MIR675 (microRNA 675) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MIR675 (microRNA 675) Homo sapiens
Analyze
Symbol: MIR675
Name: microRNA 675
RGD ID: 2290195
HGNC Page HGNC:33351
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-675; LOC102724852; MIRN675; uncharacterized LOC102724852
RGD Orthologs
Mouse
Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,996,759 - 1,996,831 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,996,759 - 1,996,831 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,017,989 - 2,018,061 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,974,564 - 1,974,636 (-)NCBINCBI36Build 36hg18NCBI36
Celera112,057,119 - 2,057,191 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,809,028 - 1,809,100 (-)NCBIHuRef
CHM1_1112,016,809 - 2,016,881 (-)NCBICHM1_1
T2T-CHM13v2.0112,084,436 - 2,084,508 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit(+) cardiac progenitor cells by promoting miR-675. Cai B, etal., J Pineal Res. 2016 Aug;61(1):82-95. doi: 10.1111/jpi.12331. Epub 2016 Apr 29.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Identifying Involvement of H19-miR-675-3p-IGF1R and H19-miR-200a-PDCD4 in Treating Pulmonary Hypertension with Melatonin. Wang R, etal., Mol Ther Nucleic Acids. 2018 Dec 7;13:44-54. doi: 10.1016/j.omtn.2018.08.015. Epub 2018 Aug 24.
4. The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy. Zhang Y, etal., Oncotarget. 2017 Apr 25;8(17):28588-28594. doi: 10.18632/oncotarget.15544.
Additional References at PubMed
PMID:10354581   PMID:10506193   PMID:11181995   PMID:16381832   PMID:17237358   PMID:18402656   PMID:19926638   PMID:20529846   PMID:21471143   PMID:22527881   PMID:22832245   PMID:23725790  
PMID:23754477   PMID:23864307   PMID:24335901   PMID:24388988   PMID:24466011   PMID:24532688   PMID:24939300   PMID:24988946   PMID:25219825   PMID:25889562   PMID:26198047   PMID:26353930  
PMID:26376677   PMID:26417995   PMID:26884465   PMID:26891291   PMID:26931432   PMID:27120794   PMID:27279905   PMID:27349231   PMID:27644634   PMID:27994496   PMID:28061476   PMID:28212565  
PMID:28719338   PMID:28848149   PMID:28963438   PMID:28970140   PMID:29111380   PMID:29544765   PMID:29604248   PMID:29626470   PMID:30106155   PMID:30592263   PMID:30803129   PMID:30815865  
PMID:31029881   PMID:31219199   PMID:31260797   PMID:31264811   PMID:31468534   PMID:31574452   PMID:31677258   PMID:32323721   PMID:32336544   PMID:32434960   PMID:32481626   PMID:32627034  
PMID:33400243   PMID:33513878   PMID:33649811   PMID:34236149   PMID:34409922   PMID:34880230   PMID:35145234   PMID:35596172   PMID:36671388   PMID:37373137   PMID:37678441  


Genomics

Comparative Map Data
MIR675
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,996,759 - 1,996,831 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,996,759 - 1,996,831 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,017,989 - 2,018,061 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,974,564 - 1,974,636 (-)NCBINCBI36Build 36hg18NCBI36
Celera112,057,119 - 2,057,191 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,809,028 - 1,809,100 (-)NCBIHuRef
CHM1_1112,016,809 - 2,016,881 (-)NCBICHM1_1
T2T-CHM13v2.0112,084,436 - 2,084,508 (-)NCBIT2T-CHM13v2.0
Mir675
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,130,801 - 142,130,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,130,801 - 142,130,884 (-)EnsemblGRCm39 Ensembl
GRCm387142,577,064 - 142,577,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,577,064 - 142,577,147 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,762,969 - 149,763,052 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera7142,332,906 - 142,332,989 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.97NCBI
Mir675
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,161,752 - 207,161,835 (-)NCBIGRCr8
mRatBN7.21197,732,275 - 197,732,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,732,275 - 197,732,358 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,105,054 - 206,105,137 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,190,886 - 213,190,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,865,042 - 205,865,125 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,745,981 - 215,746,064 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,745,981 - 215,746,064 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,640,800 - 222,640,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,824,502 - 202,824,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1195,349,673 - 195,349,756 (-)NCBICelera
Cytogenetic Map1q41NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:1975511-2888695)x3 copy number gain See cases [RCV000136112] Chr11:1975511..2888695 [GRCh38]
Chr11:1996741..2909925 [GRCh37]
Chr11:1953317..2866501 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5(chr11:1975511-2138446)x3 copy number gain See cases [RCV000137018] Chr11:1975511..2138446 [GRCh38]
Chr11:1996741..2159676 [GRCh37]
Chr11:1953317..2116252 [NCBI36]
Chr11:11p15.5
benign
GRCh38/hg38 11p15.5-15.4(chr11:1537379-3360769)x3 copy number gain See cases [RCV000136847] Chr11:1537379..3360769 [GRCh38]
Chr11:1558609..3381999 [GRCh37]
Chr11:1515185..3338575 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:1975511-3624139)x1 copy number loss See cases [RCV000137066] Chr11:1975511..3624139 [GRCh38]
Chr11:1996741..3645369 [GRCh37]
Chr11:1953317..3601945 [NCBI36]
Chr11:11p15.5-15.4
uncertain significance
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:1132899-3213923)x1 copy number loss See cases [RCV000142464] Chr11:1132899..3213923 [GRCh38]
Chr11:1126807..3235153 [GRCh37]
Chr11:1116807..3191729 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196855-5321874)x3 copy number gain See cases [RCV000142890] Chr11:196855..5321874 [GRCh38]
Chr11:196855..5343104 [GRCh37]
Chr11:186855..5299680 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5(chr11:196855-2116185)x3 copy number gain See cases [RCV000142923] Chr11:196855..2116185 [GRCh38]
Chr11:196855..2137415 [GRCh37]
Chr11:186855..2093991 [NCBI36]
Chr11:11p15.5
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-4435344)x3 copy number gain See cases [RCV000050927] Chr11:196966..4435344 [GRCh38]
Chr11:196966..4456574 [GRCh37]
Chr11:186966..4413150 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-3377077)x3 copy number gain See cases [RCV000050947] Chr11:196966..3377077 [GRCh38]
Chr11:196966..3398307 [GRCh37]
Chr11:186966..3354883 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5(chr11:758848-1998025)x1 copy number loss See cases [RCV000052645] Chr11:758848..1998025 [GRCh38]
Chr11:758848..2019255 [GRCh37]
Chr11:748848..1975831 [NCBI36]
Chr11:11p15.5
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:218365-3377077)x3 copy number gain See cases [RCV000053614] Chr11:218365..3377077 [GRCh38]
Chr11:218365..3398307 [GRCh37]
Chr11:208365..3354883 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5(chr11:1923685-2003319)x3 copy number gain See cases [RCV000053615] Chr11:1923685..2003319 [GRCh38]
Chr11:1944915..2024549 [GRCh37]
Chr11:1901491..1981125 [NCBI36]
Chr11:11p15.5
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-3624139)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|See cases [RCV000053592] Chr11:196966..3624139 [GRCh38]
Chr11:196966..3645369 [GRCh37]
Chr11:186966..3601945 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
NC_000011.10:g.(499700_4999400)_(5279346_5279697)del deletion Thalassemia, gamma-delta-beta [RCV000015529] Chr11:4999400..5279346 [GRCh38]
Chr11:11p15.5-15.4
pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
RB1hsa-miR-675-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19926638
RB1hsa-miR-675-5pOncomiRDBexternal_infoNANA19926638
RB1hsa-miR-675-3pMirecordsexternal_infoNANA19926638

Predicted Targets
Summary Value
Count of predictions:25551
Count of gene targets:11355
Count of transcripts:21684
Interacting mature miRNAs:hsa-miR-675-3p, hsa-miR-675-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
H19  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,165 - 2,018,438UniSTSGRCh37
Build 36111,974,741 - 1,975,014RGDNCBI36
Celera112,057,295 - 2,057,568RGD
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map6q23.2UniSTS
GeneMap99-GB4 RH Map1122.72UniSTS
NCBI RH Map1110.0UniSTS
PMC310880P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,012 - 2,018,759UniSTSGRCh37
Build 36111,974,588 - 1,975,335RGDNCBI36
Celera112,057,142 - 2,057,889RGD
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map6q23.2UniSTS
HuRef111,809,051 - 1,809,798UniSTS
ECD00254  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,785 - 2,019,704UniSTSGRCh37
Build 36111,975,361 - 1,976,280RGDNCBI36
Celera112,057,915 - 2,058,834RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,809,824 - 1,810,743UniSTS
ECD03283  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,017,965 - 2,018,765UniSTSGRCh37
Build 36111,974,541 - 1,975,341RGDNCBI36
Celera112,057,095 - 2,057,895RGD
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map6q23.2UniSTS
HuRef111,809,004 - 1,809,804UniSTS
REN116498  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,017,652 - 2,017,898UniSTSGRCh37
Build 36111,974,228 - 1,974,474RGDNCBI36
Celera112,056,782 - 2,057,028RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,808,691 - 1,808,937UniSTS
REN116499  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,017,954 - 2,018,182UniSTSGRCh37
Build 36111,974,530 - 1,974,758RGDNCBI36
Celera112,057,084 - 2,057,312RGD
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map6q23.2UniSTS
HuRef111,808,993 - 1,809,221UniSTS
REN116500  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,164 - 2,018,437UniSTSGRCh37
Build 36111,974,740 - 1,975,013RGDNCBI36
Celera112,057,294 - 2,057,567RGD
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map6q23.2UniSTS
HuRef111,809,203 - 1,809,476UniSTS
REN116501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,421 - 2,018,680UniSTSGRCh37
Build 36111,974,997 - 1,975,256RGDNCBI36
Celera112,057,551 - 2,057,810RGD
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map6q23.2UniSTS
HuRef111,809,460 - 1,809,719UniSTS
REN116502  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,732 - 2,018,957UniSTSGRCh37
Build 36111,975,308 - 1,975,533RGDNCBI36
Celera112,057,862 - 2,058,087RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,809,771 - 1,809,996UniSTS
REN116503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,963 - 2,019,217UniSTSGRCh37
Build 36111,975,539 - 1,975,793RGDNCBI36
Celera112,058,093 - 2,058,347RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,810,002 - 1,810,256UniSTS
REN116504  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,019,200 - 2,019,425UniSTSGRCh37
Build 36111,975,776 - 1,976,001RGDNCBI36
Celera112,058,330 - 2,058,555RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,810,239 - 1,810,464UniSTS
REN116505  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,019,401 - 2,019,647UniSTSGRCh37
Build 36111,975,977 - 1,976,223RGDNCBI36
Celera112,058,531 - 2,058,777RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,810,440 - 1,810,686UniSTS
REN116506  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,019,627 - 2,019,896UniSTSGRCh37
Build 36111,976,203 - 1,976,472RGDNCBI36
Celera112,058,757 - 2,059,026RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,810,666 - 1,810,935UniSTS
D11S4727  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,018,729 - 2,018,960UniSTSGRCh37
Build 36111,975,305 - 1,975,536RGDNCBI36
Celera112,057,859 - 2,058,090RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,809,768 - 1,809,999UniSTS
stSG548622  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37112,017,657 - 2,018,955UniSTSGRCh37
Build 36111,974,233 - 1,975,531RGDNCBI36
Celera112,056,787 - 2,058,085RGD
Cytogenetic Map11p15.5UniSTS
HuRef111,808,696 - 1,809,994UniSTS
D11S813E  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11p15.5UniSTS
D11S813E  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11p15.5UniSTS


Expression


Sequence


RefSeq Acc Id: ENST00000390168
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl111,996,759 - 1,996,831 (-)Ensembl
RefSeq Acc Id: NR_030533
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38111,996,759 - 1,996,831 (-)NCBI
GRCh37112,017,989 - 2,018,061 (-)RGD
Celera112,057,119 - 2,057,191 (-)RGD
HuRef111,809,028 - 1,809,100 (-)RGD
CHM1_1112,016,809 - 2,016,881 (-)NCBI
T2T-CHM13v2.0112,084,436 - 2,084,508 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33351 AgrOrtholog
COSMIC MIR675 COSMIC
Ensembl Genes ENSG00000284010 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000390168 ENTREZGENE
GTEx ENSG00000284010 GTEx
HGNC ID HGNC:33351 ENTREZGENE
Human Proteome Map MIR675 Human Proteome Map
miRBase MI0005416 ENTREZGENE
NCBI Gene 100033819 ENTREZGENE
OMIM 615509 OMIM
PharmGKB PA164722965 PharmGKB
RNAcentral URS000027464B RNACentral
  URS00004E5112 RNACentral
  URS0000691556 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-28 MIR675  microRNA 675  LOC102724852  uncharacterized LOC102724852  Data merged from RGD:38676155 737654 PROVISIONAL