Ccnd1Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Ccnd1Ratmelanoma pathway  IEA 6907045 KEGGrno:05218
Ccnd1Ratmyocarditis pathway  IEA 6907045 KEGGrno:05416
Ccnd1Ratnon-small cell lung carcinoma pathway   IEA 6907045 KEGGrno:05223
Ccnd1Ratp53 signaling pathway   IEA 6907045 KEGGrno:04115
Ccnd1Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Ccnd1Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215
Ccnd1Ratsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222
Ccnd1Ratthyroid cancer pathway  IEA 6907045 KEGGrno:05216
Ccnd1Raturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219
Ccnd1RatWnt signaling pathway  IEA 6907045 KEGGrno:04310
1 to 19 of 19 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccnd1RatE-cadherin signaling pathway  ISOCCND1 (Homo sapiens)6484113 PIDPID:200124
Ccnd1RatNotch signaling pathway   ISOCCND1 (Homo sapiens)6484113 PIDPID:200015
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccnd1Ratabnormal liver regeneration  IDA 704417 RGD 
Ccnd1Ratincreased cell proliferation  IDA 704417 RGD 

1 to 20 of 117 rows
#
Reference Title
Reference Citation
1. Cyclin D1 (CCND1) messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle cell lymphoma. Bacher U, etal., Exp Hematol. 2013 Dec;41(12):1028-37. doi: 10.1016/j.exphem.2013.09.004. Epub 2013 Sep 20.
2. Cyclin D1 is a strong prognostic factor for survival in pancreatic cancer: analysis of CD G870A polymorphism, FISH and immunohistochemistry. Bachmann K, etal., J Surg Oncol. 2015 Mar;111(3):316-23. doi: 10.1002/jso.23826. Epub 2014 Dec 2.
3. The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma. Bahnassy AA, etal., J Egypt Natl Canc Inst. 2006 Dec;18(4):292-302.
4. Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. Bartkova J, etal., Gastroenterology. 2001 Jun;120(7):1680-8. doi: 10.1053/gast.2001.24880.
5. Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Beauchamp RD, etal., Ann Surg. 1996 May;223(5):620-7; discussion 627-8.
6. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Bergsagel PL, etal., Blood. 2005 Jul 1;106(1):296-303. Epub 2005 Mar 8.
7. Calcium modulates the cyclin D1 expression in a rat parathyroid cell line. Bianchi S, etal., Biochem Biophys Res Commun 1994 Oct 28;204(2):691-700.
8. Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia. Biankin AV, etal., Cancer Res. 2001 Dec 15;61(24):8830-7.
9. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
10. Chronic iron overload stimulates hepatocyte proliferation and cyclin D1 expression in rodent liver. Brown KE, etal., Transl Res. 2006 Aug;148(2):55-62.
11. Effects of ischemic preconditioning on cyclinD1 expression during early ischemic reperfusion in rats. Cai FG, etal., World J Gastroenterol. 2006 May 14;12(18):2936-40.
12. Oncogenic virus-associated neoplasia: a role for cyclin D1 genotypes influencing the age of onset of disease? Catarino R, etal., Biochem Biophys Res Commun. 2008 May 23;370(1):118-22. Epub 2008 Mar 18.
13. Differential expressions of cyclin D1 associated with better prognosis of cancers of ampulla of Vater. Chang MC, etal., World J Surg. 2007 May;31(5):1135-41. doi: 10.1007/s00268-006-0032-6.
14. CCND1 G870A polymorphism with altered cyclin D1 transcripts expression is associated with the risk of glioma in a Chinese population. Chen X, etal., DNA Cell Biol. 2012 Jun;31(6):1107-13. doi: 10.1089/dna.2011.1521. Epub 2012 Feb 3.
15. Expression of cyclin D1 in endometrial hyperplasia and endometrial carcinoma. Choudhury M and Bansal S, Indian J Pathol Microbiol. 2007 Oct;50(4):708-10.
16. Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors. Christov K, etal., Breast Cancer Res Treat. 2003 Feb;77(3):253-64.
17. Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma. Ciznadija D, etal., Cancer Res. 2011 Oct 1;71(19):6174-83. doi: 10.1158/0008-5472.CAN-11-1031. Epub 2011 Aug 15.
18. Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi. Cui L, etal., Urol Res. 2006 Oct;34(5):321-8. Epub 2006 Jul 29.
19. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dai XF and Chen DF, Zhonghua Gan Zang Bing Za Zhi. 2006 Aug;14(8):597-601.
20. Expression of cell cycle proteins in blood vessels of angiotensin II-infused rats: role of AT(1) receptors. Diep QN, etal., Hypertension 2001 Feb;37(2 Part 2):604-8.
1 to 20 of 117 rows
1 to 10 of 10 rows
PMID:8114739   PMID:8889548   PMID:8988060   PMID:9190208   PMID:9236224   PMID:10419681   PMID:11747812   PMID:11793365   PMID:11809706   PMID:12048199   PMID:12124778   PMID:12373555  
PMID:12502791   PMID:12588994   PMID:12970760   PMID:15277517   PMID:15314168   PMID:15548426   PMID:15844214   PMID:15958724   PMID:16176978   PMID:16412096   PMID:16489008   PMID:16569215  
PMID:17149750   PMID:17344214   PMID:17420273   PMID:17431217   PMID:17508424   PMID:17556661   PMID:17855062   PMID:18278459   PMID:18291362   PMID:18417529   PMID:18438935   PMID:18483258  
PMID:18604197   PMID:18664382   PMID:18700867   PMID:18929742   PMID:19029821   PMID:19056892   PMID:19060913   PMID:19080278   PMID:19124461   PMID:19412162   PMID:19531352   PMID:19640308  
PMID:19767775   PMID:19847806   PMID:19885954   PMID:19909792   PMID:20037604   PMID:20075866   PMID:20227424   PMID:20235220   PMID:20399237   PMID:20501390   PMID:20924203   PMID:21092636  
PMID:21179739   PMID:21411630   PMID:21465534   PMID:21468580   PMID:21628965   PMID:21693435   PMID:21736902   PMID:21911473   PMID:21928352   PMID:21982980   PMID:22322893   PMID:22354185  
PMID:22374674   PMID:22566696   PMID:22678010   PMID:22833568   PMID:22893700   PMID:23447091   PMID:23466459   PMID:23740243   PMID:23782291   PMID:23869758   PMID:23948595   PMID:24001804  
PMID:24577313   PMID:24914206   PMID:24936138   PMID:25047835   PMID:25093615   PMID:25175461   PMID:25479410   PMID:25535395   PMID:26135564   PMID:26188547   PMID:26846850   PMID:26975029  
PMID:27322082   PMID:27333946   PMID:27443256   PMID:27521891   PMID:28983608   PMID:29215736   PMID:29328502   PMID:29351283   PMID:30207314   PMID:30551879   PMID:31034519   PMID:31549850  
PMID:32584130   PMID:32714078   PMID:33314748   PMID:33811247   PMID:34309628   PMID:37684532  
1 to 10 of 10 rows



Ccnd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,518,288 - 209,527,986 (-)NCBIGRCr8
mRatBN7.21200,089,002 - 200,098,524 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,089,002 - 200,098,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,470,197 - 208,479,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,556,434 - 215,565,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,230,641 - 208,240,163 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,090,750 - 218,100,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,090,750 - 218,100,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,960,136 - 224,969,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,357,235 - 205,366,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,510,735 - 205,520,201 (-)NCBI
Celera1197,647,068 - 197,656,590 (-)NCBICelera
Cytogenetic Map1q42NCBI
CCND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,641,156 - 69,654,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,641,156 - 69,654,474 (+)EnsemblGRCh38hg38GRCh38
GRCh371169,455,924 - 69,469,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,165,054 - 69,178,423 (+)NCBINCBI36Build 36hg18NCBI36
Build 341169,165,053 - 69,178,422NCBI
Celera1166,752,901 - 66,766,272 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,748,357 - 65,761,725 (+)NCBIHuRef
CHM1_11169,338,874 - 69,352,243 (+)NCBICHM1_1
T2T-CHM13v2.01169,658,031 - 69,671,351 (+)NCBIT2T-CHM13v2.0
Ccnd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,483,668 - 144,493,568 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,483,668 - 144,493,662 (-)EnsemblGRCm39 Ensembl
GRCm387144,929,931 - 144,939,831 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,929,931 - 144,939,925 (-)EnsemblGRCm38mm10GRCm38
MGSCv377152,115,836 - 152,125,830 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,739,321 - 144,749,220 (-)NCBIMGSCv36mm8
Celera7144,694,932 - 144,704,928 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.92NCBI
Ccnd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,448,770 - 16,463,300 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,449,921 - 16,462,676 (-)NCBIChiLan1.0ChiLan1.0
CCND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2970,605,973 - 70,620,190 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,649,950 - 71,663,325 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,737,006 - 64,750,353 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,029,134 - 68,041,553 (+)NCBIpanpan1.1PanPan1.1panPan2
CCND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,501,905 - 48,509,684 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,501,899 - 48,516,005 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,111,842 - 47,121,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,179,073 - 49,188,648 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,178,951 - 49,189,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,625,670 - 48,635,233 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,211,983 - 48,221,555 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,958,012 - 48,967,584 (-)NCBIUU_Cfam_GSD_1.0
Ccnd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,527,409 - 4,541,987 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599973,838 - 983,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
CCND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,621,246 - 3,633,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,621,242 - 3,633,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,342,276 - 2,348,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCND1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,909,616 - 4,922,272 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14,907,353 - 4,922,357 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,182,953 - 102,196,194 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccnd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,469,622 - 17,483,191 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,470,310 - 17,483,082 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ccnd1
43 total Variants

Predicted Target Of
Summary Value
Count of predictions:595
Count of miRNA genes:254
Interacting mature miRNAs:355
Transcripts:ENSRNOT00000028411
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 92 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat

1 to 10 of 92 rows
D1Wox59  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,091,550 - 200,091,697 (+)MAPPERmRatBN7.2
Rnor_6.01218,093,299 - 218,093,445NCBIRnor6.0
Rnor_5.01224,962,685 - 224,962,831UniSTSRnor5.0
RGSC_v3.41205,359,784 - 205,359,930UniSTSRGSC3.4
Celera1197,649,617 - 197,649,763UniSTS
Cytogenetic Map1q42UniSTS
RH134541  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,089,149 - 200,089,350 (+)MAPPERmRatBN7.2
Rnor_6.01218,090,898 - 218,091,098NCBIRnor6.0
Rnor_5.01224,960,284 - 224,960,484UniSTSRnor5.0
RGSC_v3.41205,357,383 - 205,357,583UniSTSRGSC3.4
Celera1197,647,216 - 197,647,416UniSTS
RH 3.4 Map11561.3UniSTS
Cytogenetic Map1q42UniSTS
BI280117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,090,348 - 200,090,568 (+)MAPPERmRatBN7.2
Rnor_6.01218,092,097 - 218,092,316NCBIRnor6.0
Rnor_5.01224,961,483 - 224,961,702UniSTSRnor5.0
RGSC_v3.41205,358,582 - 205,358,801UniSTSRGSC3.4
Celera1197,648,415 - 197,648,634UniSTS
RH 3.4 Map11562.61UniSTS
Cytogenetic Map1q42UniSTS
RH133876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,091,759 - 200,091,939 (+)MAPPERmRatBN7.2
Rnor_6.01218,093,508 - 218,093,687NCBIRnor6.0
Rnor_5.01224,962,894 - 224,963,073UniSTSRnor5.0
RGSC_v3.41205,359,993 - 205,360,172UniSTSRGSC3.4
Celera1197,649,826 - 197,650,005UniSTS
RH 3.4 Map11560.6UniSTS
Cytogenetic Map1q42UniSTS
UniSTS:465472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,090,353 - 200,090,861 (+)MAPPERmRatBN7.2
Rnor_6.01218,092,102 - 218,092,609NCBIRnor6.0
Rnor_5.01224,961,488 - 224,961,995UniSTSRnor5.0
RGSC_v3.41205,358,587 - 205,359,094UniSTSRGSC3.4
Celera1197,648,420 - 197,648,927UniSTS
Cytogenetic Map1q42UniSTS
PMC321442P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81209,525,305 - 209,526,050 (+)Marker Load Pipeline
mRatBN7.21200,096,019 - 200,096,764 (+)MAPPERmRatBN7.2
Rnor_6.01218,097,768 - 218,098,512NCBIRnor6.0
Rnor_5.01224,967,154 - 224,967,898UniSTSRnor5.0
RGSC_v3.41205,364,253 - 205,364,997UniSTSRGSC3.4
Celera1197,654,086 - 197,654,830UniSTS
Cytogenetic Map1q42UniSTS
PMC98458P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81209,527,486 - 209,527,685 (+)Marker Load Pipeline
mRatBN7.21200,098,199 - 200,098,399 (+)MAPPERmRatBN7.2
Rnor_6.01218,099,948 - 218,100,147NCBIRnor6.0
Rnor_5.01224,969,334 - 224,969,533UniSTSRnor5.0
RGSC_v3.41205,366,433 - 205,366,632UniSTSRGSC3.4
Celera1197,656,266 - 197,656,465UniSTS
Cytogenetic Map1q42UniSTS
Ccnd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,091,848 - 200,093,446 (+)MAPPERmRatBN7.2
Rnor_6.01218,093,597 - 218,095,194NCBIRnor6.0
Rnor_5.01224,962,983 - 224,964,580UniSTSRnor5.0
RGSC_v3.41205,360,082 - 205,361,679UniSTSRGSC3.4
Celera1197,649,915 - 197,651,512UniSTS
Cytogenetic Map1q42UniSTS
Ccnd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,096,780 - 200,098,354 (+)MAPPERmRatBN7.2
Rnor_6.01218,098,529 - 218,100,102NCBIRnor6.0
Rnor_5.01224,967,915 - 224,969,488UniSTSRnor5.0
Celera1197,654,847 - 197,656,420UniSTS
Cytogenetic Map1q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_171992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB042564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB256048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC095937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF148946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM258963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA510842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB326145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV775485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000028411   ⟹   ENSRNOP00000028411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1200,089,007 - 200,098,602 (-)Ensembl
Rnor_6.0 Ensembl1218,090,750 - 218,100,272 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088588   ⟹   ENSRNOP00000075372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1200,089,031 - 200,098,534 (-)Ensembl
Rnor_6.0 Ensembl1218,091,496 - 218,100,325 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108193   ⟹   ENSRNOP00000083271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1200,089,002 - 200,098,598 (-)Ensembl
RefSeq Acc Id: NM_171992   ⟹   NP_741989
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,518,288 - 209,527,810 (-)NCBI
mRatBN7.21200,089,002 - 200,098,524 (-)NCBI
Rnor_6.01218,090,750 - 218,100,272 (-)NCBI
Rnor_5.01224,960,136 - 224,969,658 (-)NCBI
RGSC_v3.41205,357,235 - 205,366,757 (-)RGD
Celera1197,647,068 - 197,656,590 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760168   ⟹   XP_008758390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,518,288 - 209,527,986 (-)NCBI
mRatBN7.21200,089,002 - 200,098,399 (-)NCBI
Rnor_6.01218,090,750 - 218,100,447 (-)NCBI
Sequence:
RefSeq Acc Id: NP_741989   ⟸   NM_171992
- UniProtKB: P39948 (UniProtKB/Swiss-Prot),   A6HYI8 (UniProtKB/TrEMBL),   A6HYI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758390   ⟸   XM_008760168
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QF92 (UniProtKB/TrEMBL),   A6HYI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028411   ⟸   ENSRNOT00000028411
Ensembl Acc Id: ENSRNOP00000075372   ⟸   ENSRNOT00000088588
Ensembl Acc Id: ENSRNOP00000083271   ⟸   ENSRNOT00000108193
Cyclin C-terminal   Cyclin N-terminal   Cyclin-like

Name Modeler Protein Id AA Range Protein Structure
AF-P39948-F1-model_v2 AlphaFold P39948 1-295 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690589
Promoter ID:EPDNEW_R1114
Type:multiple initiation site
Name:Ccnd1_1
Description:cyclin D1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01218,100,285 - 218,100,345EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56836 BioCyc
Ensembl Genes ENSRNOG00000020918 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000088588 ENTREZGENE
  ENSRNOT00000108193.1 UniProtKB/Swiss-Prot
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot
InterPro Cyclin UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  Cyclin_C-dom UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
  Cyclins_cyclin-box UniProtKB/Swiss-Prot
KEGG Report rno:58919 UniProtKB/Swiss-Prot
NCBI Gene 58919 ENTREZGENE
PANTHER PTHR10177 UniProtKB/Swiss-Prot
Pfam Cyclin_C UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
PharmGKB CCND1 RGD
PhenoGen Ccnd1 PhenoGen
PROSITE CYCLINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020918 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot
  Cyclin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt A0A0G2KAE8_RAT UniProtKB/TrEMBL
  A0A8L2QF92 ENTREZGENE, UniProtKB/TrEMBL
  A6HYI6 ENTREZGENE, UniProtKB/TrEMBL
  A6HYI8 ENTREZGENE, UniProtKB/TrEMBL
  A6HYI9 ENTREZGENE, UniProtKB/TrEMBL
  CCND1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q1JUA4_RAT UniProtKB/TrEMBL
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ccnd1  cyclin D1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease expression is lower in the thioacetamide-induced cirrhosis after partial hepatectomy 70813
gene_expression significant in blood vessels of angiotensin 2 infused rats 68887
gene_process required for G1 progression in the cell cycle 68222
gene_process mediates hepatocyte proliferation 727766
gene_regulation induced by several different growth factors including colony stimulating factor-1, epidermal growth factor, and angiotensin 68887
gene_regulation transcription inhibited by by nonessential amino acids (NEAA) deprivation 727766