CCND1 (cyclin D1) - Rat Genome Database

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Gene: CCND1 (cyclin D1) Sus scrofa
Analyze
Symbol: CCND1
Name: cyclin D1
RGD ID: 14202999
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); Leydig cell differentiation (ortholog); liver development (ortholog); PARTICIPATES IN E-cadherin signaling pathway; G1/S transition pathway; Notch signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN bicellular tight junction (inferred); cyclin D1-CDK4 complex (inferred); cyclin D1-CDK6 complex (inferred); INTERACTS WITH 3-acetyldeoxynivalenol; bifenthrin; deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G1/S-specific cyclin-D1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,621,246 - 3,633,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,621,242 - 3,633,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,342,276 - 2,348,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
Aicardi-Goutieres Syndrome 3  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
atherosclerosis  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Bowen's Disease  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Burns  (ISO)
carcinoma  (ISO)
Cecal Neoplasms  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chronic Hepatitis C  (ISO)
colon adenoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Seizures  (ISO)
Genomic Instability  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hyperparathyroidism  (ISO)
Hyperplasia  (ISO)
immunodeficiency 90  (ISO)
impotence  (ISO)
intellectual disability  (ISO)
interstitial cystitis  (ISO)
Intestinal Polyps  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Neoplasms  (ISO)
leukemia  (ISO)
liver cancer  (ISO)
Liver Neoplasms  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
mantle cell lymphoma  (ISO)
medulloblastoma  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
non-Hodgkin lymphoma  (ISO)
ovarian carcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
pancreatic solid pseudopapillary carcinoma  (ISO)
papillary thyroid carcinoma  (ISO)
papilloma  (ISO)
penile benign neoplasm  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Salivary Gland Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
von Hippel-Lindau disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cell division  (IEA)
cell population proliferation  (IEA)
DNA damage response  (IEA)
endoplasmic reticulum unfolded protein response  (IEA)
fat cell differentiation  (IEA)
G1/S transition of mitotic cell cycle  (IBA,IEA)
lactation  (IEA)
Leydig cell differentiation  (ISO)
liver development  (ISO)
liver regeneration  (IEA)
mammary gland alveolus development  (IEA)
mammary gland epithelial cell proliferation  (IEA,ISO)
mitotic G1 DNA damage checkpoint signaling  (IEA)
negative regulation of epithelial cell differentiation  (IEA)
negative regulation of neuron apoptotic process  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
neuron differentiation  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IBA)
positive regulation of G2/M transition of mitotic cell cycle  (IEA)
positive regulation of mammary gland epithelial cell proliferation  (IEA)
protein phosphorylation  (ISO)
re-entry into mitotic cell cycle  (IEA)
regulation of cell cycle  (IEA)
regulation of G1/S transition of mitotic cell cycle  (IEA)
response to calcium ion  (ISO)
response to corticosterone  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to leptin  (IEA)
response to magnesium ion  (ISO)
response to steroid hormone  (ISO)
response to UV-A  (IEA)
response to vitamin E  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
CCND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,621,246 - 3,633,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,621,242 - 3,633,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,342,276 - 2,348,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,641,156 - 69,654,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,641,156 - 69,654,474 (+)EnsemblGRCh38hg38GRCh38
GRCh371169,455,924 - 69,469,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,165,054 - 69,178,423 (+)NCBINCBI36Build 36hg18NCBI36
Build 341169,165,053 - 69,178,422NCBI
Celera1166,752,901 - 66,766,272 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,748,357 - 65,761,725 (+)NCBIHuRef
CHM1_11169,338,874 - 69,352,243 (+)NCBICHM1_1
T2T-CHM13v2.01169,658,031 - 69,671,351 (+)NCBIT2T-CHM13v2.0
Ccnd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,483,668 - 144,493,568 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,483,668 - 144,493,662 (-)EnsemblGRCm39 Ensembl
GRCm387144,929,931 - 144,939,831 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,929,931 - 144,939,925 (-)EnsemblGRCm38mm10GRCm38
MGSCv377152,115,836 - 152,125,830 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,739,321 - 144,749,220 (-)NCBIMGSCv36mm8
Celera7144,694,932 - 144,704,928 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.92NCBI
Ccnd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,518,288 - 209,527,986 (-)NCBIGRCr8
mRatBN7.21200,089,002 - 200,098,524 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,089,002 - 200,098,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,470,197 - 208,479,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,556,434 - 215,565,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,230,641 - 208,240,163 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,090,750 - 218,100,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,090,750 - 218,100,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,960,136 - 224,969,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,357,235 - 205,366,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,510,735 - 205,520,201 (-)NCBI
Celera1197,647,068 - 197,656,590 (-)NCBICelera
Cytogenetic Map1q42NCBI
Ccnd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,448,770 - 16,463,300 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,449,921 - 16,462,676 (-)NCBIChiLan1.0ChiLan1.0
CCND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2970,605,973 - 70,620,190 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,649,950 - 71,663,325 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,737,006 - 64,750,353 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,029,134 - 68,041,553 (+)NCBIpanpan1.1PanPan1.1panPan2
CCND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,501,905 - 48,509,684 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,501,899 - 48,516,005 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,111,842 - 47,121,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,179,073 - 49,188,648 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,178,951 - 49,189,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,625,670 - 48,635,233 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,211,983 - 48,221,555 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,958,012 - 48,967,584 (-)NCBIUU_Cfam_GSD_1.0
Ccnd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,527,409 - 4,541,987 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599973,838 - 983,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
CCND1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,909,616 - 4,922,272 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14,907,353 - 4,922,357 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,182,953 - 102,196,194 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccnd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,469,622 - 17,483,191 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,470,310 - 17,483,082 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCND1
236 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 5 14 12 23 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000046016   ⟹   ENSSSCP00000059262
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl23,621,246 - 3,633,296 (-)Ensembl
RefSeq Acc Id: XM_021082686   ⟹   XP_020938345
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.123,621,242 - 3,633,380 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020938345   ⟸   XM_021082686
- UniProtKB: A0A4X1SL94 (UniProtKB/TrEMBL),   A0A287BRJ4 (UniProtKB/TrEMBL),   A0A480MK38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000059262   ⟸   ENSSSCT00000046016
Protein Domains
Cyclin C-terminal   Cyclin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037900 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015004943 UniProtKB/TrEMBL
  ENSSSCG00025065543 UniProtKB/TrEMBL
  ENSSSCG00030061939 UniProtKB/TrEMBL
  ENSSSCG00035024107 UniProtKB/TrEMBL
  ENSSSCG00040064424 UniProtKB/TrEMBL
  ENSSSCG00045000128 UniProtKB/TrEMBL
  ENSSSCG00050032586 UniProtKB/TrEMBL
  ENSSSCG00055008283 UniProtKB/TrEMBL
  ENSSSCG00060047977 UniProtKB/TrEMBL
  ENSSSCG00065030390 UniProtKB/TrEMBL
  ENSSSCG00070001791 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000046016 ENTREZGENE
  ENSSSCT00000046016.2 UniProtKB/TrEMBL
  ENSSSCT00015006642.1 UniProtKB/TrEMBL
  ENSSSCT00025089943.1 UniProtKB/TrEMBL
  ENSSSCT00030086598.1 UniProtKB/TrEMBL
  ENSSSCT00035031657.1 UniProtKB/TrEMBL
  ENSSSCT00040087961.1 UniProtKB/TrEMBL
  ENSSSCT00045000145.1 UniProtKB/TrEMBL
  ENSSSCT00050043741.1 UniProtKB/TrEMBL
  ENSSSCT00055016149.1 UniProtKB/TrEMBL
  ENSSSCT00060065112.1 UniProtKB/TrEMBL
  ENSSSCT00065041055.1 UniProtKB/TrEMBL
  ENSSSCT00070003359.1 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/TrEMBL
NCBI Gene CCND1 ENTREZGENE
PANTHER PTHR10177 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A287BRJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A480MK38 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SL94 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86352 ENTREZGENE