Slc18a1 (solute carrier family 18 member A1) - Rat Genome Database

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Gene: Slc18a1 (solute carrier family 18 member A1) Rattus norvegicus
Analyze
Symbol: Slc18a1
Name: solute carrier family 18 member A1
RGD ID: 3693
Description: Enables enzyme binding activity; monoamine:proton antiporter activity; and serotonin:sodium:chloride symporter activity. Involved in several processes, including cellular response to lithium ion; positive regulation of dopamine secretion; and serotonin uptake. Located in cytoplasm. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGAT; chromaffin granule amine transporter; LOC684870; similar to solute carrier family 18 (vesicular monoamine), member 1; solute carrier family 18 (vesicular monoamine transporter), member 1; solute carrier family 18 (vesicular monoamine), member 1; solute carrier family 18 member 1; solute carrier family 18, member 1; Solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter); VAT1; vesicular amine transporter 1; vesicular monoamine transporter 1; VMAT-1; VMAT1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21620,653,268 - 20,687,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1624,022,654 - 24,055,924 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01627,452,714 - 27,485,111 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01623,387,959 - 23,421,230 (+)NCBIRnor_WKY
Rnor_6.01622,358,646 - 22,395,183 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,361,998 - 22,395,183 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01622,256,523 - 22,289,704 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,356,304 - 22,389,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11622,356,297 - 22,389,825 (+)NCBI
Celera1620,629,165 - 20,846,643 (+)NCBICelera
RH 3.4 Map16253.67RGD
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake. Brunk I, etal., J Biol Chem. 2006 Nov 3;281(44):33373-85. Epub 2006 Aug 22.
2. Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake. Brunk I, etal., J Biol Chem. 2009 Jan 9;284(2):1050-6. Epub 2008 Nov 13.
3. A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. Cartier EA, etal., J Biol Chem. 2010 Jan 15;285(3):1957-66. Epub 2009 Nov 10.
4. Lithium ions Up-regulate mRNAs encoding dense-core vesicle proteins in nerve growth factor-differentiated PC12 cells. Cordeiro ML, etal., J Neurochem. 2000 Dec;75(6):2622-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Different expression of catecholamine transporters in phaeochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. Huynh TT, etal., Eur J Endocrinol. 2005 Oct;153(4):551-63.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Liu Y, etal., Cell 1992 Aug 21;70(4):539-51.
10. Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia. Lohoff FW, etal., Neuropsychobiology. 2008;57(1-2):55-60. Epub 2008 May 2.
11. Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. Lohoff FW, etal., Neuropsychopharmacology. 2006 Dec;31(12):2739-47. Epub 2006 Aug 23.
12. Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells. Maurel A, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1592-8. Epub 2007 Jan 23.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors. Peter D, etal., J Biol Chem. 1994 Mar 11;269(10):7231-7.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12534970   PMID:22253933   PMID:23201251   PMID:31955909  


Genomics

Comparative Map Data
Slc18a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21620,653,268 - 20,687,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1624,022,654 - 24,055,924 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01627,452,714 - 27,485,111 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01623,387,959 - 23,421,230 (+)NCBIRnor_WKY
Rnor_6.01622,358,646 - 22,395,183 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,361,998 - 22,395,183 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01622,256,523 - 22,289,704 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,356,304 - 22,389,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11622,356,297 - 22,389,825 (+)NCBI
Celera1620,629,165 - 20,846,643 (+)NCBICelera
RH 3.4 Map16253.67RGD
Cytogenetic Map16p14NCBI
SLC18A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38820,144,855 - 20,183,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl820,144,855 - 20,183,206 (-)EnsemblGRCh38hg38GRCh38
GRCh37820,002,366 - 20,040,647 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36820,046,652 - 20,084,997 (-)NCBINCBI36Build 36hg18NCBI36
Build 34820,046,651 - 20,084,997NCBI
Celera818,964,997 - 19,003,346 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef818,542,580 - 18,580,897 (-)NCBIHuRef
CHM1_1820,204,176 - 20,242,504 (-)NCBICHM1_1
T2T-CHM13v2.0820,409,985 - 20,448,250 (-)NCBIT2T-CHM13v2.0
Slc18a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,490,360 - 69,547,951 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl869,490,363 - 69,541,887 (-)EnsemblGRCm39 Ensembl
GRCm38869,037,708 - 69,089,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,037,711 - 69,089,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv37871,561,607 - 71,613,121 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36871,966,697 - 72,018,211 (-)NCBIMGSCv36mm8
Celera871,585,811 - 71,639,074 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.88NCBI
Slc18a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540343,821,296 - 43,848,399 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540343,821,978 - 43,848,403 (-)NCBIChiLan1.0ChiLan1.0
SLC18A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1816,318,744 - 16,353,708 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl816,318,744 - 16,353,708 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0819,369,843 - 19,408,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC18A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12536,859,047 - 36,904,057 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2536,872,636 - 36,904,056 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2537,453,565 - 37,498,544 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02537,085,789 - 37,130,930 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,105,537 - 37,130,929 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,021,486 - 37,066,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02536,869,997 - 36,915,036 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,038,820 - 37,083,968 (+)NCBIUU_Cfam_GSD_1.0
Slc18a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494314,299,001 - 14,321,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365554,249,821 - 4,271,379 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365554,249,821 - 4,271,379 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC18A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,243,557 - 4,275,243 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,243,553 - 4,279,341 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2144,278,115 - 4,313,822 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC18A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1818,214,703 - 18,250,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl818,214,701 - 18,249,731 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605224,002,943 - 24,037,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc18a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475815,864,204 - 15,894,529 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475815,863,410 - 15,894,958 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc18a1
202 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:50
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000016193
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat

Markers in Region
RH94391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,686,870 - 20,687,031 (+)MAPPERmRatBN7.2
Rnor_6.01622,395,003 - 22,395,163NCBIRnor6.0
Rnor_5.01622,289,524 - 22,289,684UniSTSRnor5.0
RGSC_v3.41622,389,647 - 22,389,807UniSTSRGSC3.4
Celera1620,846,463 - 20,846,623UniSTS
RH 3.4 Map16253.67UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 1
Low 1 24 14 14 14 74 6 25
Below cutoff 17 15 13 4 13 2 2 29 13 5 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016193   ⟹   ENSRNOP00000016193
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)Ensembl
Rnor_6.0 Ensembl1622,361,998 - 22,395,183 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106291   ⟹   ENSRNOP00000082299
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1620,653,508 - 20,687,051 (+)Ensembl
RefSeq Acc Id: NM_013152   ⟹   NP_037284
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,653,512 - 20,687,051 (+)NCBI
Rnor_6.01622,362,002 - 22,395,183 (+)NCBI
Rnor_5.01622,256,523 - 22,289,704 (+)NCBI
RGSC_v3.41622,356,304 - 22,389,827 (+)RGD
Celera1620,629,165 - 20,846,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600001   ⟹   XP_017455490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,653,276 - 20,687,051 (+)NCBI
Rnor_6.01622,358,646 - 22,395,183 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094220   ⟹   XP_038950148
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,653,268 - 20,687,051 (+)NCBI
RefSeq Acc Id: XM_039094221   ⟹   XP_038950149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,655,581 - 20,687,051 (+)NCBI
RefSeq Acc Id: XM_039094222   ⟹   XP_038950150
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,653,268 - 20,687,051 (+)NCBI
RefSeq Acc Id: XM_039094223   ⟹   XP_038950151
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,653,277 - 20,687,051 (+)NCBI
RefSeq Acc Id: XR_005494535
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,653,287 - 20,681,658 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037284   ⟸   NM_013152
- UniProtKB: Q01818 (UniProtKB/Swiss-Prot),   F1LSA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455490   ⟸   XM_017600001
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000016193   ⟸   ENSRNOT00000016193
RefSeq Acc Id: XP_038950148   ⟸   XM_039094220
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038950150   ⟸   XM_039094222
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950151   ⟸   XM_039094223
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038950149   ⟸   XM_039094221
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000082299   ⟸   ENSRNOT00000106291
Protein Domains
MFS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01818-F1-model_v2 AlphaFold Q01818 1-521 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3693 AgrOrtholog
BioCyc Gene G2FUF-11702 BioCyc
Ensembl Genes ENSRNOG00000011992 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016193 ENTREZGENE
  ENSRNOP00000016193.2 UniProtKB/TrEMBL
  ENSRNOP00000082299.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016193 ENTREZGENE
  ENSRNOT00000016193.4 UniProtKB/TrEMBL
  ENSRNOT00000106291.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Multidrug-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25693 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25693 ENTREZGENE
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc18a1 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216694
TIGRFAMs 2_A_01_02 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTW4_RAT UniProtKB/TrEMBL
  F1LSA7 ENTREZGENE, UniProtKB/TrEMBL
  Q01818 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc18a1  solute carrier family 18 member A1  Slc18a1  solute carrier family 18 member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Slc18a1  solute carrier family 18 member 1  Slc18a1  solute carrier family 18 (vesicular monoamine transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc18a1  solute carrier family 18 (vesicular monoamine transporter), member 1  Slc18a1  solute carrier family 18 (vesicular monoamine), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-12 Slc18a1  solute carrier family 18 (vesicular monoamine), member 1  LOC684870  similar to solute carrier family 18 (vesicular monoamine), member 1  Data Merged 737654 PROVISIONAL
2006-11-19 LOC684870  similar to solute carrier family 18 (vesicular monoamine), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Slc18a1  solute carrier family 18 (vesicular monoamine), member 1    solute carrier family 18, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc18a1  solute carrier family 18, member 1    Solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter)  Name updated 629478 APPROVED
2002-06-10 Slc18a1  Solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in adrenal gland 729674