Fgf15 (fibroblast growth factor 15) - Rat Genome Database

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Gene: Fgf15 (fibroblast growth factor 15) Mus musculus
Analyze
Symbol: Fgf15
Name: fibroblast growth factor 15
RGD ID: 1550725
MGI Page MGI
Description: Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of bile acid biosynthetic process; neural crest cell migration; and response to bacterium. Predicted to localize to cytoplasm and extracellular space. Is expressed in several structures, including brain; branchial arch endoderm; embryo ectoderm; mesonephros; and sensory organ. Orthologous to human FGF19 (fibroblast growth factor 19); PARTICIPATES IN fibroblast growth factor signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-amphetamine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FGF-15; FGF19; Fgf8a; fibroblast growth factor 8a
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,450,269 - 144,454,690 (+)NCBIGRCm39mm39
GRCm39 Ensembl7144,450,268 - 144,454,690 (+)Ensembl
GRCm387144,896,532 - 144,900,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,896,531 - 144,900,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,082,437 - 152,086,858 (+)NCBIGRCm37mm9NCBIm37
MGSCv367144,705,922 - 144,710,343 (+)NCBImm8
Celera7144,661,763 - 144,666,199 (+)NCBICelera
Cytogenetic Map7F5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-amphetamine  (EXP)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (EXP)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cefalotin  (EXP)
chenodeoxycholic acid  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (EXP,ISO)
ciprofloxacin  (EXP)
clofibrate  (EXP)
DDE  (EXP)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dihydroartemisinin  (ISO)
dorsomorphin  (ISO)
enilconazole  (EXP)
entinostat  (ISO)
ethanol  (ISO)
furan  (EXP)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
heparin  (ISO)
ibuprofen  (EXP,ISO)
lithocholic acid  (EXP,ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
obeticholic acid  (EXP,ISO)
panobinostat  (ISO)
phenethyl caffeate  (EXP)
phosphatidylcholine  (EXP)
phosphatidylethanolamine  (EXP)
pirinixic acid  (EXP)
rifampicin  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (EXP)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
Salidroside  (EXP)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
taurocholic acid  (EXP)
triptonide  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2437583   PMID:9310317   PMID:10191046   PMID:10349636   PMID:10769235   PMID:11042159   PMID:11076861   PMID:11114168   PMID:11165488   PMID:11180952   PMID:11900978   PMID:11922976  
PMID:12361972   PMID:12477932   PMID:12654290   PMID:12666204   PMID:12792807   PMID:12915315   PMID:14681479   PMID:15071597   PMID:15081372   PMID:15199049   PMID:15226823   PMID:15459106  
PMID:15465490   PMID:15489334   PMID:15614767   PMID:15680361   PMID:15789410   PMID:15963767   PMID:16123981   PMID:16141072   PMID:16141073   PMID:16172976   PMID:16213224   PMID:16452096  
PMID:16543460   PMID:16679559   PMID:16782087   PMID:16818445   PMID:16930954   PMID:17072310   PMID:17150206   PMID:17442811   PMID:17623664   PMID:17654705   PMID:17953485   PMID:17959802  
PMID:18058912   PMID:18094027   PMID:18270576   PMID:18279667   PMID:18287559   PMID:18489003   PMID:18625063   PMID:18703040   PMID:18772362   PMID:18835578   PMID:19000842   PMID:19063940  
PMID:19237543   PMID:19501082   PMID:19544582   PMID:19576202   PMID:19668217   PMID:19706524   PMID:19906857   PMID:20018895   PMID:20040496   PMID:20111592   PMID:20237272   PMID:20237281  
PMID:20348033   PMID:20436479   PMID:20531290   PMID:20562862   PMID:20615956   PMID:20660733   PMID:20668538   PMID:21172336   PMID:21192082   PMID:21223962   PMID:21267068   PMID:21273545  
PMID:21436455   PMID:21502507   PMID:21641554   PMID:21664901   PMID:21747170   PMID:21873635   PMID:21876757   PMID:21909369   PMID:21925158   PMID:21976438   PMID:22323600   PMID:22396169  
PMID:22442730   PMID:22457778   PMID:22542490   PMID:22682244   PMID:22792072   PMID:22912418   PMID:23012479   PMID:23038264   PMID:23041177   PMID:23322300   PMID:23364326   PMID:23426374  
PMID:23676500   PMID:23720040   PMID:23747249   PMID:23880190   PMID:24084738   PMID:24184963   PMID:24194600   PMID:24198358   PMID:24656817   PMID:24699334   PMID:24929016   PMID:24952961  
PMID:25056539   PMID:25080475   PMID:25156247   PMID:25183423   PMID:25346390   PMID:25792196   PMID:26028580   PMID:26039452   PMID:26040986   PMID:26212322   PMID:26253404   PMID:26311466  
PMID:26441343   PMID:26450968   PMID:26634251   PMID:26656997   PMID:26723851   PMID:26748348   PMID:26911688   PMID:27146480   PMID:27573244   PMID:27633990   PMID:27666676   PMID:27793834  
PMID:27829151   PMID:27956475   PMID:28189755   PMID:28446510   PMID:28498614   PMID:28560839   PMID:28650457   PMID:28673684   PMID:28793255   PMID:29028795   PMID:29140246   PMID:29295820  
PMID:29394901   PMID:29468415   PMID:29672888   PMID:29778534   PMID:29876009   PMID:29968724   PMID:29973237   PMID:30063881   PMID:30127091   PMID:30485816   PMID:30521806   PMID:30653340  
PMID:30745141   PMID:31767164   PMID:31964831   PMID:32170006   PMID:32561646   PMID:32681035   PMID:32737167   PMID:33144503  


Genomics

Comparative Map Data
Fgf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,450,269 - 144,454,690 (+)NCBIGRCm39mm39
GRCm39 Ensembl7144,450,268 - 144,454,690 (+)Ensembl
GRCm387144,896,532 - 144,900,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,896,531 - 144,900,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,082,437 - 152,086,858 (+)NCBIGRCm37mm9NCBIm37
MGSCv367144,705,922 - 144,710,343 (+)NCBImm8
Celera7144,661,763 - 144,666,199 (+)NCBICelera
Cytogenetic Map7F5NCBI
FGF19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1169,698,238 - 69,704,022 (-)EnsemblGRCh38hg38GRCh38
GRCh381169,698,238 - 69,704,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,513,006 - 69,518,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,222,187 - 69,228,287 (-)NCBINCBI36hg18NCBI36
Build 341169,222,187 - 69,228,287NCBI
Celera1166,810,044 - 66,816,141 (-)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1165,805,191 - 65,811,289 (-)NCBIHuRef
CHM1_11169,396,002 - 69,402,103 (-)NCBICHM1_1
Fgf19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21200,056,656 - 200,059,944 (+)NCBI
Rnor_6.0 Ensembl1218,058,405 - 218,061,693 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01218,058,405 - 218,061,693 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,927,791 - 224,931,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,324,890 - 205,328,178 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,478,342 - 205,481,631 (+)NCBI
Celera1197,614,723 - 197,618,011 (+)NCBICelera
Cytogenetic Map1q42NCBI
Fgf19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,415,648 - 16,420,515 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,415,880 - 16,419,528 (+)NCBIChiLan1.0ChiLan1.0
FGF19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11168,085,306 - 68,090,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,085,306 - 68,090,028 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01164,794,157 - 64,800,512 (-)NCBIMhudiblu_PPA_v0panPan3
FGF19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,464,931 - 48,469,967 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,464,928 - 48,469,782 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,074,788 - 47,079,858 (+)NCBI
ROS_Cfam_1.01849,142,011 - 49,147,073 (+)NCBI
UMICH_Zoey_3.11848,586,353 - 48,593,734 (+)NCBI
UNSW_CanFamBas_1.01848,174,953 - 48,180,024 (+)NCBI
UU_Cfam_GSD_1.01848,920,964 - 48,926,046 (+)NCBI
Fgf19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,485,587 - 4,491,068 (+)NCBI
SpeTri2.0NW_004936599923,943 - 932,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,583,027 - 3,587,825 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,583,027 - 3,586,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,060,776 - 2,065,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF19
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,852,289 - 4,860,139 (+)NCBI
ChlSab1.1 Ensembl14,854,363 - 4,859,102 (+)Ensembl
Fgf19
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476717,434,501 - 17,439,351 (+)NCBI

Position Markers
AF007268  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387144,900,448 - 144,900,533UniSTSGRCm38
MGSCv377152,086,353 - 152,086,438UniSTSGRCm37
Celera7144,665,694 - 144,665,779UniSTS
Cytogenetic Map7F5UniSTS
Whitehead/MRC_RH71475.14UniSTS
Fgf15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377152,086,288 - 152,086,594UniSTSGRCm37
Celera7144,665,629 - 144,665,935UniSTS
Cytogenetic Map7F5UniSTS
cM Map7 UniSTS
Fgf15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Fgf15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387144,900,383 - 144,900,689UniSTSGRCm38
MGSCv377152,086,288 - 152,086,594UniSTSGRCm37
Celera7144,665,629 - 144,665,935UniSTS
Cytogenetic Map7F5UniSTS
cM Map7 UniSTS
MGI:3766735  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127844414145441459Mouse
14746988Manh63_mmandible shape 63 (mouse)7128181700145441459Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:416
Count of miRNA genes:293
Interacting mature miRNAs:326
Transcripts:ENSMUST00000033389
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033389   ⟹   ENSMUSP00000033389
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7144,896,531 - 144,900,953 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207033
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7144,896,559 - 144,897,433 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207040
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7144,896,531 - 144,898,283 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207229   ⟹   ENSMUSP00000146870
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7144,896,564 - 144,899,881 (+)Ensembl
RefSeq Acc Id: ENSMUST00000208515
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7144,896,541 - 144,897,533 (+)Ensembl
RefSeq Acc Id: NM_008003   ⟹   NP_032029
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397144,450,269 - 144,454,690 (+)NCBI
GRCm387144,896,532 - 144,900,953 (+)ENTREZGENE
MGSCv377152,082,437 - 152,086,858 (+)RGD
Celera7144,661,763 - 144,666,199 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032029   ⟸   NM_008003
- Peptide Label: precursor
- UniProtKB: O35622 (UniProtKB/Swiss-Prot),   Q790L8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033389   ⟸   ENSMUST00000033389
RefSeq Acc Id: ENSMUSP00000146870   ⟸   ENSMUST00000207229

Promoters
RGD ID:8666295
Promoter ID:EPDNEW_M11179
Type:multiple initiation site
Name:Fgf15_1
Description:Mus musculus fibroblast growth factor 15 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387144,896,531 - 144,896,591EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1096383 AgrOrtholog
Ensembl Genes ENSMUSG00000031073 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033389 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000146870 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033389 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000207229 UniProtKB/TrEMBL
InterPro FGF15/19/21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FGF15/FGF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1096383 ENTREZGENE
NCBI Gene 14170 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF74 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf15 PhenoGen
PIRSF FGF-19_FGF-21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LIL5_MOUSE UniProtKB/TrEMBL
  FGF15_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q790L8 ENTREZGENE, UniProtKB/TrEMBL