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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628700
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fadd
Name: Fas associated via death domain
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Faddaffects localizationISOFADD (Homo sapiens)6480464CTDresveratrol affects the localization of FADD proteinPMID:12902349
Faddincreases expressionISOFADD (Homo sapiens)6480464CTDresveratrol results in increased expression of FADD proteinPMID:24299158
Faddincreases localizationISOFADD (Homo sapiens)6480464CTDresveratrol results in increased localization of FADD proteinPMID:19561642
Faddincreases response to substanceISOFADD (Homo sapiens)6480464CTDFADD protein results in increased susceptibility to resveratrolPMID:19561642
Faddmultiple interactionsISOFADD (Homo sapiens)6480464CTDNystatin inhibits the reaction [resveratrol affects the localization of FADD protein]; resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]; resveratrol promotes the reaction [FAS protein binds to FADD protein]PMID:12902349 PMID:23452621
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