TH Human (+)-catechin multiple interactions ISO Th (Rattus norvegicus) 6480464 Catechin inhibits the reaction [Rotenone results in decreased activity of TH protein] CTD PMID:35337893 TH Human (+)-sesamin multiple interactions ISO Th (Rattus norvegicus) 6480464 sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:19794909 TH Human (+)-taxifolin multiple interactions ISO Th (Rattus norvegicus) 6480464 taxifolin inhibits the reaction [Rotenone results in decreased activity of TH protein] CTD PMID:35187747 TH Human (-)-epigallocatechin 3-gallate decreases expression ISO Th (Rattus norvegicus) 6480464 epigallocatechin gallate results in decreased expression of TH protein CTD PMID:27659729 TH Human (-)-selegiline multiple interactions ISO Th (Rattus norvegicus) 6480464 Selegiline inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:16490285 TH Human (-)-selegiline decreases expression ISO Th (Rattus norvegicus) 6480464 Selegiline results in decreased expression of TH mRNA CTD PMID:11862330 TH Human (R)-adrenaline increases chemical synthesis ISO Th (Mus musculus) 6480464 TH protein results in increased chemical synthesis of Epinephrine CTD PMID:9822156 TH Human (R)-adrenaline multiple interactions ISO Th (Rattus norvegicus) 6480464 [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine CTD PMID:19067675 TH Human (R)-noradrenaline multiple interactions ISO Th (Rattus norvegicus) 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine and [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine CTD PMID:19067675 TH Human (R)-noradrenaline increases chemical synthesis ISO Th (Mus musculus) 6480464 TH protein results in increased chemical synthesis of Norepinephrine CTD PMID:9822156 TH Human (R,R,R)-alpha-tocopherol multiple interactions ISO Th (Rattus norvegicus) 6480464 [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein and alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:15790535 and PMID:25891525 TH Human (S)-AMPA decreases expression ISO Th (Rattus norvegicus) 6480464 alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein CTD PMID:36775207 TH Human (S)-AMPA multiple interactions ISO Th (Rattus norvegicus) 6480464 1-naphthylacetylspermine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein] and aminophenyl fluorescein inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein] CTD PMID:36775207 TH Human (S)-amphetamine increases expression ISO Th (Mus musculus) 6480464 Dextroamphetamine results in increased expression of TH mRNA CTD PMID:18681898 TH Human (S)-naringenin decreases expression ISO Th (Rattus norvegicus) 6480464 naringenin results in decreased expression of TH protein CTD PMID:34655599 TH Human (S)-naringenin multiple interactions ISO Th (Rattus norvegicus) 6480464 naringenin inhibits the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:34655599 TH Human (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:17498763 TH Human (S)-nicotine multiple interactions ISO Th (Rattus norvegicus) 6480464 [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ... CTD PMID:29246838 TH Human (S)-nicotine increases expression ISO Th (Rattus norvegicus) 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:29246838 TH Human (S)-nicotine multiple interactions ISO Th (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 more ... TH Human (S)-nicotine multiple interactions EXP 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] CTD PMID:17498763 TH Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Th (Mus musculus) 6480464 (3R)-((2 more ... CTD PMID:16402076 more ... TH Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:30195017 and PMID:38016618 TH Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 PRKN protein inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:24140863 and PMID:25447324 TH Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:15329391 more ... TH Human 1-Naphthylacetylspermine multiple interactions ISO Th (Rattus norvegicus) 6480464 1-naphthylacetylspermine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in decreased expression of TH protein] CTD PMID:36775207 TH Human 15-deoxy-Delta(12,14)-prostaglandin J2 increases expression ISO Th (Rattus norvegicus) 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased expression of TH protein CTD PMID:15212945 TH Human 17beta-estradiol affects expression ISO Th (Rattus norvegicus) 6480464 Estradiol affects the expression of TH protein CTD PMID:16427766 TH Human 17beta-estradiol multiple interactions ISO Th (Mus musculus) 6480464 Estradiol inhibits the reaction [manganese chloride results in decreased expression of TH mRNA] and Estradiol inhibits the reaction [manganese chloride results in decreased expression of TH protein] CTD PMID:29183790 TH Human 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of TH mRNA CTD PMID:27271280 and PMID:31614463 TH Human 17beta-estradiol multiple interactions EXP 6480464 Estradiol promotes the reaction [ESR2 protein affects the expression of TH mRNA] and Estradiol results in increased expression of and results in increased secretion of TH protein CTD PMID:20404318 and PMID:27271280 TH Human 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of TH mRNA CTD PMID:14699072 TH Human 2',5'-Dideoxyadenosine multiple interactions ISO Th (Rattus norvegicus) 6480464 2' and 5'-dideoxyadenosine inhibits the reaction [epibatidine results in increased expression of TH mRNA] CTD PMID:15588622 TH Human 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO Th (Rattus norvegicus) 6480464 2 more ... CTD PMID:29233657 TH Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ... CTD PMID:19481886 more ... TH Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Th (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of TH mRNA CTD PMID:22808131 TH Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of TH protein CTD PMID:19481886 TH Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of TH mRNA and Tetrachlorodibenzodioxin results in increased expression of TH protein CTD PMID:19500377 more ... TH Human 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased activity of TH protein CTD PMID:19500377 TH Human 2,3,7,8-tetrachlorodibenzodioxine decreases methylation ISO Th (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased methylation of TH gene CTD PMID:21212295 TH Human 2,4-D increases expression ISO Th (Rattus norvegicus) 6480464 2 and 4-Dichlorophenoxyacetic Acid results in increased expression of TH protein CTD PMID:16931444 TH Human 2-methyl-6-(phenylethynyl)pyridine multiple interactions ISO Th (Rattus norvegicus) 6480464 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein] CTD PMID:33571554 TH Human 3,4-dihydroxyphenylacetaldehyde affects binding ISO Th (Rattus norvegicus) 6480464 3 and 4-dihydroxyphenylacetaldehyde binds to TH protein CTD PMID:21238438 TH Human 3,4-dihydroxyphenylacetaldehyde decreases activity ISO Th (Rattus norvegicus) 6480464 3 and 4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein CTD PMID:21514317 TH Human 3,4-dihydroxyphenylacetaldehyde multiple interactions ISO Th (Rattus norvegicus) 6480464 [3 and 4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa CTD PMID:21514317 TH Human 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide multiple interactions ISO Th (Mus musculus) 6480464 Raclopride inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:16088948 TH Human 3,7-dihydropurine-6-thione multiple interactions ISO Th (Rattus norvegicus) 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 TH Human 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO Th (Rattus norvegicus) 6480464 bisindolylmaleimide I inhibits the reaction [3-(2-hydroxy-4-(1 more ... CTD PMID:18992715 TH Human 3-Amino-1-methyl-5H-pyrido[4,3-b]indole decreases activity ISO Th (Rattus norvegicus) 6480464 3-amino-1-methyl-5H-pyrido(4 and 3-b)indole results in decreased activity of TH protein CTD PMID:2904812 TH Human 3-hydroxybutyric acid multiple interactions ISO Th (Mus musculus) 6480464 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]] more ... CTD PMID:36435477 TH Human 3-methyladenine multiple interactions ISO Th (Rattus norvegicus) 6480464 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein] and 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:28802652 and PMID:31734597 TH Human 3-phenylprop-2-enal multiple interactions ISO Th (Mus musculus) 6480464 cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:31187328 TH Human 4,4'-sulfonyldiphenol increases expression ISO Th (Rattus norvegicus) 6480464 bisphenol S results in increased expression of TH mRNA CTD PMID:26186136 TH Human 4,4'-sulfonyldiphenol affects methylation ISO Th (Mus musculus) 6480464 bisphenol S affects the methylation of TH exon CTD PMID:33297965 TH Human 4,4'-sulfonyldiphenol increases expression ISO Th (Mus musculus) 6480464 bisphenol S results in increased expression of TH mRNA CTD PMID:30951980 TH Human 4-phenylbutyric acid increases expression ISO Th (Mus musculus) 6480464 4-phenylbutyric acid results in increased expression of TH protein CTD PMID:21372141 TH Human 5-(2-chloroethyl)-4-methylthiazole multiple interactions ISO Th (Mus musculus) 6480464 Chlormethiazole inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:1381816 TH Human 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of TH mRNA CTD PMID:23441691 TH Human 5-fluorouracil affects expression ISO Th (Mus musculus) 6480464 Fluorouracil affects the expression of TH protein CTD PMID:21296659 TH Human 6-propyl-2-thiouracil increases expression ISO Th (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of TH mRNA CTD PMID:25825206 TH Human 6-propyl-2-thiouracil increases methylation ISO Th (Rattus norvegicus) 6480464 Propylthiouracil results in increased methylation of TH promoter CTD PMID:33150595 TH Human 6-propyl-2-thiouracil decreases expression ISO Th (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of TH mRNA CTD PMID:33150595 TH Human 7-nitroindazole multiple interactions ISO Th (Mus musculus) 6480464 7-nitroindazole affects the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:8931477 TH Human 8-bromo-3',5'-cyclic GMP multiple interactions ISO Th (Rattus norvegicus) 6480464 8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] and 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] CTD PMID:16023617 TH Human 9-cis-retinoic acid decreases expression EXP 6480464 Alitretinoin results in decreased expression of TH protein CTD PMID:36805303 TH Human acetic acid decreases expression ISO Th (Mus musculus) 6480464 Acetic Acid results in decreased expression of TH protein CTD PMID:21296659 TH Human acetylcholine increases expression ISO Th (Rattus norvegicus) 6480464 Acetylcholine results in increased expression of TH mRNA CTD PMID:29246838 TH Human acetylcholine multiple interactions ISO Th (Rattus norvegicus) 6480464 conotoxin AuIB inhibits the reaction [Acetylcholine results in increased expression of TH mRNA] more ... CTD PMID:29246838 TH Human acrylamide increases expression ISO Th (Rattus norvegicus) 6480464 Acrylamide results in increased expression of TH mRNA and Acrylamide results in increased expression of TH protein CTD PMID:25943760 TH Human acrylonitrile multiple interactions ISO Th (Rattus norvegicus) 6480464 Acrylonitrile inhibits the reaction [3 and 3'-iminodipropionitrile results in increased expression of TH protein] CTD PMID:19244277 TH Human aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of TH intron CTD PMID:30157460 TH Human Aflatoxin B2 alpha decreases methylation EXP 6480464 aflatoxin B2 results in decreased methylation of TH polyA tail CTD PMID:30157460 TH Human agmatine multiple interactions ISO Th (Rattus norvegicus) 6480464 Agmatine inhibits the reaction [Morphine results in increased expression of TH protein] CTD PMID:15541421 TH Human albiflorin affects expression ISO Th (Rattus norvegicus) 6480464 albiflorin affects the expression of TH CTD PMID:26475043 TH Human all-trans-retinoic acid multiple interactions EXP 6480464 [Tretinoin co-treated with CNTF protein] results in increased expression of TH more ... CTD PMID:17017122 more ... TH Human all-trans-retinoic acid increases expression ISO Th (Mus musculus) 6480464 Tretinoin results in increased expression of TH mRNA CTD PMID:34627992 TH Human all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of TH protein CTD PMID:36805303 TH Human all-trans-retinoic acid multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of TH mRNA and [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of TH mRNA CTD PMID:30951980 and PMID:36189433 TH Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of TH mRNA and Tretinoin results in increased expression of TH protein CTD PMID:15464216 more ... TH Human AM-251 multiple interactions ISO Th (Rattus norvegicus) 6480464 AM 251 affects the reaction [(3R)-((2 more ... CTD PMID:29113897 TH Human amentoflavone multiple interactions ISO Th (Mus musculus) 6480464 amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:28185818 TH Human aminoguanidine multiple interactions ISO Th (Mus musculus) 6480464 pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] CTD PMID:20455021 TH Human amitraz increases expression ISO Th (Rattus norvegicus) 6480464 amitraz results in increased expression of TH mRNA and amitraz results in increased expression of TH protein CTD PMID:28463726 TH Human amitraz multiple interactions ISO Th (Rattus norvegicus) 6480464 Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA] and Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein] CTD PMID:28463726 TH Human amitrole multiple interactions ISO Th (Rattus norvegicus) 6480464 Amitrole promotes the reaction [Sodium Chloride and Dietary results in increased expression of TH protein] CTD PMID:25891026 TH Human ammonium chloride affects expression ISO Th (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of TH mRNA CTD PMID:16483693 TH Human ammonium chloride decreases expression ISO Th (Rattus norvegicus) 6480464 Ammonium Chloride results in decreased expression of TH protein CTD PMID:16483693 TH Human amphetamine decreases expression ISO Th (Rattus norvegicus) 6480464 Amphetamine results in decreased expression of TH protein CTD PMID:12468030 more ... TH Human amphetamine multiple interactions ISO Th (Mus musculus) 6480464 PTN protein inhibits the reaction [Amphetamine results in decreased expression of TH protein] CTD PMID:20620199 TH Human amphetamine decreases expression ISO Th (Mus musculus) 6480464 Amphetamine results in decreased expression of TH protein CTD PMID:20620199 TH Human amphetamine increases expression ISO Th (Rattus norvegicus) 6480464 Amphetamine results in increased expression of TH mRNA CTD PMID:16126238 TH Human amphetamine increases expression ISO Th (Mus musculus) 6480464 Amphetamine results in increased expression of TH mRNA and Amphetamine results in increased expression of TH protein CTD PMID:16916582 and PMID:19059431 TH Human apigenin multiple interactions ISO Th (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:28389404 TH Human apocynin decreases expression ISO Th (Rattus norvegicus) 6480464 acetovanillone results in decreased expression of TH mRNA CTD PMID:25217652 TH Human apocynin multiple interactions ISO Th (Rattus norvegicus) 6480464 acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] CTD PMID:29859868 TH Human aprepitant multiple interactions ISO Th (Rattus norvegicus) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased expression of TH protein]] and Aprepitant inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:37224993 TH Human Aroclor 1254 multiple interactions ISO Th (Rattus norvegicus) 6480464 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH protein and [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1242 co-treated with aroclor 1248] results in decreased expression of TH mRNA CTD PMID:17324953 and PMID:29879404 TH Human Aroclor 1254 decreases expression ISO Th (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of TH protein CTD PMID:22094459 TH Human arsane multiple interactions ISO Th (Rattus norvegicus) 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 TH Human arsane increases expression ISO Th (Mus musculus) 6480464 Arsenic results in increased expression of TH protein CTD PMID:27413109 TH Human arsane decreases expression ISO Th (Rattus norvegicus) 6480464 Arsenic results in decreased expression of TH protein CTD PMID:22704994 TH Human arsenic atom decreases expression ISO Th (Rattus norvegicus) 6480464 Arsenic results in decreased expression of TH protein CTD PMID:22704994 TH Human arsenic atom increases expression ISO Th (Mus musculus) 6480464 Arsenic results in increased expression of TH protein CTD PMID:27413109 TH Human arsenic atom multiple interactions ISO Th (Rattus norvegicus) 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 TH Human arsenite(3-) increases expression ISO Th (Mus musculus) 6480464 arsenite results in increased expression of TH mRNA CTD PMID:33053406 TH Human arsenite(3-) decreases expression ISO Th (Rattus norvegicus) 6480464 arsenite results in decreased expression of TH protein CTD PMID:29982692 TH Human arsenite(3-) decreases expression ISO Th (Mus musculus) 6480464 arsenite results in decreased expression of TH mRNA and arsenite results in decreased expression of TH protein CTD PMID:29982692 and PMID:33053406 TH Human arsenous acid multiple interactions ISO Th (Mus musculus) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of TH mRNA] CTD PMID:23392890 TH Human arsenous acid decreases expression ISO Th (Mus musculus) 6480464 Arsenic Trioxide results in decreased expression of TH mRNA CTD PMID:23392890 and PMID:23518225 TH Human arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of TH protein CTD PMID:11027660 TH Human Asiaticoside multiple interactions ISO Th (Rattus norvegicus) 6480464 [asiaticoside co-treated with Rotenone] results in decreased expression of TH protein CTD PMID:28238857 TH Human atrazine decreases expression ISO Th (Rattus norvegicus) 6480464 Atrazine results in decreased expression of TH mRNA and Atrazine results in decreased expression of TH protein CTD PMID:14550852 more ... TH Human atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of TH mRNA CTD PMID:34146662 TH Human baicalein multiple interactions ISO Th (Mus musculus) 6480464 baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27425033 TH Human baicalin multiple interactions ISO Th (Mus musculus) 6480464 baicalin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:38016618 TH Human Bardoxolone methyl multiple interactions ISO Th (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of TH protein] CTD PMID:25637688 TH Human benzo[a]pyrene multiple interactions ISO Th (Mus musculus) 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to TH promoter] CTD PMID:19654925 TH Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TH mRNA CTD PMID:35870112 TH Human benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of TH promoter CTD PMID:27901495 TH Human benzo[a]pyrene decreases expression ISO Th (Rattus norvegicus) 6480464 Benzo(a)pyrene results in decreased expression of TH protein CTD PMID:28049045 TH Human beta-lapachone increases expression EXP 6480464 beta-lapachone results in increased expression of TH mRNA CTD PMID:38218311 TH Human bicuculline multiple interactions ISO Th (Rattus norvegicus) 6480464 Bicuculline promotes the reaction [Reserpine affects the activity of TH protein] and Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1981253 TH Human bis(2-chloroethyl) sulfide increases expression ISO Th (Mus musculus) 6480464 Mustard Gas results in increased expression of TH mRNA CTD PMID:15674843 TH Human bis(2-ethylhexyl) phthalate decreases expression ISO Th (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of TH protein CTD PMID:19481886 TH Human bis(2-ethylhexyl) phthalate increases expression ISO Th (Rattus norvegicus) 6480464 Diethylhexyl Phthalate results in increased expression of TH mRNA CTD PMID:29982774 TH Human bis(2-ethylhexyl) phthalate multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ... CTD PMID:19481886 TH Human bisphenol A affects expression ISO Th (Rattus norvegicus) 6480464 bisphenol A affects the expression of TH protein CTD PMID:16427766 TH Human bisphenol A increases expression ISO Th (Mus musculus) 6480464 bisphenol A results in increased expression of TH mRNA CTD PMID:30951980 TH Human bisphenol A multiple interactions EXP 6480464 IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH mRNA] and IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH protein] CTD PMID:27271280 TH Human bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TH mRNA and bisphenol A results in decreased expression of TH protein CTD PMID:27271280 TH Human bisphenol A increases expression ISO Th (Rattus norvegicus) 6480464 bisphenol A results in increased expression of TH mRNA CTD PMID:26141625 TH Human bisphenol A decreases expression ISO Th (Mus musculus) 6480464 bisphenol A results in decreased expression of TH protein CTD PMID:19481886 TH Human bisphenol A multiple interactions ISO Th (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein] more ... CTD PMID:19481886 and PMID:30951980 TH Human bisphenol A decreases expression ISO Th (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of TH mRNA and bisphenol A results in decreased expression of TH protein CTD PMID:16909604 more ... TH Human bisphenol F decreases expression ISO Th (Rattus norvegicus) 6480464 4 and 4'-bisphenol F results in decreased expression of TH mRNA CTD PMID:26186136 TH Human bisphenol F increases expression ISO Th (Mus musculus) 6480464 bisphenol F results in increased expression of TH mRNA CTD PMID:30951980 TH Human BQ 123 multiple interactions ISO Th (Rattus norvegicus) 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein] and cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA] CTD PMID:11911850 TH Human bromochloroacetic acid affects expression ISO Th (Mus musculus) 6480464 bromochloroacetic acid affects the expression of TH protein CTD PMID:21296659 TH Human bucladesine increases expression ISO Th (Rattus norvegicus) 6480464 Bucladesine results in increased expression of TH mRNA CTD PMID:19912776 TH Human butanal increases expression EXP 6480464 butyraldehyde results in increased expression of TH mRNA CTD PMID:26079696 TH Human Butylparaben multiple interactions ISO Th (Rattus norvegicus) 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 TH Human cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of TH mRNA CTD PMID:21694771 TH Human cadmium dichloride decreases methylation ISO Th (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased methylation of TH promoter CTD PMID:22457795 TH Human caffeine multiple interactions ISO Th (Mus musculus) 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 and PMID:7996441 TH Human calcitriol multiple interactions EXP 6480464 [Calcitriol co-treated with VDR protein] results in increased expression of TH mRNA and [Calcitriol co-treated with VDR protein] results in increased expression of TH protein CTD PMID:26210580 TH Human calcitriol decreases expression ISO Th (Rattus norvegicus) 6480464 Calcitriol results in decreased expression of TH protein CTD PMID:32147540 TH Human cannabidiol multiple interactions ISO Th (Mus musculus) 6480464 [Cannabidiol co-treated with Naltrexone] results in decreased expression of TH mRNA more ... CTD PMID:29624642 and PMID:29859012 TH Human carmustine increases activity ISO Th (Rattus norvegicus) 6480464 Carmustine results in increased activity of TH protein CTD PMID:14670008 TH Human carmustine increases expression ISO Th (Rattus norvegicus) 6480464 Carmustine results in increased expression of TH mRNA and Carmustine results in increased expression of TH protein CTD PMID:14670008 TH Human carnosic acid multiple interactions ISO Th (Rattus norvegicus) 6480464 salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:25446857 TH Human Carnosol multiple interactions ISO Th (Mus musculus) 6480464 5-iodo-3-((3 more ... CTD PMID:17047462 TH Human Carnosol increases expression ISO Th (Mus musculus) 6480464 carnosol results in increased expression of TH protein CTD PMID:17047462 TH Human carvedilol multiple interactions ISO Th (Rattus norvegicus) 6480464 carvedilol inhibits the reaction [Ethanol results in increased expression of TH protein] CTD PMID:22413959 TH Human carvedilol decreases expression ISO Th (Rattus norvegicus) 6480464 carvedilol results in decreased expression of TH mRNA and carvedilol results in decreased expression of TH protein CTD PMID:20359859 TH Human chelerythrine multiple interactions ISO Th (Rattus norvegicus) 6480464 chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1 more ... CTD PMID:18992715 TH Human chitosan multiple interactions ISO Th (Rattus norvegicus) 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 TH Human Chloralose multiple interactions ISO Th (Rattus norvegicus) 6480464 [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein CTD PMID:12088752 TH Human chlorisondamine multiple interactions ISO Th (Rattus norvegicus) 6480464 Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA] and Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1714554 TH Human chlorisondamine increases expression ISO Th (Rattus norvegicus) 6480464 Chlorisondamine results in increased expression of TH mRNA CTD PMID:1714554 TH Human chlorpyrifos increases expression ISO Th (Rattus norvegicus) 6480464 Chlorpyrifos results in increased expression of TH mRNA CTD PMID:18812211 TH Human chlorpyrifos multiple interactions EXP 6480464 CDH8 protein affects the reaction [Chlorpyrifos results in increased expression of TH protein] CTD PMID:34259569 TH Human chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of TH mRNA and Chlorpyrifos results in increased expression of TH protein CTD PMID:34259569 TH Human chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of TH protein CTD PMID:24793810 TH Human chlorpyrifos decreases expression ISO Th (Rattus norvegicus) 6480464 Chlorpyrifos results in decreased expression of TH protein CTD PMID:22714038 and PMID:29859868 TH Human chlorpyrifos multiple interactions ISO Th (Rattus norvegicus) 6480464 acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] and Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] CTD PMID:22714038 and PMID:29859868 TH Human cisplatin increases expression ISO Th (Mus musculus) 6480464 Cisplatin results in increased expression of TH mRNA CTD PMID:15464296 and PMID:15471895 TH Human clonidine multiple interactions ISO Th (Rattus norvegicus) 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ... CTD PMID:19067675 TH Human clonidine (amino form) multiple interactions ISO Th (Rattus norvegicus) 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ... CTD PMID:19067675 TH Human clonidine (imino form) multiple interactions ISO Th (Rattus norvegicus) 6480464 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine more ... CTD PMID:19067675 TH Human clozapine decreases activity ISO Th (Rattus norvegicus) 6480464 Clozapine results in decreased activity of TH protein CTD PMID:15983997 TH Human clozapine multiple interactions ISO Th (Rattus norvegicus) 6480464 Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 TH Human clozapine increases expression ISO Th (Rattus norvegicus) 6480464 Clozapine results in increased expression of TH protein CTD PMID:17028028 TH Human clozapine decreases expression ISO Th (Rattus norvegicus) 6480464 Clozapine results in decreased expression of TH mRNA and Clozapine results in decreased expression of TH protein CTD PMID:12645084 and PMID:15983997 TH Human clozapine increases activity ISO Th (Mus musculus) 6480464 Clozapine results in increased activity of TH protein CTD PMID:16415089 TH Human clozapine multiple interactions ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:16402076 and PMID:16415089 TH Human cobalt dichloride multiple interactions ISO Th (Mus musculus) 6480464 [cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein CTD PMID:16772336 TH Human cobalt dichloride increases expression ISO Th (Rattus norvegicus) 6480464 cobaltous chloride results in increased expression of TH mRNA CTD PMID:9458725 TH Human cocaine affects expression ISO Th (Rattus norvegicus) 6480464 Cocaine affects the expression of TH protein CTD PMID:12787079 TH Human cocaine multiple interactions ISO Th (Mus musculus) 6480464 resveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein] CTD PMID:23499958 TH Human cocaine decreases phosphorylation ISO Th (Mus musculus) 6480464 Cocaine results in decreased phosphorylation of TH protein CTD PMID:23499958 TH Human cocaine increases expression ISO Th (Rattus norvegicus) 6480464 Cocaine results in increased expression of TH protein CTD PMID:18992788 TH Human cocaine multiple interactions ISO Th (Rattus norvegicus) 6480464 Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine] and Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]] CTD PMID:20729865 TH Human cocaine decreases expression ISO Th (Rattus norvegicus) 6480464 Cocaine results in decreased expression of TH protein CTD PMID:11391778 TH Human colforsin daropate hydrochloride multiple interactions ISO Th (Rattus norvegicus) 6480464 3-(2-hydroxy-4-(1 more ... CTD PMID:18992715 TH Human colforsin daropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of TH protein CTD PMID:34897981 TH Human colforsin daropate hydrochloride increases activity ISO Th (Rattus norvegicus) 6480464 Colforsin results in increased activity of TH protein CTD PMID:9288946 TH Human colforsin daropate hydrochloride increases expression ISO Th (Rattus norvegicus) 6480464 Colforsin results in increased expression of TH mRNA and Colforsin results in increased expression of TH protein CTD PMID:14550852 and PMID:18992715 TH Human copper atom multiple interactions ISO Th (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of TH protein CTD PMID:36775208 TH Human copper(0) multiple interactions ISO Th (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of TH protein CTD PMID:36775208 TH Human copper(II) sulfate multiple interactions ISO Th (Mus musculus) 6480464 [Copper Sulfate results in increased abundance of Copper] which results in decreased expression of TH protein and Copper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of TH protein] CTD PMID:20184101 and PMID:36775208 TH Human copper(II) sulfate decreases expression ISO Th (Rattus norvegicus) 6480464 Copper Sulfate results in decreased expression of TH mRNA CTD PMID:18369385 TH Human corticosterone increases expression ISO Th (Mus musculus) 6480464 Corticosterone results in increased expression of TH protein CTD PMID:28186389 TH Human Cuprizon decreases expression ISO Th (Rattus norvegicus) 6480464 Cuprizone results in decreased expression of TH mRNA CTD PMID:27523638 TH Human curcumin multiple interactions ISO Th (Rattus norvegicus) 6480464 [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] and Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein] CTD PMID:19631675 more ... TH Human curcumin multiple interactions ISO Th (Mus musculus) 6480464 Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:31187328 TH Human curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:30463061 TH Human cyanazine increases expression ISO Th (Rattus norvegicus) 6480464 cyanazine results in increased expression of TH protein CTD PMID:14550852 TH Human cyanocob(III)alamin multiple interactions ISO Th (Rattus norvegicus) 6480464 Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of TH protein] CTD PMID:38049026 TH Human cyclosporin A decreases methylation EXP 6480464 Cyclosporine results in decreased methylation of TH promoter CTD PMID:27989131 TH Human cyhalothrin decreases expression ISO Th (Rattus norvegicus) 6480464 cyhalothrin results in decreased expression of TH mRNA and cyhalothrin results in decreased expression of TH protein CTD PMID:22366556 more ... TH Human cypermethrin decreases expression ISO Th (Rattus norvegicus) 6480464 cypermethrin results in decreased expression of TH mRNA and cypermethrin results in decreased expression of TH protein CTD PMID:26115703 TH Human cytarabine decreases expression EXP 6480464 Cytarabine results in decreased expression of TH protein CTD PMID:21198554 TH Human dabigatran multiple interactions ISO Th (Rattus norvegicus) 6480464 Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA] CTD PMID:28585189 TH Human DDE multiple interactions ISO Th (Rattus norvegicus) 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 TH Human desferrioxamine B increases expression ISO Th (Rattus norvegicus) 6480464 Deferoxamine results in increased expression of TH mRNA CTD PMID:9458725 TH Human desipramine multiple interactions ISO Th (Rattus norvegicus) 6480464 Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1717808 TH Human dexamethasone increases expression ISO Th (Rattus norvegicus) 6480464 Dexamethasone results in increased expression of TH protein CTD PMID:14550852 TH Human dexamethasone decreases expression ISO Th (Rattus norvegicus) 6480464 Dexamethasone results in decreased expression of TH mRNA CTD PMID:11072875 TH Human diarsenic trioxide decreases expression ISO Th (Mus musculus) 6480464 Arsenic Trioxide results in decreased expression of TH mRNA CTD PMID:23392890 and PMID:23518225 TH Human diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of TH protein CTD PMID:11027660 TH Human diarsenic trioxide multiple interactions ISO Th (Mus musculus) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of TH mRNA] CTD PMID:23392890 TH Human diazinon increases expression ISO Th (Rattus norvegicus) 6480464 Diazinon results in increased expression of TH mRNA CTD PMID:17452286 and PMID:18812211 TH Human dichlorvos increases activity ISO Th (Rattus norvegicus) 6480464 Dichlorvos results in increased activity of TH protein CTD PMID:12186780 TH Human dichlorvos multiple interactions ISO Th (Rattus norvegicus) 6480464 Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein] CTD PMID:12186780 TH Human dieldrin increases expression ISO Th (Rattus norvegicus) 6480464 Dieldrin results in increased expression of TH mRNA CTD PMID:18812211 TH Human diethyldithiocarbamic acid multiple interactions ISO Th (Rattus norvegicus) 6480464 Ditiocarb results in decreased expression of and results in increased phosphorylation of TH protein CTD PMID:22874009 TH Human dioxygen increases expression ISO Th (Rattus norvegicus) 6480464 Oxygen deficiency results in increased expression of TH mRNA CTD PMID:10486562 more ... TH Human dipyridamole decreases expression ISO Th (Rattus norvegicus) 6480464 Dipyridamole results in decreased expression of TH protein CTD PMID:17568153 TH Human dopamine increases chemical synthesis EXP 6480464 TH protein results in increased chemical synthesis of Dopamine CTD PMID:19815691 TH Human dopamine affects abundance ISO Th (Mus musculus) 6480464 TH protein affects the abundance of Dopamine CTD PMID:10984662 and PMID:8707341 TH Human dopamine increases chemical synthesis ISO Th (Rattus norvegicus) 6480464 TH protein results in increased chemical synthesis of Dopamine CTD PMID:10661506 TH Human dopamine affects abundance ISO Th (Rattus norvegicus) 6480464 TH affects the abundance of Dopamine CTD PMID:20615977 TH Human dopamine decreases activity ISO Th (Rattus norvegicus) 6480464 Dopamine results in decreased activity of TH protein CTD PMID:2884129 TH Human dopamine multiple interactions ISO Th (Rattus norvegicus) 6480464 1-phenyl-3-dimethylamino-1 more ... CTD PMID:10661506 more ... TH Human dopamine affects chemical synthesis ISO Th (Mus musculus) 6480464 TH protein affects the chemical synthesis of Dopamine CTD PMID:9822156 TH Human dopamine multiple interactions ISO Th (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:10984662 more ... TH Human dopaminechrome (enol form) decreases expression ISO Th (Rattus norvegicus) 6480464 aminochrome 1 results in decreased expression of TH protein CTD PMID:29588162 TH Human edaravone multiple interactions ISO Th (Rattus norvegicus) 6480464 Edaravone inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27108097 TH Human elemental selenium increases activity ISO Th (Rattus norvegicus) 6480464 Selenium deficiency results in increased activity of TH protein CTD PMID:11113527 TH Human elemental selenium increases expression ISO Th (Rattus norvegicus) 6480464 Selenium deficiency results in increased expression of TH mRNA CTD PMID:11113527 TH Human elemental selenium multiple interactions ISO Th (Rattus norvegicus) 6480464 [Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamine CTD PMID:11113527 TH Human enzacamene multiple interactions ISO Th (Rattus norvegicus) 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 TH Human epibatidine multiple interactions ISO Th (Rattus norvegicus) 6480464 1 more ... CTD PMID:15588622 TH Human epibatidine increases expression ISO Th (Rattus norvegicus) 6480464 epibatidine results in increased expression of TH mRNA CTD PMID:15588622 TH Human ethanol multiple interactions ISO Th (Rattus norvegicus) 6480464 carvedilol inhibits the reaction [Ethanol results in increased expression of TH protein] CTD PMID:22413959 TH Human ethanol decreases expression ISO Th (Mus musculus) 6480464 Ethanol results in decreased expression of TH protein CTD PMID:26747301 and PMID:34808223 TH Human ethanol multiple interactions ISO Th (Mus musculus) 6480464 Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein] and Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein] CTD PMID:26747301 and PMID:34590183 TH Human ethanol increases expression ISO Th (Rattus norvegicus) 6480464 Ethanol results in increased expression of TH protein CTD PMID:22413959 TH Human fasudil multiple interactions ISO Th (Rattus norvegicus) 6480464 [[propionic acid co-treated with fasudil] affects the susceptibility to Rotenone] which results in increased expression of TH mRNA CTD PMID:32481507 TH Human fenvalerate decreases expression ISO Th (Rattus norvegicus) 6480464 fenvalerate results in decreased expression of TH protein CTD PMID:31734597 TH Human fenvalerate multiple interactions ISO Th (Rattus norvegicus) 6480464 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein] and SB 203580 inhibits the reaction [fenvalerate results in decreased expression of TH protein] CTD PMID:31734597 TH Human ferrostatin-1 multiple interactions ISO Th (Mus musculus) 6480464 ferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:36435477 TH Human fipronil decreases expression EXP 6480464 fipronil results in decreased expression of TH protein CTD PMID:21296133 TH Human flavonoids increases expression ISO Th (Rattus norvegicus) 6480464 Flavonoids results in increased expression of TH mRNA CTD PMID:18035473 TH Human fluoxetine decreases expression ISO Th (Mus musculus) 6480464 Fluoxetine results in decreased expression of TH mRNA CTD PMID:20857517 TH Human fluoxetine affects expression ISO Th (Rattus norvegicus) 6480464 Fluoxetine affects the expression of TH CTD PMID:26475043 TH Human fluoxetine increases expression ISO Th (Rattus norvegicus) 6480464 Fluoxetine results in increased expression of TH mRNA CTD PMID:1351783 and PMID:20626387 TH Human fluoxetine decreases expression ISO Th (Rattus norvegicus) 6480464 Fluoxetine results in decreased expression of TH mRNA CTD PMID:15936043 TH Human fluoxetine increases expression ISO Th (Mus musculus) 6480464 Fluoxetine results in increased expression of TH mRNA CTD PMID:20374287 TH Human formaldehyde increases expression ISO Th (Mus musculus) 6480464 Formaldehyde results in increased expression of TH protein CTD PMID:15064152 TH Human fructose increases expression ISO Th (Mus musculus) 6480464 Fructose results in increased expression of TH mRNA CTD PMID:16843071 TH Human ganglioside GM1 increases activity ISO Th (Rattus norvegicus) 6480464 G(M1) Ganglioside results in increased activity of TH protein CTD PMID:14552908 TH Human genistein affects expression ISO Th (Rattus norvegicus) 6480464 Genistein affects the expression of TH protein CTD PMID:16427766 TH Human genistein multiple interactions ISO Th (Mus musculus) 6480464 Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] CTD PMID:20455021 TH Human geraniol multiple interactions ISO Th (Mus musculus) 6480464 geraniol inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23943375 TH Human ginkgetin multiple interactions ISO Th (Mus musculus) 6480464 ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:25968939 TH Human ginsenoside Re multiple interactions EXP 6480464 ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein] CTD PMID:25523949 TH Human ginsenoside Re multiple interactions ISO Th (Mus musculus) 6480464 3-((3 more ... CTD PMID:29467000 TH Human glyburide multiple interactions ISO Th (Mus musculus) 6480464 Glyburide promotes the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:16725203 TH Human glycidol decreases expression ISO Th (Rattus norvegicus) 6480464 glycidol results in decreased expression of TH mRNA CTD PMID:33150645 TH Human glycidol increases methylation ISO Th (Rattus norvegicus) 6480464 glycidol results in increased methylation of TH promoter CTD PMID:33150595 TH Human guanethidine decreases expression ISO Th (Rattus norvegicus) 6480464 Guanethidine results in decreased expression of TH protein CTD PMID:9460767 TH Human GW 1929 multiple interactions ISO Th (Rattus norvegicus) 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and GW 1929 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 TH Human haloperidol increases expression ISO Th (Rattus norvegicus) 6480464 Haloperidol results in increased expression of TH protein CTD PMID:17028028 TH Human heptachlor increases expression ISO Th (Mus musculus) 6480464 Heptachlor results in increased expression of TH protein CTD PMID:16112329 TH Human herbicide decreases expression ISO Th (Rattus norvegicus) 6480464 Herbicides results in decreased expression of TH mRNA CTD PMID:23123945 TH Human hydrogen peroxide multiple interactions EXP 6480464 TH protein inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] CTD PMID:19815691 TH Human hydrogen peroxide affects expression ISO Th (Rattus norvegicus) 6480464 Hydrogen Peroxide affects the expression of TH mRNA CTD PMID:9458725 TH Human hydrogen peroxide affects abundance ISO Th (Rattus norvegicus) 6480464 TH protein affects the abundance of Hydrogen Peroxide CTD PMID:9458725 TH Human hydrogen peroxide affects response to substance EXP 6480464 TH protein affects the susceptibility to Hydrogen Peroxide CTD PMID:19815691 TH Human icariin multiple interactions ISO Th (Rattus norvegicus) 6480464 icariin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:31251943 TH Human idazoxan increases expression ISO Th (Rattus norvegicus) 6480464 Idazoxan results in increased expression of TH mRNA CTD PMID:1351783 TH Human imidacloprid multiple interactions ISO Th (Rattus norvegicus) 6480464 [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ... CTD PMID:29246838 TH Human imidacloprid increases expression ISO Th (Rattus norvegicus) 6480464 imidacloprid results in increased expression of TH mRNA and imidacloprid results in increased expression of TH protein CTD PMID:29246838 TH Human juglone multiple interactions ISO Th (Mus musculus) 6480464 juglone inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23754278 TH Human ketoconazole multiple interactions ISO Th (Mus musculus) 6480464 Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein] more ... CTD PMID:19594327 and PMID:22334051 TH Human KT 5720 decreases expression ISO Th (Rattus norvegicus) 6480464 KT 5720 results in decreased expression of TH mRNA CTD PMID:18992715 TH Human KT 5720 multiple interactions ISO Th (Rattus norvegicus) 6480464 KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA] and KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18992715 TH Human L-ascorbic acid increases expression ISO Th (Rattus norvegicus) 6480464 Ascorbic Acid results in increased expression of TH mRNA and Ascorbic Acid results in increased expression of TH protein CTD PMID:15372504 and PMID:18772553 TH Human L-ascorbic acid decreases expression ISO Th (Rattus norvegicus) 6480464 Ascorbic Acid results in decreased expression of TH protein CTD PMID:25891525 TH Human L-ascorbic acid multiple interactions ISO Th (Rattus norvegicus) 6480464 [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein and [Ascorbic Acid co-treated with Vitamin E] results in increased expression of TH protein CTD PMID:18772553 and PMID:25891525 TH Human L-ascorbic acid decreases expression ISO Th (Mus musculus) 6480464 Ascorbic Acid results in decreased expression of TH protein CTD PMID:22285708 TH Human lead(0) decreases expression ISO Th (Mus musculus) 6480464 Lead results in decreased expression of TH protein CTD PMID:21703292 TH Human linalool decreases expression ISO Th (Rattus norvegicus) 6480464 linalool results in decreased expression of TH mRNA CTD PMID:20536181 TH Human linuron multiple interactions ISO Th (Rattus norvegicus) 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 TH Human lipopolysaccharide decreases methylation ISO Th (Mus musculus) 6480464 Lipopolysaccharides results in decreased methylation of TH gene CTD PMID:21212295 TH Human lipopolysaccharide decreases expression ISO Th (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of TH protein CTD PMID:29338785 TH Human lipopolysaccharide multiple interactions ISO Th (Rattus norvegicus) 6480464 Lipopolysaccharides results in increased phosphorylation of and results in increased activity of TH protein CTD PMID:23483921 TH Human lipopolysaccharide multiple interactions ISO Th (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of TH gene and VCE-003 analog inhibits the reaction [Lipopolysaccharides results in decreased expression of TH protein] CTD PMID:21212295 and PMID:29338785 TH Human lithium atom multiple interactions ISO Th (Rattus norvegicus) 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19149911 TH Human lithium hydride multiple interactions ISO Th (Rattus norvegicus) 6480464 Lithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19149911 TH Human lovastatin increases expression EXP 6480464 Lovastatin results in increased expression of TH protein CTD PMID:20694854 TH Human lovastatin multiple interactions ISO Th (Mus musculus) 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 TH Human lovastatin increases expression ISO Th (Mus musculus) 6480464 Lovastatin results in increased expression of TH protein CTD PMID:20694854 TH Human lovastatin multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 TH Human LY294002 multiple interactions ISO Th (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18950629 TH Human maneb decreases expression ISO Th (Mus musculus) 6480464 Maneb results in decreased expression of TH protein CTD PMID:22334051 TH Human maneb multiple interactions ISO Th (Rattus norvegicus) 6480464 [Paraquat co-treated with Maneb] results in decreased expression of TH more ... CTD PMID:24376148 and PMID:29152652 TH Human maneb multiple interactions ISO Th (Mus musculus) 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] more ... CTD PMID:11124998 more ... TH Human manganese atom decreases expression ISO Th (Rattus norvegicus) 6480464 Manganese results in decreased expression of TH mRNA and Manganese results in decreased expression of TH protein CTD PMID:16943606 more ... TH Human manganese atom multiple interactions ISO Th (Rattus norvegicus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein CTD PMID:38129942 TH Human manganese atom multiple interactions ISO Th (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein and Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein] CTD PMID:34590183 TH Human manganese(0) decreases expression ISO Th (Rattus norvegicus) 6480464 Manganese results in decreased expression of TH mRNA and Manganese results in decreased expression of TH protein CTD PMID:16943606 more ... TH Human manganese(0) multiple interactions ISO Th (Rattus norvegicus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein CTD PMID:38129942 TH Human manganese(0) multiple interactions ISO Th (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein and Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein] CTD PMID:34590183 TH Human manganese(II) chloride multiple interactions ISO Th (Rattus norvegicus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein more ... CTD PMID:21310168 more ... TH Human manganese(II) chloride increases methylation EXP 6480464 manganese chloride results in increased methylation of TH gene CTD PMID:27913844 TH Human manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of TH mRNA CTD PMID:27913844 TH Human manganese(II) chloride decreases expression ISO Th (Rattus norvegicus) 6480464 manganese chloride results in decreased expression of TH protein CTD PMID:20798247 more ... TH Human manganese(II) chloride multiple interactions ISO Th (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein more ... CTD PMID:24969583 more ... TH Human manganese(II) chloride decreases expression ISO Th (Mus musculus) 6480464 manganese chloride results in decreased expression of TH mRNA and manganese chloride results in decreased expression of TH protein CTD PMID:24969583 more ... TH Human manganese(II) chloride increases expression ISO Th (Rattus norvegicus) 6480464 manganese chloride results in increased expression of TH mRNA and manganese chloride results in increased expression of TH protein CTD PMID:12106697 TH Human manganese(II) chloride decreases activity ISO Th (Rattus norvegicus) 6480464 manganese chloride results in decreased activity of TH protein CTD PMID:21310168 TH Human manganese(II) sulfate decreases expression ISO Th (Rattus norvegicus) 6480464 manganese sulfate results in decreased expression of TH mRNA CTD PMID:16943606 TH Human melatonin multiple interactions ISO Th (Rattus norvegicus) 6480464 Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein] and Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:18289173 and PMID:19409439 TH Human melatonin multiple interactions ISO Th (Mus musculus) 6480464 Melatonin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:20964710 more ... TH Human mephedrone multiple interactions ISO Th (Mus musculus) 6480464 Ethanol promotes the reaction [mephedrone results in decreased expression of TH protein] CTD PMID:26747301 TH Human mephedrone decreases expression ISO Th (Mus musculus) 6480464 mephedrone results in decreased expression of TH protein CTD PMID:26747301 TH Human mephedrone decreases expression ISO Th (Rattus norvegicus) 6480464 mephedrone results in decreased expression of TH protein CTD PMID:25817894 TH Human mercaptopurine multiple interactions ISO Th (Rattus norvegicus) 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 TH Human metformin multiple interactions ISO Th (Rattus norvegicus) 6480464 Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein] CTD PMID:35085591 TH Human methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of TH protein CTD PMID:16622715 TH Human methamphetamine multiple interactions EXP 6480464 ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein] more ... CTD PMID:25523949 TH Human methamphetamine decreases expression ISO Th (Mus musculus) 6480464 Methamphetamine results in decreased expression of TH mRNA and Methamphetamine results in decreased expression of TH protein CTD PMID:12871582 more ... TH Human methamphetamine decreases activity ISO Th (Mus musculus) 6480464 Methamphetamine results in decreased activity of TH protein CTD PMID:1381816 more ... TH Human methamphetamine affects expression ISO Th (Rattus norvegicus) 6480464 Methamphetamine affects the expression of TH mRNA CTD PMID:24042092 TH Human methamphetamine decreases expression ISO Th (Rattus norvegicus) 6480464 Methamphetamine results in decreased expression of TH protein CTD PMID:10773198 more ... TH Human methamphetamine decreases activity ISO Th (Rattus norvegicus) 6480464 Methamphetamine results in decreased activity of TH protein CTD PMID:2579200 TH Human methamphetamine multiple interactions ISO Th (Rattus norvegicus) 6480464 diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein] more ... CTD PMID:15276877 more ... TH Human methamphetamine affects response to substance ISO Th (Mus musculus) 6480464 TH protein affects the susceptibility to Methamphetamine CTD PMID:9822156 TH Human methamphetamine multiple interactions ISO Th (Mus musculus) 6480464 3-((3 more ... CTD PMID:10984662 more ... TH Human methoxychlor increases methylation ISO Th (Rattus norvegicus) 6480464 Methoxychlor results in increased methylation of TH gene CTD PMID:23303685 TH Human methyllycaconitine multiple interactions EXP 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] CTD PMID:17498763 TH Human methylmercury chloride decreases expression ISO Th (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of TH mRNA CTD PMID:21385734 TH Human methylmercury chloride multiple interactions ISO Th (Mus musculus) 6480464 3 and 9-bis((ethylthio)methyl)-K-252a inhibits the reaction [methylmercuric chloride results in decreased expression of TH mRNA] CTD PMID:21385734 TH Human methylphenidate decreases expression ISO Th (Mus musculus) 6480464 Methylphenidate results in decreased expression of TH mRNA CTD PMID:22470460 TH Human mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 TH Human mevalonic acid multiple interactions ISO Th (Mus musculus) 6480464 Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] CTD PMID:20694854 TH Human mifepristone decreases expression EXP 6480464 Mifepristone results in decreased expression of TH mRNA CTD PMID:17584828 TH Human mifepristone multiple interactions ISO Th (Rattus norvegicus) 6480464 Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 TH Human minocycline multiple interactions ISO Th (Mus musculus) 6480464 Minocycline inhibits the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:38189626 TH Human misonidazole increases activity ISO Th (Mus musculus) 6480464 Misonidazole results in increased activity of TH protein CTD PMID:2875048 TH Human misonidazole increases expression ISO Th (Mus musculus) 6480464 Misonidazole results in increased expression of TH protein CTD PMID:2875048 TH Human mono(2-ethylhexyl) phthalate decreases expression ISO Th (Rattus norvegicus) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of TH mRNA CTD PMID:21145954 TH Human mono(2-ethylhexyl) phthalate multiple interactions ISO Th (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of TH mRNA CTD PMID:36189433 TH Human mono(2-ethylhexyl) phthalate increases expression ISO Th (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of TH mRNA CTD PMID:22401849 TH Human monocrotophos multiple interactions ISO Th (Rattus norvegicus) 6480464 Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein] CTD PMID:22305719 TH Human monocrotophos increases activity ISO Th (Rattus norvegicus) 6480464 Monocrotophos results in increased activity of TH protein CTD PMID:22305719 TH Human monosodium L-glutamate decreases expression ISO Th (Rattus norvegicus) 6480464 Sodium Glutamate results in decreased expression of TH mRNA CTD PMID:1980722 TH Human monosodium L-glutamate decreases activity ISO Th (Rattus norvegicus) 6480464 Sodium Glutamate results in decreased activity of TH protein CTD PMID:1980722 TH Human montelukast multiple interactions ISO Th (Rattus norvegicus) 6480464 montelukast inhibits the reaction [Rotenone results in increased expression of TH protein] CTD PMID:30222980 TH Human morphine multiple interactions ISO Th (Rattus norvegicus) 6480464 [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein] more ... CTD PMID:15541421 more ... TH Human morphine decreases expression ISO Th (Rattus norvegicus) 6480464 Morphine results in decreased expression of TH protein CTD PMID:26386147 TH Human morphine multiple interactions ISO Th (Mus musculus) 6480464 [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein and CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein] CTD PMID:25582704 TH Human morphine increases phosphorylation ISO Th (Rattus norvegicus) 6480464 Morphine deficiency results in increased phosphorylation of TH protein CTD PMID:24398105 TH Human morphine increases expression ISO Th (Rattus norvegicus) 6480464 Morphine results in increased expression of TH protein CTD PMID:15541421 TH Human N(gamma)-nitro-L-arginine methyl ester decreases expression ISO Th (Mus musculus) 6480464 NG-Nitroarginine Methyl Ester results in decreased expression of TH protein CTD PMID:31187328 TH Human N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO Th (Rattus norvegicus) 6480464 [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3 more ... CTD PMID:18992715 and PMID:29246838 TH Human N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases expression ISO Th (Rattus norvegicus) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of TH mRNA CTD PMID:18992715 TH Human N-acetyl-L-cysteine multiple interactions ISO Th (Rattus norvegicus) 6480464 [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein and Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein] CTD PMID:22714038 and PMID:25891525 TH Human N-acetyl-L-cysteine decreases expression ISO Th (Rattus norvegicus) 6480464 Acetylcysteine results in decreased expression of TH protein CTD PMID:25891525 TH Human N-ethyl-N-nitrosourea increases mutagenesis ISO Th (Rattus norvegicus) 6480464 Ethylnitrosourea results in increased mutagenesis of TH gene CTD PMID:16495775 TH Human N-ethylmaleimide multiple interactions ISO Th (Rattus norvegicus) 6480464 Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 TH Human N-methyl-4-phenylpyridinium multiple interactions ISO Th (Mus musculus) 6480464 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]] more ... CTD PMID:20184101 more ... TH Human N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of TH mRNA CTD PMID:24810058 TH Human N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 BMP2 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] more ... CTD PMID:20007850 more ... TH Human N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of TH protein CTD PMID:26364587 and PMID:30463061 TH Human N-methyl-4-phenylpyridinium decreases expression ISO Th (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of TH protein CTD PMID:20007850 more ... TH Human N-methyl-4-phenylpyridinium decreases expression ISO Th (Rattus norvegicus) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of TH protein CTD PMID:19794909 more ... TH Human N-methyl-4-phenylpyridinium multiple interactions ISO Th (Rattus norvegicus) 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] more ... CTD PMID:19794909 more ... TH Human N-methyl-4-phenylpyridinium decreases activity ISO Th (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in decreased activity of TH protein CTD PMID:20184101 TH Human N-nitrosodiethylamine multiple interactions ISO Th (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNA CTD PMID:20360939 TH Human N-nitrosodiethylamine multiple interactions ISO Th (Mus musculus) 6480464 [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TH gene CTD PMID:23968726 TH Human naloxone multiple interactions ISO Th (Rattus norvegicus) 6480464 [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein] and [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein CTD PMID:24398105 and PMID:25308750 TH Human naloxone multiple interactions ISO Th (Mus musculus) 6480464 [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein and CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein] CTD PMID:25582704 TH Human naloxone increases phosphorylation ISO Th (Rattus norvegicus) 6480464 Naloxone results in increased phosphorylation of TH protein CTD PMID:24398105 TH Human naltrexone multiple interactions ISO Th (Mus musculus) 6480464 [Cannabidiol co-treated with Naltrexone] results in decreased expression of TH mRNA CTD PMID:29859012 TH Human nickel atom increases expression ISO Th (Rattus norvegicus) 6480464 Nickel results in increased expression of TH mRNA CTD PMID:18812211 TH Human nickel dichloride multiple interactions EXP 6480464 nickel chloride inhibits the reaction [Tretinoin results in increased expression of TH protein] CTD PMID:25614230 TH Human nicotine increases expression ISO Th (Rattus norvegicus) 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:29246838 TH Human nicotine multiple interactions ISO Th (Rattus norvegicus) 6480464 [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]] more ... CTD PMID:29246838 TH Human nicotine multiple interactions ISO Th (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 more ... TH Human nicotine multiple interactions EXP 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] CTD PMID:17498763 TH Human nicotine increases expression EXP 6480464 Nicotine results in increased expression of TH mRNA and Nicotine results in increased expression of TH protein CTD PMID:17498763 TH Human nimodipine multiple interactions ISO Th (Rattus norvegicus) 6480464 Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein] CTD PMID:12186780 TH Human nitroprusside multiple interactions ISO Th (Rattus norvegicus) 6480464 [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein more ... CTD PMID:12088752 and PMID:16023617 TH Human nitroprusside increases expression ISO Th (Rattus norvegicus) 6480464 Nitroprusside results in increased expression of TH protein CTD PMID:12088752 TH Human Nookatone multiple interactions ISO Th (Rattus norvegicus) 6480464 nootkatone inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:35833337 TH Human Norbinaltorphimine multiple interactions ISO Th (Mus musculus) 6480464 3-((3 more ... CTD PMID:29467000 TH Human olanzapine multiple interactions ISO Th (Rattus norvegicus) 6480464 olanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:15276877 TH Human oleuropein multiple interactions ISO Th (Mus musculus) 6480464 oleuropein inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:36774383 TH Human oridonin multiple interactions ISO Th (Rattus norvegicus) 6480464 oridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA] CTD PMID:31430510 TH Human oxidopamine multiple interactions ISO Th (Rattus norvegicus) 6480464 2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein] more ... CTD PMID:12585172 more ... TH Human oxidopamine decreases expression ISO Th (Mus musculus) 6480464 Oxidopamine results in decreased expression of TH mRNA and Oxidopamine results in decreased expression of TH protein CTD PMID:15899244 more ... TH Human oxidopamine multiple interactions EXP 6480464 TH protein inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein] CTD PMID:19815691 TH Human oxidopamine decreases expression ISO Th (Rattus norvegicus) 6480464 Oxidopamine results in decreased expression of TH mRNA and Oxidopamine results in decreased expression of TH protein CTD PMID:11730701 more ... TH Human oxidopamine multiple interactions ISO Th (Mus musculus) 6480464 LY 344864 inhibits the reaction [Oxidopamine results in decreased expression of TH protein] more ... CTD PMID:16914382 more ... TH Human oxidopamine affects response to substance EXP 6480464 TH protein affects the susceptibility to Oxidopamine CTD PMID:19815691 TH Human P(1),P(4)-bis(5'-adenosyl) tetraphosphate multiple interactions ISO Th (Rattus norvegicus) 6480464 diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:19442829 TH Human paracetamol multiple interactions ISO Th (Rattus norvegicus) 6480464 [Plasticizers co-treated with Fungicides and Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA CTD PMID:34383603 TH Human paraquat decreases expression ISO Th (Mus musculus) 6480464 Paraquat results in decreased expression of TH protein CTD PMID:22334051 more ... TH Human paraquat multiple interactions EXP 6480464 MT2A protein inhibits the reaction [Paraquat results in increased expression of TH mRNA] CTD PMID:34623211 TH Human paraquat affects expression ISO Th (Mus musculus) 6480464 Paraquat affects the expression of TH protein CTD PMID:28428137 TH Human paraquat decreases expression ISO Th (Rattus norvegicus) 6480464 Paraquat results in decreased expression of TH mRNA and Paraquat results in decreased expression of TH protein CTD PMID:16190885 more ... TH Human paraquat increases expression EXP 6480464 Paraquat results in increased expression of TH protein CTD PMID:26498265 TH Human paraquat increases activity ISO Th (Rattus norvegicus) 6480464 Paraquat results in increased activity of TH protein CTD PMID:24743698 TH Human paraquat multiple interactions ISO Th (Rattus norvegicus) 6480464 [Paraquat co-treated with Maneb] results in decreased expression of TH more ... CTD PMID:20553223 more ... TH Human paraquat multiple interactions ISO Th (Mus musculus) 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein] more ... CTD PMID:11124998 more ... TH Human pentanal decreases expression EXP 6480464 pentanal results in decreased expression of TH mRNA CTD PMID:26079696 TH Human perfluorodecanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 TH Human perfluorododecanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 TH Human perfluorononanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 TH Human perfluorooctane-1-sulfonic acid decreases expression ISO Th (Mus musculus) 6480464 perfluorooctane sulfonic acid results in decreased expression of TH mRNA CTD PMID:26686188 TH Human perfluorooctane-1-sulfonic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 TH Human perfluorooctanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 TH Human perfluoroundecanoic acid multiple interactions ISO Th (Mus musculus) 6480464 [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 TH Human permethrin multiple interactions ISO Th (Rattus norvegicus) 6480464 Permethrin results in decreased expression of and results in decreased activity of TH protein CTD PMID:15461254 TH Human permethrin increases expression ISO Th (Rattus norvegicus) 6480464 Permethrin results in increased expression of TH mRNA CTD PMID:31175960 TH Human permethrin decreases expression ISO Th (Rattus norvegicus) 6480464 Permethrin results in decreased expression of TH mRNA CTD PMID:15461254 TH Human phencyclidine multiple interactions ISO Th (Mus musculus) 6480464 Phencyclidine inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:1381816 TH Human phencyclidine increases expression ISO Th (Mus musculus) 6480464 Phencyclidine results in increased expression of TH mRNA CTD PMID:12105081 TH Human Phenelzine increases expression ISO Th (Rattus norvegicus) 6480464 Phenelzine results in increased expression of TH mRNA CTD PMID:1351783 TH Human phenethyl caffeate multiple interactions ISO Th (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNA CTD PMID:20360939 TH Human phorbol 13-acetate 12-myristate increases expression ISO Th (Rattus norvegicus) 6480464 Tetradecanoylphorbol Acetate results in increased expression of TH mRNA CTD PMID:18992715 TH Human phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TH protein CTD PMID:24101030 TH Human piperazine decreases expression EXP 6480464 Piperazine analog results in decreased expression of TH protein CTD PMID:28874085 TH Human piperonyl butoxide multiple interactions ISO Th (Mus musculus) 6480464 [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TH gene CTD PMID:23968726 TH Human pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TH mRNA CTD PMID:19710929 TH Human pregabalin affects expression ISO Th (Mus musculus) 6480464 Pregabalin affects the expression of TH mRNA CTD PMID:22017514 TH Human pregabalin increases expression ISO Th (Mus musculus) 6480464 Pregabalin results in increased expression of TH mRNA CTD PMID:22489711 TH Human probenecid multiple interactions ISO Th (Mus musculus) 6480464 1 more ... CTD PMID:19653878 and PMID:25406165 TH Human progesterone decreases phosphorylation ISO Th (Rattus norvegicus) 6480464 Progesterone results in decreased phosphorylation of TH protein CTD PMID:18096660 TH Human progesterone decreases activity ISO Th (Rattus norvegicus) 6480464 Progesterone results in decreased activity of TH protein CTD PMID:18096660 TH Human propanal decreases expression EXP 6480464 propionaldehyde results in decreased expression of TH mRNA CTD PMID:26079696 TH Human propionic acid increases expression ISO Th (Rattus norvegicus) 6480464 propionic acid results in increased expression of TH mRNA CTD PMID:32481507 TH Human propionic acid multiple interactions ISO Th (Rattus norvegicus) 6480464 [[propionic acid co-treated with fasudil] affects the susceptibility to Rotenone] which results in increased expression of TH mRNA CTD PMID:32481507 TH Human propofol decreases expression ISO Th (Mus musculus) 6480464 Propofol results in decreased expression of TH protein CTD PMID:32612007 TH Human prothioconazole increases expression EXP 6480464 prothioconazole results in increased expression of TH mRNA CTD PMID:35048155 TH Human purine-6-thiol multiple interactions ISO Th (Rattus norvegicus) 6480464 [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] and Mercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 TH Human pyrrolidine dithiocarbamate multiple interactions ISO Th (Mus musculus) 6480464 pyrrolidine dithiocarbamic acid affects the reaction [GPX1 protein affects the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]] and pyrrolidine dithiocarbamic acid inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein] CTD PMID:34082047 TH Human pyrroloquinoline quinone multiple interactions ISO Th (Rattus norvegicus) 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:26276080 and PMID:27108097 TH Human pyrroloquinoline quinone multiple interactions ISO Th (Mus musculus) 6480464 PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:32860006 TH Human quercetin multiple interactions ISO Th (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Rotenone results in decreased activity of TH protein] and Quercetin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:23357119 and PMID:35337893 TH Human quercetin 3-O-beta-D-glucofuranoside multiple interactions ISO Th (Rattus norvegicus) 6480464 isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 TH Human quercetin 3-O-beta-D-glucopyranoside multiple interactions ISO Th (Rattus norvegicus) 6480464 isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 TH Human reserpine increases expression ISO Th (Mus musculus) 6480464 Reserpine results in increased expression of TH mRNA CTD PMID:8666980 TH Human reserpine increases activity ISO Th (Rattus norvegicus) 6480464 Reserpine results in increased activity of TH protein CTD PMID:1978789 more ... TH Human reserpine increases expression ISO Th (Rattus norvegicus) 6480464 Reserpine results in increased expression of TH mRNA and Reserpine results in increased expression of TH protein CTD PMID:11438978 more ... TH Human reserpine decreases expression ISO Th (Rattus norvegicus) 6480464 Reserpine results in decreased expression of TH mRNA CTD PMID:20504635 TH Human reserpine affects activity ISO Th (Rattus norvegicus) 6480464 Reserpine affects the activity of TH protein CTD PMID:1981253 TH Human reserpine increases stability ISO Th (Rattus norvegicus) 6480464 Reserpine results in increased stability of TH mRNA CTD PMID:11161478 TH Human reserpine multiple interactions ISO Th (Rattus norvegicus) 6480464 Bicuculline promotes the reaction [Reserpine affects the activity of TH protein] more ... CTD PMID:11438978 more ... TH Human resveratrol multiple interactions ISO Th (Mus musculus) 6480464 resveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein] CTD PMID:23499958 TH Human resveratrol multiple interactions ISO Th (Rattus norvegicus) 6480464 Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:34302886 TH Human resveratrol multiple interactions EXP 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of TH mRNA CTD PMID:23557933 TH Human rimonabant increases activity ISO Th (Rattus norvegicus) 6480464 Rimonabant results in increased activity of TH protein CTD PMID:15882845 TH Human rimonabant multiple interactions ISO Th (Rattus norvegicus) 6480464 Rimonabant affects the reaction [PRKN mutant form affects the activity of TH protein] and Rimonabant inhibits the reaction [Dronabinol results in increased activity of TH protein] CTD PMID:10700552 more ... TH Human risperidone increases expression ISO Th (Rattus norvegicus) 6480464 Risperidone results in increased expression of TH protein CTD PMID:17028028 TH Human rotenone multiple interactions ISO Th (Mus musculus) 6480464 baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein] more ... CTD PMID:17047462 more ... TH Human rotenone decreases activity ISO Th (Rattus norvegicus) 6480464 Rotenone results in decreased activity of TH protein CTD PMID:35187747 and PMID:35337893 TH Human rotenone increases expression ISO Th (Rattus norvegicus) 6480464 Rotenone results in increased expression of TH protein CTD PMID:30222980 TH Human rotenone decreases expression ISO Th (Rattus norvegicus) 6480464 Rotenone results in decreased expression of TH mRNA and Rotenone results in decreased expression of TH protein CTD PMID:12385818 more ... TH Human rotenone multiple interactions ISO Th (Rattus norvegicus) 6480464 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Docosahexaenoic Acids inhibits the reaction [Rotenone results in decreased expression of TH protein]] more ... CTD PMID:15790535 more ... TH Human rotenone increases response to substance ISO Th (Rattus norvegicus) 6480464 TH protein results in increased susceptibility to Rotenone CTD PMID:14622122 TH Human rotenone decreases expression ISO Th (Mus musculus) 6480464 Rotenone results in decreased expression of TH protein CTD PMID:17047462 more ... TH Human rottlerin multiple interactions ISO Th (Rattus norvegicus) 6480464 rottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein] CTD PMID:21310168 TH Human rottlerin multiple interactions ISO Th (Mus musculus) 6480464 [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein] and [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:22512859 TH Human rutin multiple interactions ISO Th (Rattus norvegicus) 6480464 Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 TH Human salubrinal multiple interactions ISO Th (Rattus norvegicus) 6480464 salubrinal inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:26446018 TH Human saxagliptin multiple interactions ISO Th (Rattus norvegicus) 6480464 saxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:25446674 TH Human SB 203580 multiple interactions ISO Th (Rattus norvegicus) 6480464 SB 203580 inhibits the reaction [fenvalerate results in decreased expression of TH protein] and SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein] CTD PMID:31734597 and PMID:9288946 TH Human SCH 23390 multiple interactions ISO Th (Mus musculus) 6480464 SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein] and SCH 23390 inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:16088948 and PMID:30922767 TH Human selenium atom increases activity ISO Th (Rattus norvegicus) 6480464 Selenium deficiency results in increased activity of TH protein CTD PMID:11113527 TH Human selenium atom increases expression ISO Th (Rattus norvegicus) 6480464 Selenium deficiency results in increased expression of TH mRNA CTD PMID:11113527 TH Human selenium atom multiple interactions ISO Th (Rattus norvegicus) 6480464 [Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamine CTD PMID:11113527 TH Human simazine decreases expression ISO Th (Rattus norvegicus) 6480464 Simazine results in decreased expression of TH protein CTD PMID:14550852 TH Human simazine decreases expression ISO Th (Mus musculus) 6480464 Simazine results in decreased expression of TH mRNA and Simazine results in decreased expression of TH protein CTD PMID:34936186 TH Human simazine affects expression ISO Th (Mus musculus) 6480464 Simazine affects the expression of TH mRNA and Simazine affects the expression of TH protein CTD PMID:29137186 TH Human simazine increases expression ISO Th (Mus musculus) 6480464 Simazine results in increased expression of TH mRNA and Simazine results in increased expression of TH protein CTD PMID:27513680 and PMID:32822773 TH Human simazine multiple interactions ISO Th (Mus musculus) 6480464 LMX1A protein promotes the reaction [Simazine results in increased expression of TH protein] CTD PMID:32822773 TH Human sodium arsenite multiple interactions ISO Th (Mus musculus) 6480464 [sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of TH mRNA] CTD PMID:23283970 TH Human sodium arsenite increases expression ISO Th (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of TH protein CTD PMID:25179238 TH Human sodium arsenite decreases expression ISO Th (Rattus norvegicus) 6480464 sodium arsenite results in decreased expression of TH protein CTD PMID:19631675 more ... TH Human sodium arsenite multiple interactions ISO Th (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein] more ... CTD PMID:19631675 more ... TH Human sodium arsenite increases expression ISO Th (Mus musculus) 6480464 sodium arsenite results in increased expression of TH protein CTD PMID:27413109 TH Human sodium arsenite decreases expression ISO Th (Mus musculus) 6480464 sodium arsenite results in decreased expression of TH mRNA CTD PMID:19121333 more ... TH Human sodium chloride increases expression ISO Th (Rattus norvegicus) 6480464 Sodium Chloride results in increased expression of TH mRNA CTD PMID:10613505 TH Human Sophoricoside multiple interactions ISO Th (Mus musculus) 6480464 sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:37741537 TH Human spiperone multiple interactions ISO Th (Rattus norvegicus) 6480464 Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]] CTD PMID:20729865 TH Human streptozocin multiple interactions ISO Th (Rattus norvegicus) 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein more ... CTD PMID:35085591 and PMID:38049026 TH Human streptozocin decreases expression ISO Th (Rattus norvegicus) 6480464 Streptozocin results in decreased expression of TH protein CTD PMID:38049026 TH Human sulforaphane multiple interactions ISO Th (Mus musculus) 6480464 sulforaphane inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:23518299 TH Human sulpiride multiple interactions ISO Th (Rattus norvegicus) 6480464 Sulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein] and Sulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:18289173 and PMID:2884129 TH Human sulpiride multiple interactions ISO Th (Mus musculus) 6480464 Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein] CTD PMID:30922767 TH Human sulpiride increases activity ISO Th (Rattus norvegicus) 6480464 Sulpiride results in increased activity of TH protein CTD PMID:2884129 TH Human Talipexole dihydrochloride multiple interactions ISO Th (Mus musculus) 6480464 talipexole inhibits the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:9655613 TH Human tamoxifen multiple interactions ISO Th (Mus musculus) 6480464 Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of TH mRNA] and Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of TH protein] CTD PMID:29183790 TH Human tamoxifen multiple interactions ISO Th (Rattus norvegicus) 6480464 Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA] and Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein] CTD PMID:28463726 TH Human tamoxifen decreases expression ISO Th (Rattus norvegicus) 6480464 Tamoxifen results in decreased expression of TH mRNA and Tamoxifen results in decreased expression of TH protein CTD PMID:28463726 TH Human taurine multiple interactions ISO Th (Mus musculus) 6480464 Taurine inhibits the reaction [arsenic trioxide results in decreased expression of TH mRNA] CTD PMID:23392890 TH Human telmisartan multiple interactions ISO Th (Mus musculus) 6480464 telmisartan inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23747572 TH Human testosterone decreases expression ISO Th (Rattus norvegicus) 6480464 Testosterone results in decreased expression of TH protein CTD PMID:11883789 TH Human topiramate affects expression ISO Th (Mus musculus) 6480464 topiramate affects the expression of TH mRNA CTD PMID:22017514 TH Human topiramate increases expression ISO Th (Mus musculus) 6480464 topiramate results in increased expression of TH mRNA CTD PMID:22489711 TH Human trichloroethene decreases expression ISO Th (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of TH protein CTD PMID:33636387 TH Human trichloroethene increases expression ISO Th (Rattus norvegicus) 6480464 Trichloroethylene results in increased expression of TH mRNA CTD PMID:33387578 TH Human triprolidine multiple interactions ISO Th (Rattus norvegicus) 6480464 Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1 more ... CTD PMID:10661506 TH Human tris(2-butoxyethyl) phosphate affects expression EXP 6480464 tris(2-butoxyethyl) phosphate affects the expression of TH mRNA CTD PMID:29024780 TH Human urethane multiple interactions ISO Th (Rattus norvegicus) 6480464 [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein CTD PMID:12088752 TH Human valproic acid affects expression ISO Th (Mus musculus) 6480464 Valproic Acid affects the expression of TH mRNA CTD PMID:17963808 TH Human valproic acid increases methylation ISO Th (Rattus norvegicus) 6480464 Valproic Acid results in increased methylation of TH promoter CTD PMID:33150595 TH Human valproic acid multiple interactions ISO Th (Mus musculus) 6480464 Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH mRNA] and Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH protein] CTD PMID:29778792 TH Human valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of TH mRNA CTD PMID:25979313 TH Human valproic acid increases expression ISO Th (Rattus norvegicus) 6480464 Valproic Acid results in increased expression of TH mRNA and Valproic Acid results in increased expression of TH protein CTD PMID:18976638 TH Human valproic acid decreases expression ISO Th (Rattus norvegicus) 6480464 Valproic Acid results in decreased expression of TH mRNA and Valproic Acid results in decreased expression of TH protein CTD PMID:18976638 and PMID:33150595 TH Human valproic acid multiple interactions ISO Th (Rattus norvegicus) 6480464 CREB1 protein affects the reaction [Valproic Acid results in increased expression of TH mRNA] and Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:18976638 and PMID:19149911 TH Human valproic acid affects expression ISO Th (Rattus norvegicus) 6480464 Valproic Acid affects the expression of TH protein CTD PMID:19460635 TH Human vitamin D decreases expression ISO Th (Rattus norvegicus) 6480464 Vitamin D deficiency results in decreased expression of TH mRNA and Vitamin D deficiency results in decreased expression of TH protein CTD PMID:28365874 TH Human vitamin E multiple interactions ISO Th (Rattus norvegicus) 6480464 [Ascorbic Acid co-treated with Vitamin E] results in increased expression of TH protein CTD PMID:18772553 TH Human vorinostat decreases expression EXP 6480464 vorinostat results in decreased expression of TH mRNA CTD PMID:27188386 TH Human WIN 55212-2 affects expression ISO Th (Rattus norvegicus) 6480464 (3R)-((2 more ... CTD PMID:29113897 TH Human WIN 55212-2 multiple interactions ISO Th (Rattus norvegicus) 6480464 AM 251 affects the reaction [(3R)-((2 more ... CTD PMID:29113897 TH Human WIN 55212-2 multiple interactions ISO Th (Mus musculus) 6480464 (3R)-((2 more ... CTD PMID:28092019 TH Human wortmannin multiple interactions ISO Th (Mus musculus) 6480464 wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18950629 TH Human wortmannin multiple interactions ISO Th (Rattus norvegicus) 6480464 [wortmannin co-treated with manganese chloride] results in decreased expression of TH protein CTD PMID:23604964 TH Human Y-27632 multiple interactions ISO Th (Mus musculus) 6480464 [cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein CTD PMID:16772336 TH Human zearalenone decreases expression EXP 6480464 Zearalenone results in decreased expression of TH mRNA CTD PMID:24412706 TH Human zinc atom increases expression ISO Th (Rattus norvegicus) 6480464 Zinc results in increased expression of TH protein CTD PMID:11165868 TH Human zinc atom decreases expression ISO Th (Rattus norvegicus) 6480464 Zinc results in decreased expression of TH protein CTD PMID:32060784 TH Human zinc atom multiple interactions ISO Th (Rattus norvegicus) 6480464 Paraquat promotes the reaction [Zinc results in decreased expression of TH protein] and Zinc promotes the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:32060784 TH Human zinc sulfate multiple interactions ISO Th (Rattus norvegicus) 6480464 Paraquat promotes the reaction [Zinc Sulfate results in decreased expression of TH protein] and Zinc Sulfate promotes the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:20553223 TH Human zinc sulfate decreases expression ISO Th (Rattus norvegicus) 6480464 Zinc Sulfate results in decreased expression of TH protein CTD PMID:20553223 TH Human zinc(0) increases expression ISO Th (Rattus norvegicus) 6480464 Zinc results in increased expression of TH protein CTD PMID:11165868 TH Human zinc(0) multiple interactions ISO Th (Rattus norvegicus) 6480464 Paraquat promotes the reaction [Zinc results in decreased expression of TH protein] and Zinc promotes the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:32060784 TH Human zinc(0) decreases expression ISO Th (Rattus norvegicus) 6480464 Zinc results in decreased expression of TH protein CTD PMID:32060784 TH Human zonisamide increases expression EXP 6480464 zonisamide results in increased expression of TH mRNA and zonisamide results in increased expression of TH protein CTD PMID:20196486 TH Human zonisamide multiple interactions ISO Th (Mus musculus) 6480464 [zonisamide co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:19199078 and PMID:19948168 TH Human zonisamide increases expression ISO Th (Mus musculus) 6480464 zonisamide results in increased expression of TH protein CTD PMID:19199078
