GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | FGF19 | increases expression | EXP | | 6480464 | CTD | GW 4064 results in increased expression of FGF19 mRNA | PMID:16269825 | FGF19 | multiple interactions | EXP | | 6480464 | CTD | [[GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter | PMID:22561792 | FGF19 | increases expression | ISO | Fgf15 (Mus musculus) | 6480464 | CTD | GW 4064 results in increased expression of FGF15 mRNA; GW 4064 results in increased expression of FGF15 protein; GW 4064 results in increased expression of FGF19 mRNA; GW 4064 results in increased expression of FGF19 protein | PMID:22918042 PMID:22961653 PMID:27609522 PMID:36511616 | FGF19 | multiple interactions | ISO | Fgf15 (Mus musculus) | 6480464 | CTD | [GW 4064 co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA; epiallopregnanolone sulfate inhibits the reaction [GW 4064 results in increased expression of FGF19 mRNA]; epiallopregnanolone sulfate inhibits the reaction [GW 4064 results in increased expression of FGF19 protein]; FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG8 mRNA]; FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of SCARB1 mRNA]; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA]; GW 4064 promotes the reaction [NR1H4 protein binds to FGF15 gene]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of FGF15 mRNA]; systhane inhibits the reaction [GW 4064 results in increased expression of FGF15 mRNA] | PMID:20091679 PMID:22918042 PMID:22961653 PMID:28223344 PMID:30996006 PMID:36511616 | | ||||||||||||||||||||||
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