Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620166
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf19
Name: fibroblast growth factor 19
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf19increases expressionISOFGF19 (Homo sapiens)6480464CTDCholic Acid results in increased expression of FGF19 mRNAPMID:25055961
Fgf19increases expressionISOFgf15 (Mus musculus)6480464CTDCholic Acid results in increased expression of FGF15 mRNAPMID:25582706
Fgf19multiple interactionsISOFGF19 (Homo sapiens)6480464CTD[[Cholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [Cholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoterPMID:22561792
Go Back to source page   Continue to Ontology report