Th (tyrosine hydroxylase) - Rat Genome Database

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Gene: Th (tyrosine hydroxylase) Rattus norvegicus
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Symbol: Th
Name: tyrosine hydroxylase
RGD ID: 3853
Description: Exhibits several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Localizes to several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; hypoglycemia; polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-sesamin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: The; tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21198,071,500 - 198,078,832 (-)NCBI
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
Celera1195,642,057 - 195,649,203 (-)NCBICelera
RH 2.0 Map11080.1RGD
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-sesamin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-selegiline  (EXP)
(24S)-24-hydroxycholesterol  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
3,4-dihydroxyphenylacetaldehyde  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7-NITROINDAZOLE  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
acetic acid  (ISO)
acetylcholine  (EXP)
acrylamide  (EXP)
acrylonitrile  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
agmatine  (EXP)
albiflorin  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (EXP)
amentoflavone  (ISO)
aminoguanidine  (ISO)
amitraz  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
apigenin  (EXP)
apocynin  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Asiaticoside  (EXP)
atrazine  (EXP)
baicalein  (ISO)
benzo[a]pyrene  (EXP,ISO)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
BQ 123  (EXP)
bromochloroacetic acid  (ISO)
bucladesine  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (EXP,ISO)
carmustine  (EXP)
carnosic acid  (EXP)
Carnosol  (ISO)
carvedilol  (EXP)
chelerythrine  (EXP)
chitosan  (EXP)
Chloralose  (EXP)
chlorisondamine  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (EXP,ISO)
corticosterone  (ISO)
curcumin  (EXP,ISO)
cyanazine  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytarabine  (ISO)
dabigatran  (EXP)
desferrioxamine B  (EXP)
desipramine  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichlorvos  (EXP)
dieldrin  (EXP)
diethyldithiocarbamic acid  (EXP)
dioxygen  (EXP)
dipyridamole  (EXP)
dopamine  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (EXP)
epibatidine  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
fipronil  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
formaldehyde  (ISO)
fructose  (ISO)
ganglioside GM1  (EXP)
genistein  (EXP,ISO)
geraniol  (ISO)
ginkgetin  (ISO)
ginsenoside Re  (ISO)
glyburide  (ISO)
guanethidine  (EXP)
GW 1929  (EXP)
haloperidol  (EXP)
heptachlor  (ISO)
herbicide  (EXP)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP)
idazoxan  (EXP)
imidacloprid  (EXP)
juglone  (ISO)
ketoconazole  (ISO)
KT 5720  (EXP)
L-ascorbic acid  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
linalool  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
LY294002  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (EXP)
melatonin  (EXP,ISO)
mephedrone  (EXP,ISO)
mercaptopurine  (EXP)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP)
montelukast  (EXP)
morphine  (EXP,ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naloxone  (EXP,ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitroprusside  (EXP)
Norbinaltorphimine  (ISO)
olanzapine  (EXP)
oridonin  (EXP)
oxidopamine  (EXP,ISO)
P(1),P(4)-bis(5'-adenosyl) tetraphosphate  (EXP)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phencyclidine  (ISO)
Phenelzine  (EXP)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregabalin  (ISO)
probenecid  (ISO)
progesterone  (EXP)
propanal  (ISO)
propofol  (ISO)
purine-6-thiol  (EXP)
pyrroloquinoline quinone  (EXP)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
reserpine  (EXP,ISO)
resveratrol  (ISO)
rimonabant  (EXP)
risperidone  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
rutin  (EXP)
salubrinal  (EXP)
saxagliptin  (EXP)
SB 203580  (EXP)
SCH 23390  (ISO)
selenium atom  (EXP)
simazine  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
spiperone  (EXP)
sulforaphane  (ISO)
sulpiride  (EXP,ISO)
Talipexole dihydrochloride  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
telmisartan  (ISO)
testosterone  (EXP)
topiramate  (ISO)
triprolidine  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vitamin D  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP,ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aminergic neurotransmitter loading into synaptic vesicle  (IDA)
animal organ morphogenesis  (ISO)
catecholamine biosynthetic process  (IDA)
cellular response to alkaloid  (IEP)
cellular response to drug  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to manganese ion  (IEP)
cellular response to nicotine  (IEP)
cerebral cortex development  (IEP)
circadian sleep/wake cycle  (IEP)
cognition  (IEP)
dopamine biosynthetic process  (ISO)
dopamine biosynthetic process from tyrosine  (IBA,IDA,IMP,ISO)
eating behavior  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
epinephrine biosynthetic process  (ISO)
eye photoreceptor cell development  (ISO)
fatty acid metabolic process  (IEP)
glycoside metabolic process  (IEP)
heart development  (IBA,IDA,ISO)
hyaloid vascular plexus regression  (ISO,ISS)
isoquinoline alkaloid metabolic process  (IEP)
learning  (ISO)
locomotory behavior  (ISO)
mating behavior  (ISO)
memory  (ISO)
multicellular organism aging  (IEP)
neurotransmitter biosynthetic process  (IEA)
norepinephrine biosynthetic process  (ISO)
phthalate metabolic process  (IEP)
phytoalexin metabolic process  (IEP)
regulation of heart contraction  (ISO)
response to activity  (IEP)
response to amphetamine  (IEP)
response to corticosterone  (IEP)
response to drug  (IEP)
response to electrical stimulus  (IEP)
response to estradiol  (IEP)
response to ethanol  (IBA,IEP,ISO)
response to ether  (IEP)
response to growth factor  (IEP)
response to herbicide  (IEP)
response to hypoxia  (IBA,IDA,IEP,ISO)
response to immobilization stress  (IEP)
response to insecticide  (IEP)
response to isolation stress  (IEP)
response to light stimulus  (IEP)
response to lipopolysaccharide  (IEP)
response to metal ion  (IEP)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to pyrethroid  (IEP)
response to salt stress  (IEP)
response to steroid hormone  (IEP)
response to water deprivation  (IEP)
response to zinc ion  (IEP)
sensory perception of sound  (IEP)
social behavior  (IEP)
sphingolipid metabolic process  (IEP)
synaptic transmission, dopaminergic  (ISO)
terpene metabolic process  (IEP)
visual perception  (ISO)

Cellular Component

References

References - curated
1. Abramova MA, etal., Brain Struct Funct. 2011 Jan;215(3-4):195-207. Epub 2010 Nov 27.
2. Aguilar-Valles A and Luheshi GN, Psychoneuroendocrinology. 2010 Oct 7.
3. Allard S, etal., Neurobiol Aging. 2010 Jan 21.
4. Altamura AC, etal., Neurosci Lett. 1978 Jan;7(1):83-7.
5. Alves S, etal., Hum Mol Genet. 2008 Jul 15;17(14):2071-83. Epub 2008 Apr 1.
6. Anney RJ, etal., Pharmacogenetics. 2004 Feb;14(2):73-81.
7. Asmus SE, etal., Brain Res. 2011 Feb 3.
8. Bangasser D, etal., Physiol Behav. 2011 Mar 5.
9. Bodeau-Pean S, etal., J Biol Chem. 1999 Feb 5;274(6):3469-75.
10. Buller KM, etal., Pediatr Res. 2008 Apr;63(4):364-9.
11. Bundzikova J, etal., Cell Mol Neurobiol. 2010 Nov 9.
12. Cartier EA, etal., J Biol Chem. 2010 Jan 15;285(3):1957-66. Epub 2009 Nov 10.
13. Chen T, etal., Toxicol Lett. 2011 Feb 25;201(1):34-41. Epub 2010 Dec 9.
14. Chiou SH, etal., Anal Biochem. 2007 Apr 1;363(1):46-57. Epub 2007 Jan 17.
15. Chow MS, etal., J Am Chem Soc. 2009 Jun 10;131(22):7685-98.
16. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
17. Coll M, etal., Liver Int. 2010 Apr;30(4):593-602. Epub 2009 Nov 30.
18. Cruz-Muros I, etal., Exp Neurol. 2007 Mar;204(1):147-61. Epub 2006 Nov 16.
19. Dahmen N, etal., Psychiatr Genet. 2005 Mar;15(1):13-6.
20. Damon DH Am J Physiol Heart Circ Physiol. 2011 Jan 7.
21. Eser BE and Fitzpatrick PF, Biochemistry. 2010 Jan 26;49(3):645-52.
22. Fan DS, etal., Hum Gene Ther. 1998 Nov 20;9(17):2527-35.
23. Frantom PA, etal., Biochemistry. 2006 Feb 21;45(7):2372-9.
24. Garcia AP, etal., PLoS One. 2011 Feb 18;6(2):e17313.
25. Garcia C, etal., Br J Pharmacol. 2011 Feb 16. doi: 10.1111/j.1476-5381.2011.01278.x.
26. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Gavrilovic L, etal., Braz J Med Biol Res. 2009 Dec;42(12):1185-90. Epub 2009 Nov 6.
28. GOA data from the GO Consortium
29. Gompf HS, etal., J Neurosci. 2010 Oct 27;30(43):14543-51.
30. Gu D, etal., Hypertension. 2006 Jun;47(6):1147-54. Epub 2006 Apr 24.
31. Hoffmann GF, etal., Ann Neurol. 2003;54 Suppl 6:S56-65.
32. Horellou P, etal., FEBS Lett. 1986 Sep 1;205(1):6-10.
33. Hosp JA, etal., J Neurosci. 2011 Feb 16;31(7):2481-7.
34. Huang HS, etal., J Asian Nat Prod Res. 2009 Oct;11(10):867-75.
35. Inouye KE, etal., Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.
36. Iwakura Y, etal., J Neurochem. 2005 May;93(4):974-83.
37. Jang S, etal., Neurochem Res. 2011 Feb;36(2):258-67. Epub 2010 Nov 13.
38. Jezova M, etal., Endocrinology 2003 May;144(5):2092-101.
39. Jin CM, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):88-95. Epub 2008 Jun 19.
40. Jin CM, etal., J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):747-55.
41. Joh TH, etal., Proc Natl Acad Sci U S A. 1978 Oct;75(10):4744-8.
42. Kang YM, etal., Basic Res Cardiol. 2011 Feb 2.
43. KEGG
44. Khaindrava V, etal., Neurobiol Dis. 2011 Feb 3.
45. Khuwaja G, etal., Brain Res. 2011 Jan 12;1368:254-63. Epub 2010 Oct 15.
46. Kim Y, etal., Nutr Res Pract. 2010 Aug;4(4):270-5. Epub 2010 Aug 31.
47. Klintschar M, etal., Forensic Sci Int. 2005 Oct 29;153(2-3):142-6. Epub 2004 Nov 6.
48. Kritzer MF Cereb Cortex 2003 Mar;13(3):282-96.
49. Kumar A, etal., Free Radic Res. 2010 Aug;44(8):950-65.
50. Kumar GK, etal., J Appl Physiol. 2003 Aug;95(2):536-44. Epub 2003 Apr 11.
51. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
52. Laborie C, etal., Neurosci Lett. 2005 Jun 24;381(3):211-6.
53. Lai FJ, etal., J Histochem Cytochem. 2005 Jan;53(1):45-53.
54. Lee JJ, etal., Molecules. 2008 Feb 27;13(2):475-87.
55. Liu D, etal., Exp Biol Med (Maywood). 2014 Mar;239(3):330-6. doi: 10.1177/1535370213513987. Epub 2014 Feb 4.
56. Liu GP and Shi N, Toxicol Lett. 2006 Mar 1;161(3):195-9. Epub 2005 Oct 17.
57. Ludecke B, etal., Hum Genet. 1995 Jan;95(1):123-5.
58. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
59. Marques Pereira P, etal., J Neurochem. 2008 Dec;107(5):1325-34. Epub 2008 Sep 24.
60. Maximino JR, etal., Neurosci Res. 2006 Jul;55(3):292-9. Epub 2006 May 2.
61. Mengual E and Pickel VM, J Comp Neurol. 2004 Jan 12;468(3):395-409.
62. MGD data from the GO Consortium
63. Micutkova L, etal., Endocr Regul 2001 Dec;35(4):195-200.
64. Minton GO, etal., Neuropsychopharmacology. 2009 Sep;34(10):2265-74. Epub 2009 Jun 3.
65. Mohankumar SM, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Mar;300(3):R693-9. Epub 2010 Dec 22.
66. Morrison JF, etal., Ann N Y Acad Sci. 2006 Nov;1084:267-79.
67. Moura E, etal., Life Sci. 2005 May 6;76(25):2953-64. Epub 2005 Jan 27.
68. Mousa SA, etal., J Comp Neurol. 2011 Apr 1;519(5):957-71. doi: 10.1002/cne.22560.
69. Mukda S, etal., Neurosci Lett. 2011 Jan 20;488(2):154-7. Epub 2010 Nov 13.
70. Mulcahy P, etal., Neuroscience. 2011 Jan 26.
71. Mullen BJ and Wang M, J Nutr. 1986 Jul;116(7):1298-305.
72. Nabhen SL, etal., Neurochem Int. 2011 Feb;58(2):196-205. Epub 2010 Dec 1.
73. Nascimento PS, etal., Brain Res. 2011 Mar 25;1382:173-80. Epub 2011 Jan 26.
74. Navarro-Zaragoza J, etal., Br J Pharmacol. 2011 Feb;162(4):851-62. doi: 10.1111/j.1476-5381.2010.01090.x.
75. NCBI rat LocusLink and RefSeq merged data July 26, 2002
76. OMIM Disease Annotation Pipeline
77. Park HJ, etal., Korean J Physiol Pharmacol. 2010 Dec;14(6):371-6. Epub 2010 Dec 31.
78. Patterson-Buckendahl P, etal., Alcohol. 2005 Nov;37(3):157-66.
79. Perez RG, etal., J Neurosci. 2002 Apr 15;22(8):3090-9.
80. Perry ML, etal., J Neurochem. 2010 Aug;114(3):666-74. Epub 2010 Apr 20.
81. Pipeline to import KEGG annotations from KEGG into RGD
82. Pipeline to import SMPDB annotations from SMPDB into RGD
83. Pohorecky LA, etal., Neuroendocrinology. 2004;80(1):42-51. Epub 2004 Sep 2.
84. Puskas N, etal., Peptides. 2010 Aug;31(8):1589-97. Epub 2010 Apr 29.
85. Ray K, etal., Neurochem Int. 2011 Jan;58(1):112-8. Epub 2010 Nov 12.
86. Reynolds KB, etal., Brain Res. 2011 Mar 8.
87. RGD automated data pipeline
88. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
89. RGD automated import pipeline for gene-chemical interactions
90. Rodriguez S, etal., Eur J Hum Genet. 2006 Jan;14(1):109-16.
91. Rorato RC, etal., Exp Physiol. 2011 Jan 14.
92. Royo M, etal., Arch Biochem Biophys. 2005 Feb 15;434(2):266-74.
93. Schnell PO, etal., J Neurochem 2003 Apr;85(2):483-91.
94. Serova L, etal., Neuroendocrinology 2002 Mar;75(3):193-200.
95. Sharma U, etal., Clin Exp Hypertens. 2002 Apr;24(3):141-53.
96. Shin SS, etal., Brain Res. 2011 Jan 19;1369:208-15. Epub 2010 Nov 1.
97. Sorg BA, etal., Neuroscience. 2011 Mar 10;176:284-95. Epub 2010 Dec 24.
98. Sriram K, etal., Arch Toxicol. 2010 Jul;84(7):521-40. Epub 2010 Mar 12.
99. Stahl K, etal., Brain Res. 2011 Mar 10;1378:105-18. Epub 2011 Jan 12.
100. Sun M, etal., Hum Gene Ther. 2004 Dec;15(12):1177-96.
101. Suzuki T, etal., J Biol Chem 2002 Oct 25;277(43):40768-74.
102. Swaans RJ, etal., Ann Hum Genet. 2000 Jan;64(Pt 1):25-31.
103. Takahashi S Tohoku J Exp Med. 2008 Nov;216(3):239-48.
104. Tanriover G, etal., Folia Histochem Cytobiol. 2010 Sep 30;48(3):434-41.
105. Temel S, etal., Endocrinology 2002 Oct;143(10):3974-83.
106. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
107. Tong L, etal., Hear Res. 2005 Aug;206(1-2):28-41.
108. Tsudzuki T and Tsujita M, J Biochem (Tokyo). 2004 Aug;136(2):239-43.
109. Ulusoy A, etal., Mol Ther. 2009 Sep;17(9):1574-84. Epub 2009 Jul 7.
110. Urbanavicius J, etal., J Neurochem. 2007 Aug;102(3):723-30. Epub 2007 Apr 16.
111. Wang D, etal., Neurosci Lett. 2015 Oct 8;606:60-5. doi: 10.1016/j.neulet.2015.08.024. Epub 2015 Aug 18.
112. Wang J, etal., Neurotoxicology. 2009 Nov;30(6):926-33. Epub 2009 Sep 23.
113. Wang Y, etal., J Neurol Sci. 2011 Mar 2.
114. Wolff JA, etal., Proc Natl Acad Sci U S A. 1989 Nov;86(22):9011-4.
115. Yang YJ, etal., J Neurosci Res. 2009 Jun;87(8):1929-37.
116. Yin LL, etal., Neurosci Lett. 2010 Aug 2;479(3):231-5. doi: 10.1016/j.neulet.2010.05.068. Epub 2010 Jun 1.
117. Zhang D, etal., J Neurosci. 2007 May 16;27(20):5349-62.
118. Zhou QY, etal., Nature 1995 Apr 13;374(6523):640-3.
119. Zhu Y, etal., Int J Biochem Cell Biol. 2011 Feb 15.
120. Zuhayra M, etal., Neuropathol Appl Neurobiol. 2011 Mar 2. doi: 10.1111/j.1365-2990.2011.01169.x.
Additional References at PubMed
PMID:1672315   PMID:2857492   PMID:2882469   PMID:2884660   PMID:2889468   PMID:2896667   PMID:2905129   PMID:7518394   PMID:7592982   PMID:9228951   PMID:9520487   PMID:9753429  
PMID:9829800   PMID:10212311   PMID:10350535   PMID:10707987   PMID:10802666   PMID:10907721   PMID:11430814   PMID:11502746   PMID:11841594   PMID:11902120   PMID:11922614   PMID:12074840  
PMID:12130711   PMID:12147212   PMID:12423254   PMID:12457228   PMID:12538862   PMID:12604788   PMID:12631248   PMID:12675153   PMID:12742186   PMID:12929090   PMID:14651963   PMID:14660060  
PMID:14684249   PMID:14697237   PMID:14739357   PMID:15223360   PMID:15260122   PMID:15317940   PMID:15374756   PMID:15471880   PMID:15643613   PMID:15747353   PMID:15809070   PMID:15814794  
PMID:15860555   PMID:15935066   PMID:16076648   PMID:16165221   PMID:16195501   PMID:16338639   PMID:16445854   PMID:16452470   PMID:16503426   PMID:16584838   PMID:16618490   PMID:16805833  
PMID:17135716   PMID:17196177   PMID:17273802   PMID:17363452   PMID:17416971   PMID:17520326   PMID:17524356   PMID:17543899   PMID:17626271   PMID:17713852   PMID:17761882   PMID:17823252  
PMID:17900529   PMID:17951370   PMID:18032527   PMID:18047555   PMID:18072084   PMID:18185104   PMID:18258664   PMID:18343820   PMID:18536752   PMID:18572382   PMID:18589406   PMID:18772553  
PMID:18778785   PMID:19060113   PMID:19104749   PMID:19112418   PMID:19120093   PMID:19249909   PMID:19289463   PMID:19371093   PMID:19409439   PMID:19482560   PMID:19505538   PMID:19524553  
PMID:19581298   PMID:19703902   PMID:19756365   PMID:19818101   PMID:19844994   PMID:19945993   PMID:20037632   PMID:20102321   PMID:20143408   PMID:20170714   PMID:20620242   PMID:20811774  
PMID:20814066   PMID:20884338   PMID:21125428   PMID:21396433   PMID:21514317   PMID:21689789   PMID:21767616   PMID:21777029   PMID:21818658   PMID:21871514   PMID:22212880   PMID:22242182  
PMID:22372951   PMID:22815976   PMID:23153692   PMID:23321789   PMID:23327742   PMID:23368961   PMID:23608099   PMID:23680462   PMID:23868341   PMID:24117713   PMID:24317346   PMID:24480406  
PMID:24837549   PMID:25074751   PMID:25957836   PMID:26024204   PMID:26225746   PMID:26583134   PMID:26599339   PMID:26658810   PMID:26969276   PMID:27095027   PMID:27365397   PMID:27789384  
PMID:28132600   PMID:28630892   PMID:28637871   PMID:28726094   PMID:28750831   PMID:28887039   PMID:28984618   PMID:30056575   PMID:30634592   PMID:31279527  


Genomics

Comparative Map Data
Th
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21198,071,500 - 198,078,832 (-)NCBI
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
Celera1195,642,057 - 195,649,203 (-)NCBICelera
RH 2.0 Map11080.1RGD
Cytogenetic Map1q41NCBI
TH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,163,929 - 2,171,815 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl112,163,929 - 2,171,877 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,163,929 - 2,174,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,185,159 - 2,193,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,141,735 - 2,149,611 (-)NCBINCBI36hg18NCBI36
Build 34112,141,735 - 2,149,605NCBI
Celera112,221,752 - 2,229,624 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,975,424 - 1,983,299 (-)NCBIHuRef
CHM1_1112,183,941 - 2,191,817 (-)NCBICHM1_1
Th
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,446,516 - 142,453,732 (-)NCBIGRCm39mm39
GRCm39 Ensembl7142,446,489 - 142,484,865 (-)Ensembl
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBImm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
Th
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,943,552 - 13,951,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,943,590 - 13,951,102 (-)NCBIChiLan1.0ChiLan1.0
TH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,234,095 - 2,242,030 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,231,248 - 2,242,433 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,204,820 - 2,212,750 (-)NCBIMhudiblu_PPA_v0panPan3
TH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,327,136 - 46,334,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,936,923 - 44,944,750 (-)NCBI
ROS_Cfam_1.01847,006,609 - 47,014,412 (-)NCBI
UMICH_Zoey_3.11846,455,359 - 46,462,897 (-)NCBI
UNSW_CanFamBas_1.01846,035,687 - 46,043,215 (-)NCBI
UU_Cfam_GSD_1.01846,782,129 - 46,789,967 (-)NCBI
Th
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,535,447 - 2,543,939 (-)NCBI
SpeTri2.0NW_004936794478,651 - 486,887 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,499,618 - 1,506,615 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,499,628 - 1,506,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,969,194 - 1,977,263 (-)NCBI
ChlSab1.1 Ensembl11,966,460 - 1,977,218 (-)Ensembl
Th
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476715,003,073 - 15,010,207 (-)NCBI

Position Markers
D1Smu3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,081,083 - 198,081,184 (+)MAPPER
Rnor_6.01216,082,612 - 216,082,712NCBIRnor6.0
Rnor_5.01222,945,040 - 222,945,140UniSTSRnor5.0
RGSC_v3.41203,173,831 - 203,173,931UniSTSRGSC3.4
Celera1195,651,528 - 195,651,628UniSTS
Cytogenetic Map1q41UniSTS
M69200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,071,580 - 198,071,684 (+)MAPPER
Rnor_6.01216,073,109 - 216,073,212NCBIRnor6.0
Rnor_5.01222,935,537 - 222,935,640UniSTSRnor5.0
RGSC_v3.41203,164,328 - 203,164,431UniSTSRGSC3.4
Celera1195,642,132 - 195,642,235UniSTS
Cytogenetic Map1q41UniSTS
PMC18740P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,072,757 - 198,073,166 (+)MAPPER
Rnor_6.01216,074,286 - 216,074,694NCBIRnor6.0
Rnor_5.01222,936,714 - 222,937,122UniSTSRnor5.0
RGSC_v3.41203,165,505 - 203,165,913UniSTSRGSC3.4
Celera1195,643,309 - 195,643,717UniSTS
Cytogenetic Map1q41UniSTS
RH94698  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,076,403 - 198,076,537 (+)MAPPER
Rnor_6.01216,077,932 - 216,078,065NCBIRnor6.0
Rnor_5.01222,940,360 - 222,940,493UniSTSRnor5.0
RGSC_v3.41203,169,151 - 203,169,284UniSTSRGSC3.4
Celera1195,646,955 - 195,647,088UniSTS
Cytogenetic Map1q41UniSTS
PMC151031P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,075,720 - 198,076,641 (+)MAPPER
Rnor_6.01216,077,249 - 216,078,169NCBIRnor6.0
Rnor_5.01222,939,677 - 222,940,597UniSTSRnor5.0
RGSC_v3.41203,168,468 - 203,169,388UniSTSRGSC3.4
Celera1195,646,272 - 195,647,192UniSTS
Cytogenetic Map1q41UniSTS
Th  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,075,568 - 198,076,698 (+)MAPPER
Rnor_6.01216,077,097 - 216,078,226NCBIRnor6.0
Rnor_5.01222,939,525 - 222,940,654UniSTSRnor5.0
RGSC_v3.41203,168,316 - 203,169,445UniSTSRGSC3.4
Celera1195,646,120 - 195,647,249UniSTS
Cytogenetic Map1q41UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1153834077232297227Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1156446196243311614Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1161784169219232156Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1161784169219232156Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1161784169219232156Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169219232156Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1161784422246226103Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1167394665219232156Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1167394665238830534Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700233490237Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700264802994Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1175447029220447029Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1175447029220447029Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1175462885220462885Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1185390068230390068Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1188850303233850303Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1189170900234170900Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1189170900234170900Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1189170900234170900Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1189170900234170900Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1189170900234170900Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1189170900234170900Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1189170900234170900Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1189170900234170900Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1189514504234514504Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1190282646235282646Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1193220385238220385Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1193968438261264776Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1194554354239554354Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1194872362239872362Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1195598053265002735Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1196738546241738546Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1197187728230420772Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1197187728238220385Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1197963658242963658Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1198446729240017341Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1198585664236763415Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1198655722244992610Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1201146802241482368Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1201358068221983732Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1201358068252480016Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1202571665264802994Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1202571665264802994Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1205195290250195290Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1205603081244401301Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1206950905218614387Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1208517798266948272Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1210019247217054418Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1210360774264802828Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1210652654255652654Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1210960636236763528Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210990171255990171Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1215097781216213510Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1215494321218614387Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1215684498260684498Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1215711860258765521Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1215711860260711860Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1215828102260828102Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1215828102260828102Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1215828102260828102Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7drno-let-7d-5pMirtarbaseexternal_infoReporter assay;qRT-PCRFunctional MTI20557304

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:51
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000027682
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 30 8
Low 2 2 2 2 44 10 16
Below cutoff 1 23 13 7 16 7 3 3 14 14 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027682   ⟹   ENSRNOP00000027682
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)Ensembl
RefSeq Acc Id: NM_012740   ⟹   NP_036872
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,506 - 198,078,759 (-)NCBI
Rnor_6.01216,073,034 - 216,080,287 (-)NCBI
Rnor_5.01222,935,462 - 222,942,715 (-)NCBI
RGSC_v3.41203,164,253 - 203,171,506 (-)RGD
Celera1195,642,057 - 195,649,203 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101320   ⟹   XP_038957248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,500 - 198,078,829 (-)NCBI
RefSeq Acc Id: XM_039101324   ⟹   XP_038957252
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,500 - 198,078,832 (-)NCBI
RefSeq Acc Id: XM_039101327   ⟹   XP_038957255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21198,071,500 - 198,078,829 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036872   ⟸   NM_012740
- UniProtKB: P04177 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027682   ⟸   ENSRNOT00000027682
RefSeq Acc Id: XP_038957252   ⟸   XM_039101324
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957255   ⟸   XM_039101327
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038957248   ⟸   XM_039101320
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 222940777 222940778 C T snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (KNAW), FHL/EurMcwi (KNAW), LEC/Tj (KyushuU), LE/Stm (SOLiD) (KNAW), LE/OrlBarth (UDEL), LE/Stm (KyushuU), LE/Stm (Illumina) (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 216078349 216078350 C T snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), LE/Stm (RGD), FHH/EurMcwi (RGD), FHL/EurMcwi (RGD)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 203169568 203169569 C T snv FHH/EurMcwi (MDC), LE/Stm (KNAW), FHH/EurMcwi (MCW), FHL/EurMcwi (ICL), LE/Stm (ICL), FHH/EurMcwi (ICL), FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3853 AgrOrtholog
Ensembl Genes ENSRNOG00000020410 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000027682 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027682 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot
InterPro ArAA_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot
  Eu_TyrOH_cat UniProtKB/Swiss-Prot
  Tyr_3_mOase UniProtKB/Swiss-Prot
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot
  Tyrosine_hydroxylase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25085 UniProtKB/Swiss-Prot
NCBI Gene 25085 ENTREZGENE
PANTHER PTHR11473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Biopterin_H UniProtKB/Swiss-Prot
  TOH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Th PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot
PRINTS FYWHYDRXLASE UniProtKB/Swiss-Prot
PROSITE BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56534 UniProtKB/Swiss-Prot
TIGR TC228643
TIGRFAMs Tyr_3_monoox UniProtKB/Swiss-Prot
UniProt P04177 ENTREZGENE
  P97904_RAT UniProtKB/TrEMBL
  TY3H_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Th  Tyrosine hydroxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression basal levels of mRNA is expressed by norepinephrine (NE) and epinephrine neurons,expression is higher in young animals during the steroid induced surge 628385
gene_regulation mRNA levels are regulated by gonadal steroids 628385