PARKINSON DISEASE PATHWAY (PW:0000018)

View Ontology Report

Description

Parkinson's disease (PD) is a progressive neurodegenerative condition of complex etiology exhibiting a range of movement syndromes caused by the selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The second most prevalent neurodegenerative disease after Alzheimer's disease, PD is largely sporadic - ~90-95% of cases, the remaining 5-10% being familial; age is a major risk factor. As life span is expected to increase, the incidence of PD is also likely to i

Pathway Diagram:

Elsevier Inc. vesicular trafficking PD 6 PD 7 PD 20 transcriptional modulation neuromelanin Fe3+ ---- neuromelanin complex architecture Ca2+ calcium homeostasis pathway pacemaker activity donwregulated miRNA ---> upregulated target translation potential PD miRNA ---> Parkinson Disease (PD) upregulated miRNA ---> downregulated target translation downregulated target translation upregulated miRNA donwregulated miRNA upregulated target translation PD 8 PD 1 Snca ---> PD 1 PD 17 autosomal dominant PD sporadic PD autosomal recessive PD Vps35 Synj1 other PD related proteins Pink1 Park2 respiratory complex I Lrrk2 Park7 Lrrk2 ---> Lrrk2 Rab substrates altered mitochondrial autophagy pathway ---| mitochondria dynamics pathway Lrrk2 ---| chaperone mediated autophagy pathway Snca ---| chaperone mediated autophagy pathway Snca ---| DNA modification pathway Snca ---| unfolded protein response pathway Snca ---| respiratory complex I Dnmt1 Snca unfolded protein response pathway electron transport chain pathway Snca ---> mitochondria dynamics pathway loss of DA neurons in SNc mitochondria function Park7 interacting proteins altered mitochondria homeostasis pathway ---> Parkinson Disease (PD) ROS ---> Parkinson Disease (PD) Parkinson Disease (PD) altered mitochondria homeostasis pathway altered mitochondria dynamics pathway Fe2+ ---- Fe3+ Fe2+ Fe3+ Wnt signaling, canonical pathway Wnt signaling, canonical pathway ---> dopaminergic neuron mitochondria dynamics pathway altered mitochondrial autophagy pathway Lrrk2 interacting proteins Park2 ---> autosomal recessive PD lysosomal function endocytosis Park7 ---> anti-oxidant anti-oxidant Park7 ---> transcriptional modulation altered retromer-mediated pathway ---> Parkinson Disease (PD) altered retromer-mediated pathway altered clathrin-dependent synaptic vesicle endocytosis Lrrk2 ---> PD 8 Lrrk2 ---> sporadic PD Pink1 ---> PD 6 Park7 ---> PD 7 Lrrk2 ---> mitochondria function Lrrk2 ---> cytoskeletal system cytoskeletal system Lrrk2 ---> immune system Lrrk2 ---> vesicular trafficking Lrrk2 ---- Lrrk2 interacting proteins mitochondria dynamics pathway ---> altered mitochondria dynamics pathway Park7 ---> mitochondria function Snca ---> mitochondria function Vps35 ---> PD 17 Synj1 ---> PD 20 Snca ---> sporadic PD altered clathrin-dependent synaptic vesicle endocytosis ---> Parkinson Disease (PD) Park7 ---- Park7 interacting proteins dopaminergic neuron immune system altered mitochondria dynamics pathway ---> altered mitochondria homeostasis pathway calcium homeostasis pathway ---> Parkinson Disease (PD) potential PD miRNA Snca ---> synaptic vesicle homeostasis Snca interacting proteins Snca ---- Snca interacting proteins synaptic vesicle homeostasis DNA modification pathway Dnmt1 ---- Snca chaperone mediated autophagy pathway ROS Lrrk2 Rab substrates
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Genes in Pathway:

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Parkinson's disease pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6907045
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:10450518
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6907045
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:6907045
G Atp5f1c ATP synthase F1 subunit gamma JBrowse link 17 72,209,321 72,231,562 RGD:6907045
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:6907045
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:6907045
G Atp5hl1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d-like 1 JBrowse link 16 51,816,495 51,817,031 RGD:6907045
G Atp5mc1 ATP synthase membrane subunit c locus 1 JBrowse link 10 83,895,941 83,898,640 RGD:6907045
G Atp5mc2 ATP synthase membrane subunit c locus 2 JBrowse link 7 144,264,207 144,272,578 RGD:6907045
G Atp5mc3 ATP synthase membrane subunit c locus 3 JBrowse link 3 60,811,218 60,813,903 RGD:6907045
G Atp5pb ATP synthase peripheral stalk-membrane subunit b JBrowse link 2 208,566,385 208,577,147 RGD:6907045
G Atp5pd ATP synthase peripheral stalk subunit d JBrowse link 10 103,967,340 103,972,552 RGD:6907045
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link 11 24,286,806 24,294,419 RGD:6907045
G Atp5po ATP synthase peripheral stalk subunit OSCP JBrowse link 11 32,081,606 32,087,918 RGD:6907045
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Cox4i1 cytochrome c oxidase subunit 4i1 JBrowse link 19 54,245,958 54,252,198 RGD:6907045
G Cox4i2 cytochrome c oxidase subunit 4i2 JBrowse link 3 148,234,546 148,245,424 RGD:6907045
G Cox5a cytochrome c oxidase subunit 5A JBrowse link 8 62,298,358 62,309,765 RGD:6907045
G Cox5b cytochrome c oxidase subunit 5B JBrowse link 9 43,259,706 43,262,039 RGD:6907045
G Cox6a1 cytochrome c oxidase subunit 6A1 JBrowse link 12 47,024,442 47,027,495 RGD:6907045
G Cox6a2 cytochrome c oxidase subunit 6A2 JBrowse link 1 199,624,037 199,626,255 RGD:6907045
G Cox6b1 cytochrome c oxidase subunit 6B1 JBrowse link 1 89,075,987 89,084,834 RGD:6907045
G Cox6b2 cytochrome c oxidase subunit 6B2 JBrowse link 1 72,661,099 72,662,436 RGD:6907045
G Cox6c cytochrome c oxidase subunit 6C JBrowse link 7 74,723,177 74,735,650 RGD:6907045
G Cox7a2 cytochrome c oxidase subunit 7A2 JBrowse link 8 87,209,529 87,213,627 RGD:6907045
G Cox7a2l cytochrome c oxidase subunit 7A2 like JBrowse link 6 6,695,807 6,709,790 RGD:6907045
G Cox7a2l2 cytochrome c oxidase subunit VIIa polypeptide 2-like 2 JBrowse link 14 52,661,933 52,662,375 RGD:6907045
G Cox7b cytochrome c oxidase subunit 7B JBrowse link X 77,065,427 77,071,676 RGD:6907045
G Cox7c cytochrome c oxidase subunit 7C JBrowse link 2 14,699,878 14,701,903 RGD:6907045
G Cox8a cytochrome c oxidase subunit 8A JBrowse link 1 222,466,575 222,468,896 RGD:6907045
G Cox8b cytochrome c oxidase, subunit VIIIb JBrowse link 1 213,648,787 213,650,247 RGD:6907045
G Cox8c cytochrome c oxidase subunit 8C JBrowse link 6 126,766,967 126,768,290 RGD:6907045
G Cyc1 cytochrome c-1 JBrowse link 7 117,409,576 117,411,953 RGD:6907045
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 3 63,204,779 63,211,847 RGD:6907045
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 JBrowse link 8 112,697,907 112,830,445 RGD:10450845
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 JBrowse link 5 120,330,372 120,492,515 RGD:10450521
RGD:10450553
G Fbxo7 F-box protein 7 JBrowse link 7 23,815,246 23,843,505 RGD:10450518
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:10450518
RGD:10450521
G Gpr37 G protein-coupled receptor 37 JBrowse link 4 51,822,163 51,844,228 RGD:6907045
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:6907045
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:6907045
RGD:10450521
RGD:10450518
G Maob monoamine oxidase B JBrowse link X 6,430,694 6,533,520 RGD:1358484
G Mir1 microRNA 1 JBrowse link 18 2,054,933 2,055,019 RGD:10755488
G Mir106a microRNA 106a JBrowse link X 140,117,891 140,117,968 RGD:10450788
G Mir132 microRNA 132 JBrowse link 10 62,014,995 62,015,095 RGD:10450788
G Mir19b1 microRNA 19b-1 JBrowse link 15 100,180,464 100,180,550 RGD:10755479
G Mir22 microRNA 22 JBrowse link 10 62,299,592 62,299,686 RGD:10755488
G Mir29b1 microRNA 29b-1 JBrowse link 4 58,344,310 58,344,390 RGD:10755479
G Mir301a microRNA 301a JBrowse link 10 74,417,746 74,417,845 RGD:10755479
G Mir34b microRNA 34b JBrowse link 8 55,492,542 55,492,625 RGD:10755477
G Mir34c microRNA 34c JBrowse link 8 55,492,024 55,492,100 RGD:10755477
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 JBrowse link X 123,803,109 123,806,760 RGD:6907045
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 JBrowse link 9 99,617,051 99,651,827 RGD:6907045
G Ndufa10l1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 JBrowse link 6 62,796,951 62,798,384 RGD:6907045
G Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 JBrowse link 9 10,334,104 10,338,163 RGD:6907045
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 JBrowse link 7 35,125,516 35,163,182 RGD:6907045
G Ndufa13-ps1 NADH:ubiquinone oxidoreductase subunit A13, pseudogene 1 JBrowse link 7 36,826,357 36,826,837 RGD:6907045
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 JBrowse link 18 29,585,671 29,587,760 RGD:6907045
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 JBrowse link 1 64,172,462 64,175,174 RGD:6907045
G Ndufa4 NDUFA4, mitochondrial complex associated JBrowse link 4 38,233,680 38,240,848 RGD:6907045
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 JBrowse link 4 51,590,413 51,598,771 RGD:6907045
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 JBrowse link 7 123,583,062 123,586,919 RGD:6907045
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 JBrowse link 7 18,683,553 18,696,332 RGD:6907045
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 JBrowse link 3 15,362,888 15,379,386 RGD:6907045
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 JBrowse link 4 159,371,263 159,399,636 RGD:6907045
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 JBrowse link 1 192,044,209 192,057,644 RGD:6907045
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 JBrowse link 10 14,090,128 14,092,289 RGD:6907045
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 JBrowse link X 1,787,266 1,789,524 RGD:6907045
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 JBrowse link 4 67,378,188 67,385,267 RGD:6907045
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 JBrowse link 9 65,478,496 65,488,708 RGD:6907045
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 JBrowse link 11 65,960,277 65,966,899 RGD:6907045
G Ndufb4l1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1 JBrowse link 14 7,949,217 7,949,662 RGD:6907045
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 JBrowse link 2 119,139,717 119,153,753 RGD:6907045
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 JBrowse link 5 56,567,109 56,576,676 RGD:6907045
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 JBrowse link 19 24,701,067 24,705,405 RGD:6907045
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6907045
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 JBrowse link 7 98,813,062 98,819,408 RGD:6907045
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 JBrowse link 1 162,369,801 162,376,024 RGD:6907045
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 JBrowse link 9 69,919,863 69,953,182 RGD:6907045
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 JBrowse link 13 89,606,848 89,623,506 RGD:6907045
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 JBrowse link 3 79,721,686 79,728,863 RGD:6907045
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 JBrowse link 2 46,372,488 46,476,162 RGD:6907045
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 JBrowse link 5 141,390,577 141,405,507 RGD:6907045
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 JBrowse link 2 26,471,173 26,471,587 RGD:6907045
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 JBrowse link 7 12,318,776 12,326,403 RGD:6907045
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 JBrowse link 1 219,141,289 219,144,610 RGD:6907045
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 JBrowse link 1 219,254,293 219,259,328 RGD:6907045
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 JBrowse link 9 113,875,718 113,900,169 RGD:6907045
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 JBrowse link 20 10,265,826 10,275,298 RGD:6907045
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:1358519
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 JBrowse link 3 43,111,258 43,128,391 RGD:1358553
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:6907045
RGD:10450523
G Pink1 PTEN induced putative kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:6907045
RGD:10450527
RGD:10450521
RGD:10450518
G Ppid peptidylprolyl isomerase D JBrowse link 2 178,354,830 178,366,843 RGD:6907045
G Ppidl1 peptidylprolyl isomerase D-like 1 JBrowse link 9 121,456,762 121,458,035 RGD:6907045
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:6907045
RGD:10450527
RGD:10450521
RGD:10450518
RGD:1302872
G RGD1559629 similar to H+ ATP synthase JBrowse link 6 69,950,129 69,951,013 RGD:6907045
G RGD1560088 similar to NADH:ubiquinone oxidoreductase B15 subunit JBrowse link 1 90,729,267 90,729,711 RGD:6907045
G RGD1560648 similar to DJ-1 protein JBrowse link 16 42,508,926 42,509,284 RGD:6907045
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:6907045
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:6907045
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:6907045
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:6907045
G Sept5 septin 5 JBrowse link 11 86,516,377 86,522,169 RGD:6907045
G Slc18a1 solute carrier family 18 member A1 JBrowse link 16 22,358,646 22,395,183 RGD:6907045
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:6907045
G Slc25a31 solute carrier family 25 member 31 JBrowse link 2 127,538,323 127,554,276 RGD:6907045
G Slc25a4 solute carrier family 25 member 4 JBrowse link 16 49,266,903 49,270,698 RGD:6907045
G Slc25a5 solute carrier family 25 member 5 JBrowse link X 123,404,570 123,407,637 RGD:6907045
G Slc25a6 solute carrier family 25 member 6 JBrowse link 18 70,959,872 70,961,040 RGD:6907045
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:6907045
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6907045
RGD:10450521
RGD:10450518
RGD:10450517
RGD:730239
G Sncaip synuclein, alpha interacting protein JBrowse link 18 47,739,284 47,877,679 RGD:6907045
G Synj1 synaptojanin 1 JBrowse link 11 31,105,784 31,181,573 RGD:10450521
RGD:10450553
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6907045
G Uba1 ubiquitin-like modifier activating enzyme 1 JBrowse link X 1,723,135 1,745,147 RGD:6907045
G Uba7 ubiquitin-like modifier activating enzyme 7 JBrowse link 8 116,754,178 116,766,765 RGD:6907045
G Ubb ubiquitin B JBrowse link 10 48,880,231 48,881,896 RGD:6907045
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 JBrowse link 10 59,173,268 59,254,458 RGD:6907045
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 JBrowse link 20 11,700,089 11,721,823 RGD:6907045
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 JBrowse link 5 48,274,387 48,292,699 RGD:6907045
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 JBrowse link 5 173,372,659 173,387,084 RGD:6907045
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 JBrowse link 11 88,047,186 88,088,477 RGD:6907045
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 JBrowse link 3 72,191,533 72,206,190 RGD:6907045
G Uchl1 ubiquitin C-terminal hydrolase L1 JBrowse link 14 43,133,224 43,143,942 RGD:6907045
G Uqcrb ubiquinol-cytochrome c reductase binding protein JBrowse link 7 71,264,501 71,269,869 RGD:6907045
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 JBrowse link 8 117,679,328 117,691,073 RGD:6907045
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 JBrowse link 1 190,555,177 190,585,741 RGD:6907045
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 JBrowse link 17 35,677,984 35,682,262 RGD:6907045
G Uqcrh ubiquinol-cytochrome c reductase hinge protein JBrowse link 5 134,919,040 134,927,235 RGD:6907045
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII JBrowse link 10 38,779,132 38,782,489 RGD:6907045
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6907045
G Vdac2 voltage-dependent anion channel 2 JBrowse link 15 2,634,622 2,648,548 RGD:6907045
G Vdac3 voltage-dependent anion channel 3 JBrowse link 16 74,292,466 74,308,910 RGD:6907045
G Vps35 VPS35 retromer complex component JBrowse link 19 27,464,937 27,500,636 RGD:10450518
RGD:10450845
RGD:10450542
RGD:10450521

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Parkinson disease pathway
Disease TermsGene Symbols
3-Methylglutaconic Aciduria Type VIIIHtra2
achalasiaNos1
acute kidney failureAtp5f1b
adult respiratory distress syndromeSept5
Agenesis of Corpus CallosumNdufs1
alcohol use disorderSnca
alcoholic cardiomyopathyNos1 , Slc25a4
Alzheimer's diseaseAtp5f1a , Atp5pf , Casp3 , Htra2 , Maob , Prkn , Slc25a4 , Snca , Uchl1
amphetamine abuseNos1 , Slc6a3 , Snca
amyotrophic lateral sclerosisCasp3 , Casp9 , Lrrk2
Animal Disease ModelsSnca
anxiety disorderSlc6a3
ARC syndromeGba
Arsenic PoisoningNdufb8 , Nr4a2
arteriosclerosisNdufs6 , Nos1
Arthrogryposis Multiplex Congenita, Distal, X-LinkedUba1
asphyxia neonatorumHtra2
asthmaNos1
attention deficit hyperactivity disorderSlc6a3
autism spectrum disorderNr4a2 , Sept5
autistic disorderMaob , Nr4a2 , Prkn
autoimmune polyendocrine syndrome type 1Ube2g2
autosomal dominant Parkinson's disease 1Snca
autosomal dominant Parkinson's disease 4Snca
autosomal dominant Parkinson's disease 8Lrrk2
autosomal recessive early-onset Parkinson's disease 15Fbxo7
autosomal recessive early-onset Parkinson's disease 6Park7 , Pink1
autosomal recessive early-onset Parkinson's disease 7Park7
autosomal recessive juvenile Parkinson's disease 2Prkn
bacterial infectious diseaseCasp3 , Casp9
bipolar disorderNdufs7 , Ndufv2 , Slc18a1 , Snca
brain diseaseTh
Brain Diseases, Metabolic, InbornNdufs4
Brain InjuriesApaf1 , Casp3 , Mir132 , Snca , Th
brain ischemiaApaf1 , Casp3 , Casp9 , Cycs , Nos1 , Ppid , Th
breast ductal carcinomaHtra2
Breast NeoplasmsCasp3 , Casp9 , Mir132 , Ndufs3
Bronchial HyperreactivityNos1
BurnsCasp3 , Vdac2
calcinosisCasp3
Carcinoid TumorMir34b , Mir34c
Carcinoid Tumors, IntestinalSdhd
CardiomegalyCox5b , Nos1 , Slc25a4
cardiomyopathyHtra2 , Ndufs2 , Ndufv2 , Nos1
Carney TriadSdha , Sdhb , Sdhc
Carney-Stratakis SyndromeSdhb , Sdhc , Sdhd
Carotid Body TumorSdhd
CatalepsyTh
Cell Transformation, NeoplasticMir106a , Mir34b , Mir34c
cerebellar diseaseNos1
Cerebral HemorrhageCasp3
cerebral infarctionPark7
Charcot-Marie-Tooth diseaseSdhc
Charcot-Marie-Tooth disease intermediate typeSdhc
Charcot-Marie-Tooth disease recessive intermediate DCox6a1
Charcot-Marie-Tooth disease type 1Sdhc
Charcot-Marie-Tooth disease type 1BSdhc
Charcot-Marie-Tooth disease type 4ESdhc
Chemical and Drug Induced Liver InjuryMir132 , Mir22 , Mir301a , Mir34c , Ndufs3 , Park7
ChloracneCycs
cholangiocarcinomaCycs
cholestasisMaob
chronic obstructive pulmonary diseaseNos1
chronic progressive external ophthalmoplegiaSlc25a4
Ciliary Motility DisordersNdufv3 , Synj1
cleft palateUbb
Cocaine-Related DisordersSlc6a3 , Snca
Cognition DisordersPrkn
colitisLrrk2
Colonic NeoplasmsCasp3 , Maob , Prkn
Colorectal NeoplasmsCasp9 , Nr4a2
combined oxidative phosphorylation deficiencyAtp5f1a
Combined Oxidative Phosphorylation Deficiency 22Atp5f1a
Combined Oxidative Phosphorylation Deficiency 8Sdhd
congenital diaphragmatic herniaUchl1
congenital disorder of glycosylationPink1
congenital muscular dystrophySdhc
congenital myasthenic syndromeUbe2j2
congenital myasthenic syndrome 8Ube2j2
congestive heart failureNos1 , Th
ContusionsTh
Copper-Overload CirrhosisCasp3
Cowden diseaseSdhb , Sdhd
Cowden-Like SyndromeSdhb , Sdhd
Craniofacial AbnormalitiesApaf1
Creutzfeldt-Jakob diseaseSnca
Crohn's diseaseLrrk2
cryptorchidismCasp3 , Htra2
Currarino TriadNdufb5
cutaneous T cell lymphomaMir22
cystic fibrosisNdufs1 , Nos1
Cystic Leukoencephalopathy without MegalencephalyNdufa2
cytochrome-c oxidase deficiency diseaseCox6b1 , Cox8a
Danon diseaseNdufa1
Deglutition DisordersUchl1
dementiaGba , Slc6a3
diabetic angiopathyCasp3
Diabetic CardiomyopathiesSlc25a4
Diabetic NephropathiesCasp3 , Nos1 , Vdac1 , Vdac2
diabetic neuropathyCasp3 , Lrrk2
diabetic retinopathyCasp3 , Casp9 , Nos1
DiGeorge syndromeSept5
dilated cardiomyopathySdha , Slc25a4
dilated cardiomyopathy 1GGSdha
dilated cardiomyopathy 1HSlc25a4
disease of cellular proliferationLrrk2
disease of mental healthNos1
Disease ProgressionNdufa2 , Ndufs1 , Ndufv1
Drug-Induced DyskinesiaTh
dystoniaTh
Early Infantile Epileptic Encephalopathy, 53Synj1
early-onset Parkinson's disease 20Synj1
EdemaCasp3 , Casp9
End Stage Liver DiseaseNos1
end stage renal failureNos1
Endometrial NeoplasmsHtra2
endometriosisLrrk2 , Maob
EndotoxemiaAtp5f1a , Casp3 , Prkn
epilepsyNr4a2 , Th , Vdac1 , Vdac2
Esophageal NeoplasmsUchl1
essential tremorDnajc13
Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, and Calvarial HyperostosisCox4i2
Experimental Autoimmune EncephalomyelitisCasp3 , Casp9
Experimental Diabetes MellitusCasp3 , Casp9 , Ndufs2 , Ndufs3 , Nos1 , Th , Vdac1
Experimental Liver CirrhosisApaf1 , Prkn , Slc25a4 , Th
Experimental NeoplasmsMir34b
Extra-Adrenal ParagangliomaSdhd
Eye AbnormalitiesApaf1
Facial Nerve InjuriesNdufa5
facioscapulohumeral muscular dystrophySlc25a4
familial hyperlipidemiaGba
fatty liver diseaseCycs
Female InfertilityHtra2
fetal alcohol spectrum disorderNos1
Fetal Growth RetardationCasp3 , Nos1
Fetal HypoxiaNos1
FeverNos1
frontotemporal dementiaLrrk2 , Prkn
Gallbladder NeoplasmsUchl1
gangliosidosis GM2Snca
gastrointestinal stromal tumorSdhb , Sdhc
Gaucher Disease, Type IIIcGba
Gaucher's diseaseGba , Snca
Gaucher's disease perinatal lethalGba
Gaucher's disease type IGba
Gaucher's disease type IIGba
Gaucher's disease type IIIGba
genetic diseaseApaf1 , Atp13a2 , Lrrk2 , Ndufa1 , Ndufa10 , Ndufb3 , Ndufs3 , Ndufv1 , Slc18a2 , Slc25a4 , Synj1 , Th , Vps35
Gilles de la Tourette syndromeSlc6a3
glioblastoma multiformePrkn
guanidinoacetate methyltransferase deficiencyNdufs7
heart diseaseAtp5pf , Casp9 , Th
heart valve diseaseCasp3
Heat StrokeNos1
hepatic encephalopathyMaob , Nos1
Hepatitis B, ChronicUbe2l3
Hepatitis, ChronicCasp3
hepatocellular carcinomaAtp5pd , Park7 , Prkn , Th , Uchl1
Hereditary Neoplastic SyndromesNdufa2 , Sdha , Sdhb , Sdhc , Sdhd , Sncaip , Uqcrq , Vdac1
Hereditary Paraganglioma-Pheochromocytoma SyndromesSdhb , Sdhc , Sdhd
heroin dependenceSlc6a3
Human InfluenzaNos1 , Ube2l6
Huntington's diseaseCasp3 , Casp9 , Cycs , Htra2 , Maob , Mir132 , Mir22 , Prkn
HyperalgesiaNos1
HyperkinesisSlc6a3 , Th
hyperprolactinemiaSlc6a3 , Th
hypertensionCasp3 , Cox5b , Gba , Nos1 , Slc6a3 , Th
hypertrophic cardiomyopathyCasp3 , Ndufs1 , Ndufs2 , Slc25a4
hypertrophic cardiomyopathy 1Slc25a4
hypertrophic pyloric stenosisNos1
Hypertrophy, Left VentricularPrkn , Slc25a4
hypoglycemiaTh
HypotensionMaob
HypoxiaAtp5f1b , Casp3 , Nos1
Hypoxia-Ischemia, BrainCasp3
impotenceCasp3 , Nos1
infantile histiocytoid cardiomyopathyNdufb11
InflammationGba , Mir22
inherited metabolic disorderNdufs1 , Ndufs2 , Uqcrb
intellectual disabilityTh
intermittent claudicationCasp3
intestinal diseaseCasp3
intestinal perforationNos1
intracranial aneurysmNos1
ischemiaCycs
isolated cleft palateUbb
juvenile onset Parkinson's disease 19ADnajc6
juvenile rheumatoid arthritisNr4a2
Kabuki Syndrome 2Maob
Kidney Reperfusion InjuryCasp3
Kufor-Rakeb syndromeAtp13a2
Lameness, AnimalSnca
late onset Parkinson's diseaseDnajc13 , Gba , Lrrk2 , Nr4a2 , Park7 , Pink1 , Sncaip , Vps35
learning disabilityTh
Leber hereditary optic neuropathyNdufs2
Leigh diseaseNdufa10 , Ndufa12 , Ndufa2 , Ndufa9 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8 , Ndufv1 , Sdha
Leigh Syndrome Due To Mitochondrial Complex I DeficiencyNdufa10 , Ndufa12 , Ndufa2 , Ndufa9 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8
Leigh Syndrome due to Mitochondrial Complex II DeficiencySdha
leprosyPrkn
Lewy body dementiaGba , Gpr37 , Prkn , Snca
LINEAR SKIN DEFECTS WITH MULTIPLE CONGENITAL ANOMALIES 2Cox7b
LINEAR SKIN DEFECTS WITH MULTIPLE CONGENITAL ANOMALIES 3Ndufb11
Liver Neoplasms, ExperimentalMir301a
lung adenocarcinomaAtp5pd , Prkn
lung cancerPrkn
Lung NeoplasmsMir34b , Mir34c , Prkn
Lung Reperfusion InjuryCasp3
Lymphatic MetastasisCasp9
Machado-Joseph diseaseSlc18a2 , Th
major affective disorder 1Slc6a3
malignant gliomaSlc6a3
malignant mesotheliomaGpr37
Mammary Neoplasms, ExperimentalApaf1 , Casp3 , Casp9
Manganese PoisoningAtp13a2 , Prkn , Snca
maturity-onset diabetes of the youngTh
megaloblastic anemiaMaob
Meier-Gorlin syndromeVps35
melanomaSdhd
MELAS syndromeNdufs1
Memory DisordersNos1 , Slc6a3
mental depressionNos1 , Slc18a2 , Snca , Th
Merkel cell carcinomaSdhd
methylmalonic acidemiaCycs
Micronuclei, Chromosome-DefectiveSlc6a3
middle cerebral artery infarctionCasp3 , Htra2 , Park7 , Th
mitochondrial complex I deficiencyNdufa1 , Ndufa10 , Ndufa11 , Ndufa2 , Ndufb11 , Ndufb3 , Ndufb9 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2
mitochondrial complex II deficiencySdha , Sdhd
mitochondrial complex III deficiencyUqcrb , Uqcrq
mitochondrial complex III deficiency nuclear type 1Cyc1 , Uqcrb , Uqcrc2 , Uqcrq
mitochondrial complex III deficiency nuclear type 3Uqcrb
mitochondrial complex III deficiency nuclear type 4Uqcrq
mitochondrial complex III deficiency nuclear type 5Uqcrc2
mitochondrial complex III deficiency nuclear type 6Cyc1
mitochondrial complex V (ATP synthase) deficiency nuclear type 3Atp5f1d , Atp5f1e
mitochondrial complex V (ATP synthase) deficiency nuclear type 4Atp5f1a
mitochondrial DNA depletion syndrome 12Slc25a4
MITOCHONDRIAL DNA DEPLETION SYNDROME 12A (CARDIOMYOPATHIC TYPE), AUTOSOMAL DOMINANTSlc25a4
MITOCHONDRIAL DNA DEPLETION SYNDROME 12B (CARDIOMYOPATHIC TYPE), AUTOSOMAL RECESSIVESlc25a4
mitochondrial encephalomyopathyNdufs2 , Ndufv2
mitochondrial metabolism diseaseAtp5f1d , Slc25a4 , Uqcrfs1
mitochondrial myopathySlc25a4 , Vdac1
morphine dependenceNos1
motor neuron diseaseHtra2 , Nos1
Mouth NeoplasmsVdac2
movement diseaseGba
Multiple AbnormalitiesNdufa1 , Vps35
multiple sclerosisNdufs2 , Prkn
multiple system atrophySnca
Muscle RigidityGba
muscular atrophyApaf1
muscular diseaseSdha
muscular dystrophySdhc
Mycoplasma InfectionsCasp3
myeloid leukemiaSnca
myocardial infarctionCasp3 , Th , Vdac1 , Vdac2
Myocardial IschemiaCox5b , Uqcrfs1
Myocardial Reperfusion InjuryCasp3 , Casp9 , Htra2 , Mir34c , Slc25a4 , Vdac1
myopiaSlc25a4
neonatal diabetes mellitusTh
Neoplasm MetastasisCasp3 , Mir106a , Mir34b , Mir34c
nephrotic syndromeNos1
Nerve DegenerationAtp13a2 , Casp3 , Lrrk2 , Nos1 , Pink1 , Prkn , Slc18a2 , Slc6a3 , Snca , Th
nervous system diseaseCasp3 , Casp9 , Nos1 , Slc18a2 , Slc6a3
Netherton syndromeGba
NeuralgiaNos1
neurilemmomaSnca
neuroaxonal dystrophyUchl1
Neurobehavioral ManifestationsNos1
neuroblastomaPink1 , Th
neurodegenerative diseaseGba , Lrrk2 , Sept5 , Snca
neuronal ceroid lipofuscinosisAtp13a2
nicotine dependenceSlc6a3
non-small cell lung carcinomaCasp3 , Casp9 , Mir29b1 , Uchl1
nonalcoholic fatty liver diseaseAtp5f1b
Noonan syndromeApaf1
obesityCox7c , Cox8b , Cycs , Nos1 , Slc6a3 , Th , Uqcrc2
optic atrophyNdufs3
osteoarthritisNdufs8 , Ndufv1 , Sdha , Vdac2
osteopetrosisNdufs8
osteoporosisPark7
ovarian cancerPrkn
ovarian cystPrkn
Ovarian NeoplasmsHtra2 , Prkn
pancreatic cancerApaf1 , Casp9 , Cycs
pancreatitisCasp3 , Mir22
Pancreatitis, Acute NecrotizingCasp3 , Nos1
pantothenate kinase-associated neurodegenerationSnca
paragangliomaSdha , Sdhb , Sdhc , Sdhd
Paragangliomas 3Sdhc
Paragangliomas 4Sdhb
Paragangliomas 5Sdha
Paragangliomas with Sensorineural Hearing LossSdhd
Paranoid DisordersSlc6a3
Parkinson's diseaseApaf1 , Atp13a2 , Casp3 , Casp9 , Dnajc13 , Dnajc6 , Fbxo7 , Gba , Gpr37 , Htra2 , Lrrk2 , Maob , Mir1 , Mir106a , Mir132 , Mir19b1 , Mir22 , Mir29b1 , Mir301a , Mir34b , Mir34c , Ndufb8 , Ndufs1 , Ndufs4 , Ndufv2 , Nos1 , Nr4a2 , Park7 , Pink1 , Prkn , Sdha , Slc18a2 , Slc6a3 , Snca , Sncaip , Synj1 , Th , Uchl1 , Vdac1 , Vps35
Parkinson's Disease 13Htra2
Parkinson's disease 17Vps35
Parkinson's Disease 21Dnajc13
Parkinson's Disease 5Uchl1
Parkinson's Disease 5, Autosomal Dominant, Susceptibility ToUchl1
Parkinson's Disease 8Lrrk2
Parkinson's Disease, MitochondrialNdufv2
Parkinsonian DisordersApaf1 , Atp13a2 , Casp3 , Casp9 , Gba , Htra2 , Lrrk2 , Nos1 , Park7 , Pink1 , Prkn , Slc18a2 , Slc6a3 , Snca , Th , Vdac1
Parkinsonism-Dystonia, InfantileSlc6a3
perinatal necrotizing enterocolitisPark7
peripheral nervous system diseaseCasp9 , Uchl1
phaeochromocytomaMaob , Sdha , Sdhb , Sdhc , Sdhd , Th
Pick's diseaseSnca
Plaque, AmyloidMaob
pleomorphic xanthoastrocytomaCycs , Gpr37 , Mir29b1 , Ndufa5 , Ndufb2
Pneumonia, StaphylococcalPrkn
polycystic ovary syndromeTh
portal hypertensionTh
pre-malignant neoplasmAtp5f1b
PrehypertensionNos1
Premature AgingHtra2
primary ciliary dyskinesiaNdufv3 , Synj1
Primary Hyperoxaluria Type 1Ndufa10
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 2Slc25a4
progressive myoclonus epilepsyNdufv3
prostate cancerDnajc6 , Vdac1
Prostatic NeoplasmsCasp3 , Casp9 , Htra2
protein-energy malnutritionCox4i1
Pseudovaginal Perineoscrotal HypospadiasGba
psoriasisGba
psoriatic arthritisNr4a2
Psychomotor DisordersVdac1
pulmonary hypertensionGba
Pyloric Stenosis, Infantile Hypertrophic 1Nos1
Radiation Injuries, ExperimentalNos1
renal carcinomaSdhb
renal cell carcinomaApaf1 , Casp3 , Lrrk2 , Sdhb , Sdhd
renovascular hypertensionNos1
Reperfusion InjuryApaf1 , Casp3 , Casp9 , Nos1 , Th
ReticulocytosisPark7
retinal detachmentApaf1 , Casp3 , Casp9
retinal diseaseCasp3 , Uchl1
retinopathy of prematurityNos1
rheumatoid arthritisLrrk2
salivary gland diseaseCasp3
schizophreniaMaob , Ndufv2 , Nos1 , Nr4a2 , Prkn , Slc18a1 , Slc6a3 , Snca , Uqcrc2 , Vps35
secondary Parkinson diseaseAtp13a2
Segawa Syndrome, Autosomal RecessiveTh
SepsisCasp3 , Htra2 , Nos1
Skin AbnormalitiesApaf1
skin diseaseNdufb8 , Nr4a2
sleep disorderSlc6a3
Smith-Magenis syndromeAtp5mc1 , Atp5pd
SPASTIC PARAPLEGIA 78, AUTOSOMAL RECESSIVEAtp13a2
SPASTIC PARAPLEGIA 79, AUTOSOMAL RECESSIVEUchl1
speech disorderGba
Spermatogenic Failure 12Nos1
Spinal Cord InjuriesCasp3 , Nos1
spinocerebellar ataxia type 17Atp5f1b
SplenomegalyHtra2
squamous cell carcinomaUba1 , Uba7 , Vdac2
status epilepticusCasp3 , Htra2 , Nos1
Stomach NeoplasmsHtra2 , Ndufa2 , Ndufs1 , Ndufv1
StrokeCasp3 , Ndufc2 , Nos1
Subarachnoid HemorrhageCasp3 , Prkn
substance-induced psychosisSlc6a3 , Snca
substance-related disorderSlc18a2
temporal lobe epilepsyNos1 , Vdac2
thrombocytopeniaCycs
Thrombocytopenia 4Cycs
tic disorderSlc6a3
Tobacco Addiction, Susceptibility ToSlc6a3
toxic encephalopathyCasp3 , Slc18a2
transient cerebral ischemiaCasp3 , Casp9 , Cycs , Htra2 , Nos1 , Prkn
transitional cell carcinomaApaf1 , Casp3
Trauma, Nervous SystemNos1
TremorGba
Tumor Predisposition SyndromeSdha , Sdhb , Sdhc , Sdhd
type 1 diabetes mellitusCasp3 , Casp9 , Nos1 , Slc18a2
type 2 diabetes mellitusCasp3 , Casp9 , Nos1 , Prkn
ulcerative colitisCasp3
uremiaTh
urethral obstructionNos1
urinary bladder cancerAtp5f1d , Casp3 , Casp9
Urination DisordersNos1
Uterine Cervical NeoplasmsCasp3 , Ndufs6 , Prkn
varicoceleCasp9
vascular dementiaSnca
Ventricular Dysfunction, LeftVdac1
Ventricular RemodelingNos1
visual epilepsyApaf1 , Nos1 , Vdac1 , Vdac2
von Hippel-Lindau diseaseSlc18a1
Weight GainNdufb9
Wilson diseaseNdufb7 , Snca
withdrawal disorderTh
Pathway Annotations Associated with Genes in the Parkinson disease pathway
Pathway TermsGene Symbols
AGAT deficiency pathwayNos1
alfentanil pharmacodynamics pathwaySlc6a3
altered citric acid cycle pathwaySdhb , Sdhd
altered clathrin-dependent synaptic vesicle endocytosisDnajc6 , Synj1
altered mitochondrial autophagy pathwayPink1 , Prkn
altered retromer-mediated pathwayDnajc13 , Vps35
altered ubiquitin/proteasome degradation pathwaySnca , Ube2g1
Alzheimer's disease pathwayApaf1 , Atp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Casp3 , Casp9 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Cycs , Cyct , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Nos1 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Snca , Ube2g1 , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq
amyotrophic lateral sclerosis pathwayApaf1 , Casp3 , Casp9 , Cycs , Cyct , Nos1
apoptotic cell death pathwayApaf1 , Casp3 , Casp9 , Cycs , Cyct
arginine and proline metabolic pathwayMaob , Nos1
aromatic L-amino acid decarboxylase deficiency pathwayTh
bupivacaine pharmacodynamics pathwaySlc6a3
buprenorphine pharmacodynamics pathwaySlc6a3
calcium/calcium-mediated signaling pathwayNos1 , Ppid , Ppidl1 , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Vdac1 , Vdac2 , Vdac3
cardiolipin metabolic pathwayCycs
catecholamine biosynthetic pathwayTh
ceramide signaling pathwayCasp9 , Cycs
chloroprocaine pharmacodynamics pathwaySlc6a3
citalopram pharmacodynamics pathwayMaob , Slc6a3
citalopram pharmacokinetics pathwayMaob
citric acid cycle pathwaySdha , Sdhb , Sdhc , Sdhd
clathrin-dependent synaptic vesicle endocytosisDnajc6 , Synj1
cocaine pharmacodynamics pathwaySlc6a3
codeine and morphine pharmacodynamics pathwaySlc6a3
colorectal cancer pathwayCasp3 , Casp9 , Cycs , Cyct
desipramine pharmacodynamics pathwaySlc6a3
diphenoxylate pharmacodynamics pathwaySlc6a3
dopamine biosynthetic pathwaySlc18a2 , Th
doxorubicin pharmacokinetics pathwayNdufs2 , Ndufs3 , Ndufs7
electron transport chain pathwayAtp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5mc2 , Atp5pb , Cycs , Ndufa1 , Sdha , Sdhb , Sdhc , Sdhd , Slc25a4 , Uqcrc1 , Uqcrh
endocytosis pathwayDnajc6
endometrial cancer pathwayCasp9
Endoplasmic Reticulum-associated degradation pathwayPrkn , Ube2g1 , Ube2g2 , Ube2j1 , Ube2j2
Entamoebiasis pathwayCasp3
ephrin - ephrin receptor bidirectional signaling axisSynj1
epinephrine biosynthetic pathwaySlc18a2 , Th
escitalopram pharmacodynamics pathwaySlc6a3
estrogen signaling pathwayPpid
ethylmorphine pharmacodynamics pathwaySlc6a3
extrinsic apoptotic pathwayCasp3
Fabry disease pathwayGba
FasL mediated signaling pathwayCasp3
fentanyl pharmacodynamics pathwaySlc6a3
fluoxetine pharmacodynamics pathwaySlc6a3
forkhead class A signaling pathwayAtp5pf , Ndufv3
fumaric aciduria pathwaySdha , Sdhb , Sdhc , Sdhd
Gaucher's disease pathwayGba
glycine, serine and threonine metabolic pathwayMaob
guanidinoacetate methyltransferase deficiency pathwayNos1
gyrate atrophy pathwayNos1
heroin pharmacodynamics pathwaySlc6a3
histidine metabolic pathwayMaob
Huntington's disease pathwayApaf1 , Atp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Casp3 , Casp9 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Cycs , Cyct , Mir132 , Mir22 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Ppid , Ppidl1 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq , Vdac1 , Vdac2 , Vdac3
hydrocodone pharmacodynamics pathwaySlc6a3
hydromorphone pharmacodynamics pathwaySlc6a3
hyperprolinemia type I pathwayNos1
hyperprolinemia type II pathwayNos1
imipramine pharmacodynamics pathwaySlc6a3
influenza A pathwayCasp9 , Cycs , Cyct , Vdac1
inositol phosphate metabolic pathwaySynj1
intrinsic apoptotic pathwayApaf1 , Casp3 , Casp9 , Cycs , Htra2
Krabbe disease pathwayGba
levacetylmethadol pharmacodynamics pathwaySlc6a3
levobupivacaine phgarmacodynamics pathwaySlc6a3
levorphanol pharmacodynamics pathwaySlc6a3
lidocaine pharmacodynamics pathwaySlc6a3
long term depressionNos1
mepivacaine pharmacodynamics pathwaySlc6a3
metachromatic leukodystrophy pathwayGba
methadone pharmacodynamics pathwaySlc6a3
mitochondria dynamics pathwayPink1
mitochondrial autophagy pathwayPink1 , Prkn , Ube2l3
mitochondrial complex II deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
mitogen activated protein kinase signaling pathwayCasp3
mTOR signaling pathwayCycs
myocarditis pathwayCasp3 , Casp9 , Cycs , Cyct
nalbuphine pharmacodynamics pathwaySlc6a3
naloxone pharmacodynamics pathwaySlc6a3
naltrexone pharmacodynamics pathwaySlc6a3
nicotine pharmacodynamics pathwaySlc6a3
non-small cell lung carcinoma pathwayCasp9
norepinephrine biosynthetic pathwaySlc18a2 , Th
ornithine translocase deficiency pathwayNos1
oxidative phosphorylation pathwayAtp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq
oxybuprocaine pharmacodynamics pathwaySlc6a3
oxycodone pharmacodynamics pathwaySlc6a3
oxymorphone pharmacodynamics pathwaySlc6a3
p53 signaling pathwayApaf1 , Casp3 , Casp9 , Cycs , Cyct
pancreatic cancer pathwayCasp9
Parkinson's disease pathwayApaf1 , Atp13a2 , Atp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Casp3 , Casp9 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Cycs , Cyct , Dnajc13 , Dnajc6 , Fbxo7 , Gba , Gpr37 , Htra2 , Lrrk2 , Maob , Mir1 , Mir106a , Mir132 , Mir19b1 , Mir22 , Mir29b1 , Mir301a , Mir34b , Mir34c , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Nos1 , Nr4a2 , Park7 , Pink1 , Ppid , Ppidl1 , Prkn , RGD1559629 , RGD1560088 , RGD1560648 , Sdha , Sdhb , Sdhc , Sdhd , Sept5 , Slc18a1 , Slc18a2 , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Slc6a3 , Snca , Sncaip , Synj1 , Th , Uba1 , Uba7 , Ubb , Ube2g1 , Ube2g2 , Ube2j1 , Ube2j2 , Ube2l3 , Ube2l6 , Uchl1 , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq , Vdac1 , Vdac2 , Vdac3 , Vps35
pentazocine pharmacodynamics pathwaySlc6a3
phagocytosis pathwayNos1
phase I biotransformation pathway via cytochrome P450Maob
phenylalanine metabolic pathwayMaob
phosphatidylinositol 3-kinase signaling pathwaySynj1
phosphatidylinositol 3-kinase-Akt signaling pathwayCasp9
phosphoinositide metabolic pathwaySynj1
prilocaine pharmacodynamics pathwaySlc6a3
procaine pharmacodynamics pathwaySlc6a3
prolidase deficiency pathwayNos1
prostate cancer pathwayCasp9
pyruvate dehydrogenase E2 deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
pyruvate dehydrogenase E3 deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
remifentanil pharmacodynamics pathwaySlc6a3
renal cell carcinoma pathwaySdhb , Sdhd
retromer-mediated pathwayDnajc13 , Vps35
ropivacaine pharmacodynamics pathwaySlc6a3
small cell lung carcinoma pathwayApaf1 , Casp9 , Cycs , Cyct
sphingolipid metabolic pathwayGba
syndecan signaling pathwayCasp3
titanium dioxide nanoparticle response pathwayCasp3
toxoplasmosis pathwayCasp3 , Casp9 , Cycs , Cyct
Trail mediated signaling pathwayCasp3
tramadol pharmacodynamics pathwaySlc6a3
tryptophan metabolic pathwayMaob
tuberculosis pathwayApaf1 , Casp3 , Casp9 , Cycs , Cyct
tyrosine metabolic pathwayMaob , Th
ubiquitin/proteasome degradation pathwayPrkn , Snca , Uba1 , Uba7 , Ube2g1 , Ube2g2 , Ube2j1 , Ube2j2 , Ube2l3 , Ube2l6
vascular endothelial growth factor signaling pathwayCasp9
Phenotype Annotations Associated with Genes in the Parkinson disease pathway
Phenotype TermsGene Symbols
abnormal gaitPark7 , Pink1
abnormal motor coordination/balancePark7 , Pink1
abnormal muscle tonePark7 , Pink1
decreased brain tyrosine 3-monooxygenase activityPark7 , Pink1
decreased circulating alanine transaminase levelLrrk2
decreased circulating aspartate transaminase levelLrrk2
decreased circulating bilirubin levelLrrk2
decreased circulating chloride levelLrrk2
decreased circulating potassium levelLrrk2
decreased circulating prolactin levelLrrk2
decreased circulating triglyceride levelLrrk2
decreased eosinophil cell numberLrrk2
decreased erythrocyte cell numberLrrk2
decreased grip strengthPink1
decreased hematocritLrrk2
decreased hemoglobin contentLrrk2
decreased lymphocyte cell numberLrrk2
decreased surfactant secretionLrrk2
decreased vertical activityPark7 , Pink1
enlarged alveolar lamellar bodiesLrrk2
failure of embryo implantationNdufc2
hypersecretion of adrenocorticotropinLrrk2
hypoactivityPink1
increased alveolar lamellar body numberLrrk2
increased body weightLrrk2 , Pink1
increased brain sizeLrrk2
increased brain weightLrrk2
increased circulating cholesterol levelLrrk2
increased circulating creatinine levelLrrk2
increased circulating luteinizing hormone levelLrrk2
increased circulating serum albumin levelLrrk2
increased circulating testosterone levelLrrk2
increased dopamine levelPark7 , Pink1
increased insulin secretionLrrk2
increased serotonin levelPark7 , Pink1
increased susceptibility to weight gainLrrk2
increased urine protein levelNdufc2
loss of dopaminergic neuronsPark7 , Pink1

References Associated with the Parkinson disease pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: