Gene: Casp8 (caspase 8) Rattus norvegicus
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Symbol: Casp8
Name: caspase 8
Description: Exhibits cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Localizes to several cellular components, including the CD95 death-inducing signaling complex; cytosol; and membrane raft. Used to study pre-malignant neoplasm. Biomarker of several diseases, including brain disease (multiple); heart disease (multiple); kidney disease (multiple); retinal detachment; and sciatic neuropathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; hepatocellular carcinoma; pancreatic cancer; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8); PARTICIPATES IN FasL mediated signaling pathway; ceramide signaling pathway; extrinsic apoptotic pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CASP-8; caspase-8
Orthologs:
Homo sapiens (human) : CASP8 (caspase 8)  HGNC  Alliance
Mus musculus (house mouse) : Casp8 (caspase 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp8 (caspase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP8 (caspase 8)
Canis lupus familiaris (dog) : CASP8 (caspase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp8 (caspase 8)
Sus scrofa (pig) : CASP8 (caspase 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Celera957,705,001 - 57,753,027 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)