Fadd (Fas associated via death domain) - Rat Genome Database

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Gene: Fadd (Fas associated via death domain) Mus musculus
Analyze
Symbol: Fadd
Name: Fas associated via death domain (Ensembl:Fas (TNFRSF6)-associated via death domain)
RGD ID: 732106
MGI Page MGI
Description: Enables signaling adaptor activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; and regulation of apoptotic process. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and negative regulation of necroptotic process. Predicted to be located in cell body; cytosol; and plasma membrane. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia and primary immunodeficiency disease. Orthologous to human FADD (Fas associated via death domain).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; mediator of receptor induced toxicity; Mort1/F; Mort1/FADD
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)EnsemblGRCm39 Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBIMGSCv36mm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
aconitine  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Beta-Solamarine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
cadmium sulfide  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
casticin  (ISO)
celecoxib  (ISO)
cholesterol  (ISO)
cisplatin  (EXP)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Destruxin B  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
Dimethyl phthalate  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenthion  (EXP)
ferrosoferric oxide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
iron dichloride  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium oxide  (ISO)
mercury dichloride  (EXP)
methidathion  (EXP)
methimazole  (ISO)
ML-7  (ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
Myrtucommulone A  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
naproxen  (ISO)
naringin  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
potassium chromate  (ISO)
probenecid  (EXP)
progesterone  (EXP)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rutin  (ISO)
S-allylcysteine  (ISO)
SB 203580  (ISO)
SCH 23390  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (ISO)
Suillin  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
behavioral response to cocaine  (ISO)
cardiac muscle tissue development  (TAS)
cellular response to mechanical stimulus  (ISO)
death-inducing signaling complex assembly  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway  (IBA,IDA,IGI,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO,TAS)
immune system process  (IEA)
innate immune response  (TAS)
kidney development  (ISO)
lymph node development  (IGI)
motor neuron apoptotic process  (IMP)
necroptotic signaling pathway  (ISO)
negative regulation of activation-induced cell death of T cells  (IMP)
negative regulation of necroptotic process  (IGI)
positive regulation of activated T cell proliferation  (IMP)
positive regulation of adaptive immune response  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (IMP)
positive regulation of execution phase of apoptosis  (IDA,IMP)
positive regulation of extrinsic apoptotic signaling pathway  (IGI,ISO)
positive regulation of innate immune response  (IBA)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of T cell mediated cytotoxicity  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
positive regulation of type II interferon production  (IMP)
regulation of apoptotic process  (IEA)
regulation of necroptotic process  (ISO)
response to cocaine  (ISO)
signal transduction  (IEA)
spleen development  (IGI)
T cell differentiation  (TAS)
T cell differentiation in thymus  (IMP)
T cell homeostasis  (IMP)
thymus development  (IGI)
TRAIL-activated apoptotic signaling pathway  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal embryo size  (IEA)
abnormal enterocyte physiology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal erythrocyte cell number  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neural tube closure  (IEA)
abnormal oligodendrocyte apoptosis  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymocyte apoptosis  (IAGP)
abnormal uterus morphology  (IEA)
cecum inflammation  (IAGP)
colitis  (IAGP)
crypts of Lieberkuhn abscesses  (IAGP)
decreased activated T cell number  (IAGP)
decreased apoptosis  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast apoptosis  (IAGP)
decreased lean body mass  (IEA)
decreased Paneth cell number  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
diarrhea  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
increased B cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased enterocyte apoptosis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased total body fat amount  (IEA)
internal hemorrhage  (IAGP)
intestinal ulcer  (IAGP)
liver inflammation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
spleen hypoplasia  (IAGP)
thin myocardium  (IAGP)
thymus hypoplasia  (IAGP)
trabecula carnea hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Bhattacharya D, etal., J Cell Physiol. 2017 Mar;232(3):526-539. doi: 10.1002/jcp.25447. Epub 2016 Jun 21.
2. Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats. Bi FF, etal., Brain Res. 2008 Jan 29;1191:30-8. Epub 2007 Nov 12.
3. Pretreatment with low-dose gadolinium chloride attenuates myocardial ischemia/reperfusion injury in rats. Chen M, etal., Acta Pharmacol Sin. 2016 Apr;37(4):453-62. doi: 10.1038/aps.2015.156. Epub 2016 Mar 7.
4. Activated apoptotic and anti-survival effects on rat hearts with fructose induced metabolic syndrome. Cheng SM, etal., Cell Biochem Funct. 2014 Mar;32(2):133-41. doi: 10.1002/cbf.2982. Epub 2013 May 9.
5. Effect of infliximab combined with methylprednisolone on expressions of NF-kappaB, TRADD, and FADD in rat acute spinal cord injury. Chengke L, etal., Spine (Phila Pa 1976). 2013 Jun 15;38(14):E861-9. doi: 10.1097/BRS.0b013e318294892c.
6. Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Deng JS, etal., Chem Biol Interact. 2014 Feb 25;209:77-84. doi: 10.1016/j.cbi.2013.11.017. Epub 2013 Dec 17.
7. A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. Dzietko M, etal., Ann Neurol. 2008 Dec;64(6):664-73. doi: 10.1002/ana.21516.
8. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
9. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. Hafez MM, etal., Biol Res. 2015 Jun 11;48:30. doi: 10.1186/s40659-015-0022-y.
10. Common variation in genes related to immune response and risk of childhood leukemia. Han S, etal., Hum Immunol. 2012 Mar;73(3):316-9. doi: 10.1016/j.humimm.2011.12.018. Epub 2011 Dec 28.
11. Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. Hernández-Hernández E, etal., Neurobiol Aging. 2018 Jul 29;71:115-126. doi: 10.1016/j.neurobiolaging.2018.07.014.
12. Estrogen inhibits Fas-mediated apoptosis in experimental stroke. Jia J, etal., Exp Neurol. 2009 Jan;215(1):48-52. doi: 10.1016/j.expneurol.2008.09.015. Epub 2008 Oct 7.
13. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
14. Rice Hull Extract Suppresses Benign Prostate Hyperplasia by Decreasing Inflammation and Regulating Cell Proliferation in Rats. Kim CY, etal., J Med Food. 2016 Aug;19(8):746-54. doi: 10.1089/jmf.2016.3686. Epub 2016 Jul 21.
15. Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Kim SJ, etal., Shock. 2013 Apr;39(4):380-8. doi: 10.1097/SHK.0b013e31828aab7f.
16. The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis. Lee SD, etal., J Appl Physiol. 2008 Apr;104(4):1144-53. Epub 2008 Jan 17.
17. Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. Li C, etal., Int J Biochem Cell Biol. 2018 Jun;99:169-177. doi: 10.1016/j.biocel.2018.03.020. Epub 2018 Apr 7.
18. Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-alpha levels, and IL-10 mRNA, TNF-alpha mRNA expression levels, cerebral TGF-beta1 positive expression level and its neuroprotective mechanisms in CIR rats. Liang XY, etal., Mol Biol Rep. 2013 Apr;40(4):3419-27. doi: 10.1007/s11033-012-2419-9. Epub 2013 Feb 2.
19. Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. Lin YY, etal., Cardiovasc Toxicol. 2017 Apr;17(2):163-174. doi: 10.1007/s12012-016-9370-2.
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia. Pai P, etal., J Appl Physiol (1985). 2016 Apr 15;120(8):982-90. doi: 10.1152/japplphysiol.01109.2014. Epub 2016 Jan 14.
24. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of alpha(2)-adrenoceptors and extracellular signal-regulated kinases. Ramos-Miguel A, etal., J Psychopharmacol. 2011 Dec;25(12):1691-702. doi: 10.1177/0269881110387842. Epub 2010 Nov 18.
28. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. The many roles of FAS receptor signaling in the immune system. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
32. Absence or low expression of fas-associated protein with death domain in acute myeloid leukemia cells predicts resistance to chemotherapy and poor outcome. Tourneur L, etal., Cancer Res. 2004 Nov 1;64(21):8101-8.
33. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
34. Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy. Wang F, etal., Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E861-73. doi: 10.1152/ajpendo.00215.2015. Epub 2015 Sep 29.
35. MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD. Wang JX, etal., Circ Res. 2015 Jul 31;117(4):352-63. doi: 10.1161/CIRCRESAHA.117.305781. Epub 2015 Jun 2.
36. Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease. Wu CK, etal., Exp Neurol. 2005 Oct;195(2):484-96. doi: 10.1016/j.expneurol.2005.06.020.
37. Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats. Xu DQ, etal., Acta Pharmacol Sin. 2013 Dec;34(12):1515-25. doi: 10.1038/aps.2013.96. Epub 2013 Oct 14.
38. Anti-apoptosis effects on hearts of SHSST cyclodextrin complex in a carbon tetrachloride-induced cirrhotic cardiomyopathy rat model. Yang CH, etal., Chin J Physiol. 2015 Feb 28;58(1):38-45. doi: 10.4077/CJP.2015.BAD286.
39. Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl -induced hepatotoxicity in rats. Yang CH, etal., Environ Toxicol. 2014 Nov 28. doi: 10.1002/tox.22078.
Additional References at PubMed
PMID:7536190   PMID:8565075   PMID:8649383   PMID:9506948   PMID:9521326   PMID:9916988   PMID:10026132   PMID:10072523   PMID:10101687   PMID:10347191   PMID:10349636   PMID:10403638  
PMID:10442092   PMID:10588860   PMID:10862756   PMID:10964568   PMID:11034606   PMID:11042159   PMID:11076861   PMID:11353862   PMID:11498534   PMID:11978827   PMID:12063258   PMID:12115619  
PMID:12477932   PMID:12500197   PMID:12705854   PMID:12743602   PMID:12817005   PMID:12884866   PMID:12887920   PMID:13679421   PMID:14701813   PMID:15017386   PMID:15173180   PMID:15337758  
PMID:15355863   PMID:15376191   PMID:15383280   PMID:15489334   PMID:15549108   PMID:15632112   PMID:15635090   PMID:15782199   PMID:16009710   PMID:16061179   PMID:16116191   PMID:16141072  
PMID:16141073   PMID:16177127   PMID:16183742   PMID:16437623   PMID:16469705   PMID:16585540   PMID:16688118   PMID:16709845   PMID:17041756   PMID:17159908   PMID:17277150   PMID:17292824  
PMID:17553783   PMID:17785432   PMID:18287559   PMID:18309324   PMID:18417150   PMID:18445587   PMID:18455983   PMID:18543108   PMID:18708583   PMID:18946037   PMID:19176810   PMID:19194472  
PMID:19203997   PMID:19301394   PMID:19342627   PMID:19524513   PMID:19727529   PMID:19855068   PMID:20353946   PMID:20487000   PMID:20615958   PMID:20889682   PMID:20943999   PMID:21052097  
PMID:21068410   PMID:21115735   PMID:21267068   PMID:21368761   PMID:21368763   PMID:21382479   PMID:21677750   PMID:21746883   PMID:21804564   PMID:21873635   PMID:21876153   PMID:22000287  
PMID:22037414   PMID:22089168   PMID:22362782   PMID:22406316   PMID:22582393   PMID:22675671   PMID:23144495   PMID:23689606   PMID:23727238   PMID:23744592   PMID:23828893   PMID:23898178  
PMID:23935974   PMID:24058479   PMID:24144979   PMID:24194600   PMID:24375410   PMID:24453255   PMID:24557836   PMID:24799700   PMID:24813850   PMID:24832470   PMID:24901044   PMID:24901053  
PMID:24971483   PMID:25078620   PMID:25132550   PMID:25150572   PMID:25278099   PMID:25443631   PMID:25500368   PMID:25567679   PMID:25581503   PMID:25628462   PMID:25641109   PMID:25704009  
PMID:25767797   PMID:25874713   PMID:26104484   PMID:26303234   PMID:26437781   PMID:26555174   PMID:26649818   PMID:26982364   PMID:27007676   PMID:27253414   PMID:27258329   PMID:27286445  
PMID:27321907   PMID:27357657   PMID:27458237   PMID:27498868   PMID:27523270   PMID:27561390   PMID:27584790   PMID:27619661   PMID:27626380   PMID:27676214   PMID:27767039   PMID:27799292  
PMID:27819681   PMID:27819682   PMID:28273458   PMID:28445730   PMID:28574501   PMID:28628031   PMID:28842570   PMID:28919893   PMID:29053143   PMID:29167229   PMID:29203883   PMID:29440439  
PMID:29581256   PMID:29695863   PMID:29879109   PMID:29891719   PMID:30185824   PMID:30209212   PMID:30250469   PMID:30420664   PMID:30692261   PMID:30741936   PMID:30988397   PMID:31147458  
PMID:31149635   PMID:31239234   PMID:31346084   PMID:31493386   PMID:31511692   PMID:31513427   PMID:31519886   PMID:31519887   PMID:31723262   PMID:31869420   PMID:32075762   PMID:32296175  
PMID:32428502   PMID:33271062   PMID:33278357   PMID:33641090   PMID:33976111   PMID:34029184   PMID:34462571   PMID:34625556   PMID:34625557   PMID:34675436   PMID:35753028   PMID:36191211  
PMID:36281535   PMID:37516311  


Genomics

Comparative Map Data
Fadd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)EnsemblGRCm39 Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBIMGSCv36mm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
FADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,203,296 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,049,402 - 70,053,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36Build 36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
T2T-CHM13v2.01170,218,250 - 70,222,344 (+)NCBIT2T-CHM13v2.0
Fadd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,126,497 - 208,128,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,210,505 - 215,212,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,884,688 - 207,887,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
Fadd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,031,280 - 16,036,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,026,323 - 16,035,808 (-)NCBIChiLan1.0ChiLan1.0
FADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11172,214,724 - 72,218,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01165,300,889 - 65,305,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,590,184 - 68,593,905 (+)NCBIpanpan1.1PanPan1.1panPan2
FADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,765,607 - 48,771,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBIUU_Cfam_GSD_1.0
Fadd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,192,521 - 4,197,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599633,330 - 639,456 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936599633,501 - 639,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,185,675 - 3,194,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fadd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,055,509 - 17,059,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,050,929 - 17,059,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fadd
94 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1424
Count of miRNA genes:644
Interacting mature miRNAs:798
Transcripts:ENSMUST00000033394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse

Markers in Region
U50406  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map770.0UniSTS
Whitehead/MRC_RH71464.75UniSTS
PMC305633P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387144,580,540 - 144,580,798UniSTSGRCm38
MGSCv377151,766,445 - 151,766,703UniSTSGRCm37
Celera7144,344,409 - 144,344,667UniSTS
Cytogenetic Map7F5UniSTS
cM Map770.0UniSTS
Fadd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387144,579,909 - 144,580,051UniSTSGRCm38
MGSCv377151,765,814 - 151,765,956UniSTSGRCm37
Celera7144,343,778 - 144,343,920UniSTS
Cytogenetic Map7F5UniSTS
cM Map770.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033394   ⟹   ENSMUSP00000033394
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)Ensembl
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)Ensembl
RefSeq Acc Id: NM_010175   ⟹   NP_034305
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397144,132,060 - 144,136,178 (-)NCBI
GRCm387144,578,323 - 144,582,441 (-)NCBI
MGSCv377151,764,228 - 151,768,341 (-)RGD
Celera7144,342,191 - 144,346,305 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034305   ⟸   NM_010175
- UniProtKB: Q3TC37 (UniProtKB/Swiss-Prot),   Q61082 (UniProtKB/Swiss-Prot),   Q61160 (UniProtKB/Swiss-Prot),   Q8CD57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033394   ⟸   ENSMUST00000033394
Protein Domains
Death   DED

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61160-F1-model_v2 AlphaFold Q61160 1-205 view protein structure

Promoters
RGD ID:8666287
Promoter ID:EPDNEW_M11175
Type:initiation region
Name:Fadd_1
Description:Mus musculus Fas -associated via death domain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387144,582,441 - 144,582,501EPDNEW
RGD ID:6841064
Promoter ID:MM_KWN:53435
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000083781
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367151,768,029 - 151,768,529 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109324 AgrOrtholog
Ensembl Genes ENSMUSG00000031077 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033394 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14082 UniProtKB/Swiss-Prot
MGD MGI:109324 ENTREZGENE
NCBI Gene 14082 ENTREZGENE
PANTHER FAS-ASSOCIATED DEATH DOMAIN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15077 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fadd PhenoGen
PIRSF FADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FADD_MOUSE UniProtKB/Swiss-Prot
  Q3TC37 ENTREZGENE
  Q61082 ENTREZGENE
  Q61160 ENTREZGENE
  Q8CD57 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3TC37 UniProtKB/Swiss-Prot
  Q61082 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Fadd  Fas associated via death domain  Fadd  Fas (TNFRSF6)-associated via death domain  Symbol and/or name change 5135510 APPROVED