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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of TH proteinPMID:28049045
Thaffects methylationISOTH (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of TH promoterPMID:27901495
Thincreases expressionISOTH (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of TH mRNAPMID:35870112
Thmultiple interactionsISOTh (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to TH promoter]PMID:19654925
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