Mir675 (microRNA 675) - Rat Genome Database

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Gene: Mir675 (microRNA 675) Rattus norvegicus
Analyze
Symbol: Mir675
Name: microRNA 675
RGD ID: 2314883
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in response to alkaloid and response to hormone. Biomarker of dilated cardiomyopathy. Orthologous to human MIR675 (microRNA 675); INTERACTS WITH 2,5-hexanedione; doxorubicin; melatonin.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-675; rno-mir-675
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,161,752 - 207,161,835 (-)NCBIGRCr8
mRatBN7.21197,732,275 - 197,732,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,732,275 - 197,732,358 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,105,054 - 206,105,137 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,190,886 - 213,190,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,865,042 - 205,865,125 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,745,981 - 215,746,064 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,745,981 - 215,746,064 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,640,800 - 222,640,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,824,502 - 202,824,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1195,349,673 - 195,349,756 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir675Ratdilated cardiomyopathy amelioratesIEP 156430329 RGD 
Mir675RatPulmonary Arterial Hypertension treatmentIEP 156430315 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir675Ratdelta beta-thalassemia  ISORGD:22901958554872ClinVar Annotator: match by term: Thalassemia, gamma-delta-betaClinVarPMID:2798417

1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir675Rat17beta-estradiol multiple interactionsISORGD:22901956480464[Progesterone co-treated with Estradiol] results in decreased expression of MIR675 mRNACTDPMID:22950660
Mir675Rat2,5-hexanedione increases expressionEXP 64804642,5-hexanedione results in increased expression of MIR675 mRNACTDPMID:31760062
Mir675Ratbis(2-ethylhexyl) phthalate multiple interactionsISORGD:22901956480464[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated more ...CTDPMID:32949613
Mir675RatButylbenzyl phthalate multiple interactionsISORGD:22901956480464[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated more ...CTDPMID:32949613
Mir675Ratdiisononyl phthalate multiple interactionsISORGD:22901956480464[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated more ...CTDPMID:32949613
Mir675Ratdoxorubicin decreases expressionISORGD:22901956480464Doxorubicin results in decreased expression of MIR675 mRNACTDPMID:26842497
Mir675Ratdoxorubicin increases expression EXP 156430329doxorubicin increases expression of Mir675 RNA in cardiomyocytesRGD 
Mir675Rathexadecanoic acid multiple interactionsISORGD:22901956480464[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of MIR675 mRNACTDPMID:39423997
Mir675Rathydrogen peroxide decreases expression ISORGD:1625870158013773hydrogen peroxide decreases expression of Mir675 RNA in C-kit+ cardiac progenitor cellsRGD 
Mir675Rathydrogen peroxide multiple interactionsISORGD:1625870158013773[melatonin inhibits the reaction [hydrogen peroxide decreases expression of Mir675 RNA in C-kit+ cardiac progenitor more ...RGD 
Mir675Ratlead nitrate multiple interactionsISORGD:22901956480464[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated more ...CTDPMID:32949613
Mir675RatLicochalcone B decreases expressionISORGD:22901956480464licochalcone B results in decreased expression of MIR675 mRNACTDPMID:33647349
Mir675Ratluzindole multiple interactionsISORGD:1625870158013773luzindole inhibits the reaction [melatonin inhibits the reaction [hydrogen peroxide decreases expression of Mir675 RNA more ...RGD 
Mir675Ratmelatonin increases expression EXP 156430315melatonin increases expression of Mir675 RNA in pulmonary artery smooth muscle cellsRGD 
Mir675Ratmercury atom multiple interactionsISORGD:22901956480464[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated more ...CTDPMID:32949613
Mir675Ratmercury(0) multiple interactionsISORGD:22901956480464[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated more ...CTDPMID:32949613
Mir675Ratmonocrotaline multiple interactionsEXP 156430315melatonin inhibits the reaction [monocrotaline decreases expression of Mir675 RNA in pulmonary artery smooth muscle more ...RGD 
Mir675Ratmonocrotaline decreases expression EXP 156430315monocrotaline decreases expression of Mir675 RNA in pulmonary artery smooth muscle cellsRGD 
Mir675Ratnitrofen increases expressionEXP 6480464nitrofen results in increased expression of MIR675 mRNACTDPMID:26720608
Mir675Ratoleic acid multiple interactionsISORGD:22901956480464[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of MIR675 mRNACTDPMID:39423997

1 to 20 of 24 rows

Biological Process
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir675RatmiRNA-mediated post-transcriptional gene silencing involved_inISORGD:22901951624291 PMID:26891291, PMID:31574452RGDPMID:26891291|PMID:31574452
Mir675Ratnegative regulation of ATP biosynthetic process acts_upstream_ofISORGD:22901951624291 PMID:31574452RGDPMID:31574452
Mir675Ratnegative regulation of BMP signaling pathway acts_upstream_of_or_withinISORGD:16258701624291 PMID:24532688RGDPMID:24532688
Mir675Ratnegative regulation of gene expression acts_upstream_of_or_withinISORGD:16258701624291 PMID:24532688RGDPMID:24532688
Mir675Ratnegative regulation of reactive oxygen species metabolic process acts_upstream_ofISORGD:22901951624291 PMID:31574452RGDPMID:31574452
Mir675Ratpositive regulation of cytokine production involved in inflammatory response acts_upstream_ofISORGD:22901951624291 PMID:31574452RGDPMID:31574452
Mir675Ratpositive regulation of hepatocyte apoptotic process acts_upstream_ofISORGD:22901951624291 PMID:31574452RGDPMID:31574452
Mir675Ratpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_ofISORGD:22901951624291 PMID:31574452RGDPMID:31574452
Mir675Ratpositive regulation of reactive oxygen species biosynthetic process acts_upstream_ofISORGD:22901951624291 PMID:31574452RGDPMID:31574452
Mir675Ratpositive regulation of skeletal muscle cell differentiation acts_upstream_of_or_withinISORGD:16258701624291 PMID:24532688RGDPMID:24532688
Mir675Ratpositive regulation of skeletal muscle tissue regeneration acts_upstream_of_or_withinISORGD:16258701624291 PMID:24532688RGDPMID:24532688
Mir675Ratresponse to alkaloid  IEP 156430315 RGD 
Mir675Ratresponse to hormone  IEP 156430315 RGD 
1 to 13 of 13 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir675RatmRNA 3'-UTR binding enablesISORGD:22901951624291 PMID:31574452RGDPMID:31574452
Mir675RatmRNA base-pairing post-transcriptional repressor activity enablesISORGD:22901951624291 PMID:26891291, PMID:31574452RGDPMID:26891291|PMID:31574452


#
Reference Title
Reference Citation
1. Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit(+) cardiac progenitor cells by promoting miR-675. Cai B, etal., J Pineal Res. 2016 Aug;61(1):82-95. doi: 10.1111/jpi.12331. Epub 2016 Apr 29.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin. Wang R, etal., Mol Ther Nucleic Acids. 2018 Dec 7;13:44-54. doi: 10.1016/j.omtn.2018.08.015. Epub 2018 Aug 24.
4. The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy. Zhang Y, etal., Oncotarget. 2017 Apr 25;8(17):28588-28594. doi: 10.18632/oncotarget.15544.
PMID:16381832   PMID:18215311   PMID:20403161   PMID:24532688   PMID:27796346   PMID:28063931  



Mir675
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,161,752 - 207,161,835 (-)NCBIGRCr8
mRatBN7.21197,732,275 - 197,732,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,732,275 - 197,732,358 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,105,054 - 206,105,137 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,190,886 - 213,190,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,865,042 - 205,865,125 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,745,981 - 215,746,064 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,745,981 - 215,746,064 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,640,800 - 222,640,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,824,502 - 202,824,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1195,349,673 - 195,349,756 (-)NCBICelera
Cytogenetic Map1q41NCBI
MIR675
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,996,759 - 1,996,831 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,996,759 - 1,996,831 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,017,989 - 2,018,061 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,974,564 - 1,974,636 (-)NCBINCBI36Build 36hg18NCBI36
Celera112,057,119 - 2,057,191 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,809,028 - 1,809,100 (-)NCBIHuRef
CHM1_1112,016,809 - 2,016,881 (-)NCBICHM1_1
T2T-CHM13v2.0112,084,436 - 2,084,508 (-)NCBIT2T-CHM13v2.0
Mir675
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,130,801 - 142,130,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,130,801 - 142,130,884 (-)EnsemblGRCm39 Ensembl
GRCm387142,577,064 - 142,577,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,577,064 - 142,577,147 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,762,969 - 149,763,052 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera7142,332,906 - 142,332,989 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.97NCBI

.

.
Variants in Mir675
5 total Variants

Predicted Targets
Summary Value
Count of predictions:13600
Count of gene targets:7174
Count of transcripts:7699
Interacting mature miRNAs:rno-miR-675-3p, rno-miR-675-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 93 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat

1 to 10 of 93 rows
H19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,732,669 - 197,733,352 (+)MAPPERmRatBN7.2
Rnor_6.01215,746,376 - 215,747,058NCBIRnor6.0
Rnor_5.01222,641,195 - 222,641,877UniSTSRnor5.0
RGSC_v3.41202,824,897 - 202,825,579UniSTSRGSC3.4
Celera1195,350,068 - 195,350,750UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:532168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,731,774 - 197,731,908 (+)MAPPERmRatBN7.2
Rnor_6.01215,745,481 - 215,745,614NCBIRnor6.0
Rnor_5.01222,640,300 - 222,640,433UniSTSRnor5.0
Celera1195,349,173 - 195,349,306UniSTS
Cytogenetic Map1q41UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 89 59 25 59 6 217 97 91 44 60 30


RefSeq Transcripts NR_032754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000062103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1197,732,275 - 197,732,358 (-)Ensembl
Rnor_6.0 Ensembl1215,745,981 - 215,746,064 (-)Ensembl
RefSeq Acc Id: NR_032754
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,161,752 - 207,161,835 (-)NCBI
mRatBN7.21197,732,275 - 197,732,358 (-)NCBI
Rnor_6.01215,745,981 - 215,746,064 (-)NCBI
Rnor_5.01222,640,800 - 222,640,883 (-)NCBI
RGSC_v3.41202,824,502 - 202,824,585 (-)RGD
Celera1195,349,673 - 195,349,756 (-)RGD
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 9 of 9 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56900 BioCyc
Ensembl Genes ENSRNOG00000040350 Ensembl
miRBase MI0012603 ENTREZGENE
NCBI Gene 100314133 ENTREZGENE
PhenoGen Mir675 PhenoGen
RatGTEx ENSRNOG00000040350 RatGTEx
RNAcentral URS00002A79D7 RNACentral
  URS000075AB80 RNACentral
  URS000075B5A1 RNACentral
1 to 9 of 9 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir675  microRNA 675  Mir675  microRNA mir-675  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-04 Mir675  microRNA mir-675      Symbol and Name status set to provisional 70820 PROVISIONAL