Casp8 (caspase 8) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Casp8 (caspase 8) Rattus norvegicus
Symbol: Casp8
Name: caspase 8
RGD ID: 620945
Description: Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Located in several cellular components, including cell body; cytosol; and membrane raft. Part of CD95 death-inducing signaling complex. Used to study pre-malignant neoplasm. Biomarker of several diseases, including heart disease (multiple); kidney disease (multiple); retinal detachment; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8); PARTICIPATES IN FasL mediated signaling pathway; ceramide signaling pathway; extrinsic apoptotic pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
Also known as: CASP-8; caspase-8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2960,263,863 - 60,312,542 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl960,264,075 - 60,312,542 (+)Ensembl
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Celera957,705,001 - 57,753,027 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcohol-Related Disorders  (IEP)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (IEP,ISO)
atopic dermatitis  (ISS)
autoimmune disease  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (IEP)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (IEP)
Cerebral Hemorrhage  (IEP,ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chronic obstructive pulmonary disease  (IEP)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (IEP)
Edema  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Familial Prostate Cancer  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (IEP)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP,ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hypertension  (IEP)
Hypoxia-Ischemia, Brain  (IEP)
Insulin Resistance  (IEP)
kidney disease  (IEP)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung cancer  (ISO,ISS)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (IEP)
melanoma  (ISO)
mitochondrial metabolism disease  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
nephritis  (IEP)
Neurodevelopmental Disorders  (ISO)
Osteoarthritis, Experimental  (IEP)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
pre-malignant neoplasm  (IDA)
primary immunodeficiency disease  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Radiation Injuries, Experimental  (IEP)
Reperfusion Injury  (ISO)
retinal detachment  (IEP)
sciatic neuropathy  (IEP)
Sepsis  (IEP)
Skin Neoplasms  (ISO)
status epilepticus  (IEP,ISO)
Stomach Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(E)-Dacarbazine  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
25-hydroxycholesterol  (EXP)
28-deoxonimbolide  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (EXP,ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-formylpterin  (ISO)
7-ketocholesterol  (EXP)
9'-cis-neoxanthin  (ISO)
9-cis-retinoic acid  (ISO)
9-hydroxycanthin-6-one  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
aclacinomycin A  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (EXP,ISO)
aflatoxin B1  (ISO)
Ala-Gln  (ISO)
alantolactone  (ISO)
alborixin  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-acitretin  (ISO)
all-trans-neoxanthin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
amiodarone  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
andrographolide  (EXP,ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
arecoline  (EXP)
arjunolic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asarone  (ISO)
atorvastatin calcium  (EXP,ISO)
auranofin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azadiradione  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
beauvericin  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (EXP,ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
borrelidin  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
Brusatol  (ISO)
bupropion  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
Calpeptin  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
casticin  (ISO)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
ceruletide  (EXP)
chalcone  (ISO)
chalcones  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chromone  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP)
cimetidine  (ISO)
Cinobufotalin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clavulone II  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucitol  (EXP)
D-gluconic acid  (ISO)
D-glucose  (EXP,ISO)
dacarbazine  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dieckol  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
Dihydrotanshinone I  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
docebenone  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
Echinocystic acid  (ISO)
eckol  (ISO)
edaravone  (EXP)
elemental carbon  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
epichlorohydrin  (ISO)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (ISO)
fangchinoline  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
flavanone  (ISO)
flavones  (ISO)
flavonols  (ISO)
fluoxetine  (ISO)
fluticasone  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
formononetin  (ISO)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gallic acid  (ISO)
gallium atom  (ISO)
gardenin B  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
geraniol  (EXP,ISO)
gibberellin A3  (EXP)
gingerol  (ISO)
glabridin  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Grifolin  (ISO)
guggulsterone  (ISO)
helenalin  (ISO)
Heliotrine  (ISO)
hexachlorobenzene  (EXP)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hyperforin  (ISO)
icariside II  (ISO)
idelalisib  (ISO)
Ilimaquinone  (ISO)
imipramine  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoflavones  (EXP)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
juglone  (ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
Licochalcone A  (ISO)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
Loratadine  (ISO)
losartan  (EXP)
lovastatin  (ISO)
lupeol  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (EXP)
LY294002  (ISO)
lycopene  (EXP,ISO)
magnesium oxide  (ISO)
malathion  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
masoprocol  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
Methylone  (EXP)
methylseleninic acid  (ISO)
metiram  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
molybdenum atom  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nelfinavir  (ISO)
neohesperidin dihydrochalcone  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nicotine  (EXP)
Niflumic acid  (ISO)
nimesulide  (ISO)
nimustine  (ISO)
nitric oxide  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (ISO)
nocodazole  (ISO)
Nodularin  (EXP,ISO)
norfloxacin  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
nystatin  (ISO)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleandrin  (ISO)
oleanolic acid  (ISO)
omeprazole  (ISO)
omethoate  (ISO)
orlistat  (EXP,ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
Parthenin  (ISO)
parthenolide  (ISO)
patulin  (ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
pepstatin A  (EXP)
perfluorononanoic acid  (EXP)
perifosine  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phylloquinone  (ISO)
Pinacidil  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(I:C)  (ISO)
pomalidomide  (ISO)
porphyrins  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
prazosin  (ISO)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
protoporphyrin  (ISO)
Psymberin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Punicalagin  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxine  (ISO)
pyrimethamine  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
reactive oxygen species  (ISO)
regorafenib  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ribavirin  (ISO)
riboflavin  (ISO)
rifampicin  (ISO)
Riluzole  (ISO)
Risedronate sodium  (EXP)
Ro 31-8220  (ISO)
rolipram  (EXP)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
rubitecan  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
safrole  (ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
Sesamol  (ISO)
sesquiterpene  (ISO)
silibinin  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Sodium salicylate  (EXP)
sorafenib  (ISO)
spermine  (ISO)
spironolactone  (EXP)
spiruchostatin B  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
styrene  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
swainsonine  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacedinaline  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tangeretin  (ISO)
Tanshinone I  (ISO)
taurocholic acid  (EXP)
tellurium atom  (EXP)
temozolomide  (ISO)
Terfenadine  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (EXP)
tetrazolium violet  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thiazoles  (ISO)
thioacetamide  (EXP)
thiosalicylic acid  (EXP)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP)
tioguanine  (ISO)
Tiron  (ISO)
Tomentosin  (ISO)
topotecan  (ISO)
tranilast  (EXP)
trans-chalcone  (ISO)
triamcinolone acetonide  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trifluridine  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanillic acid  (EXP)
vemurafenib  (ISO)
venom  (ISO)
verapamil  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,ISO)
angiogenesis  (ISO,ISS)
apoptotic process  (IBA,IMP,ISO)
apoptotic signaling pathway  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IEP)
execution phase of apoptosis  (ISO,ISS)
extrinsic apoptotic signaling pathway  (ISO,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA,ISO)
heart development  (ISO,ISS)
hepatocyte apoptotic process  (ISO)
macrophage differentiation  (IBA,ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of necroptotic process  (ISO,ISS)
neural tube formation  (ISO)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of neuron death  (IMP)
positive regulation of proteolysis  (ISO)
protein processing  (ISO,ISS)
proteolysis  (IDA,ISO)
proteolysis involved in cellular protein catabolic process  (ISO,ISS)
pyroptosis  (ISO,ISS)
regulation of apoptotic signaling pathway  (ISO)
regulation of cytokine production  (ISO,ISS)
regulation of innate immune response  (ISO,ISS)
regulation of thymocyte apoptotic process  (ISO)
response to antibiotic  (IEP)
response to auditory stimulus  (ISO)
response to cobalt ion  (IEP)
response to cold  (IEP)
response to estradiol  (IEP)
response to ethanol  (IDA)
response to lipopolysaccharide  (IEP)
response to tumor necrosis factor  (ISO)
self proteolysis  (ISO,ISS)
TRAIL-activated apoptotic signaling pathway  (ISO)

Cellular Component


References - curated
1. Al-Mashat HA, etal., Diabetes. 2006 Feb;55(2):487-95.
2. Arroba AI, etal., Endocrinology. 2005 Oct;146(10):4417-24. Epub 2005 Jun 23.
3. Beil M, etal., Am J Physiol Gastrointest Liver Physiol 2002 Mar;282(3):G450-60.
4. Bi FF, etal., Brain Res. 2008 Jan 29;1191:30-8. Epub 2007 Nov 12.
5. Chandirasegaran G, etal., Biomed Pharmacother. 2017 Nov;95:175-185. doi: 10.1016/j.biopha.2017.08.040. Epub 2017 Sep 12.
6. Chun HJ, etal., Nature 2002 Sep 26;419(6905):395-9.
7. Contreras JL, etal., Surgery. 2004 Aug;136(2):390-400. doi: 10.1016/j.surg.2004.05.015.
8. Couch FJ, etal., Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3044-8. Epub 2009 Oct 20.
9. Cudrici C, etal., J Immunol. 2006 Mar 1;176(5):3173-80.
10. Das A, etal., J Neurosci Res. 2008 Oct;86(13):2992-3001.
11. Davis AR, etal., J Neurotrauma. 2007 May;24(5):823-34.
12. De Franco S, etal., Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):567-76.
13. DeBiasi RL, etal., J Card Fail. 2010 Nov;16(11):901-10. doi: 10.1016/j.cardfail.2010.05.030.
14. Decallonne B, etal., J Autoimmun. 2003 May;20(3):219-26.
15. Ding GL, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Mar;29(2):119-23.
16. Dong K, etal., Am J Pathol. 2017 Aug;187(8):1763-1771. doi: 10.1016/j.ajpath.2017.04.015. Epub 2017 Jun 17.
17. El-Kharashi OA, etal., Biomed Pharmacother. 2018 Aug 14;107:665-674. doi: 10.1016/j.biopha.2018.08.032.
18. Elsherbiny NM, etal., Toxicol Mech Methods. 2018 Jul;28(6):467-473. doi: 10.1080/15376516.2018.1459995. Epub 2018 Apr 16.
19. Eroglu O, etal., Injury. 2017 Dec;48(12):2675-2682. doi: 10.1016/j.injury.2017.09.032. Epub 2017 Sep 28.
20. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
21. Fan X and Mu L, Neuropsychiatr Dis Treat. 2016 Dec 28;13:77-85. doi: 10.2147/NDT.S120496. eCollection 2017.
22. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. GOA data from the GO Consortium
24. Granado M, etal., Mol Cell Endocrinol. 2009 Jun 18.
25. Gukovskaya AS, etal., J Biol Chem 2002 Jun 21;277(25):22595-604.
26. Helmy SA, etal., Chem Biol Interact. 2018 Jan 5;279:84-94. doi: 10.1016/j.cbi.2017.11.009. Epub 2017 Nov 10.
27. Huang YH, etal., Exp Biol Med (Maywood). 2018 Jan;243(1):13-21. doi: 10.1177/1535370217741500. Epub 2017 Nov 6.
28. Jung JY, etal., Brain Res Bull. 2008 Aug 15;76(6):579-85. Epub 2008 May 16.
29. KEGG
30. Kim HH and Kim K, FEBS Lett 2003 Jan 30;535(1-3):190-4.
31. Kim KW, etal., Spine (Phila Pa 1976). 2007 Oct 15;32(22):2443-8.
32. Kim SJ, etal., Shock. 2013 Apr;39(4):380-8. doi: 10.1097/SHK.0b013e31828aab7f.
33. Kong L, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Dec;29(6):782-6.
34. Kumar S Cell Death Differ. 2007 Jan;14(1):32-43. Epub 2006 Nov 3.
35. Kumral A, etal., Early Hum Dev. 2013 Mar;89(3):165-73. doi: 10.1016/j.earlhumdev.2012.09.016. Epub 2012 Oct 6.
36. Li C, etal., Int J Biochem Cell Biol. 2018 Jun;99:169-177. doi: 10.1016/j.biocel.2018.03.020. Epub 2018 Apr 7.
37. Li J, etal., Mol Med Rep. 2014 Sep;10(3):1433-7. doi: 10.3892/mmr.2014.2334. Epub 2014 Jun 16.
38. Li PF, etal., Mol Cell 2002 Aug;10(2):247-58.
39. Li W, etal., J Surg Res. 2017 Dec;220:247-254. doi: 10.1016/j.jss.2017.06.090. Epub 2017 Aug 5.
40. Liadis N, etal., Diabetes. 2007 Sep;56(9):2302-11. Epub 2007 Jun 11.
41. Lin YY, etal., Int J Mol Sci. 2016 Dec 6;17(12). pii: ijms17122036. doi: 10.3390/ijms17122036.
42. Liu F, etal., Apoptosis. 2017 Aug;22(8):1035-1047. doi: 10.1007/s10495-017-1385-z.
43. Liu L, etal., J Neurochem. 2008 Jul;106(2):541-50. Epub 2008 Apr 12.
44. Liu Q, etal., Int J Physiol Pathophysiol Pharmacol. 2018 Apr 20;10(2):83-94. eCollection 2018.
45. Liu X, etal., Int J Chron Obstruct Pulmon Dis. 2017 May 2;12:1309-1324. doi: 10.2147/COPD.S124547. eCollection 2017.
46. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
47. Matsui T, etal., J Neuropathol Exp Neurol. 2006 May;65(5):508-15. doi: 10.1097/01.jnen.0000229238.05748.12.
48. Messaris E, etal., Surg Infect (Larchmt). 2008 Jun;9(3):377-88.
49. MGD data from the GO Consortium
50. NCBI rat LocusLink and RefSeq merged data July 26, 2002
51. Nephan G, etal., Cell Biochem Funct. 2018 Jun;36(4):212-220. doi: 10.1002/cbf.3333. Epub 2018 May 10.
52. OMIM Disease Annotation Pipeline
53. Pandey A and Gaikwad AB, Biochem Biophys Res Commun. 2017 Jun 10;487(4):827-833. doi: 10.1016/j.bbrc.2017.04.134. Epub 2017 Apr 27.
54. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
55. Pipeline to import KEGG annotations from KEGG into RGD
56. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
57. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
58. Rajkumar L, etal., Steroids. 2011 Jan;76(1-2):31-7. doi: 10.1016/j.steroids.2010.08.004. Epub 2010 Aug 21.
59. RGD automated data pipeline
60. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
61. RGD automated import pipeline for gene-chemical interactions
62. Roy DN, etal., Br J Pharmacol. 2010 Aug;160(7):1823-43.
63. Sanchez I, etal., Neuron 1999 Mar;22(3):623-33.
64. Scarabelli TM, etal., Circ Res. 2002 Apr 5;90(6):745-8.
65. Schindler CK, etal., Neurosci Lett. 2004 Feb 19;356(3):163-6.
66. Shan H, etal., J Trace Elem Med Biol. 2015;31:85-91. doi: 10.1016/j.jtemb.2015.03.005. Epub 2015 Apr 16.
67. Sharangpani A, etal., Brain Res. 2008 Mar 20;1200C:138-45. Epub 2008 Jan 26.
68. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
69. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
70. Tan WQ, etal., Circulation. 2008 Nov 25;118(22):2268-76. doi: 10.1161/CIRCULATIONAHA.107.750869. Epub 2008 Nov 10.
71. Tsai NM, etal., J Neurochem. 2006 Nov;99(4):1251-62. Epub 2006 Sep 20.
72. Wei Y, etal., Cell Physiol Biochem. 2018;46(2):687-698. doi: 10.1159/000488725. Epub 2018 Mar 29.
73. Weishaupt JH, etal., Neurobiol Dis 2003 Jul;13(2):124-35.
74. Wiberg R, etal., Neuroreport. 2018 Jun 13;29(9):779-785. doi: 10.1097/WNR.0000000000001031.
75. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
76. Xu B, etal., Biosci Rep. 2018 Jun 12;38(3). pii: BSR20171529. doi: 10.1042/BSR20171529. Print 2018 Jun 29.
77. Yan Z, etal., Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
78. Yang BY, etal., Molecules. 2018 Apr 10;23(4). pii: molecules23040870. doi: 10.3390/molecules23040870.
79. Yang CH, etal., Environ Toxicol. 2014 Nov 28. doi: 10.1002/tox.22078.
80. Yang M, etal., Clin Cancer Res. 2008 May 15;14(10):3230-6.
81. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
82. Yoo KC, etal., Int J Nanomedicine. 2012;7:1203-14. doi: 10.2147/IJN.S28647. Epub 2012 Mar 5.
83. Yumusak N, etal., Nucl Med Commun. 2018 Feb;39(2):131-139. doi: 10.1097/MNM.0000000000000788.
84. Zender L, etal., Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7797-802. doi: 10.1073/pnas.1330920100. Epub 2003 Jun 16.
85. Zhan L, etal., FASEB J. 2018 Aug 27:fj201800111RR. doi: 10.1096/fj.201800111RR.
86. Zhang HB, e