FGF19 (fibroblast growth factor 19) - Rat Genome Database

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Gene: FGF19 (fibroblast growth factor 19) Homo sapiens
Analyze
Symbol: FGF19
Name: fibroblast growth factor 19
RGD ID: 1344909
HGNC Page HGNC
Description: Exhibits fibroblast growth factor receptor binding activity. Involved in several processes, including negative regulation of bile acid biosynthetic process; positive regulation of MAPK cascade; and positive regulation of glucose import. Predicted to localize to cytoplasm and extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FGF-19
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1169,698,238 - 69,704,022 (-)EnsemblGRCh38hg38GRCh38
GRCh381169,698,238 - 69,704,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,513,006 - 69,518,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,222,187 - 69,228,287 (-)NCBINCBI36hg18NCBI36
Build 341169,222,187 - 69,228,287NCBI
Celera1166,810,044 - 66,816,141 (-)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1165,805,191 - 65,811,289 (-)NCBIHuRef
CHM1_11169,396,002 - 69,402,103 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (EXP)
beta-hexachlorocyclohexane  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cefalotin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
cholesterol  (EXP)
cholic acid  (EXP,ISO)
ciprofloxacin  (ISO)
clofibrate  (ISO)
DDE  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dihydroartemisinin  (ISO)
dorsomorphin  (EXP)
enilconazole  (ISO)
entinostat  (EXP)
ethanol  (ISO)
furan  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
heparin  (EXP)
ibuprofen  (ISO)
lithocholic acid  (EXP,ISO)
methotrexate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
obeticholic acid  (EXP,ISO)
panobinostat  (EXP)
phenethyl caffeate  (ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
pirinixic acid  (ISO)
rifampicin  (EXP)
ritonavir  (EXP)
rotenone  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salidroside  (ISO)
SB 431542  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
taurocholic acid  (ISO)
triptonide  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:9931477   PMID:10525310   PMID:10579907   PMID:10652257   PMID:11110663   PMID:11294897   PMID:11956156   PMID:12057932   PMID:12477932   PMID:12792807   PMID:12815072   PMID:12975309  
PMID:14730967   PMID:14976145   PMID:15199049   PMID:15340161   PMID:15489334   PMID:16597617   PMID:17000708   PMID:17339340   PMID:17599042   PMID:17623664   PMID:17627937   PMID:17711860  
PMID:18187602   PMID:18559909   PMID:18829467   PMID:19085950   PMID:19185005   PMID:19233843   PMID:19237543   PMID:19681655   PMID:20013647   PMID:20018895   PMID:20093562   PMID:20453838  
PMID:20691689   PMID:21397858   PMID:21436455   PMID:21437243   PMID:21574752   PMID:21653700   PMID:21691104   PMID:21747170   PMID:21873635   PMID:21953282   PMID:22166511   PMID:22267484  
PMID:22396169   PMID:22442730   PMID:22561792   PMID:23038264   PMID:23064887   PMID:23205607   PMID:23329754   PMID:23456506   PMID:23628619   PMID:23803094   PMID:23840612   PMID:23940810  
PMID:23981126   PMID:24248542   PMID:24260557   PMID:24321096   PMID:24728076   PMID:24798001   PMID:24813368   PMID:24827712   PMID:24841294   PMID:25080475   PMID:25547779   PMID:25595885  
PMID:25664662   PMID:25854696   PMID:26028580   PMID:26152288   PMID:26256900   PMID:26259981   PMID:26293907   PMID:26323668   PMID:26343925   PMID:26498355   PMID:26567701   PMID:26723851  
PMID:26943773   PMID:27053348   PMID:27192118   PMID:27384874   PMID:27447573   PMID:28003563   PMID:28069043   PMID:28498614   PMID:28570655   PMID:28746779   PMID:28906590   PMID:28951455  
PMID:29174027   PMID:29438906   PMID:29734515   PMID:29964017   PMID:29968724   PMID:30074276   PMID:30089729   PMID:30122083   PMID:30127091   PMID:30317562   PMID:30334297   PMID:30517925  
PMID:30518874   PMID:30679232   PMID:30682184   PMID:30698907   PMID:30826062   PMID:30852757   PMID:30933374   PMID:30944224   PMID:31074061   PMID:32111983   PMID:32219747   PMID:32275977  
PMID:32305136   PMID:32626734   PMID:32681035   PMID:33144503  


Genomics

Comparative Map Data
FGF19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1169,698,238 - 69,704,022 (-)EnsemblGRCh38hg38GRCh38
GRCh381169,698,238 - 69,704,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,513,006 - 69,518,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,222,187 - 69,228,287 (-)NCBINCBI36hg18NCBI36
Build 341169,222,187 - 69,228,287NCBI
Celera1166,810,044 - 66,816,141 (-)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1165,805,191 - 65,811,289 (-)NCBIHuRef
CHM1_11169,396,002 - 69,402,103 (-)NCBICHM1_1
Fgf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,450,269 - 144,454,690 (+)NCBIGRCm39mm39
GRCm39 Ensembl7144,450,268 - 144,454,690 (+)Ensembl
GRCm387144,896,532 - 144,900,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,896,531 - 144,900,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,082,437 - 152,086,858 (+)NCBIGRCm37mm9NCBIm37
MGSCv367144,705,922 - 144,710,343 (+)NCBImm8
Celera7144,661,763 - 144,666,199 (+)NCBICelera
Cytogenetic Map7F5NCBI
Fgf19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21200,056,656 - 200,059,944 (+)NCBI
Rnor_6.0 Ensembl1218,058,405 - 218,061,693 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01218,058,405 - 218,061,693 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,927,791 - 224,931,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,324,890 - 205,328,178 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,478,342 - 205,481,631 (+)NCBI
Celera1197,614,723 - 197,618,011 (+)NCBICelera
Cytogenetic Map1q42NCBI
Fgf19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,415,648 - 16,420,515 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,415,880 - 16,419,528 (+)NCBIChiLan1.0ChiLan1.0
FGF19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11168,085,306 - 68,090,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,085,306 - 68,090,028 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01164,794,157 - 64,800,512 (-)NCBIMhudiblu_PPA_v0panPan3
FGF19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,464,931 - 48,469,967 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,464,928 - 48,469,782 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,074,788 - 47,079,858 (+)NCBI
ROS_Cfam_1.01849,142,011 - 49,147,073 (+)NCBI
UMICH_Zoey_3.11848,586,353 - 48,593,734 (+)NCBI
UNSW_CanFamBas_1.01848,174,953 - 48,180,024 (+)NCBI
UU_Cfam_GSD_1.01848,920,964 - 48,926,046 (+)NCBI
Fgf19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,485,587 - 4,491,068 (+)NCBI
SpeTri2.0NW_004936599923,943 - 932,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,583,027 - 3,587,825 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,583,027 - 3,586,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,060,776 - 2,065,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF19
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,852,289 - 4,860,139 (+)NCBI
ChlSab1.1 Ensembl14,854,363 - 4,859,102 (+)Ensembl
Fgf19
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476717,434,501 - 17,439,351 (+)NCBI

Position Markers
RH67988  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,513,159 - 69,513,273UniSTSGRCh37
Build 361169,222,340 - 69,222,454RGDNCBI36
Celera1166,810,197 - 66,810,311RGD
Cytogenetic Map11q13.1UniSTS
HuRef1165,805,344 - 65,805,458UniSTS
GeneMap99-GB4 RH Map11262.04UniSTS
NCBI RH Map11589.5UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:528
Count of miRNA genes:439
Interacting mature miRNAs:459
Transcripts:ENST00000294312
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 51 21 19 15 21 126 8 25 17
Low 107 106 76 51 78 63 17 211 22 240 81 4 1
Below cutoff 652 405 476 187 258 162 950 361 1009 45 500 287 26 206 600

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000294312   ⟹   ENSP00000294312
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1169,698,238 - 69,704,022 (-)Ensembl
RefSeq Acc Id: NM_005117   ⟹   NP_005108
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,698,238 - 69,704,022 (-)NCBI
GRCh371169,513,006 - 69,519,106 (-)ENTREZGENE
Build 361169,222,187 - 69,228,287 (-)NCBI Archive
HuRef1165,805,191 - 65,811,289 (-)ENTREZGENE
CHM1_11169,396,002 - 69,402,103 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005108   ⟸   NM_005117
- Peptide Label: precursor
- UniProtKB: O95750 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000294312   ⟸   ENST00000294312

Promoters
RGD ID:7221355
Promoter ID:EPDNEW_H16423
Type:multiple initiation site
Name:FGF19_1
Description:fibroblast growth factor 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16424  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,704,022 - 69,704,082EPDNEW
RGD ID:7221357
Promoter ID:EPDNEW_H16424
Type:multiple initiation site
Name:FGF19_2
Description:fibroblast growth factor 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16423  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,704,664 - 69,704,724EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.2-13.4(chr11:68031693-71593495)x1 copy number loss See cases [RCV000142138] Chr11:68031693..71593495 [GRCh38]
Chr11:67799160..71304541 [GRCh37]
Chr11:67555736..70982189 [NCBI36]
Chr11:11q13.2-13.4
likely pathogenic
GRCh37/hg19 11q13.3(chr11:68686958-69803426)x3 copy number gain See cases [RCV000448627] Chr11:68686958..69803426 [GRCh37]
Chr11:11q13.3
uncertain significance
GRCh37/hg19 11q13.2-13.4(chr11:67799160-70701268)x1 copy number loss See cases [RCV000510219] Chr11:67799160..70701268 [GRCh37]
Chr11:11q13.2-13.4
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3675 AgrOrtholog
COSMIC FGF19 COSMIC
Ensembl Genes ENSG00000162344 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000294312 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000294312 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000162344 GTEx
HGNC ID HGNC:3675 ENTREZGENE
Human Proteome Map FGF19 Human Proteome Map
InterPro FGF15/19/21 UniProtKB/Swiss-Prot
  FGF15/FGF19 UniProtKB/Swiss-Prot
  Fibroblast_GF_fam UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report hsa:9965 UniProtKB/Swiss-Prot
NCBI Gene 9965 ENTREZGENE
OMIM 603891 OMIM
PANTHER PTHR11486 UniProtKB/Swiss-Prot
  PTHR11486:SF74 UniProtKB/Swiss-Prot
Pfam FGF UniProtKB/Swiss-Prot
PharmGKB PA28114 PharmGKB
PIRSF FGF-19_FGF-21 UniProtKB/Swiss-Prot
PRINTS HBGFFGF UniProtKB/Swiss-Prot
PROSITE HBGF_FGF UniProtKB/Swiss-Prot
SMART FGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt FGF19_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE