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Gene: Th (tyrosine hydroxylase) Rattus norvegicus
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Symbol: Th
Name: tyrosine hydroxylase
Description: Exhibits several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Localizes to the cytoplasm; neuron projection; and perikaryon. Used to study Parkinson's disease. Biomarker of several diseases, including cerebrovascular disease (multiple); hyperprolactinemia; hypoglycemia; neurodegenerative disease (multiple); and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-sesamin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: The; tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
Orthologs:
Homo sapiens (human) : TH (tyrosine hydroxylase)  HGNC  Alliance
Mus musculus (house mouse) : Th (tyrosine hydroxylase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Th (tyrosine hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : TH (tyrosine hydroxylase)
Canis lupus familiaris (dog) : TH (tyrosine hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Th (tyrosine hydroxylase)
Sus scrofa (pig) : TH (tyrosine hydroxylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
Celera1195,642,057 - 195,649,203 (-)NCBICelera
Cytogenetic Map1q41NCBI
RH 2.0 Map11080.1RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Th
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3853
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.