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Gene: Ighmbp2 (immunoglobulin mu DNA binding protein 2) Rattus norvegicus
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Symbol: Ighmbp2
Name: immunoglobulin mu DNA binding protein 2
RGD ID: 68325
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to localize to several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and distal spinal muscular atrophy 1. Orthologous to human IGHMBP2 (immunoglobulin mu DNA binding protein 2); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AEP; antifreeze enhancer-binding protein; antifreeze enhancer-binding protein ortholog; ATP-dependent helicase IGHMBP2; DNA-binding protein SMUBP-2; immunoglobulin mu binding protein 2; immunoglobulin S mu binding protein 2; MGC124598
Orthologs:
Homo sapiens (human) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Ighmbp2 (immunoglobulin mu binding protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ighmbp2 (immunoglobulin mu DNA binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Canis lupus familiaris (dog) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ighmbp2 (immunoglobulin mu DNA binding protein 2)
Sus scrofa (pig) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Chlorocebus sabaeus (African green monkey) : IGHMBP2 (immunoglobulin mu DNA binding protein 2)
Heterocephalus glaber (naked mole-rat) : Ighmbp2 (immunoglobulin mu DNA binding protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01218,509,274 - 218,531,922 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,508,950 - 218,532,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,377,073 - 225,399,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,792,891 - 205,815,212 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,946,343 - 205,968,665 (-)NCBI
Celera1198,061,146 - 198,084,182 (-)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ighmbp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68325
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.