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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628700
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fadd
Name: Fas associated via death domain
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fadddecreases phosphorylationISOFADD (Homo sapiens)6480464CTDpyrazolanthrone results in decreased phosphorylation of FADD proteinPMID:16450001
Faddmultiple interactionsISOFADD (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [polyphenon E results in increased phosphorylation of FADD protein]PMID:16450001 PMID:21138480 PMID:23285096
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