Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thdecreases activityEXP 6480464CTDClozapine results in decreased activity of TH proteinPMID:15983997
Thdecreases expressionEXP 6480464CTDClozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH proteinPMID:12645084 PMID:15983997
Thincreases expressionEXP 6480464CTDClozapine results in increased expression of TH proteinPMID:17028028
Thmultiple interactionsEXP 6480464CTDEthylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]PMID:15983997
Thincreases activityISOTh (Mus musculus)6480464CTDClozapine results in increased activity of TH proteinPMID:16415089
Thmultiple interactionsISOTh (Mus musculus)6480464CTD1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of DopaminePMID:16402076 PMID:16415089
Go Back to source page   Continue to Ontology report