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The synthesis and release of catecholamines dopamine, norepinephrine and epinephrine are triggered by various but distinct conditions and stresses. Norepinephrine and epinephrine, also known as noradrenaline and adrenaline, act as neurotransmitters and hormones. They signal via various adrenergic receptors, G protein-coupled receptors (GPCR) which couple to distinct G alpha subunits of heterotrimeric G proteins. Stresses such as cold and pain prompt the synthesis of norepinpehrine in sympathetic

Pathway Diagram:

Elsevier Inc. L-Phe hydroxylation norepinephrine dopamine L-DOPA BH2 BH4 tyrosine Dbh Ddc Th Qdpr Slc18a2 ---> dopamine Slc18a2 Ddc ---- Slc18a2 Slc18a2 ---- Th diet BH4 ---> BH2 L-DOPA ---> dopamine tyrosine ---> L-DOPA diet ---> tyrosine L-Phe hydroxylation ---> tyrosine BH2 ---> BH4 dopamine ---> norepinephrine

Genes in Pathway:

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norepinephrine biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbh dopamine beta-hydroxylase JBrowse link 3 5,709,236 5,731,895 RGD:4139904
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:4139904
G Qdpr quinoid dihydropteridine reductase JBrowse link 14 70,164,682 70,178,284 RGD:4139904
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:5128868
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:4139904

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeBH2dihydrobiopterin
Small MoleculeL-DOPALevodopa
Small MoleculeBH4tetrahydrobiopterin

Pathway Gene Annotations

Disease Annotations Associated with Genes in the norepinephrine biosynthetic pathway
Disease TermsGene Symbols
alcohol use disorderDbh
aromatic L-amino acid decarboxylase deficiencyDdc
attention deficit hyperactivity disorderDbh , Ddc
bipolar disorderDdc
brain diseaseTh
Brain InjuriesTh
brain ischemiaDbh , Th
congestive heart failureTh
ContusionsDbh , Th
Diabetes Mellitus, Experimental Dbh , Qdpr , Th
disease of mental healthDdc
dopamine beta-hydroxylase deficiencyDbh
Drug-Induced DyskinesiaDdc , Th
end stage renal failureDdc
Experimental Liver CirrhosisDbh , Ddc , Th
genetic diseaseSlc18a2 , Th
heart diseaseTh
hepatocellular carcinomaDbh , Th
Hyperphenylalaninemia, BH4-Deficient, CQdpr
hypertensionDbh , Qdpr , Th
inherited metabolic disorderDdc
intellectual disabilityDbh , Th
late onset Parkinson's diseaseDbh
Lead PoisoningQdpr
learning disabilityTh
Machado-Joseph diseaseSlc18a2 , Th
maturity-onset diabetes of the youngTh
mental depressionDbh , Slc18a2 , Th
middle cerebral artery infarctionTh
migraine with auraDbh
myocardial infarctionTh
neonatal diabetes mellitusTh
nephrotic syndromeDdc
Nerve DegenerationDdc , Slc18a2 , Th
nervous system diseaseSlc18a2
neuroblastomaDbh , Th
Paranoid DisordersDbh
Parkinson's diseaseDbh , Ddc , Slc18a2 , Th
Parkinsonian DisordersDdc , Slc18a2 , Th
pheochromocytomaDbh , Ddc , Th
pleomorphic xanthoastrocytomaDdc
polycystic ovary syndromeTh
portal hypertensionDbh , Ddc , Th
Reperfusion InjuryTh
Segawa Syndrome, Autosomal RecessiveTh
status epilepticusQdpr
substance-related disorderSlc18a2
toxic encephalopathySlc18a2
type 1 diabetes mellitusSlc18a2
withdrawal disorderTh
Pathway Annotations Associated with Genes in the norepinephrine biosynthetic pathway

References Associated with the norepinephrine biosynthetic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: