Cttn (cortactin) - Rat Genome Database

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Gene: Cttn (cortactin) Rattus norvegicus
Analyze
Symbol: Cttn
Name: cortactin
RGD ID: 619839
Description: Enables Arp2/3 complex binding activity and proline-rich region binding activity. Involved in several processes, including focal adhesion assembly; modification of postsynaptic actin cytoskeleton; and plasma membrane bounded cell projection organization. Located in cell junction and clathrin-coated pit. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Colocalizes with actin filament; focal adhesion; and growth cone. Orthologous to human CTTN (cortactin); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cortactin isoform B; Cttnb; MGC93456; src substrate cortactin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21199,599,710 - 199,635,254 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1199,599,710 - 199,635,164 (-)Ensembl
Rnor_6.01217,602,698 - 217,638,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01215,255,385 - 215,290,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,255,381 - 215,290,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,602,698 - 217,638,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,159,088 - 222,194,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01224,459,485 - 224,494,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,865,768 - 204,901,221 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,020,464 - 205,048,384 (-)NCBI
Celera1197,159,379 - 197,194,704 (-)NCBICelera
RH 3.4 Map11561.5RGD
Cytogenetic Map1q41-q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexadecanoic acid  (ISO)
ifosfamide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
metformin  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
potassium dichromate  (ISO)
probucol  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Sunset Yellow FCF  (ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Cai L, etal., Cell. 2008 Sep 5;134(5):828-42. doi: 10.1016/j.cell.2008.06.054.
2. Cao H, etal., Mol Cell Biol 2003 Mar;23(6):2162-70.
3. Cao H, etal., Mol Cell Biol. 2010 Feb;30(3):781-92. doi: 10.1128/MCB.00330-09. Epub 2009 Dec 7.
4. Desmarais V, etal., Cell Motil Cytoskeleton. 2009 Jun;66(6):303-16. doi: 10.1002/cm.20361.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Gray NW, etal., J Cell Sci. 2005 Mar 15;118(Pt 6):1279-90. Epub 2005 Mar 1.
8. Hattan D, etal., J Biol Chem. 2002 Oct 11;277(41):38596-606. Epub 2002 Jul 31.
9. Hering H and Sheng M, J Neurosci. 2003 Dec 17;23(37):11759-69.
10. Kaneko T, etal., J Endod. 2010 Mar;36(3):459-64.
11. Kruchten AE, etal., Am J Physiol Cell Physiol. 2008 Nov;295(5):C1113-22. doi: 10.1152/ajpcell.00238.2008. Epub 2008 Sep 3.
12. Kurklinsky S, etal., J Neurochem. 2011 Apr;117(1):48-60. doi: 10.1111/j.1471-4159.2011.07169.x. Epub 2011 Feb 9.
13. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Ohoka Y and Takai Y, Genes Cells 1998 Sep;3(9):603-12.
17. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
18. Oser M, etal., J Cell Biol. 2009 Aug 24;186(4):571-87. doi: 10.1083/jcb.200812176.
19. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Racz B and Weinberg RJ, J Neurosci. 2004 Nov 17;24(46):10310-7.
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10637315   PMID:10760273   PMID:11583995   PMID:12853475   PMID:12913069   PMID:14742709   PMID:15383621   PMID:15522889   PMID:15821732   PMID:16162656   PMID:16533564   PMID:17893324  
PMID:17959782   PMID:17959830   PMID:18353971   PMID:19414610   PMID:19540230   PMID:19605363   PMID:19684413   PMID:20457763   PMID:21423176   PMID:21725361   PMID:22282019   PMID:22660580  
PMID:23038781   PMID:23365224   PMID:23376485   PMID:23536706   PMID:24700464   PMID:25468996   PMID:26261183   PMID:28235806   PMID:29515177   PMID:32357304   PMID:32711564   PMID:33446758  
PMID:34426822  


Genomics

Comparative Map Data
Cttn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21199,599,710 - 199,635,254 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1199,599,710 - 199,635,164 (-)Ensembl
Rnor_6.01217,602,698 - 217,638,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01215,255,385 - 215,290,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,255,381 - 215,290,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,602,698 - 217,638,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,159,088 - 222,194,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01224,459,485 - 224,494,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,865,768 - 204,901,221 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,020,464 - 205,048,384 (-)NCBI
Celera1197,159,379 - 197,194,704 (-)NCBICelera
RH 3.4 Map11561.5RGD
Cytogenetic Map1q41-q42NCBI
CTTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,398,529 - 70,436,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1170,398,404 - 70,436,584 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,244,635 - 70,282,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,922,292 - 69,960,338 (+)NCBINCBI36hg18NCBI36
Build 341169,922,291 - 69,960,337NCBI
Celera1167,505,807 - 67,543,876 (+)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1166,505,811 - 66,543,873 (+)NCBIHuRef
CHM1_11170,128,086 - 70,166,161 (+)NCBICHM1_1
T2T-CHM13v2.01170,418,951 - 70,456,993 (+)NCBI
Cttn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,989,461 - 144,024,743 (-)NCBIGRCm39mm39
GRCm39 Ensembl7143,989,470 - 144,024,746 (-)Ensembl
GRCm387144,435,724 - 144,471,560 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,435,733 - 144,471,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,621,629 - 151,656,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv367144,245,114 - 144,280,131 (-)NCBImm8
Celera7144,198,389 - 144,233,423 (-)NCBICelera
Cytogenetic Map7F5NCBI
Cttn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542215,835,145 - 15,874,108 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542215,838,036 - 15,874,067 (-)NCBIChiLan1.0ChiLan1.0
CTTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11168,792,135 - 68,823,859 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,794,162 - 68,823,857 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01165,500,074 - 65,539,158 (+)NCBIMhudiblu_PPA_v0panPan3
CTTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11847,932,367 - 47,960,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1847,916,632 - 47,960,674 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,539,259 - 46,571,258 (-)NCBI
ROS_Cfam_1.01848,606,497 - 48,638,577 (-)NCBI
ROS_Cfam_1.0 Ensembl1848,590,898 - 48,637,751 (-)Ensembl
UMICH_Zoey_3.11848,053,474 - 48,085,478 (-)NCBI
UNSW_CanFamBas_1.01847,639,312 - 47,671,323 (-)NCBI
UU_Cfam_GSD_1.01848,385,244 - 48,417,504 (-)NCBI
Cttn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,038,885 - 4,063,551 (-)NCBI
SpeTri2.0NW_004936599481,234 - 503,857 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,031,102 - 3,060,855 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,031,103 - 3,060,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,444,656 - 1,455,002 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,139,045 - 4,176,962 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl14,137,814 - 4,176,446 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,394,443 - 101,445,469 (-)NCBIVero_WHO_p1.0
Cttn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476716,847,459 - 16,880,183 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476716,842,341 - 16,884,449 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH142385  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11561.5UniSTS
Cytogenetic Map1q41-q42UniSTS
RH126596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,599,777 - 199,599,987 (+)MAPPERmRatBN7.2
Rnor_6.01215,255,453 - 215,255,662NCBIRnor6.0
Rnor_6.01217,602,766 - 217,602,975NCBIRnor6.0
Rnor_5.01222,159,156 - 222,159,365UniSTSRnor5.0
Rnor_5.01224,459,553 - 224,459,762UniSTSRnor5.0
RGSC_v3.41204,865,836 - 204,866,045UniSTSRGSC3.4
Celera1197,159,447 - 197,159,656UniSTS
Cytogenetic Map1q41-q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
6480773Gluco64Glucose level QTL 645.09blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459200611765Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:903
Count of miRNA genes:210
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000028283, ENSRNOT00000047669, ENSRNOT00000054859
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 2 2 2 53 20 28
Below cutoff 22 28 28 28 10 4 4 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF054618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF054619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028283   ⟹   ENSRNOP00000028283
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,599,711 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1215,255,386 - 215,290,838 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000047669   ⟹   ENSRNOP00000050255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,599,712 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1215,255,381 - 215,290,845 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000054859   ⟹   ENSRNOP00000051742
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,599,717 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1217,602,698 - 217,638,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078514   ⟹   ENSRNOP00000070873
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,603,942 - 217,631,862 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079805   ⟹   ENSRNOP00000072540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,599,718 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1217,603,942 - 217,631,862 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090375   ⟹   ENSRNOP00000073253
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,599,710 - 199,635,164 (-)Ensembl
Rnor_6.0 Ensembl1215,256,629 - 215,284,548 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092783   ⟹   ENSRNOP00000076003
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,604,892 - 217,620,420 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092916   ⟹   ENSRNOP00000075952
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,599,719 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1217,602,698 - 217,638,152 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,603,922 - 217,605,397 (-)Ensembl
RefSeq Acc Id: NM_021868   ⟹   NP_068640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,599,710 - 199,635,168 (-)NCBI
Rnor_6.01217,602,698 - 217,638,152 (-)NCBI
Rnor_5.01224,459,485 - 224,494,974 (-)NCBI
RGSC_v3.41204,865,768 - 204,901,221 (-)RGD
Celera1197,159,379 - 197,194,704 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230622   ⟹   XP_006230684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,599,710 - 199,635,253 (-)NCBI
Rnor_6.01215,255,385 - 215,290,882 (-)NCBI
Rnor_5.01222,159,088 - 222,194,579 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230625   ⟹   XP_006230687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,599,710 - 199,635,253 (-)NCBI
Rnor_6.01215,255,385 - 215,290,882 (-)NCBI
Rnor_5.01222,159,088 - 222,194,579 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089006   ⟹   XP_038944934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,599,710 - 199,635,254 (-)NCBI
RefSeq Acc Id: XM_039089013   ⟹   XP_038944941
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,599,710 - 199,635,254 (-)NCBI
RefSeq Acc Id: XM_039089019   ⟹   XP_038944947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,599,710 - 199,635,253 (-)NCBI
RefSeq Acc Id: XM_039089022   ⟹   XP_038944950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,599,710 - 199,635,254 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_068640   ⟸   NM_021868
- UniProtKB: Q66HL2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006230687   ⟸   XM_006230625
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JZ13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230684   ⟸   XM_006230622
- Peptide Label: isoform X1
- UniProtKB: D3ZGE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076003   ⟸   ENSRNOT00000092783
RefSeq Acc Id: ENSRNOP00000028283   ⟸   ENSRNOT00000028283
RefSeq Acc Id: ENSRNOP00000072540   ⟸   ENSRNOT00000079805
RefSeq Acc Id: ENSRNOP00000050255   ⟸   ENSRNOT00000047669
RefSeq Acc Id: ENSRNOP00000075952   ⟸   ENSRNOT00000092916
RefSeq Acc Id: ENSRNOP00000073253   ⟸   ENSRNOT00000090375
RefSeq Acc Id: ENSRNOP00000070873   ⟸   ENSRNOT00000078514
RefSeq Acc Id: ENSRNOP00000051742   ⟸   ENSRNOT00000054859
RefSeq Acc Id: XP_038944941   ⟸   XM_039089013
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038944950   ⟸   XM_039089022
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038944934   ⟸   XM_039089006
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944947   ⟸   XM_039089019
- Peptide Label: isoform X5
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HL2-F1-model_v2 AlphaFold Q66HL2 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690558
Promoter ID:EPDNEW_R1081
Type:initiation region
Name:Cttn_2
Description:cortactin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1108  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,290,822 - 215,290,882EPDNEW
RGD ID:13690584
Promoter ID:EPDNEW_R1108
Type:multiple initiation site
Name:Cttn_1
Description:cortactin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1081  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,638,167 - 217,638,227EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619839 AgrOrtholog
BioCyc Gene G2FUF-56851 BioCyc
Ensembl Genes ENSRNOG00000047280 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000050994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028283 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000050255 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000051742 UniProtKB/TrEMBL
  ENSRNOP00000070873 UniProtKB/TrEMBL
  ENSRNOP00000072540 UniProtKB/Swiss-Prot
  ENSRNOP00000073253 UniProtKB/TrEMBL
  ENSRNOP00000075952 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076003 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028283 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000047669 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000054859 UniProtKB/TrEMBL
  ENSRNOT00000078514 UniProtKB/TrEMBL
  ENSRNOT00000079805 UniProtKB/Swiss-Prot
  ENSRNOT00000090375 UniProtKB/TrEMBL
  ENSRNOT00000092783 UniProtKB/TrEMBL
  ENSRNOT00000092916 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107292 IMAGE-MGC_LOAD
InterPro Cortactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cortactin_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hs1_Cortactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60465 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93456 IMAGE-MGC_LOAD
NCBI Gene 60465 ENTREZGENE
PANTHER PTHR10829:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HS1_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cttn PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CORTACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ13 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GWS4_RAT UniProtKB/TrEMBL
  D3ZGE6 ENTREZGENE, UniProtKB/TrEMBL
  Q66HL2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3ZRB0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Cttn  cortactin    cortactin isoform B  Name updated 1299863 APPROVED
2004-09-10 Cttn  cortactin isoform B  Cttnb    Symbol and Name updated 1299863 APPROVED
2002-08-07 Cttnb  cortactin isoform B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membrane ruffles 727733
gene_physical_interaction binds to large GTPase dynamin 727733