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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620166
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf19
Name: fibroblast growth factor 19
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf19increases expressionISOFGF19 (Homo sapiens)6480464CTDDeoxycholic Acid results in increased expression of FGF19; Deoxycholic Acid results in increased expression of FGF19 mRNAPMID:22268002 PMID:25055961
Fgf19increases expressionISOFgf15 (Mus musculus)6480464CTDDeoxycholic Acid results in increased expression of FGF15 mRNAPMID:25582706
Fgf19multiple interactionsISOFGF19 (Homo sapiens)6480464CTD[[Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [Deoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoterPMID:22561792
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