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Gene: Igf2 (insulin-like growth factor 2) Rattus norvegicus
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Symbol: Igf2
Name: insulin-like growth factor 2
Description: Predicted to have protein serine/threonine kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Localizes to the extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IGF-II; IGFII; insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); insulin-like growth factor II isoform 2 variant 4 preprotein; MSA; multiplication-stimulating activity; multiplication-stimulating polypeptide; RNIGF2
Orthologs:
Homo sapiens (human) : IGF2 (insulin like growth factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Igf2 (insulin-like growth factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf2 (insulin like growth factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF2 (insulin like growth factor 2)
Canis lupus familiaris (dog) : IGF2 (insulin like growth factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf2 (insulin like growth factor 2)
Sus scrofa (pig) : IGF2 (insulin like growth factor 2)
more info ...
Is Marker For: Strains:   SHR.BN-(D1Mit3-Igf2)/Ipcv   BB.SHR-(Acsm3-Igf2)/K  
QTLs:   Bp30   Bp42   Thym4   Bw39  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Igf2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2870
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.