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Gene: Fadd (Fas (TNFRSF6)-associated via death domain) Mus musculus
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Symbol: Fadd
Name: Fas (TNFRSF6)-associated via death domain
Description: Predicted to have several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; hematopoietic or lymphoid organ development; and regulation of programmed cell death. Predicted to localize to several cellular components, including CD95 death-inducing signaling complex; membrane raft; and ripoptosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; mediator of receptor induced toxicity; Mort1/FADD
Orthologs:
Homo sapiens (human) : FADD (Fas associated via death domain)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fadd (Fas associated via death domain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fadd (Fas associated via death domain)
Pan paniscus (bonobo/pygmy chimpanzee) : FADD (Fas associated via death domain)
Canis lupus familiaris (dog) : FADD (Fas associated via death domain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fadd (Fas associated via death domain)
Sus scrofa (pig) : FADD (Fas associated via death domain)
Chlorocebus sabaeus (African green monkey) : FADD (Fas associated via death domain)
Heterocephalus glaber (naked mole-rat) : Fadd (Fas associated via death domain)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBImm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Fadd
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732106
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.