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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:4803
Term: epibatidine
Definition: An alkaloid that has formula C11H13ClN2.
Chemical ID: MESH:C082748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thincreases expressionEXP 6480464CTDepibatidine results in increased expression of TH mRNAPMID:15588622
Thmultiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [epibatidine results in increased expression of TH mRNA]; 2',5'-dideoxyadenosine inhibits the reaction [epibatidine results in increased expression of TH mRNA]PMID:15588622
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