Fadd (Fas (TNFRSF6)-associated via death domain) - Rat Genome Database

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Gene: Fadd (Fas (TNFRSF6)-associated via death domain) Mus musculus
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Symbol: Fadd
Name: Fas (TNFRSF6)-associated via death domain
RGD ID: 732106
MGI Page MGI
Description: Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; mediator of receptor induced toxicity; Mort1/F; Mort1/FADD
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBImm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
aconitine  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (EXP)
cadmium sulfide  (ISO)
capsaicin  (ISO)
casticin  (ISO)
celecoxib  (ISO)
cholesterol  (ISO)
cisplatin  (EXP)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
ferrosoferric oxide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furosemide  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
magnesium oxide  (ISO)
mercury dichloride  (EXP)
ML-7  (ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
naproxen  (ISO)
naringin  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
potassium chromate  (ISO)
probenecid  (EXP)
progesterone  (EXP)
propylparaben  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rutin  (ISO)
S-allylcysteine  (ISO)
SB 203580  (ISO)
SCH 23390  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
behavioral response to cocaine  (ISO)
cardiac muscle tissue development  (TAS)
cellular response to mechanical stimulus  (ISO)
death-inducing signaling complex assembly  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway  (IDA,IGI,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
immune system process  (IEA)
innate immune response  (TAS)
kidney development  (ISO)
lymph node development  (IGI)
motor neuron apoptotic process  (IMP)
necroptotic signaling pathway  (ISO)
negative regulation of activation-induced cell death of T cells  (IMP)
negative regulation of necroptotic process  (IGI)
positive regulation of activated T cell proliferation  (IMP)
positive regulation of adaptive immune response  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (IMP)
positive regulation of extrinsic apoptotic signaling pathway  (IBA,IGI,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interferon-gamma production  (IMP)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of T cell mediated cytotoxicity  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
regulation of apoptotic process  (IEA)
regulation of necroptotic process  (ISO)
response to cocaine  (ISO)
response to morphine  (ISO)
signal transduction  (IEA)
spleen development  (IGI)
T cell differentiation  (TAS)
T cell differentiation in thymus  (IMP)
T cell homeostasis  (IMP)
thymus development  (IGI)
TRAIL-activated apoptotic signaling pathway  (IBA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal embryo size  (IEA)
abnormal enterocyte physiology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal erythrocyte cell number  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neural tube closure  (IEA)
abnormal oligodendrocyte apoptosis  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymocyte apoptosis  (IAGP)
abnormal uterus morphology  (IEA)
cecum inflammation  (IAGP)
colitis  (IAGP)
crypts of Lieberkuhn abscesses  (IAGP)
decreased activated T cell number  (IAGP)
decreased apoptosis  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast apoptosis  (IAGP)
decreased lean body mass  (IEA)
decreased Paneth cell number  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
diarrhea  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
increased B cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased enterocyte apoptosis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased total body fat amount  (IEA)
internal hemorrhage  (IAGP)
intestinal ulcer  (IAGP)
liver inflammation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
spleen hypoplasia  (IAGP)
thin myocardium  (IAGP)
thymus hypoplasia  (IAGP)
trabecula carnea hypoplasia  (IAGP)
References

References - curated
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2. Chen M, etal., Acta Pharmacol Sin. 2016 Apr;37(4):453-62. doi: 10.1038/aps.2015.156. Epub 2016 Mar 7.
3. Cheng SM, etal., Cell Biochem Funct. 2014 Mar;32(2):133-41. doi: 10.1002/cbf.2982. Epub 2013 May 9.
4. Chengke L, etal., Spine (Phila Pa 1976). 2013 Jun 15;38(14):E861-9. doi: 10.1097/BRS.0b013e318294892c.
5. Deng JS, etal., Chem Biol Interact. 2014 Feb 25;209:77-84. doi: 10.1016/j.cbi.2013.11.017. Epub 2013 Dec 17.
6. Dzietko M, etal., Ann Neurol. 2008 Dec;64(6):664-73. doi: 10.1002/ana.21516.
7. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
8. Hafez MM, etal., Biol Res. 2015 Jun 11;48:30. doi: 10.1186/s40659-015-0022-y.
9. Han S, etal., Hum Immunol. 2012 Mar;73(3):316-9. doi: 10.1016/j.humimm.2011.12.018. Epub 2011 Dec 28.
10. Hernández-Hernández E, etal., Neurobiol Aging. 2018 Jul 29;71:115-126. doi: 10.1016/j.neurobiolaging.2018.07.014.
11. Jia J, etal., Exp Neurol. 2009 Jan;215(1):48-52. doi: 10.1016/j.expneurol.2008.09.015. Epub 2008 Oct 7.
12. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
13. Kim CY, etal., J Med Food. 2016 Aug;19(8):746-54. doi: 10.1089/jmf.2016.3686. Epub 2016 Jul 21.
14. Kim SJ, etal., Shock. 2013 Apr;39(4):380-8. doi: 10.1097/SHK.0b013e31828aab7f.
15. Lee SD, etal., J Appl Physiol. 2008 Apr;104(4):1144-53. Epub 2008 Jan 17.
16. Li C, etal., Int J Biochem Cell Biol. 2018 Jun;99:169-177. doi: 10.1016/j.biocel.2018.03.020. Epub 2018 Apr 7.
17. Liang XY, etal., Mol Biol Rep. 2013 Apr;40(4):3419-27. doi: 10.1007/s11033-012-2419-9. Epub 2013 Feb 2.
18. Lin YY, etal., Cardiovasc Toxicol. 2017 Apr;17(2):163-174. doi: 10.1007/s12012-016-9370-2.
19. MGD data from the GO Consortium
20. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. OMIM Disease Annotation Pipeline
22. Pai P, etal., J Appl Physiol (1985). 2016 Apr 15;120(8):982-90. doi: 10.1152/japplphysiol.01109.2014. Epub 2016 Jan 14.
23. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Ramos-Miguel A, etal., J Psychopharmacol. 2011 Dec;25(12):1691-702. doi: 10.1177/0269881110387842. Epub 2010 Nov 18.
27. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
28. RGD automated import pipeline
29. RGD automated import pipeline for gene-chemical interactions
30. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
31. Tourneur L, etal., Cancer Res. 2004 Nov 1;64(21):8101-8.
32. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
33. Wang F, etal., Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E861-73. doi: 10.1152/ajpendo.00215.2015. Epub 2015 Sep 29.
34. Wang JX, etal., Circ Res. 2015 Jul 31;117(4):352-63. doi: 10.1161/CIRCRESAHA.117.305781. Epub 2015 Jun 2.
35. Wu CK, etal., Exp Neurol. 2005 Oct;195(2):484-96. doi: 10.1016/j.expneurol.2005.06.020.
36. Xu DQ, etal., Acta Pharmacol Sin. 2013 Dec;34(12):1515-25. doi: 10.1038/aps.2013.96. Epub 2013 Oct 14.
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38. Yang CH, etal., Environ Toxicol. 2014 Nov 28. doi: 10.1002/tox.22078.
Additional References at PubMed
PMID:7536190   PMID:8565075   PMID:8649383   PMID:9506948   PMID:9521326   PMID:9916988   PMID:10026132   PMID:10072523   PMID:10101687   PMID:10347191   PMID:10349636   PMID:10403638  
PMID:10442092   PMID:10588860   PMID:10862756   PMID:10964568   PMID:11034606   PMID:11042159   PMID:11076861   PMID:11353862   PMID:11498534   PMID:11978827   PMID:12063258   PMID:12115619  
PMID:12477932   PMID:12500197   PMID:12705854   PMID:12743602   PMID:12817005   PMID:12884866   PMID:13679421   PMID:14701813   PMID:15017386   PMID:15173180   PMID:15337758   PMID:15355863  
PMID:15376191   PMID:15383280   PMID:15489334   PMID:15549108   PMID:15632112   PMID:15635090   PMID:15782199   PMID:16009710   PMID:16061179   PMID:16116191   PMID:16141072   PMID:16141073  
PMID:16177127   PMID:16183742   PMID:16437623   PMID:16469705   PMID:16585540   PMID:16688118   PMID:16709845   PMID:17041756   PMID:17159908   PMID:17277150   PMID:17292824   PMID:17553783  
PMID:17785432   PMID:18287559   PMID:18309324   PMID:18417150   PMID:18445587   PMID:18455983   PMID:18543108   PMID:18708583   PMID:18946037   PMID:19176810   PMID:19194472   PMID:19203997  
PMID:19301394   PMID:19342627   PMID:19524513   PMID:19727529   PMID:19855068   PMID:20353946   PMID:20487000   PMID:20615958   PMID:20889682   PMID:20943999   PMID:21052097   PMID:21068410  
PMID:21115735   PMID:21267068   PMID:21368761   PMID:21368763   PMID:21382479   PMID:21677750   PMID:21746883   PMID:21804564   PMID:21873635   PMID:21876153   PMID:22000287   PMID:22037414  
PMID:22089168   PMID:22362782   PMID:22406316   PMID:22582393   PMID:22675671   PMID:23144495   PMID:23689606   PMID:23727238   PMID:23744592   PMID:23828893   PMID:23898178   PMID:23935974  
PMID:24058479   PMID:24144979   PMID:24194600   PMID:24375410   PMID:24453255   PMID:24557836   PMID:24799700   PMID:24813850   PMID:24832470   PMID:24901044   PMID:24901053   PMID:24971483  
PMID:25078620   PMID:25132550   PMID:25150572   PMID:25278099   PMID:25443631   PMID:25500368   PMID:25567679   PMID:25581503   PMID:25628462   PMID:25641109   PMID:25704009   PMID:25767797  
PMID:25874713   PMID:26104484   PMID:26303234   PMID:26437781   PMID:26555174   PMID:26649818   PMID:26982364   PMID:27007676   PMID:27258329   PMID:27286445   PMID:27321907   PMID:27357657  
PMID:27458237   PMID:27498868   PMID:27523270   PMID:27561390   PMID:27584790   PMID:27619661   PMID:27626380   PMID:27676214   PMID:27767039   PMID:27799292   PMID:27819681   PMID:27819682  
PMID:28273458   PMID:28445730   PMID:28574501   PMID:28628031   PMID:28842570   PMID:28919893   PMID:29167229   PMID:29203883   PMID:29440439   PMID:29581256   PMID:29695863   PMID:29879109  
PMID:29891719   PMID:30185824   PMID:30209212   PMID:30250469   PMID:30420664   PMID:30692261   PMID:30741936   PMID:30988397   PMID:31147458   PMID:31149635   PMID:31239234   PMID:31346084  
PMID:31493386   PMID:31513427   PMID:31519886   PMID:31519887   PMID:31723262   PMID:31869420   PMID:32075762   PMID:33271062   PMID:33278357   PMID:34029184  


Genomics

Comparative Map Data
Fadd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,132,060 - 144,136,178 (-)NCBIGRCm39mm39
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)Ensembl
GRCm387144,578,323 - 144,582,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv377151,764,228 - 151,768,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv367144,387,713 - 144,391,826 (-)NCBImm8
Celera7144,342,191 - 144,346,305 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.85NCBI
FADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1170,203,296 - 70,207,390 (+)EnsemblGRCh38hg38GRCh38
GRCh381170,203,296 - 70,207,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371170,049,402 - 70,053,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,726,917 - 69,731,144 (+)NCBINCBI36hg18NCBI36
Build 341169,726,916 - 69,731,134NCBI
Celera1167,315,851 - 67,320,090 (+)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1166,308,990 - 66,313,229 (+)NCBIHuRef
CHM1_11169,932,172 - 69,936,414 (+)NCBICHM1_1
Fadd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21199,743,200 - 199,745,746 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1199,739,994 - 199,745,653 (-)Ensembl
Rnor_6.01217,746,176 - 217,748,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,742,929 - 217,748,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,603,556 - 224,605,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,010,363 - 205,012,768 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,163,017 - 205,166,234 (-)NCBI
Celera1197,302,715 - 197,305,120 (-)NCBICelera
Cytogenetic Map1q42NCBI
Fadd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,031,280 - 16,036,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,026,323 - 16,035,808 (-)NCBIChiLan1.0ChiLan1.0
FADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11168,590,184 - 68,593,905 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01165,300,889 - 65,305,020 (+)NCBIMhudiblu_PPA_v0panPan3
FADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,087,447 - 48,094,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1846,692,062 - 46,704,606 (-)NCBI
ROS_Cfam_1.01848,765,020 - 48,771,948 (-)NCBI
UMICH_Zoey_3.11848,212,163 - 48,219,087 (-)NCBI
UNSW_CanFamBas_1.01847,792,264 - 47,804,830 (-)NCBI
UU_Cfam_GSD_1.01848,543,968 - 48,550,895 (-)NCBI
Fadd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,192,521 - 4,197,087 (-)NCBI
SpeTri2.0NW_004936599633,501 - 639,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,186,744 - 3,194,792 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.123,191,718 - 3,194,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,388,619 - 1,389,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,358,314 - 4,361,863 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038101,642,664 - 101,647,269 (-)NCBIVero_WHO_p1.0
Fadd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476717,050,929 - 17,059,648 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
U50406  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map770.0UniSTS
Whitehead/MRC_RH71464.75UniSTS
PMC305633P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387144,580,540 - 144,580,798UniSTSGRCm38
MGSCv377151,766,445 - 151,766,703UniSTSGRCm37
Celera7144,344,409 - 144,344,667UniSTS
Cytogenetic Map7F5UniSTS
cM Map770.0UniSTS
Fadd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387144,579,909 - 144,580,051UniSTSGRCm38
MGSCv377151,765,814 - 151,765,956UniSTSGRCm37
Celera7144,343,778 - 144,343,920UniSTS
Cytogenetic Map7F5UniSTS
cM Map770.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127844414145441459Mouse
14746988Manh63_mmandible shape 63 (mouse)7128181700145441459Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir134mmu-miR-134-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI17916804

Predicted Target Of
Summary Value
Count of predictions:1424
Count of miRNA genes:644
Interacting mature miRNAs:798
Transcripts:ENSMUST00000033394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033394   ⟹   ENSMUSP00000033394
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7144,131,055 - 144,136,200 (-)Ensembl
GRCm38.p6 Ensembl7144,577,318 - 144,582,463 (-)Ensembl
RefSeq Acc Id: NM_010175   ⟹   NP_034305
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397144,132,060 - 144,136,178 (-)NCBI
GRCm387144,578,323 - 144,582,441 (-)NCBI
MGSCv377151,764,228 - 151,768,341 (-)RGD
Celera7144,342,191 - 144,346,305 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034305   ⟸   NM_010175
- UniProtKB: Q61160 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033394   ⟸   ENSMUST00000033394
Protein Domains
Death   DED

Promoters
RGD ID:8666287
Promoter ID:EPDNEW_M11175
Type:initiation region
Name:Fadd_1
Description:Mus musculus Fas -associated via death domain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387144,582,441 - 144,582,501EPDNEW
RGD ID:6841064
Promoter ID:MM_KWN:53435
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000083781
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367151,768,029 - 151,768,529 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109324 AgrOrtholog
Ensembl Genes ENSMUSG00000031077 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000033394 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033394 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14082 UniProtKB/Swiss-Prot
MGD MGI:109324 ENTREZGENE
NCBI Gene 14082 ENTREZGENE
PANTHER PTHR15077 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fadd PhenoGen
PIRSF FADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FADD_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CD57_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TC37 UniProtKB/Swiss-Prot
  Q61082 UniProtKB/Swiss-Prot