RGD Reference Report - Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment. - Rat Genome Database

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Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.

Authors: Gompf, HS  Mathai, C  Fuller, PM  Wood, DA  Pedersen, NP  Saper, CB  Lu, J 
Citation: Gompf HS, etal., J Neurosci. 2010 Oct 27;30(43):14543-51.
RGD ID: 5128829
Pubmed: PMID:20980612   (View Abstract at PubMed)
PMCID: PMC2989851   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.3037-10.2010   (Journal Full-text)

Locus ceruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here, we report that sustained elevations in neurobehavioral and EEG arousal in response to exposure to an environment with novel stimuli, including social interaction, are prevented by selective chemical lesions of the LC in rats. Similar results are seen when the anterior cingulate cortex (ACC), which receives especially dense LC innervation, is selectively denervated of LC input or is ablated by the cell-specific neurotoxin ibotenic acid. Anterograde tracing combined with tyrosine hydroxylase immunohistochemistry demonstrates ACC terminals in apposition with the distal dendrites of LC neurons. Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
circadian sleep/wake cycle  IEP 5128829 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Th  (tyrosine hydroxylase)


Additional Information