Insul19 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Insul19 (Insulin level QTL 19) Rattus norvegicus

Symbol: Insul19
Name: Insulin level QTL 19
RGD ID: 6480783
Previously known as: QUICKI
Trait: blood insulin amount   (VT:0001560)    
Measurement Type: plasma insulin level   (CMO:0000342)    
LOD Score: 4.33
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,489,281 - 200,611,765RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01215,494,321 - 218,614,387RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01218,337,839 - 225,482,294RGDRnor5.0
RGSC_v3.41198,853,034 - 205,897,680RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: NMcwi:HS 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Tpcn2 is a candidate Gene for Insul19

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition
fasting  (IDA)

Measurement Method

Vertebrate Trait

Rat Strain
NMcwi:HS  (IEA)

References

References - curated
# Reference Title Reference Citation
1. QTLs registered by Dr. Solberg Woods Personal communication between Dr. Leah Solberg Woods and the RGD curators.
2. Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Solberg Woods LC, etal., Physiol Genomics. 2012 Sep 4.
3. Identification of a novel gene for diabetic traits in rats, mice, and humans. Tsaih SW, etal., Genetics. 2014 Sep;198(1):17-29. doi: 10.1534/genetics.114.162982.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1563319Ifitm10interferon induced transmembrane protein 101197507501197524180Rat
621511Ctsdcathepsin D1197527467197539343Rat
41338033LOC120097365uncharacterized LOC1200973651197546933197550986Rat
41194153Rnu6-81RNA, U6 small nuclear 811197577435197577542Rat
68399Syt8synaptotagmin 81197588126197593598Rat
62050Tnni2troponin I2, fast skeletal type1197595012197597554Rat
1306133Lsp1lymphocyte-specific protein 11197614677197648414Rat
1592568Prr33proline rich 331197644903197650774Rat
3883Tnnt3troponin T3, fast skeletal type1197652535197669736Rat
68343Mrpl23mitochondrial ribosomal protein L231197687452197695222Rat
7669488LOC102548505uncharacterized LOC1025485051197705332197782594Rat
2775H19H19 imprinted maternally expressed transcript1197730698197733374Rat
2314883Mir675microRNA 6751197732275197732358Rat
2870Igf2insulin-like growth factor 21197814409197831802Rat
2314879Mir483microRNA 4831197818396197818468Rat
7711326LOC102548568vegetative cell wall protein gp1-like1197830951197834453Rat
2916Ins2insulin 21197843277197992522Rat
11378084LOC108349673uncharacterized LOC1083496731197950020197994765Rat
3853Thtyrosine hydroxylase1198071500198078832Rat
41341459LOC120099959uncharacterized LOC1200999591198077644198123085Rat
2159Ascl2achaete-scute family bHLH transcription factor 21198148999198151406Rat
1308721Tspan32tetraspanin 321198190128198204447Rat
2315Cd81Cd81 molecule1198235861198251660Rat
1307043Tssc4tumor suppressing subtransferable candidate 41198251986198254810Rat
1310620Trpm5transient receptor potential cation channel, subfamily M, member 51198254956198277824Rat
621503Kcnq1potassium voltage-gated channel subfamily Q member 11198291711198624683Rat
41187783LOC120099963uncharacterized LOC1200999631198355931198361600Rat
727892Cdkn1ccyclin-dependent kinase inhibitor 1C1198655394198658097Rat
1303323Slc22a18solute carrier family 22, member 181198670626198694977Rat
1304755Phlda2pleckstrin homology-like domain, family A, member 21198696897198699292Rat
1305391Nap1l4nucleosome assembly protein 1-like 41198709697198746093Rat
41081613Snora54small nucleolar RNA, H/ACA box 541198727462198727588Rat
1310747Cars1cysteinyl-tRNA synthetase 11198753689198796016Rat
41196423Trnav-aac16transfer RNA valine (anticodon AAC) 161198797943198798023Rat
1309693Tnfrsf26tumor necrosis factor receptor superfamily, member 261198802968198823032Rat
1586688Tnfrsf22tumor necrosis factor receptor superfamily, member 221198840452198860713Rat
1308402Osbpl5oxysterol binding protein-like 51198862071198916469Rat
1562011Mrgprgl1MAS related GPR family member G like 11198937757198938662Rat
738044MrgprgMAS related GPR family member G1198947648198951556Rat
738045MrgpreMAS related GPR family member E1198963786198969862Rat
727801Nadsyn1NAD synthetase 11198981559199009853Rat
621769Dhcr77-dehydrocholesterol reductase1199015081199031055Rat
7506405LOC102552318actin-like1199035831199062916Rat
628772Shank2SH3 and multiple ankyrin repeat domains 21199146210199590962Rat
41079295LOC12009996460S ribosomal protein L21-like1199147655199158744Rat
619839Cttncortactin1199599710199635254Rat
1309009Ppfia1PTPRF interacting protein alpha 11199641277199718371Rat
11497536LOC10834967660S ribosomal protein L7a pseudogene1199684456199685258Rat
628700FaddFas associated via death domain1199743200199745746Rat
1310786Ano1anoctamin 11199751439199900099Rat
620126Fgf3fibroblast growth factor 31200001162200005539Rat
11455008LOC108349678uncharacterized LOC1083496781200007802200018418Rat
620127Fgf4fibroblast growth factor 41200023937200027793Rat
620166Fgf19fibroblast growth factor 191200056526200060980Rat
2193Bc1brain cytoplasmic RNA 11200073610200073763Rat
1304637Lto1LTO1 maturation factor of ABCE11200074247200080951Rat
41399942Rps10-ps18ribosomal protein S10, pseudogene 181200084281200084735Rat
68384Ccnd1cyclin D11200089002200098524Rat
41238308LOC120099967uncharacterized LOC1200999671200189261200203943Rat
11418059LOC108349679uncharacterized LOC1083496791200210221200234295Rat
41286380LOC120099968uncharacterized LOC1200999681200250061200268329Rat
41071816LOC120099969uncharacterized LOC1200999691200344504200353691Rat
628800Smim38small integral membrane protein 381200366561200371976Rat
1311779Tpcn2two pore segment channel 21200416538200446252Rat
708478MrgprfMAS related GPR family member F1200464100200473588Rat
738040MrgprdMAS related GPR family member D1200479204200487902Rat
68325Ighmbp2immunoglobulin mu DNA binding protein 21200506641200529293Rat
1310203Mrpl21mitochondrial ribosomal protein L211200529416200542568Rat
2396Cpt1acarnitine palmitoyltransferase 1A1200564634200627059Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10768D1Wox221301197816378197816499Ratregion
10769D1Arb242591197816307197816572Ratregion
33878D1Mit271951198211513198211706Ratregion
34244D1Mgh101381199050459199050587Ratregion
11413D1Smu31011198081083198081184Ratregion
11435D1Arb233001197655883197656196Ratregion
33753D1Mit51651197697768197697933Ratregion
35204D1Rat3671601197898742197898893Ratregion
35204D1Rat3671601197933504197933671Ratregion
35615D1Rat701521199773958199774075Ratregion
38854D1Rat1682091199368955199369166Ratregion
38954D1Rat1812161197670404197670618Ratregion
42524D1Rat3662001197712219197712419Ratregion
43377D1Wox91131198324342198324465Ratregion
43379D1Got1842151199463338199463553Ratregion
43381D1Got1851441199050488199050632Ratregion
43384D1Got1892641200611501200611765Ratregion
43388D1Got1901731200408630200408806Ratregion
629602D1Hmgc82811197816348197816613Ratregion
1631819D1Wox591471200091550200091697Ratregion
1627045D1Mco271731197816331197816504Ratregion
1641445D1Wox581761197816375197816551Ratregion
1632933D1Cebr31211200396561200396680Ratregion
1635093D1Got3581841198692683198692867Ratregion
1635610D1Got3701501198874578198874723Ratregion
1635784D1Wox552041197655456197655660Ratregion
1637095D1Wox812071199587887199588094Ratregion
7206000Ccnd11831200096780200098354Ratregion
7204417H195311197730795197731437Ratregion
7204418Igf25181197817046197817789Ratregion
7192170Nap1l42051198731750198732119Ratregion
7192850H196831197732669197733352Ratregion
7192852H191481197730845197730993Ratregion
7192868Igf23301197817313197817868Ratregion
7192870Igf26071197817230197817837Ratregion
7192874Ins21241197843329197843453Ratregion
7192878Kcnq101198292160198292200Ratregion
7192880Kcnq101198367696198367736Ratregion
7192882Kcnq101198334404198334444Ratregion
7192884Kcnq11441198623523198623667Ratregion
7192536D1Mgh221501197816356197816506Ratregion
7192481Ins13121197843338197844149Ratregion
5035799PMC18740P14091198072757198073166Ratregion
5035833PMC21231P13011197843360197844160Ratregion
5035835PMC21334P12291197843378197844106Ratregion
5035915PMC307617P11981198655877198656075Ratregion
5036111UniSTS:1413112121198655835198656047Ratregion
7206676Tnnt32381197665586197666040Ratregion
5036332H192001197730795197730995Ratregion
5036386Kcnq1921198376261198377441Ratregion
5036406UniSTS:1438302571198150752198151009Ratregion
5036424Nap1l401198709772198709941Ratregion
5036927AU0496501361200478033200478169Ratregion
5031268PMC123023P17071197843426197844133Ratregion
7206114UniSTS:53213801197816737197817322Ratregion
7206116UniSTS:5321392251197817514197819181Ratregion
7206120UniSTS:5321568081198696960198697768Ratregion
7206130UniSTS:5321681341197731774197731908Ratregion
7206132Cdkn1c01198656232198656943Ratregion
5026576RH1327421921197644936197645128Ratregion
5034508BI2801172201200090348200090568Ratregion
5029425Huc11931197744928197745121Ratregion
5027050RH1345412011200089149200089350Ratregion
5032599RH1345991971197507615197507812Ratregion
5030131BE09886701197815641197815797Ratregion
5030159BF3891631231198432655198432778Ratregion
5025042AW7424462491197814854197815103Ratregion
5027801RH947943601197815192197815553Ratregion
5025488RH1285142191198947777198947996Ratregion
5033621RH1394952131200506428200506641Ratregion
5028482M692001041198071580198071684Ratregion
5031131AA9642101531198440181198440334Ratregion
5051857RH946981341198076403198076537Ratregion
5052029RH947982591197844162197844421Ratregion
5052031RH947993001197843380197844179Ratregion
5051437AI4625381041198862086198862190Ratregion
5057183D1Bda445351197843811197844346Ratregion
5057181D1Bda433131197527713197528026Ratregion
5057428BF4183841861198228990198229176Ratregion
5057876BF3862971941198708256198708450Ratregion
5057223D1Bda703111198149057198149368Ratregion
5050398RH1340332131198624450198624663Ratregion
5057688BF3925921301197514666197514796Ratregion
5050124RH1338761801200091759200091939Ratregion
5052472M903161051197648190197648295Ratregion
5052633RH1421742141200471827200472041Ratregion
5051018RH1343901931199641378199641571Ratregion
5050368RH1340161881198770517198770705Ratregion
5051719RH946181781198251329198251507Ratregion
5040666RH1284141841197730747197730931Ratregion
5044654RH1307281961198936955198937151Ratregion
5044654RH1307281961198946297198946483Ratregion
5044104RH1304122201198697152198697670Ratregion
5044546RH1306651971198254460198254657Ratregion
5047946RH1326202101198753781198753991Ratregion
5046948RH1320471961199031677199031873Ratregion
5039478RH1277282171198251331198251548Ratregion
5039504RH1277432011199742479199742680Ratregion
5040038RH1280542101199030690199030900Ratregion
5040590RH1283702171197814588197814805Ratregion
7192429Osbpl54171198862756198863173Ratregion
7193045Fgf411471200024301200025448Ratregion
7193046Ins19721197843373197844345Ratregion
7204413Igf22551197817507197819204Ratregion
5074610RH1381161401199341510199341650Ratregion
5077568RH1398312051197656672197656877Ratregion
5079328RH1409191901197648219197648409Ratregion
5078684RH1404891221198709782198709904Ratregion
5073598RH1375281331197984958197985091Ratregion
5070668RH1346351891198862116198862313Ratregion
5072938RH1371411901197648188197648378Ratregion
5072942RH1371432191198204224198204443Ratregion
5071330RH1350202151198164034198164249Ratregion
5072470RH1368682191200080683200080902Ratregion
5067736AU0475672611198406029198406285Ratregion
5068116AU0473381341198549957198550091Ratregion
5070295RH945851831197823685197823868Ratregion
5060066BI2859961991198659744198659943Ratregion
5060186BI2796601611198771529198771690Ratregion
5060536BE0983171201198803117198803237Ratregion
5062406BE1066482071200195313200195520Ratregion
5065886AA9643061281200473409200473537Ratregion
5063128BI2959351551198963896198964051Ratregion
5066310PMC151031P19211198075720198076641Ratregion
5066350PMC15822P16161197596548197597164Ratregion
5061424BF3963901251197867384197867509Ratregion
5084182AA7994651081198178784198179153Ratregion
5087912UniSTS:1432962881197730698197730986Ratregion
5088032Slc22a1l1911198672506198672697Ratregion
5082999BF3906001501198167394198167544Ratregion
5087362AW5323611741197503296197503470Ratregion
5087462PMC187562P13911198657980198658371Ratregion
5089891AU0494251291198460069198460200Ratregion
5088130Tssc301198697812198697852Ratregion
5081503BF4201422161198637048198637264Ratregion
5087181AA8008861881199641385199641573Ratregion
5088473AU0485901251200489819200489944Ratregion
5082859BF3902961501200510026200510176Ratregion
5083523BF3916721181199590729199590847Ratregion
5503029MARC_54883-54884:1155673702:101198657463198658048Ratregion
5503476UniSTS:4626872541197843339197844092Ratregion
5503625UniSTS:4653962971198472540198472837Ratregion
5507537REN1159132601197592163197592423Ratregion
5507606Ccnd11671200091848200093446Ratregion
5507608Cdkn1c01198656296198657287Ratregion
5503652UniSTS:4654725081200090353200090861Ratregion
5507610Cdkn1c6041198656919198657523Ratregion
5507658AA24195801198254116198254155Ratregion
5503603UniSTS:4647855731200024838200025411Ratregion
5503629UniSTS:4653982571198709992198710249Ratregion
5503756UniSTS:47055201198657162198657938Ratregion
5504564PMC305633P12681199743261199743529Ratregion
5504618PMC316622P13881197741712197742100Ratregion
5504642PMC321442P22061200096019200096764Ratregion
5504989Cdkn1c1511198655895198656046Ratregion
5504994Cdkn1c7461198655568198656314Ratregion
5504774PMC98458P12001200098199200098399Ratregion
5504953Phlda201198696954198697647Ratregion
5504991Cdkn1c01198656285198656937Ratregion
5505071Cdkn1c1931198657094198657287Ratregion
5505130Cdkn1c01198656284198656938Ratregion
5505887UniSTS:4960014881198272553198273041Ratregion
5506513UniSTS:276141851197819139197819224Ratregion
5501730UniSTS:2670032181197843338197844055Ratregion
550015702.MMHAP94FRA8.seq6631200389913200390576Ratregion
5499965UniSTS:2358162001198149023198149223Ratregion
5499897UniSTS:23534001198866212198867552Ratregion
5500479Osbp2-pending9991198880142198881141Ratregion
5500501RH1265962101199599777199599987Ratregion
5501199PMC153767P22131197843431197844143Ratregion
5501544D8S51212741198208764198210038Ratregion
5501019PMC123023P33321197843337197844168Ratregion
5501171PMC151856P11161197817495197817836Ratregion
5501339ECD217422331197821931197822164Ratregion
5501389Ascl22371198150162198150399Ratregion
5501453Th11301198075568198076698Ratregion
5501644UniSTS:2654591631197730830197730993Ratregion
5503896Osbpl59941198880142198881136Ratregion
5504584PMC309645P22561197832788197833044Ratregion
5505020Igf21341197817882197819233Ratregion
5501650UniSTS:2654866051198656918198657523Ratregion
5501652UniSTS:2654912511197731147197731509Ratregion
5501654UniSTS:2654926071197730743197731461Ratregion
5501657PMC24644P61881197843343197844030Ratregion
5506191UniSTS:4987568791197527747197529055Ratregion
5502226Fgf411781200024265200025443Ratregion
12790683rs6530962301200385273200385273Ratregion
Position Markers

Flank 1: (D1Rat129)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01218,337,839 - 218,338,087NCBI
RGSC_v3.41198,853,034 - 198,853,281RGD
RGSC_v3.11199,003,017 - 199,003,326RGD
RH 3.4 Map11437.9UniSTS
RH 3.4 Map11437.9RGD
SHRSP x BN Map1101.4699RGD
SHRSP x BN Map1101.4699UniSTS
Peak: (D1Mgh10)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,050,459 - 199,050,587 (+)MAPPER
Rnor_6.01217,054,291 - 217,054,418NCBI
Rnor_5.01223,910,550 - 223,910,677UniSTS
RGSC_v3.41204,280,278 - 204,280,406RGD
RGSC_v3.41204,280,279 - 204,280,406UniSTS
RGSC_v3.11204,433,664 - 204,433,956RGD
Celera1196,613,223 - 196,613,350UniSTS
RH 2.0 Map11099.1RGD
Flank 2: (D1Got189)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21200,611,501 - 200,611,765 (+)MAPPER
Rnor_6.01218,614,124 - 218,614,387NCBI
Rnor_5.01225,482,031 - 225,482,294UniSTS
RGSC_v3.41205,897,416 - 205,897,680RGD
RGSC_v3.41205,897,417 - 205,897,680UniSTS
RGSC_v3.11206,050,870 - 206,051,133RGD
Celera1198,166,955 - 198,167,218UniSTS
RH 3.4 Map11560.5UniSTS
RH 3.4 Map11560.5RGD
RH 2.0 Map11113.7RGD
Cytogenetic Map1q43UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1199773958202166723Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
6480773Gluco64Glucose level QTL 645.09blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459200611765Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1197260913198211706Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general measurement method:at 16 weeks of age animals were fasted overnight, blood samples were collected from the tail at 15, 30, 60, and 90 min after 1 g/kg body wt glucose injection; plasma insulin level was measured by the ELISA kit; insulin resistance was measured by quantitative insulin sensitivity check index (QUICKI) 6893578
qtl_general number of animals used: 10-21 male rats from the founders and 782 male NMcwi:HS rats 6893578
qtl_general software used:ANOVA 6893578
qtl_general sharp peak for expression of Tpcn2 was observed, there was a nonsynonymous amino acid change in F344, this negatively correlates to fasting glucose 9587420
qtl_map 204.38-204 Mb 6893578