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The synthesis and release of catecholamines epinephrine, norepinephrine and dopamine are triggered by various but distinct conditions and stresses. Dopamine (DA) acts a neurotransmitter and neuromodulator in the brain and peripherally, as an autocrine/paracrine hormone. Dopamine exerts its major role in the nervous system where is involved in motor control and action selection, reward and motivation, behavior, memory and cognition. The five G protein-coupled (GPCR) DA receptors are subdivided in

Pathway Diagram:

Elsevier Inc. L-DOPA dopamine tyrosine BH2 BH4 Ddc Th Qdpr dopamine signaling pathway dopamine --+> dopamine signaling pathway Slc18a2 ---> dopamine Slc18a2 Ddc ---- Slc18a2 Slc18a2 ---- Th diet L-Phe hydroxylation BH4 ---> BH2 L-DOPA ---> dopamine tyrosine ---> L-DOPA diet ---> tyrosine L-Phe hydroxylation ---> tyrosine BH2 ---> BH4

Genes in Pathway:

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dopamine biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:4139904
G Qdpr quinoid dihydropteridine reductase JBrowse link 14 70,164,682 70,178,284 RGD:4139904
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:5128868
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:4139904

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeBH2dihydrobiopterin
Small MoleculeL-DOPALevodopa
Small MoleculeBH4tetrahydrobiopterin

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the dopamine biosynthetic pathway

References Associated with the dopamine biosynthetic pathway:

Ontology Path Diagram:

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