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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thdecreases expressionEXP 6480464CTDAmphetamine results in decreased expression of TH proteinPMID:12468030 PMID:15836913 PMID:19145071
Thincreases expressionEXP 6480464CTDAmphetamine results in increased expression of TH mRNAPMID:16126238
Thdecreases expressionISOTh (Mus musculus)6480464CTDAmphetamine results in decreased expression of TH proteinPMID:20620199
Thincreases expressionISOTh (Mus musculus)6480464CTDAmphetamine results in increased expression of TH mRNA; Amphetamine results in increased expression of TH proteinPMID:16916582 PMID:19059431
Thmultiple interactionsISOTh (Mus musculus)6480464CTDPTN protein inhibits the reaction [Amphetamine results in decreased expression of TH protein]PMID:20620199
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