Casp8 (caspase 8) - Rat Genome Database

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Gene: Casp8 (caspase 8) Rattus norvegicus
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Symbol: Casp8
Name: caspase 8
RGD ID: 620945
Description: Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Located in several cellular components, including cell body; cytosol; and membrane raft. Part of CD95 death-inducing signaling complex. Used to study pre-malignant neoplasm. Biomarker of several diseases, including heart disease (multiple); kidney disease (multiple); retinal detachment; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8); PARTICIPATES IN FasL mediated signaling pathway; ceramide signaling pathway; extrinsic apoptotic pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CASP-8; caspase-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,263,863 - 60,312,542 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl960,264,075 - 60,312,542 (+)Ensembl
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Celera957,705,001 - 57,753,027 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcohol-Related Disorders  (IEP)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (IEP,ISO)
atopic dermatitis  (ISS)
autoimmune disease  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (IEP)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (IEP)
Cerebral Hemorrhage  (IEP,ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chronic obstructive pulmonary disease  (IEP)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (IEP)
Edema  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Familial Prostate Cancer  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (IEP)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP,ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hypertension  (IEP)
Hypoxia-Ischemia, Brain  (IEP)
Insulin Resistance  (IEP)
kidney disease  (IEP)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung cancer  (ISO,ISS)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (IEP)
melanoma  (ISO)
mitochondrial metabolism disease  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
nephritis  (IEP)
Neurodevelopmental Disorders  (ISO)
Osteoarthritis, Experimental  (IEP)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
pre-malignant neoplasm  (IDA)
primary immunodeficiency disease  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Radiation Injuries, Experimental  (IEP)
Reperfusion Injury  (ISO)
retinal detachment  (IEP)
sciatic neuropathy  (IEP)
Sepsis  (IEP)
Skin Neoplasms  (ISO)
status epilepticus  (IEP,ISO)
Stomach Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(E)-Dacarbazine  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
25-hydroxycholesterol  (EXP)
28-deoxonimbolide  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (EXP,ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-formylpterin  (ISO)
7-ketocholesterol  (EXP)
9'-cis-neoxanthin  (ISO)
9-cis-retinoic acid  (ISO)
9-hydroxycanthin-6-one  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
aclacinomycin A  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (EXP,ISO)
aflatoxin B1  (ISO)
Ala-Gln  (ISO)
alantolactone  (ISO)
alborixin  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-acitretin  (ISO)
all-trans-neoxanthin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
amiodarone  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
andrographolide  (EXP,ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
arecoline  (EXP)
arjunolic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asarone  (ISO)
atorvastatin calcium  (EXP,ISO)
auranofin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azadiradione  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
beauvericin  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (EXP,ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
borrelidin  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
Brusatol  (ISO)
bupropion  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
Calpeptin  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
casticin  (ISO)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
ceruletide  (EXP)
chalcone  (ISO)
chalcones  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chromone  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP)
cimetidine  (ISO)
Cinobufotalin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clavulone II  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucitol  (EXP)
D-gluconic acid  (ISO)
D-glucose  (EXP,ISO)
dacarbazine  (ISO)
daunorubicin  (ISO)
DDE  (EXP,ISO)
deguelin  (ISO)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dieckol  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
Dihydrotanshinone I  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
docebenone  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
Echinocystic acid  (ISO)
eckol  (ISO)
edaravone  (EXP)
elemental carbon  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
epichlorohydrin  (ISO)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (ISO)
fangchinoline  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
flavanone  (ISO)
flavones  (ISO)
flavonols  (ISO)
fluoxetine  (ISO)
fluticasone  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
formononetin  (ISO)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gallic acid  (ISO)
gallium atom  (ISO)
gardenin B  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
geraniol  (EXP,ISO)
gibberellin A3  (EXP)
gingerol  (ISO)
glabridin  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Grifolin  (ISO)
guggulsterone  (ISO)
helenalin  (ISO)
Heliotrine  (ISO)
hexachlorobenzene  (EXP)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hyperforin  (ISO)
icariside II  (ISO)
idelalisib  (ISO)
Ilimaquinone  (ISO)
imipramine  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoflavones  (EXP)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
juglone  (ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
Licochalcone A  (ISO)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
Loratadine  (ISO)
losartan  (EXP)
lovastatin  (ISO)
lupeol  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (EXP)
LY294002  (ISO)
lycopene  (EXP,ISO)
magnesium oxide  (ISO)
malathion  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
masoprocol  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
Methylone  (EXP)
methylseleninic acid  (ISO)
metiram  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
molybdenum atom  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nelfinavir  (ISO)
neohesperidin dihydrochalcone  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nicotine  (EXP)
Niflumic acid  (ISO)
nimesulide  (ISO)
nimustine  (ISO)
nitric oxide  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (ISO)
nocodazole  (ISO)
Nodularin  (EXP,ISO)
norfloxacin  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
nystatin  (ISO)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleandrin  (ISO)
oleanolic acid  (ISO)
omeprazole  (ISO)
omethoate  (ISO)
orlistat  (EXP,ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
Parthenin  (ISO)
parthenolide  (ISO)
patulin  (ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
pepstatin A  (EXP)
perfluorononanoic acid  (EXP)
perifosine  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phylloquinone  (ISO)
Pinacidil  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(I:C)  (ISO)
pomalidomide  (ISO)
porphyrins  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
prazosin  (ISO)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
protoporphyrin  (ISO)
Psymberin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Punicalagin  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxine  (ISO)
pyrimethamine  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
reactive oxygen species  (ISO)
regorafenib  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ribavirin  (ISO)
riboflavin  (ISO)
rifampicin  (ISO)
Riluzole  (ISO)
Risedronate sodium  (EXP)
Ro 31-8220  (ISO)
rolipram  (EXP)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
rubitecan  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
safrole  (ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
selumetinib  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
Sesamol  (ISO)
sesquiterpene  (ISO)
silibinin  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Sodium salicylate  (EXP)
sorafenib  (ISO)
spermine  (ISO)
spironolactone  (EXP)
spiruchostatin B  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
styrene  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
swainsonine  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacedinaline  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tangeretin  (ISO)
Tanshinone I  (ISO)
taurocholic acid  (EXP)
tellurium atom  (EXP)
temozolomide  (ISO)
Terfenadine  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (EXP)
tetrazolium violet  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thiazoles  (ISO)
thioacetamide  (EXP)
thiosalicylic acid  (EXP)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP)
tioguanine  (ISO)
Tiron  (ISO)
Tomentosin  (ISO)
topotecan  (ISO)
tranilast  (EXP)
trans-chalcone  (ISO)
triamcinolone acetonide  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trifluridine  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanillic acid  (EXP)
vemurafenib  (ISO)
venom  (ISO)
verapamil  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,ISO)
angiogenesis  (ISO,ISS)
apoptotic process  (IBA,IMP,ISO)
apoptotic signaling pathway  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IEP)
execution phase of apoptosis  (ISO,ISS)
extrinsic apoptotic signaling pathway  (ISO,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA,ISO)
heart development  (ISO,ISS)
hepatocyte apoptotic process  (ISO)
macrophage differentiation  (IBA,ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of necroptotic process  (ISO,ISS)
neural tube formation  (ISO)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of neuron death  (IMP)
positive regulation of proteolysis  (ISO)
protein processing  (ISO,ISS)
proteolysis  (IDA,ISO)
proteolysis involved in cellular protein catabolic process  (ISO,ISS)
pyroptosis  (ISO,ISS)
regulation of apoptotic signaling pathway  (ISO)
regulation of cytokine production  (ISO,ISS)
regulation of innate immune response  (ISO,ISS)
regulation of thymocyte apoptotic process  (ISO)
response to antibiotic  (IEP)
response to auditory stimulus  (ISO)
response to cobalt ion  (IEP)
response to cold  (IEP)
response to estradiol  (IEP)
response to ethanol  (IDA)
response to lipopolysaccharide  (IEP)
response to tumor necrosis factor  (ISO)
self proteolysis  (ISO,ISS)
TRAIL-activated apoptotic signaling pathway  (ISO)

Cellular Component

References

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