Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in bile acid and bile salt transport; response to ethanol; and response to organic cyclic compound. Predicted to be active in cytoplasm and extracellular space. Biomarker of alcoholic hepatitis. Orthologous to human FGF19 (fibroblast growth factor 19); PARTICIPATES IN fibroblast growth factor signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH ammonium chloride; bis(2-ethylhexyl) phthalate; bisphenol A.
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of FGF15 mRNA and alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in increased expression of FGF15 mRNA]
fexaramine inhibits the reaction [Aflatoxin B1 results in decreased expression of FGF15 mRNA] and fexaramine inhibits the reaction [Aflatoxin B1 results in decreased expression of FGF15 protein]
pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA] and pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA]
[[Chenodeoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA and [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter
[[Cholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA and [Cholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter
[[Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA and [Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter
[Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 mRNA and [Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 protein
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF19 mRNA
fexaramine inhibits the reaction [Aflatoxin B1 results in decreased expression of FGF15 mRNA] and fexaramine inhibits the reaction [Aflatoxin B1 results in decreased expression of FGF15 protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine]]
[[GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA and [GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter
[Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 mRNA and [Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 protein
[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF19 mRNA
[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA and GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA]
[Dietary Fats co-treated with Streptozocin] results in increased expression of FGF15 mRNA and [Dietary Fats co-treated with Streptozocin] results in increased expression of FGF15 protein