FGF19 (fibroblast growth factor 19) - Rat Genome Database

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Gene: FGF19 (fibroblast growth factor 19) Homo sapiens
Analyze
Symbol: FGF19
Name: fibroblast growth factor 19
RGD ID: 1344909
HGNC Page HGNC:3675
Description: Enables fibroblast growth factor receptor binding activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of MAPK cascade; and positive regulation of glucose import. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FGF-19
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,698,238 - 69,704,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,698,238 - 69,704,022 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,513,006 - 69,518,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,222,187 - 69,228,287 (-)NCBINCBI36Build 36hg18NCBI36
Build 341169,222,187 - 69,228,287NCBI
Celera1166,810,044 - 66,816,141 (-)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,805,191 - 65,811,289 (-)NCBIHuRef
CHM1_11169,396,002 - 69,402,103 (-)NCBICHM1_1
T2T-CHM13v2.01169,715,112 - 69,720,896 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atorvastatin calcium  (ISO)
Augmentin  (EXP)
benzo[a]pyrene  (EXP)
beta-hexachlorocyclohexane  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cefalotin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
cholesterol  (EXP)
cholic acid  (EXP,ISO)
ciprofloxacin  (ISO)
clavulanic acid  (EXP)
clofibrate  (ISO)
DDE  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dihydroartemisinin  (ISO)
diosgenin  (ISO)
dorsomorphin  (EXP)
enilconazole  (ISO)
entinostat  (EXP)
ethanol  (ISO)
Fexaramine  (ISO)
furan  (ISO)
gentamycin  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
heparin  (EXP)
ibuprofen  (ISO)
lithocholic acid  (EXP,ISO)
metformin  (ISO)
methotrexate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
niclosamide  (EXP)
obeticholic acid  (EXP,ISO)
panobinostat  (EXP)
paracetamol  (ISO)
phenethyl caffeate  (ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
pirinixic acid  (ISO)
procymidone  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
rifampicin  (EXP)
ritonavir  (EXP)
rotenone  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salidroside  (ISO)
SB 431542  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sotorasib  (EXP)
streptozocin  (ISO)
taurocholic acid  (ISO)
trametinib  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
Additional References at PubMed
PMID:9931477   PMID:10525310   PMID:10579907   PMID:10652257   PMID:11110663   PMID:11294897   PMID:11956156   PMID:12057932   PMID:12477932   PMID:12792807   PMID:12815072   PMID:12975309  
PMID:14730967   PMID:14976145   PMID:15199049   PMID:15340161   PMID:15489334   PMID:16597617   PMID:17000708   PMID:17339340   PMID:17599042   PMID:17623664   PMID:17627937   PMID:17711860  
PMID:18187602   PMID:18559909   PMID:18829467   PMID:19085950   PMID:19185005   PMID:19233843   PMID:19237543   PMID:19681655   PMID:20013647   PMID:20018895   PMID:20093562   PMID:20453838  
PMID:20691689   PMID:21397858   PMID:21436455   PMID:21437243   PMID:21574752   PMID:21653700   PMID:21691104   PMID:21747170   PMID:21873635   PMID:21953282   PMID:22166511   PMID:22267484  
PMID:22396169   PMID:22442730   PMID:22561792   PMID:23038264   PMID:23064887   PMID:23205607   PMID:23329754   PMID:23456506   PMID:23628619   PMID:23803094   PMID:23840612   PMID:23940810  
PMID:23981126   PMID:24248542   PMID:24260557   PMID:24321096   PMID:24728076   PMID:24798001   PMID:24813368   PMID:24827712   PMID:24841294   PMID:25080475   PMID:25547779   PMID:25595885  
PMID:25664662   PMID:25854696   PMID:26028580   PMID:26152288   PMID:26256900   PMID:26259981   PMID:26293907   PMID:26323668   PMID:26343925   PMID:26498355   PMID:26567701   PMID:26723851  
PMID:26943773   PMID:27053348   PMID:27192118   PMID:27384874   PMID:27447573   PMID:28003563   PMID:28069043   PMID:28498614   PMID:28570655   PMID:28746779   PMID:28906590   PMID:28951455  
PMID:29174027   PMID:29438906   PMID:29734515   PMID:29964017   PMID:29968724   PMID:30074276   PMID:30089729   PMID:30122083   PMID:30127091   PMID:30317562   PMID:30334297   PMID:30517925  
PMID:30518874   PMID:30679232   PMID:30682184   PMID:30698907   PMID:30826062   PMID:30852757   PMID:30933374   PMID:30944224   PMID:31074061   PMID:31529503   PMID:32111983   PMID:32219747  
PMID:32275977   PMID:32305136   PMID:32513031   PMID:32528406   PMID:32546231   PMID:32626734   PMID:32681035   PMID:33101202   PMID:33144503   PMID:33171307   PMID:33383173   PMID:33506572  
PMID:33754043   PMID:33961781   PMID:34163030   PMID:34200439   PMID:34231484   PMID:34405516   PMID:34742678   PMID:34858337   PMID:34907727   PMID:35145481   PMID:35156505   PMID:35277004  
PMID:35301051   PMID:36598638   PMID:36751636   PMID:36764368   PMID:36919699   PMID:36923538   PMID:37186335   PMID:37782406  


Genomics

Comparative Map Data
FGF19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,698,238 - 69,704,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,698,238 - 69,704,022 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,513,006 - 69,518,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,222,187 - 69,228,287 (-)NCBINCBI36Build 36hg18NCBI36
Build 341169,222,187 - 69,228,287NCBI
Celera1166,810,044 - 66,816,141 (-)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,805,191 - 65,811,289 (-)NCBIHuRef
CHM1_11169,396,002 - 69,402,103 (-)NCBICHM1_1
T2T-CHM13v2.01169,715,112 - 69,720,896 (-)NCBIT2T-CHM13v2.0
Fgf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,450,269 - 144,454,690 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,450,268 - 144,454,690 (+)EnsemblGRCm39 Ensembl
GRCm387144,896,532 - 144,900,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,896,531 - 144,900,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,082,437 - 152,086,858 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,705,922 - 144,710,343 (+)NCBIMGSCv36mm8
Celera7144,661,763 - 144,666,199 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.92NCBI
Fgf19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,485,813 - 209,490,267 (+)NCBIGRCr8
mRatBN7.21200,056,526 - 200,060,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,056,644 - 200,060,287 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,437,858 - 208,441,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,524,089 - 215,527,377 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,198,296 - 208,201,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,058,405 - 218,061,693 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,058,405 - 218,061,693 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,927,791 - 224,931,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,324,890 - 205,328,178 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,478,342 - 205,481,631 (+)NCBI
Celera1197,614,723 - 197,618,011 (+)NCBICelera
Cytogenetic Map1q42NCBI
Fgf19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,415,648 - 16,420,515 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,415,880 - 16,419,528 (+)NCBIChiLan1.0ChiLan1.0
FGF19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2970,663,990 - 70,669,899 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,707,114 - 71,712,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,794,157 - 64,800,512 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,085,306 - 68,090,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,085,306 - 68,090,028 (-)Ensemblpanpan1.1panPan2
FGF19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,464,931 - 48,469,967 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,464,928 - 48,469,782 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,074,788 - 47,079,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,142,011 - 49,147,073 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,142,011 - 49,146,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,586,353 - 48,593,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,174,953 - 48,180,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,920,964 - 48,926,046 (+)NCBIUU_Cfam_GSD_1.0
Fgf19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,485,587 - 4,491,068 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599923,943 - 932,321 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936599923,943 - 932,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,582,828 - 3,587,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,583,027 - 3,586,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,060,776 - 2,065,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,852,289 - 4,860,139 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14,854,363 - 4,859,102 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,128,324 - 102,135,894 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,432,358 - 17,438,173 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,434,501 - 17,439,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF19
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.2-13.4(chr11:68031693-71593495)x1 copy number loss See cases [RCV000142138] Chr11:68031693..71593495 [GRCh38]
Chr11:67799160..71304541 [GRCh37]
Chr11:67555736..70982189 [NCBI36]
Chr11:11q13.2-13.4
likely pathogenic
GRCh37/hg19 11q13.3(chr11:68686958-69803426)x3 copy number gain See cases [RCV000448627] Chr11:68686958..69803426 [GRCh37]
Chr11:11q13.3
uncertain significance
GRCh37/hg19 11q13.2-13.4(chr11:67799160-70701268)x1 copy number loss See cases [RCV000510219] Chr11:67799160..70701268 [GRCh37]
Chr11:11q13.2-13.4
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_005117.3(FGF19):c.253G>A (p.Val85Ile) single nucleotide variant Inborn genetic diseases [RCV003240876] Chr11:69703344 [GRCh38]
Chr11:69518112 [GRCh37]
Chr11:11q13.3
uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NC_000011.9:g.(?_64973914)_(70052579_?)dup duplication Aicardi-Goutieres syndrome 3 [RCV003113322]|FADD-related immunodeficiency [RCV003107753] Chr11:64973914..70052579 [GRCh37]
Chr11:11q13.1-13.3
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh37/hg19 11q13.3-13.4(chr11:69214835-70821137)x1 copy number loss not provided [RCV001834393] Chr11:69214835..70821137 [GRCh37]
Chr11:11q13.3-13.4
pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25
pathogenic
NM_005117.3(FGF19):c.550G>A (p.Glu184Lys) single nucleotide variant Inborn genetic diseases [RCV002945297] Chr11:69699363 [GRCh38]
Chr11:69514131 [GRCh37]
Chr11:11q13.3
uncertain significance
NM_005117.3(FGF19):c.535C>T (p.Leu179Phe) single nucleotide variant Inborn genetic diseases [RCV002752237] Chr11:69699378 [GRCh38]
Chr11:69514146 [GRCh37]
Chr11:11q13.3
uncertain significance
NM_005117.3(FGF19):c.613G>A (p.Gly205Arg) single nucleotide variant Inborn genetic diseases [RCV002970160] Chr11:69699300 [GRCh38]
Chr11:69514068 [GRCh37]
Chr11:11q13.3
uncertain significance
NM_005117.3(FGF19):c.419G>A (p.Arg140His) single nucleotide variant Inborn genetic diseases [RCV002759030] Chr11:69699494 [GRCh38]
Chr11:69514262 [GRCh37]
Chr11:11q13.3
likely benign
NM_005117.3(FGF19):c.119A>G (p.Asp40Gly) single nucleotide variant Inborn genetic diseases [RCV002804846] Chr11:69703758 [GRCh38]
Chr11:69518526 [GRCh37]
Chr11:11q13.3
uncertain significance
NM_005117.3(FGF19):c.347C>G (p.Ser116Trp) single nucleotide variant Inborn genetic diseases [RCV002939952] Chr11:69699566 [GRCh38]
Chr11:69514334 [GRCh37]
Chr11:11q13.3
uncertain significance
NM_005117.3(FGF19):c.613G>C (p.Gly205Arg) single nucleotide variant Inborn genetic diseases [RCV003352251] Chr11:69699300 [GRCh38]
Chr11:69514068 [GRCh37]
Chr11:11q13.3
uncertain significance
NM_005117.3(FGF19):c.367G>A (p.Glu123Lys) single nucleotide variant Inborn genetic diseases [RCV003356101] Chr11:69699546 [GRCh38]
Chr11:69514314 [GRCh37]
Chr11:11q13.3
uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:528
Count of miRNA genes:439
Interacting mature miRNAs:459
Transcripts:ENST00000294312
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH67988  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371169,513,159 - 69,513,273UniSTSGRCh37
Build 361169,222,340 - 69,222,454RGDNCBI36
Celera1166,810,197 - 66,810,311RGD
Cytogenetic Map11q13.1UniSTS
HuRef1165,805,344 - 65,805,458UniSTS
GeneMap99-GB4 RH Map11262.04UniSTS
NCBI RH Map11589.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 51 21 19 15 21 126 8 25 17
Low 107 106 76 51 78 63 17 211 22 240 81 4 1
Below cutoff 652 405 476 187 258 162 950 361 1009 45 500 287 26 206 600

Sequence


RefSeq Acc Id: ENST00000294312   ⟹   ENSP00000294312
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1169,698,238 - 69,704,022 (-)Ensembl
RefSeq Acc Id: NM_005117   ⟹   NP_005108
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,698,238 - 69,704,022 (-)NCBI
GRCh371169,513,006 - 69,519,106 (-)ENTREZGENE
Build 361169,222,187 - 69,228,287 (-)NCBI Archive
HuRef1165,805,191 - 65,811,289 (-)ENTREZGENE
CHM1_11169,396,002 - 69,402,103 (-)NCBI
T2T-CHM13v2.01169,715,112 - 69,720,896 (-)NCBI
Sequence:
RefSeq Acc Id: NP_005108   ⟸   NM_005117
- Peptide Label: precursor
- UniProtKB: O95750 (UniProtKB/Swiss-Prot),   A0A7U3L4E7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000294312   ⟸   ENST00000294312

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O95750-F1-model_v2 AlphaFold O95750 1-216 view protein structure

Promoters
RGD ID:7221355
Promoter ID:EPDNEW_H16423
Type:multiple initiation site
Name:FGF19_1
Description:fibroblast growth factor 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16424  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,704,022 - 69,704,082EPDNEW
RGD ID:7221357
Promoter ID:EPDNEW_H16424
Type:multiple initiation site
Name:FGF19_2
Description:fibroblast growth factor 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16423  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381169,704,664 - 69,704,724EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3675 AgrOrtholog
COSMIC FGF19 COSMIC
Ensembl Genes ENSG00000162344 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000294312 ENTREZGENE
  ENST00000294312.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000162344 GTEx
HGNC ID HGNC:3675 ENTREZGENE
Human Proteome Map FGF19 Human Proteome Map
InterPro FGF15/19/21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9965 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 9965 ENTREZGENE
OMIM 603891 OMIM
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF74 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28114 PharmGKB
PIRSF FGF-19_FGF-21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7U3L4E7 ENTREZGENE, UniProtKB/TrEMBL
  FGF19_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE