DOPAMINE BIOSYNTHETIC PATHWAY (PW:0000802)

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Description

The synthesis and release of catecholamines epinephrine, norepinephrine and dopamine are triggered by various but distinct conditions and stresses. Dopamine (DA) acts a neurotransmitter and neuromodulator in the brain and peripherally, as an autocrine/paracrine hormone. Dopamine exerts its major role in the nervous system where is involved in motor control and action selection, reward and motivation, behavior, memory and cognition. The five G protein-coupled (GPCR) DA receptors are subdivided in

Pathway Diagram:

Elsevier Inc. L-DOPA dopamine tyrosine BH2 BH4 Ddc Th Qdpr dopamine signaling pathway dopamine --+> dopamine signaling pathway Slc18a2 ---> dopamine Slc18a2 Ddc ---- Slc18a2 Slc18a2 ---- Th diet L-Phe hydroxylation BH4 ---> BH2 L-DOPA ---> dopamine tyrosine ---> L-DOPA diet ---> tyrosine L-Phe hydroxylation ---> tyrosine BH2 ---> BH4
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Genes in Pathway:

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dopamine biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:4139904
G Qdpr quinoid dihydropteridine reductase JBrowse link 14 70,164,682 70,178,284 RGD:4139904
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:5128868
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:4139904

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeBH2dihydrobiopterin
Small MoleculeL-DOPALevodopa
Small MoleculeBH4tetrahydrobiopterin

Pathway Gene Annotations

Disease Annotations Associated with Genes in the dopamine biosynthetic pathway
Disease TermsGene Symbols
aromatic L-amino acid decarboxylase deficiencyDdc
attention deficit hyperactivity disorderDdc
bipolar disorderDdc
brain diseaseTh
Brain InjuriesTh
brain ischemiaTh
CatalepsyTh
congestive heart failureTh
ContusionsTh
Diabetes Mellitus, Experimental Qdpr , Th
disease of mental healthDdc
Drug-Induced DyskinesiaDdc , Th
dystoniaTh
end stage renal failureDdc
epilepsyTh
Experimental Liver CirrhosisDdc , Th
genetic diseaseSlc18a2 , Th
heart diseaseTh
hepatocellular carcinomaTh
hyperinsulinismDdc
HyperkinesisTh
Hyperphenylalaninemia, BH4-Deficient, CQdpr
hyperprolactinemiaTh
hypertensionQdpr , Th
hypoglycemiaTh
inherited metabolic disorderDdc
intellectual disabilityTh
Lead PoisoningQdpr
learning disabilityTh
Machado-Joseph diseaseSlc18a2 , Th
maturity-onset diabetes of the youngTh
mental depressionSlc18a2 , Th
middle cerebral artery infarctionTh
myocardial infarctionTh
neonatal diabetes mellitusTh
nephrotic syndromeDdc
Nerve DegenerationDdc , Slc18a2 , Th
nervous system diseaseSlc18a2
neuroblastomaTh
obesityTh
Parkinson's diseaseDdc , Slc18a2 , Th
Parkinsonian DisordersDdc , Slc18a2 , Th
PARKINSONISM-DYSTONIA, INFANTILE, 2Slc18a2
phenylketonuriaQdpr
pheochromocytomaDdc , Th
pleomorphic xanthoastrocytomaDdc
polycystic ovary syndromeTh
portal hypertensionDdc , Th
Reperfusion InjuryTh
Segawa Syndrome, Autosomal RecessiveTh
status epilepticusQdpr
substance-related disorderSlc18a2
toxic encephalopathySlc18a2
type 1 diabetes mellitusSlc18a2
uremiaTh
withdrawal disorderTh
Pathway Annotations Associated with Genes in the dopamine biosynthetic pathway

References Associated with the dopamine biosynthetic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: