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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620166
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf19
Name: fibroblast growth factor 19
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf19increases expressionEXP 6480464CTDChenodeoxycholic Acid results in increased expression of FGF15 mRNA; Chenodeoxycholic Acid results in increased expression of FGF19 proteinPMID:20835427 PMID:29222744
Fgf19multiple interactionsEXP 6480464CTD[Chenodeoxycholic Acid results in increased expression of FGF19 protein] which results in decreased expression of CYP7A1 proteinPMID:20835427
Fgf19increases expressionISOFGF19 (Homo sapiens)6480464CTDChenodeoxycholic Acid results in increased expression of FGF19 mRNAPMID:16269825 PMID:17696253 PMID:25055961 PMID:27174168
Fgf19increases expressionISOFgf15 (Mus musculus)6480464CTDChenodeoxycholic Acid results in increased expression of FGF15 mRNAPMID:25582706
Fgf19multiple interactionsISOFGF19 (Homo sapiens)6480464CTD[[Chenodeoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoterPMID:22561792
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