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Gene: Fadd (Fas associated via death domain) Rattus norvegicus
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Symbol: Fadd
Name: Fas associated via death domain
Description: Exhibits protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in kidney development; regulation of necroptotic process; and response to alkaloid. Localizes to several cellular components, including CD95 death-inducing signaling complex; cell body; and membrane raft. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; mental depression; middle cerebral artery infarction; and obesity. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Fas (TNFRSF6)-associated via death domain; Mort1
Orthologs:
Homo sapiens (human) : FADD (Fas associated via death domain)  HGNC  Alliance
Mus musculus (house mouse) : Fadd (Fas (TNFRSF6)-associated via death domain)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fadd (Fas associated via death domain)
Pan paniscus (bonobo/pygmy chimpanzee) : FADD (Fas associated via death domain)
Canis lupus familiaris (dog) : FADD (Fas associated via death domain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fadd (Fas associated via death domain)
Sus scrofa (pig) : FADD (Fas associated via death domain)
Chlorocebus sabaeus (African green monkey) : FADD (Fas associated via death domain)
Heterocephalus glaber (naked mole-rat) : Fadd (Fas associated via death domain)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fadd
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628700
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.