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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3693
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc18a1
Name: solute carrier family 18 member A1
Acc ID: CHEBI:9467
Term: tetrabenazine
Definition: A racemate consisting of equal amounts of (3R,11bR)- and (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one. An adrenergic uptake inhibitor, it was formerly used as an antipsychotic, but it is now used mainly for the treatment of various movement disorders including chorea, ballism, dystonias, and tardive dyskinesia.
Chemical ID: MESH:D013747
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc18a1multiple interactionsISORGD:7373196480464CTDTetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]PMID:8245983
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