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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thdecreases expressionEXP 6480464CTDAscorbic Acid results in decreased expression of TH proteinPMID:25891525
Thincreases expressionEXP 6480464CTDAscorbic Acid results in increased expression of TH mRNAPMID:15372504
Thmultiple interactionsEXP 6480464CTD[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH proteinPMID:25891525
Thdecreases expressionISOTh (Mus musculus)6480464CTDAscorbic Acid results in decreased expression of TH proteinPMID:22285708
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