Exhibits protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in kidney development; regulation of necroptotic process; and response to alkaloid. Localizes to several cellular components, including CD95 death-inducing signaling complex; cell body; and membrane raft. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; mental depression; middle cerebral artery infarction; and obesity. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein] more ...
Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of FADD protein], Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of FADD protein]
Folic Acid inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with MAPT protein mutant form] results in increased expression of FADD protein]
Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of FADD protein], Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of FADD protein]
[Selenium analog co-treated with Magnesium Oxide analog] promotes the reaction [Diazinon results in decreased expression of FADD mRNA], Magnesium Oxide promotes the reaction [Diazinon results in decreased expression of FADD mRNA]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of FADD protein]
S-allylcysteine promotes the reaction [FAS protein binds to FADD protein], SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FADD protein]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
