FGF19 (fibroblast growth factor 19) - Rat Genome Database

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Gene: FGF19 (fibroblast growth factor 19) Canis lupus familiaris
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Symbol: FGF19
Name: fibroblast growth factor 19
RGD ID: 12181783
Description: ENCODES a protein that exhibits fibroblast growth factor receptor binding (inferred); growth factor activity (inferred); INVOLVED IN bile acid and bile salt transport (ortholog); fibroblast growth factor receptor signaling pathway (ortholog); heart development (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); alcoholic hepatitis (ortholog); colitis (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,464,931 - 48,469,967 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,464,928 - 48,469,782 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,074,788 - 47,079,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,142,011 - 49,147,073 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,142,011 - 49,146,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,586,353 - 48,593,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,174,953 - 48,180,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,920,964 - 48,926,046 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGF19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,464,931 - 48,469,967 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,464,928 - 48,469,782 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,074,788 - 47,079,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,142,011 - 49,147,073 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,142,011 - 49,146,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,586,353 - 48,593,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,174,953 - 48,180,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,920,964 - 48,926,046 (+)NCBIUU_Cfam_GSD_1.0
FGF19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,698,238 - 69,704,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,698,238 - 69,704,022 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,513,006 - 69,518,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,222,187 - 69,228,287 (-)NCBINCBI36Build 36hg18NCBI36
Build 341169,222,187 - 69,228,287NCBI
Celera1166,810,044 - 66,816,141 (-)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,805,191 - 65,811,289 (-)NCBIHuRef
CHM1_11169,396,002 - 69,402,103 (-)NCBICHM1_1
T2T-CHM13v2.01169,715,112 - 69,720,896 (-)NCBIT2T-CHM13v2.0
Fgf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,450,269 - 144,454,690 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,450,268 - 144,454,690 (+)EnsemblGRCm39 Ensembl
GRCm387144,896,532 - 144,900,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,896,531 - 144,900,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,082,437 - 152,086,858 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,705,922 - 144,710,343 (+)NCBIMGSCv36mm8
Celera7144,661,763 - 144,666,199 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.92NCBI
Fgf19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,485,813 - 209,490,267 (+)NCBIGRCr8
mRatBN7.21200,056,526 - 200,060,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,056,644 - 200,060,287 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,437,858 - 208,441,149 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,524,089 - 215,527,377 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,198,296 - 208,201,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,058,405 - 218,061,693 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,058,405 - 218,061,693 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,927,791 - 224,931,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,324,890 - 205,328,178 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,478,342 - 205,481,631 (+)NCBI
Celera1197,614,723 - 197,618,011 (+)NCBICelera
Cytogenetic Map1q42NCBI
Fgf19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,415,648 - 16,420,515 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,415,880 - 16,419,528 (+)NCBIChiLan1.0ChiLan1.0
FGF19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2970,663,990 - 70,669,899 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,707,114 - 71,712,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,794,157 - 64,800,512 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,085,306 - 68,090,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,085,306 - 68,090,028 (-)Ensemblpanpan1.1panPan2
Fgf19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,485,587 - 4,491,068 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599923,943 - 932,321 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936599923,943 - 932,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,582,828 - 3,587,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,583,027 - 3,586,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,060,776 - 2,065,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,852,289 - 4,860,139 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14,854,363 - 4,859,102 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,128,324 - 102,135,894 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,432,358 - 17,438,173 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,434,501 - 17,439,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF19
66 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hepatobiliary system integumental system nervous system reproductive system
High
Medium
Low 1 6
Below cutoff 1 2 1 1 1 3

Sequence


RefSeq Acc Id: ENSCAFT00000017003   ⟹   ENSCAFP00000015731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1848,464,928 - 48,469,782 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027035   ⟹   ENSCAFP00845021274
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1849,142,011 - 49,146,933 (+)Ensembl
RefSeq Acc Id: XM_038425537   ⟹   XP_038281465
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01849,142,011 - 49,147,073 (+)NCBI
RefSeq Acc Id: XM_038501858   ⟹   XP_038357786
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11848,586,353 - 48,593,734 (+)NCBI
RefSeq Acc Id: XM_038564492   ⟹   XP_038420420
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01848,920,964 - 48,926,046 (+)NCBI
RefSeq Acc Id: XM_038628611   ⟹   XP_038484539
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01848,174,953 - 48,180,024 (+)NCBI
RefSeq Acc Id: XM_540802   ⟹   XP_540802
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11848,464,931 - 48,469,967 (+)NCBI
Dog10K_Boxer_Tasha1847,074,788 - 47,079,858 (+)NCBI
Sequence:
RefSeq Acc Id: XP_540802   ⟸   XM_540802
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QPM1 (UniProtKB/TrEMBL),   A0A8I3NVV1 (UniProtKB/TrEMBL),   A0A8C0KN41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000015731   ⟸   ENSCAFT00000017003
RefSeq Acc Id: XP_038357786   ⟸   XM_038501858
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038484539   ⟸   XM_038628611
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038281465   ⟸   XM_038425537
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QPM1 (UniProtKB/TrEMBL),   A0A8I3NVV1 (UniProtKB/TrEMBL),   A0A8C0KN41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420420   ⟸   XM_038564492
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KN41 (UniProtKB/TrEMBL),   A0A8C0QPM1 (UniProtKB/TrEMBL),   A0A8I3NVV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845021274   ⟸   ENSCAFT00845027035


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010693 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024537 UniProtKB/TrEMBL
  ENSCAFG00040007122 UniProtKB/TrEMBL
  ENSCAFG00845015136 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017003.4 UniProtKB/TrEMBL
  ENSCAFT00030045123.1 UniProtKB/TrEMBL
  ENSCAFT00040013195.1 UniProtKB/TrEMBL
  ENSCAFT00845027035 ENTREZGENE
  ENSCAFT00845027035.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro FGF15/19/21 UniProtKB/TrEMBL
  Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene FGF19 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF74 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PIRSF FGF-19_FGF-21 UniProtKB/TrEMBL
PRINTS IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A8C0KN41 ENTREZGENE
  A0A8C0QPM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NVV1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40846 ENTREZGENE