Fadd (Fas associated via death domain) - Rat Genome Database

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Gene: Fadd (Fas associated via death domain) Rattus norvegicus
Analyze
Symbol: Fadd
Name: Fas associated via death domain
RGD ID: 628700
Description: Enables protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in kidney development; regulation of necroptotic process; and response to alkaloid. Located in several cellular components, including cell body; membrane raft; and neuron projection. Part of CD95 death-inducing signaling complex. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; cerebrovascular disease (multiple); mental depression; and obesity. Human ortholog(s) of this gene implicated in leukemia and primary immunodeficiency disease. Orthologous to human FADD (Fas associated via death domain); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fas (TNFRSF6)-associated via death domain; Mort1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIRnor_WKY
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
4-nitrophenol  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aconitine  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
ammonium chloride  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
arecoline  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Beta-Solamarine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
casticin  (ISO)
celecoxib  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Destruxin B  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
ferrosoferric oxide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
magnesium oxide  (ISO)
mercury dichloride  (ISO)
methidathion  (ISO)
ML-7  (ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
naproxen  (EXP)
naringin  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
potassium chromate  (ISO)
probenecid  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rutin  (EXP)
S-allylcysteine  (ISO)
SB 203580  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (EXP)
Suillin  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
syringic acid  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
triamcinolone acetonide  (EXP)
trichloroethene  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
apoptotic process  (ISO,ISS)
apoptotic signaling pathway  (ISO)
behavioral response to cocaine  (IEP)
cellular response to mechanical stimulus  (ISO)
death-inducing signaling complex assembly  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
innate immune response  (IEA)
kidney development  (IEP)
lymph node development  (ISO,ISS)
motor neuron apoptotic process  (ISO)
necroptotic signaling pathway  (ISO)
negative regulation of activation-induced cell death of T cells  (ISO,ISS)
negative regulation of necroptotic process  (ISO)
positive regulation of activated T cell proliferation  (ISO,ISS)
positive regulation of adaptive immune response  (ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (ISO,ISS)
positive regulation of extrinsic apoptotic signaling pathway  (IBA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
positive regulation of type II interferon production  (ISO,ISS)
regulation of necroptotic process  (IMP)
response to cocaine  (IEP)
response to morphine  (IDA)
spleen development  (ISO,ISS)
T cell differentiation in thymus  (ISO,ISS)
T cell homeostasis  (ISO,ISS)
thymus development  (ISO,ISS)
TRAIL-activated apoptotic signaling pathway  (IBA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats. Alvaro-Bartolome M, etal., Neuroscience. 2011 Nov 24;196:1-15. doi: 10.1016/j.neuroscience.2011.08.074. Epub 2011 Sep 8.
2. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Bhattacharya D, etal., J Cell Physiol. 2017 Mar;232(3):526-539. doi: 10.1002/jcp.25447. Epub 2016 Jun 21.
3. Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats. Bi FF, etal., Brain Res. 2008 Jan 29;1191:30-8. Epub 2007 Nov 12.
4. Pretreatment with low-dose gadolinium chloride attenuates myocardial ischemia/reperfusion injury in rats. Chen M, etal., Acta Pharmacol Sin. 2016 Apr;37(4):453-62. doi: 10.1038/aps.2015.156. Epub 2016 Mar 7.
5. Activated apoptotic and anti-survival effects on rat hearts with fructose induced metabolic syndrome. Cheng SM, etal., Cell Biochem Funct. 2014 Mar;32(2):133-41. doi: 10.1002/cbf.2982. Epub 2013 May 9.
6. Effect of infliximab combined with methylprednisolone on expressions of NF-kappaB, TRADD, and FADD in rat acute spinal cord injury. Chengke L, etal., Spine (Phila Pa 1976). 2013 Jun 15;38(14):E861-9. doi: 10.1097/BRS.0b013e318294892c.
7. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici C, etal., J Immunol. 2006 Mar 1;176(5):3173-80.
8. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. Davis AR, etal., J Neurotrauma. 2007 May;24(5):823-34.
9. Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Deng JS, etal., Chem Biol Interact. 2014 Feb 25;209:77-84. doi: 10.1016/j.cbi.2013.11.017. Epub 2013 Dec 17.
10. A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. Dzietko M, etal., Ann Neurol. 2008 Dec;64(6):664-73. doi: 10.1002/ana.21516.
11. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
12. Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse. Garcia-Fuster MJ, etal., Neuropsychopharmacology. 2009 Apr;34(5):1123-34. doi: 10.1038/npp.2008.88. Epub 2008 Jun 25.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. Hafez MM, etal., Biol Res. 2015 Jun 11;48:30. doi: 10.1186/s40659-015-0022-y.
15. Common variation in genes related to immune response and risk of childhood leukemia. Han S, etal., Hum Immunol. 2012 Mar;73(3):316-9. doi: 10.1016/j.humimm.2011.12.018. Epub 2011 Dec 28.
16. Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. Hernández-Hernández E, etal., Neurobiol Aging. 2018 Jul 29;71:115-126. doi: 10.1016/j.neurobiolaging.2018.07.014.
17. Estrogen inhibits Fas-mediated apoptosis in experimental stroke. Jia J, etal., Exp Neurol. 2009 Jan;215(1):48-52. doi: 10.1016/j.expneurol.2008.09.015. Epub 2008 Oct 7.
18. Rice Hull Extract Suppresses Benign Prostate Hyperplasia by Decreasing Inflammation and Regulating Cell Proliferation in Rats. Kim CY, etal., J Med Food. 2016 Aug;19(8):746-54. doi: 10.1089/jmf.2016.3686. Epub 2016 Jul 21.
19. Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli. Kim PK, etal., J Biol Chem 2002 Oct 11;277(41):38855-62.
20. Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Kim SJ, etal., Shock. 2013 Apr;39(4):380-8. doi: 10.1097/SHK.0b013e31828aab7f.
21. The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis. Lee SD, etal., J Appl Physiol. 2008 Apr;104(4):1144-53. Epub 2008 Jan 17.
22. Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. Li C, etal., Int J Biochem Cell Biol. 2018 Jun;99:169-177. doi: 10.1016/j.biocel.2018.03.020. Epub 2018 Apr 7.
23. Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-alpha levels, and IL-10 mRNA, TNF-alpha mRNA expression levels, cerebral TGF-beta1 positive expression level and its neuroprotective mechanisms in CIR rats. Liang XY, etal., Mol Biol Rep. 2013 Apr;40(4):3419-27. doi: 10.1007/s11033-012-2419-9. Epub 2013 Feb 2.
24. Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. Lin YY, etal., Cardiovasc Toxicol. 2017 Apr;17(2):163-174. doi: 10.1007/s12012-016-9370-2.
25. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia. Pai P, etal., J Appl Physiol (1985). 2016 Apr 15;120(8):982-90. doi: 10.1152/japplphysiol.01109.2014. Epub 2016 Jan 14.
29. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of alpha(2)-adrenoceptors and extracellular signal-regulated kinases. Ramos-Miguel A, etal., J Psychopharmacol. 2011 Dec;25(12):1691-702. doi: 10.1177/0269881110387842. Epub 2010 Nov 18.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Roy DN, etal., Br J Pharmacol. 2010 Aug;160(7):1823-43.
36. Differential activation of CD95-mediated apoptosis related proteins in proximal and distal tubules during rat renal development. Song XF, etal., Tissue Cell. 2016 Oct;48(5):417-24. doi: 10.1016/j.tice.2016.08.006. Epub 2016 Aug 21.
37. The many roles of FAS receptor signaling in the immune system. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
38. Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Tan WQ, etal., Circulation. 2008 Nov 25;118(22):2268-76. doi: 10.1161/CIRCULATIONAHA.107.750869. Epub 2008 Nov 10.
39. Absence or low expression of fas-associated protein with death domain in acute myeloid leukemia cells predicts resistance to chemotherapy and poor outcome. Tourneur L, etal., Cancer Res. 2004 Nov 1;64(21):8101-8.
40. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
41. Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy. Wang F, etal., Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E861-73. doi: 10.1152/ajpendo.00215.2015. Epub 2015 Sep 29.
42. MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD. Wang JX, etal., Circ Res. 2015 Jul 31;117(4):352-63. doi: 10.1161/CIRCRESAHA.117.305781. Epub 2015 Jun 2.
43. Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease. Wu CK, etal., Exp Neurol. 2005 Oct;195(2):484-96. doi: 10.1016/j.expneurol.2005.06.020.
44. Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats. Xu DQ, etal., Acta Pharmacol Sin. 2013 Dec;34(12):1515-25. doi: 10.1038/aps.2013.96. Epub 2013 Oct 14.
45. Anti-apoptosis effects on hearts of SHSST cyclodextrin complex in a carbon tetrachloride-induced cirrhotic cardiomyopathy rat model. Yang CH, etal., Chin J Physiol. 2015 Feb 28;58(1):38-45. doi: 10.4077/CJP.2015.BAD286.
46. Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl -induced hepatotoxicity in rats. Yang CH, etal., Environ Toxicol. 2014 Nov 28. doi: 10.1002/tox.22078.
Additional References at PubMed
PMID:7536190   PMID:8681376   PMID:9208847   PMID:9343261   PMID:10588860   PMID:11101870   PMID:11717445   PMID:11821383   PMID:12761501   PMID:13679421   PMID:13679576   PMID:16127453  
PMID:16183742   PMID:16226958   PMID:16482086   PMID:16538385   PMID:16611992   PMID:17047155   PMID:18387192   PMID:19593445   PMID:20935634   PMID:21109225   PMID:21525013   PMID:21737330  
PMID:21785459   PMID:21796105   PMID:21803845   PMID:21876153   PMID:22089168   PMID:22510408   PMID:22675671   PMID:22891283   PMID:25502805   PMID:30561431   PMID:31515488  


Genomics

Comparative Map Data
Fadd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIRnor_WKY
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
FADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1170,203,296 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,049,402 - 70,053,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36Build 36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
T2T-CHM13v2.01170,218,250 - 70,222,344 (+)NCBIT2T-CHM13v2.0
Fadd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)EnsemblGRCm39 Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBIMGSCv36mm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
Fadd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,031,280 - 16,036,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,026,323 - 16,035,808 (-)NCBIChiLan1.0ChiLan1.0
FADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11168,590,184 - 68,593,905 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01165,300,889 - 65,305,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBIUU_Cfam_GSD_1.0
Fadd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,192,521 - 4,197,087 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936599633,501 - 639,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fadd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,055,509 - 17,059,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,050,929 - 17,059,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH127743  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,742,479 - 199,742,680 (+)MAPPERmRatBN7.2
Rnor_6.01217,745,456 - 217,745,656NCBIRnor6.0
Rnor_5.01224,602,836 - 224,603,036UniSTSRnor5.0
RGSC_v3.41205,009,643 - 205,009,843UniSTSRGSC3.4
Celera1197,301,995 - 197,302,195UniSTS
RH 3.4 Map11549.11UniSTS
Cytogenetic Map1q42UniSTS
PMC305633P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,743,261 - 199,743,529 (+)MAPPERmRatBN7.2
Rnor_6.01217,746,238 - 217,746,505NCBIRnor6.0
Rnor_5.01224,603,618 - 224,603,885UniSTSRnor5.0
RGSC_v3.41205,010,425 - 205,010,692UniSTSRGSC3.4
Celera1197,302,777 - 197,303,044UniSTS
Cytogenetic Map1q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
6480773Gluco64Glucose level QTL 645.09blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459200611765Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:480
Count of miRNA genes:257
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000075089
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 6 6 6 35 20 28
Low 1 17 51 35 19 35 8 11 39 15 13 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075089   ⟹   ENSRNOP00000066289
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)Ensembl
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)Ensembl
RefSeq Acc Id: NM_152937   ⟹   NP_690920
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,743,200 - 199,745,606 (-)NCBI
Rnor_6.01217,746,176 - 217,748,581 (-)NCBI
Rnor_5.01224,603,556 - 224,605,961 (-)NCBI
RGSC_v3.41205,010,363 - 205,012,768 (-)RGD
Celera1197,302,715 - 197,305,120 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102426   ⟹   XP_038958354
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21199,743,458 - 199,745,746 (-)NCBI
Protein Sequences
Protein RefSeqs NP_690920 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958354 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN01113 (Get FASTA)   NCBI Sequence Viewer  
  CAD29628 (Get FASTA)   NCBI Sequence Viewer  
  EDM12244 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_690920   ⟸   NM_152937
- UniProtKB: Q8R2E7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066289   ⟸   ENSRNOT00000075089
RefSeq Acc Id: XP_038958354   ⟸   XM_039102426
- Peptide Label: isoform X1
Protein Domains
Death   DED

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2E7-F1-model_v2 AlphaFold Q8R2E7 1-208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690585
Promoter ID:EPDNEW_R1110
Type:initiation region
Name:Fadd_1
Description:Fas associated via death domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,748,569 - 217,748,629EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628700 AgrOrtholog
BioCyc Gene G2FUF-56847 BioCyc
Ensembl Genes ENSRNOG00000047035 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000066289 ENTREZGENE
  ENSRNOP00000066289.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075089 ENTREZGENE
  ENSRNOT00000075089.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
  FADD UniProtKB/TrEMBL
KEGG Report rno:266610 UniProtKB/TrEMBL
NCBI Gene 266610 ENTREZGENE
PANTHER PTHR15077 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
PhenoGen Fadd PhenoGen
PIRSF FADD UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt Q8R2E7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Fadd  Fas associated via death domain  Fadd  Fas (TNFRSF6)-associated via death domain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fadd  Fas (TNFRSF6)-associated via death domain      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Fadd  Fas (TNFRSF6)-associated via death domain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation protein expression induced by cellular stresses including actinomycin D, ultraviolet irradiation and heat shock 632757