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Gene: Th (tyrosine hydroxylase) Mus musculus
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Symbol: Th
Name: tyrosine hydroxylase
Description: Predicted to have several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including dopamine biosynthetic process from tyrosine; eye morphogenesis; and learning or memory. Localizes to several cellular components, including axon; nucleus; and perikaryon. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; INTERACTS WITH (R)-adrenaline; (R)-mevalonic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
Orthologs:
Homo sapiens (human) : TH (tyrosine hydroxylase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Th (tyrosine hydroxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Th (tyrosine hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : TH (tyrosine hydroxylase)
Canis lupus familiaris (dog) : TH (tyrosine hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Th (tyrosine hydroxylase)
Sus scrofa (pig) : TH (tyrosine hydroxylase)
Chlorocebus sabaeus (African green monkey) : TH (tyrosine hydroxylase)
Heterocephalus glaber (naked mole-rat) : Th (tyrosine hydroxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)EnsemblGRCm38mm10GRCm38
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBImm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Th
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11414
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.