CCND1 (cyclin D1) - Rat Genome Database
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Gene: CCND1 (cyclin D1) Sus scrofa
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Symbol: CCND1
Name: cyclin D1
RGD ID: 14202999
Description: ENCODES a protein that exhibits enzyme binding (ortholog); kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to DNA damage stimulus (ortholog); cellular response to organic substance (ortholog); PARTICIPATES IN E-cadherin signaling pathway; G1/S transition pathway; Notch signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN bicellular tight junction (inferred); membrane (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol; etoxazole; ivermectin
Type: protein-coding
RefSeq Status: MODEL
Also known as: G1/S-specific cyclin-D1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,621,246 - 3,633,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,621,242 - 3,633,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,342,276 - 2,348,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
astrocytoma  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Bowen's Disease  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Burns  (ISO)
carcinoma  (ISO)
Cecal Neoplasms  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chronic Hepatitis C  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Genomic Instability  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
hyperparathyroidism  (ISO)
Hyperplasia  (ISO)
impotence  (ISO)
Intestinal Polyps  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Neoplasms  (ISO)
leukemia  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
malignant glioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mantle cell lymphoma  (ISO)
medulloblastoma  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
non-Hodgkin lymphoma  (ISO)
ovarian carcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
pancreatic solid pseudopapillary carcinoma  (ISO)
papilloma  (ISO)
penile benign neoplasm  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Salivary Gland Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
thyroid gland papillary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
visual epilepsy  (ISO)
von Hippel-Lindau disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to organic substance  (ISO)
endoplasmic reticulum unfolded protein response  (IEA)
fat cell differentiation  (IEA)
G1/S transition of mitotic cell cycle  (IEA)
lactation  (IEA)
Leydig cell differentiation  (ISO)
liver development  (ISO)
liver regeneration  (IEA)
mammary gland alveolus development  (IEA)
mammary gland epithelial cell proliferation  (IEA)
mitotic cell cycle phase transition  (IBA)
mitotic G1 DNA damage checkpoint  (IEA)
negative regulation of cell cycle arrest  (IEA)
negative regulation of epithelial cell differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA)
positive regulation of G1/S transition of mitotic cell cycle  (IBA)
positive regulation of G2/M transition of mitotic cell cycle  (IEA)
positive regulation of mammary gland epithelial cell proliferation  (IEA)
positive regulation of protein phosphorylation  (ISO)
protein phosphorylation  (IEA)
re-entry into mitotic cell cycle  (IEA)
regulation of cell cycle  (ISO)
regulation of cyclin-dependent protein serine/threonine kinase activity  (IBA)
regulation of G1/S transition of mitotic cell cycle  (ISO)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
response to drug  (IEA)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to leptin  (IEA)
response to magnesium ion  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to steroid hormone  (ISO)
response to UV-A  (IEA)
response to vitamin E  (ISO)
response to X-ray  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
CCND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,621,246 - 3,633,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,621,242 - 3,633,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,342,276 - 2,348,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1169,641,156 - 69,654,474 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1169,641,087 - 69,654,474 (+)EnsemblGRCh38hg38GRCh38
GRCh381169,641,156 - 69,654,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,455,873 - 69,469,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,165,054 - 69,178,423 (+)NCBINCBI36hg18NCBI36
Build 341169,165,053 - 69,178,422NCBI
Celera1166,752,901 - 66,766,272 (+)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1165,748,357 - 65,761,725 (+)NCBIHuRef
CHM1_11169,338,874 - 69,352,243 (+)NCBICHM1_1
Ccnd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,483,668 - 144,493,568 (-)NCBIGRCm39mm39
GRCm387144,929,931 - 144,939,831 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,929,931 - 144,939,925 (-)EnsemblGRCm38mm10GRCm38
MGSCv377152,115,836 - 152,125,830 (-)NCBIGRCm37mm9NCBIm37
MGSCv367144,739,321 - 144,749,220 (-)NCBImm8
Celera7144,694,932 - 144,704,928 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.92NCBI
Ccnd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01218,090,750 - 218,100,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,090,750 - 218,100,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,960,136 - 224,969,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,357,235 - 205,366,757 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,510,735 - 205,520,201 (-)NCBI
Celera1197,647,068 - 197,656,590 (-)NCBICelera
Cytogenetic Map1q42NCBI
Ccnd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,448,770 - 16,463,300 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,449,921 - 16,462,676 (-)NCBIChiLan1.0ChiLan1.0
CCND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11168,029,134 - 68,041,553 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01164,737,006 - 64,750,353 (+)NCBIMhudiblu_PPA_v0panPan3
CCND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1848,501,899 - 48,516,005 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11848,501,905 - 48,509,684 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CCND1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,909,616 - 4,922,272 (-)NCBI
ChlSab1.1 Ensembl14,907,353 - 4,922,357 (-)Ensembl
Ccnd1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476717,470,310 - 17,483,082 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 3 2 3 2 2
Low 9 2 3 2 20 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000046016   ⟹   ENSSSCP00000059262
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl23,621,246 - 3,633,296 (-)Ensembl
RefSeq Acc Id: XM_021082686   ⟹   XP_020938345
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.123,621,242 - 3,633,380 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020938345 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020938345   ⟸   XM_021082686
- Sequence:
RefSeq Acc Id: ENSSSCP00000059262   ⟸   ENSSSCT00000046016
Protein Domains
Cyclin N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037900 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070001791 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000059262 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070002785 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000046016 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070003359 UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/TrEMBL
  Cyclin_D UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
NCBI Gene CCND1 ENTREZGENE
PANTHER PTHR10177 UniProtKB/TrEMBL
  PTHR10177:SF67 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniGene Ssc.54683 ENTREZGENE
UniProt A0A287BRJ4_PIG UniProtKB/TrEMBL
  A0A4X1SL94_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86352 ENTREZGENE