Ripk1 (receptor interacting serine/threonine kinase 1) - Rat Genome Database

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Gene: Ripk1 (receptor interacting serine/threonine kinase 1) Rattus norvegicus
Analyze
Symbol: Ripk1
Name: receptor interacting serine/threonine kinase 1
RGD ID: 1310158
Description: Enables death receptor binding activity. Involved in positive regulation of necroptotic process; positive regulation of neuron apoptotic process; and positive regulation of non-canonical NF-kappaB signal transduction. Part of protein-containing complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1); PARTICIPATES IN ceramide signaling pathway; FasL mediated signaling pathway; Toll-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC306886; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,044,983 - 31,077,167 (-)NCBIGRCr8
mRatBN7.21730,839,639 - 30,871,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,839,650 - 30,871,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,653,759 - 30,685,973 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,257,504 - 32,289,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,649,503 - 30,681,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01731,537,580 - 31,569,904 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1731,537,591 - 31,569,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01733,430,650 - 33,462,906 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,183,591 - 37,216,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,188,622 - 37,213,864 (-)NCBI
Celera1730,403,934 - 30,436,026 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
betaxolol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
ceruletide  (EXP)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
DDE  (ISO)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
Dihydrotanshinone I  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
ferric oxide  (EXP)
fingolimod hydrochloride  (ISO)
fumonisin B1  (ISO)
furosemide  (EXP)
galangin  (EXP)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
lycopene  (EXP)
maneb  (ISO)
mangiferin  (ISO)
Melarsoprol  (ISO)
melatonin  (ISO)
metformin  (ISO)
methamidophos  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
Myrtucommulone A  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
omethoate  (ISO)
osthole  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
Pranoprofen  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propacetamol  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
pterostilbene  (ISO)
quetiapine fumarate  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
scutellarin  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium sulfite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tricalcium bis(phosphate)  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IEA,ISO,ISS)
apoptotic process  (IEA,ISO,ISS)
canonical NF-kappaB signal transduction  (ISO)
cellular response to cytokine stimulus  (IEA)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
MAPK cascade  (IEA)
necroptotic process  (IEA,ISO,ISS)
necroptotic signaling pathway  (IBA,IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
negative regulation of necroptotic process  (IEA,ISO)
peptidyl-serine autophosphorylation  (ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of defense response  (IEA)
positive regulation of execution phase of apoptosis  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-6-mediated signaling pathway  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of metabolic process  (IEA)
positive regulation of miRNA processing  (IEA,ISO)
positive regulation of necroptotic process  (IEA,IMP,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IMP)
positive regulation of phosphorylation  (IEA,ISO)
positive regulation of programmed cell death  (IEA,ISO)
positive regulation of programmed necrotic cell death  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transferase activity  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
programmed necrotic cell death  (IEA,ISO)
protein autophosphorylation  (ISO)
protein catabolic process  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
response to oxidative stress  (IEA,ISO)
response to tumor necrosis factor  (IEA,ISO)
ripoptosome assembly  (IEA,ISO,ISS)
ripoptosome assembly involved in necroptotic process  (IEA,ISO)
signal transduction  (IEA)
T cell apoptotic process  (IEA,ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tumor necrosis factor. Chu WM, Cancer Lett. 2013 Jan 28;328(2):222-5. doi: 10.1016/j.canlet.2012.10.014. Epub 2012 Oct 22.
2. Fas antigen/CD-95 upregulation and activation during castration-induced regression of the rat ventral prostate gland. de la Taille A, etal., Prostate. 1999 Jul 1;40(2):89-96.
3. Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia. Fricker M, etal., J Biol Chem. 2013 Mar 29;288(13):9145-52. doi: 10.1074/jbc.M112.427880. Epub 2013 Feb 5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
7. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Murakami Y, etal., Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14598-603. doi: 10.1073/pnas.1206937109. Epub 2012 Aug 20.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway. Qi Y, etal., Cell Cycle. 2020 Jun;19(11):1298-1313. doi: 10.1080/15384101.2020.1749472. Epub 2020 Apr 19.
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. [Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions]. Shi YJ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Sep;29(9):1802-5.
15. [Expression of caspase-8, receptor interacting protein and nuclear factor-kappaBp65 in oral lichen planus]. Shi YJ, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2010 Jan;45(1):11-5.
16. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
17. Staurosporine induces apoptosis and necroptosis in cultured rat astrocytes. Simenc J and Lipnik-Stangelj M, Drug Chem Toxicol. 2012 Oct;35(4):399-405. doi: 10.3109/01480545.2011.633087. Epub 2012 Feb 29.
18. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
19. MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD. Wang JX, etal., Circ Res. 2015 Jul 31;117(4):352-63. doi: 10.1161/CIRCRESAHA.117.305781. Epub 2015 Jun 2.
Additional References at PubMed
PMID:7538908   PMID:8612133   PMID:9044836   PMID:10521396   PMID:11101870   PMID:12761501   PMID:14743216   PMID:15001576   PMID:16127453   PMID:16507998   PMID:16611992   PMID:17047155  
PMID:17389591   PMID:18450452   PMID:19498109   PMID:20125124   PMID:20550618   PMID:21052097   PMID:21525013   PMID:21737330   PMID:21876153   PMID:21931591   PMID:22028622   PMID:22037414  
PMID:22089168   PMID:22173242   PMID:22265413   PMID:22265414   PMID:22274400   PMID:22817896   PMID:22891283   PMID:23473668   PMID:23788031   PMID:25416956   PMID:25907058   PMID:26020802  
PMID:26985994   PMID:27258785   PMID:27538408   PMID:27929749   PMID:28140659   PMID:28289909   PMID:28701375   PMID:28816233   PMID:28842570   PMID:29102662   PMID:29440439   PMID:30185824  
PMID:30439713   PMID:30867408   PMID:30988283   PMID:31511692   PMID:31519886   PMID:31519887   PMID:31827280   PMID:32471717   PMID:34384567   PMID:35008931   PMID:35165268   PMID:37329446  
PMID:39012929  


Genomics

Comparative Map Data
Ripk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,044,983 - 31,077,167 (-)NCBIGRCr8
mRatBN7.21730,839,639 - 30,871,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,839,650 - 30,871,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,653,759 - 30,685,973 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,257,504 - 32,289,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,649,503 - 30,681,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01731,537,580 - 31,569,904 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1731,537,591 - 31,569,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01733,430,650 - 33,462,906 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,183,591 - 37,216,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,188,622 - 37,213,864 (-)NCBI
Celera1730,403,934 - 30,436,026 (-)NCBICelera
Cytogenetic Map17p12NCBI
RIPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3863,063,967 - 3,115,187 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl63,063,824 - 3,115,187 (+)EnsemblGRCh38hg38GRCh38
GRCh3763,064,201 - 3,115,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3663,022,057 - 3,060,420 (+)NCBINCBI36Build 36hg18NCBI36
Build 3463,022,056 - 3,060,420NCBI
Celera64,306,075 - 4,344,292 (+)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,949,918 - 2,985,831 (+)NCBIHuRef
CHM1_163,079,388 - 3,115,320 (+)NCBICHM1_1
T2T-CHM13v2.062,932,866 - 2,983,225 (+)NCBIT2T-CHM13v2.0
Ripk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391334,181,072 - 34,219,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1334,186,346 - 34,221,130 (+)EnsemblGRCm39 Ensembl
GRCm381334,002,225 - 34,035,170 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1334,002,363 - 34,037,147 (+)EnsemblGRCm38mm10GRCm38
MGSCv371334,094,743 - 34,127,039 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361334,010,339 - 34,042,635 (+)NCBIMGSCv36mm8
Celera1335,132,366 - 35,164,663 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.01NCBI
Ripk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,128,931 - 10,168,399 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546510,127,907 - 10,167,895 (-)NCBIChiLan1.0ChiLan1.0
RIPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,695,539 - 17,746,113 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,685,437 - 13,736,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,893,802 - 2,943,162 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,997,290 - 3,046,230 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,997,343 - 3,045,078 (+)Ensemblpanpan1.1panPan2
RIPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,367,796 - 3,407,631 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,263,226 - 3,405,883 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,389,823 - 3,415,320 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,438,752 - 3,464,273 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,423,918 - 3,463,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,314,211 - 3,339,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,335,923 - 3,361,423 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,668,563 - 4,694,064 (+)NCBIUU_Cfam_GSD_1.0
Ripk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494621,056,263 - 21,092,741 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365349,325,249 - 9,361,949 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365349,326,307 - 9,361,943 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,841,239 - 1,880,699 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.171,841,143 - 1,880,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,905,685 - 1,945,193 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RIPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,065,509 - 69,117,825 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,063,047 - 69,105,348 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660442,996,251 - 3,043,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475621,805,599 - 21,830,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475621,806,570 - 21,837,351 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Ripk1
307 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:413
Count of miRNA genes:234
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000023962
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat

Markers in Region
RH134680  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,839,781 - 30,839,980 (+)MAPPERmRatBN7.2
Rnor_6.01731,537,723 - 31,537,921NCBIRnor6.0
Rnor_5.01733,430,793 - 33,430,991UniSTSRnor5.0
RGSC_v3.41737,183,723 - 37,183,921UniSTSRGSC3.4
Celera1730,404,066 - 30,404,264UniSTS
Cytogenetic Map17p12UniSTS
RH141522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,841,517 - 30,841,730 (+)MAPPERmRatBN7.2
Rnor_6.01731,539,459 - 31,539,671NCBIRnor6.0
Rnor_5.01733,432,529 - 33,432,741UniSTSRnor5.0
RGSC_v3.41737,185,459 - 37,185,671UniSTSRGSC3.4
Celera1730,405,802 - 30,406,014UniSTS
RH 3.4 Map17327.01UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023962   ⟹   ENSRNOP00000023962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,839,650 - 30,871,824 (-)Ensembl
Rnor_6.0 Ensembl1731,537,591 - 31,569,904 (-)Ensembl
RefSeq Acc Id: NM_001107350   ⟹   NP_001100820
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,044,994 - 31,077,167 (-)NCBI
mRatBN7.21730,839,650 - 30,871,824 (-)NCBI
Rnor_6.01731,537,591 - 31,569,904 (-)NCBI
Rnor_5.01733,430,650 - 33,462,906 (-)NCBI
RGSC_v3.41737,183,591 - 37,216,533 (-)RGD
Celera1730,403,934 - 30,436,026 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600526   ⟹   XP_017456015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,044,983 - 31,077,004 (-)NCBI
mRatBN7.21730,839,639 - 30,871,661 (-)NCBI
Rnor_6.01731,537,580 - 31,569,690 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600528   ⟹   XP_017456017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,044,983 - 31,077,005 (-)NCBI
mRatBN7.21730,839,639 - 30,871,660 (-)NCBI
Rnor_6.01731,537,580 - 31,569,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600529   ⟹   XP_017456018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,044,983 - 31,077,004 (-)NCBI
mRatBN7.21730,839,639 - 30,871,661 (-)NCBI
Rnor_6.01731,537,580 - 31,569,690 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095696   ⟹   XP_038951624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,044,983 - 31,066,663 (-)NCBI
mRatBN7.21730,839,639 - 30,861,319 (-)NCBI
RefSeq Acc Id: XM_063276410   ⟹   XP_063132480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,044,983 - 31,077,004 (-)NCBI
RefSeq Acc Id: NP_001100820   ⟸   NM_001107350
- UniProtKB: D3ZYL0 (UniProtKB/TrEMBL),   A6J7H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456018   ⟸   XM_017600529
- Peptide Label: isoform X1
- UniProtKB: D3ZYL0 (UniProtKB/TrEMBL),   A6J7H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456015   ⟸   XM_017600526
- Peptide Label: isoform X1
- UniProtKB: D3ZYL0 (UniProtKB/TrEMBL),   A6J7H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456017   ⟸   XM_017600528
- Peptide Label: isoform X1
- UniProtKB: D3ZYL0 (UniProtKB/TrEMBL),   A6J7H3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023962   ⟸   ENSRNOT00000023962
RefSeq Acc Id: XP_038951624   ⟸   XM_039095696
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132480   ⟸   XM_063276410
- Peptide Label: isoform X1
- UniProtKB: A6J7H3 (UniProtKB/TrEMBL),   D3ZYL0 (UniProtKB/TrEMBL)
Protein Domains
Death   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYL0-F1-model_v2 AlphaFold D3ZYL0 1-658 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700414
Promoter ID:EPDNEW_R10938
Type:multiple initiation site
Name:Ripk1_1
Description:receptor interacting serine/threonine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01731,569,895 - 31,569,955EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310158 AgrOrtholog
BioCyc Gene G2FUF-9598 BioCyc
Ensembl Genes ENSRNOG00000017787 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023962 ENTREZGENE
  ENSRNOT00000023962.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  RHIM_dom UniProtKB/TrEMBL
  RIP1_Death UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Ser/Thr_Kinases-Pseudokinases UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:306886 UniProtKB/TrEMBL
NCBI Gene 306886 ENTREZGENE
PANTHER RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 1 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  RHIM UniProtKB/TrEMBL
PhenoGen Ripk1 PhenoGen
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017787 RatGTEx
SMART DEATH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A6J7H3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYL0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Ripk1  receptor interacting serine/threonine kinase 1  Ripk1  receptor (TNFRSF)-interacting serine-threonine kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ripk1  receptor (TNFRSF)-interacting serine-threonine kinase 1   Ripk1_predicted  receptor (TNFRSF)-interacting serine-threonine kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ripk1_predicted  receptor (TNFRSF)-interacting serine-threonine kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED