1-naphthyl isothiocyanate multiple interactions ISO RGD:1320897 6480464 O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RIPK1 mRNA] CTD PMID:15913567 1-naphthyl isothiocyanate increases expression ISO RGD:1320897 6480464 1-Naphthylisothiocyanate results in increased expression of RIPK1 mRNA CTD PMID:15913567 17alpha-ethynylestradiol increases expression ISO RGD:1320897 6480464 Ethinyl Estradiol results in increased expression of RIPK1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1320897 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RIPK1 mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO RGD:1320896 6480464 Estradiol results in decreased expression of RIPK1 mRNA CTD PMID:23373633 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:1320896 6480464 2 more ... CTD PMID:27589474 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1320897 6480464 Tetrachlorodibenzodioxin results in increased expression of RIPK1 mRNA CTD PMID:12167310 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1320897 6480464 Tetrachlorodibenzodioxin affects the expression of RIPK1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1320897 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RIPK1 mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of RIPK1 mRNA CTD PMID:21346803 2-acetamidofluorene decreases expression EXP 6480464 2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA CTD PMID:22584684 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin analog results in increased expression of RIPK1 protein CTD PMID:29860048 3-chloropropane-1,2-diol increases expression ISO RGD:1320897 6480464 alpha-Chlorohydrin analog results in increased expression of RIPK1 mRNA, alpha-Chlorohydrin analog results in increased expression of RIPK1 protein CTD PMID:29860048 4,4'-diaminodiphenylmethane increases expression ISO RGD:1320897 6480464 4, 4'-diaminodiphenylmethane results in increased expression of RIPK1 mRNA CTD PMID:18648102 acrolein multiple interactions EXP 6480464 [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein CTD PMID:24847785 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of RIPK1 mRNA CTD PMID:28959563 adenosine multiple interactions ISO RGD:1320896 6480464 [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 aflatoxin B1 increases expression ISO RGD:1320897 6480464 Aflatoxin B1 results in increased expression of RIPK1 mRNA CTD PMID:19770486 antirheumatic drug decreases expression ISO RGD:1320896 6480464 Antirheumatic Agents results in decreased expression of RIPK1 mRNA CTD PMID:24449571 arsenous acid increases cleavage ISO RGD:1320896 6480464 Arsenic Trioxide results in increased cleavage of RIPK1 protein CTD PMID:15314284 benzo[a]pyrene increases expression ISO RGD:1320896 6480464 Benzo(a)pyrene results in increased expression of RIPK1 mRNA CTD PMID:22316170 bisphenol A increases expression ISO RGD:1320897 6480464 bisphenol A results in increased expression of RIPK1 mRNA CTD PMID:26063408 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of RIPK1 mRNA CTD PMID:25181051 bortezomib increases expression ISO RGD:1320897 6480464 Bortezomib results in increased expression of RIPK1 protein CTD PMID:26769846 bortezomib decreases expression ISO RGD:1320896 6480464 Bortezomib results in decreased expression of RIPK1 mRNA CTD PMID:20471514 carbon nanotube increases expression ISO RGD:1320897 6480464 Nanotubes, Carbon analog results in increased expression of RIPK1 mRNA, Nanotubes, Carbon results in increased expression of RIPK1 mRNA CTD PMID:25554681 ceruletide increases cleavage EXP 6480464 Ceruletide results in increased cleavage of RIPK1 protein CTD PMID:16339139 cisplatin increases expression ISO RGD:1320897 6480464 Cisplatin results in increased expression of RIPK1 mRNA, Cisplatin results in increased expression of RIPK1 protein CTD PMID:21151649 , PMID:26546572 cisplatin multiple interactions ISO RGD:1320897 6480464 4-methyl-N1-(3-phenylpropyl)benzene-1, 2-diamine inhibits the reaction [Cisplatin results in increased expression of RIPK1 protein] CTD PMID:26546572 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of RIPK1 mRNA CTD PMID:17898221 copper(II) sulfate decreases expression ISO RGD:1320896 6480464 Copper Sulfate results in decreased expression of RIPK1 mRNA CTD PMID:19549813 curcumin multiple interactions ISO RGD:1320896 6480464 Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA] CTD PMID:23452621 dextran sulfate multiple interactions ISO RGD:1320897 6480464 15, 16-dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of RIPK1 protein] CTD PMID:29496522 dextran sulfate increases expression ISO RGD:1320897 6480464 Dextran Sulfate results in increased expression of RIPK1 protein CTD PMID:29496522 diarsenic trioxide increases cleavage ISO RGD:1320896 6480464 Arsenic Trioxide results in increased cleavage of RIPK1 protein CTD PMID:15314284 dibutyl phthalate increases expression ISO RGD:1320897 6480464 Dibutyl Phthalate results in increased expression of RIPK1 mRNA CTD PMID:21266533 dioxygen increases expression ISO RGD:1320896 6480464 Oxygen deficiency results in increased expression of RIPK1 mRNA CTD PMID:23452621 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of RIPK1 protein CTD PMID:29605020 dioxygen multiple interactions ISO RGD:1320896 6480464 3 more ... CTD PMID:23452621 ethanol decreases expression ISO RGD:1320897 6480464 Ethanol results in decreased expression of RIPK1 mRNA, Ethanol results in decreased expression of RIPK1 protein CTD PMID:26769846 ethanol affects expression ISO RGD:1320897 6480464 Ethanol affects the expression of RIPK1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1320896 6480464 Ethanol results in increased expression of RIPK1 protein CTD PMID:30853489 ethanol multiple interactions ISO RGD:1320896 6480464 Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK1 protein] CTD PMID:30853489 ferric oxide multiple interactions EXP 6480464 [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein CTD PMID:24847785 fingolimod hydrochloride multiple interactions ISO RGD:1320896 6480464 necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein] CTD PMID:25939952 fingolimod hydrochloride increases expression ISO RGD:1320896 6480464 Fingolimod Hydrochloride results in increased expression of RIPK1 protein CTD PMID:25939952 furosemide affects expression EXP 6480464 Furosemide affects the expression of RIPK1 mRNA CTD PMID:17497460 gallic acid multiple interactions ISO RGD:1320896 6480464 Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK1 protein] CTD PMID:30853489 genistein multiple interactions ISO RGD:1320896 6480464 Genistein inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA] CTD PMID:23452621 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of RIPK1 mRNA CTD PMID:22061828 homocysteine multiple interactions ISO RGD:1320896 6480464 [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 hydralazine multiple interactions ISO RGD:1320896 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of RIPK1 mRNA CTD PMID:17183730 kaempferol multiple interactions ISO RGD:1320897 6480464 kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein] CTD PMID:29574133 leflunomide decreases expression ISO RGD:1320896 6480464 leflunomide results in decreased expression of RIPK1 mRNA CTD PMID:28988120 lipopolysaccharide multiple interactions ISO RGD:1320897 6480464 15 more ... CTD PMID:29496522 , PMID:30633930 maneb multiple interactions ISO RGD:1320897 6480464 [Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA, Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA] CTD PMID:23963992 mangiferin decreases expression ISO RGD:1320897 6480464 mangiferin results in decreased expression of RIPK1 mRNA CTD PMID:15135318 Melarsoprol multiple interactions ISO RGD:1320896 6480464 Melarsoprol results in decreased expression of and results in increased cleavage of RIPK1 protein CTD PMID:15314284 melatonin multiple interactions ISO RGD:1320897 6480464 Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK1 protein] CTD PMID:29763682 metformin multiple interactions ISO RGD:1320896 6480464 [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein] more ... CTD PMID:25412314 methamidophos decreases expression ISO RGD:1320896 6480464 methamidophos results in decreased expression of RIPK1 mRNA CTD PMID:26688254 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of RIPK1 mRNA CTD PMID:22584684 methoxyacetic acid affects expression EXP 6480464 methoxyacetic acid affects the expression of RIPK1 mRNA CTD PMID:20864626 methyl methanesulfonate increases expression ISO RGD:1320896 6480464 Methyl Methanesulfonate results in increased expression of RIPK1 mRNA CTD PMID:23649840 nickel atom increases expression ISO RGD:1320896 6480464 Nickel results in increased expression of RIPK1 mRNA CTD PMID:25583101 o-anisidine increases expression ISO RGD:1320896 6480464 2-anisidine results in increased expression of RIPK1 mRNA CTD PMID:28089782 ochratoxin A decreases expression ISO RGD:1320896 6480464 ochratoxin A results in decreased expression of RIPK1 mRNA CTD PMID:30763683 omethoate decreases expression ISO RGD:1320896 6480464 dimethoxon results in decreased expression of RIPK1 mRNA CTD PMID:26688254 osthole increases expression ISO RGD:1320896 6480464 osthol results in increased expression of RIPK1 protein CTD PMID:29319219 p-menthan-3-ol increases expression ISO RGD:1320896 6480464 Menthol results in increased expression of RIPK1 mRNA CTD PMID:26760959 paracetamol multiple interactions ISO RGD:1320897 6480464 Acetaminophen inhibits the reaction [Acetaminophen results in increased expression of RIPK1 protein] CTD PMID:24440347 paracetamol increases expression ISO RGD:1320896 6480464 Acetaminophen results in increased expression of RIPK1 mRNA CTD PMID:25704631 paracetamol increases expression ISO RGD:1320897 6480464 Acetaminophen results in increased expression of RIPK1 protein CTD PMID:24440347 paraquat multiple interactions ISO RGD:1320897 6480464 [Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA, Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA] CTD PMID:23963992 parathion-methyl decreases expression ISO RGD:1320896 6480464 Methyl Parathion results in decreased expression of RIPK1 mRNA CTD PMID:26688254 pentachlorophenol increases expression ISO RGD:1320897 6480464 Pentachlorophenol results in increased expression of RIPK1 mRNA CTD PMID:23892564 pirinixic acid decreases expression ISO RGD:1320897 6480464 pirinixic acid results in decreased expression of RIPK1 mRNA CTD PMID:23811191 propacetamol increases expression ISO RGD:1320897 6480464 propacetamol results in increased expression of RIPK1 protein CTD PMID:29574133 propacetamol multiple interactions ISO RGD:1320897 6480464 kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein] CTD PMID:29574133 propylparaben increases expression ISO RGD:1320896 6480464 propylparaben results in increased expression of RIPK1 mRNA CTD PMID:24481588 quetiapine fumarate increases expression ISO RGD:1320897 6480464 Quetiapine Fumarate results in increased expression of RIPK1 protein CTD PMID:31220554 quetiapine fumarate multiple interactions ISO RGD:1320897 6480464 AM 281 inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein], Rimonabant inhibits the reaction [Quetiapine Fumarate results in increased expression of RIPK1 protein] CTD PMID:31220554 resveratrol decreases expression ISO RGD:1320897 6480464 resveratrol analog results in decreased expression of RIPK1 protein CTD PMID:15652768 resveratrol multiple interactions ISO RGD:1320896 6480464 resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA] CTD PMID:23452621 rotenone decreases expression ISO RGD:1320896 6480464 Rotenone results in decreased expression of RIPK1 mRNA CTD PMID:29955902 Shikonin multiple interactions ISO RGD:1320897 6480464 shikonin promotes the reaction [RIPK1 protein binds to RIPK3 protein] CTD PMID:23261677 silver atom decreases expression ISO RGD:1320896 6480464 Silver analog results in decreased expression of RIPK1 mRNA CTD PMID:24462830 silver(0) decreases expression ISO RGD:1320896 6480464 Silver analog results in decreased expression of RIPK1 mRNA CTD PMID:24462830 simvastatin multiple interactions ISO RGD:1320896 6480464 [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein] more ... CTD PMID:25412314 sodium arsenate increases expression ISO RGD:1320897 6480464 sodium arsenate results in increased expression of RIPK1 mRNA CTD PMID:30953684 sodium arsenite decreases expression ISO RGD:1320897 6480464 sodium arsenite results in decreased expression of RIPK1 mRNA CTD PMID:31233874 sodium arsenite increases expression ISO RGD:1320897 6480464 sodium arsenite results in increased expression of RIPK1 protein CTD PMID:29763682 sodium arsenite multiple interactions ISO RGD:1320897 6480464 Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK1 protein] CTD PMID:29763682 sodium sulfite increases expression ISO RGD:1320896 6480464 sodium sulfite results in increased expression of RIPK1 protein CTD PMID:23973939 Soman increases expression EXP 6480464 Soman results in increased expression of RIPK1 mRNA CTD PMID:19281266 sunitinib decreases expression ISO RGD:1320896 6480464 Sunitinib results in decreased expression of RIPK1 mRNA CTD PMID:31533062 Triptolide multiple interactions ISO RGD:1320897 6480464 [triptolide co-treated with Lipopolysaccharides] results in increased expression of RIPK1 protein, necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of RIPK1 protein] CTD PMID:30633930 tungsten decreases expression ISO RGD:1320897 6480464 Tungsten results in decreased expression of RIPK1 mRNA CTD PMID:30912803 tunicamycin increases expression ISO RGD:1320896 6480464 Tunicamycin results in increased expression of RIPK1 mRNA CTD PMID:29453283 urethane increases expression ISO RGD:1320896 6480464 Urethane results in increased expression of RIPK1 mRNA CTD PMID:28818685 ursodeoxycholic acid multiple interactions ISO RGD:1320896 6480464 RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein] more ... CTD PMID:21362627 valproic acid affects expression ISO RGD:1320897 6480464 Valproic Acid affects the expression of RIPK1 mRNA CTD PMID:17963808 valproic acid multiple interactions ISO RGD:1320896 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of RIPK1 mRNA CTD PMID:17183730 valproic acid decreases expression ISO RGD:1320897 6480464 Valproic Acid results in decreased expression of RIPK1 mRNA CTD PMID:21427059 vorinostat multiple interactions ISO RGD:1320896 6480464 [vorinostat co-treated with TNFSF10 protein] affects the localization of RIPK1 protein, benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[vorinostat co-treated with TNFSF10 protein] affects the localization of RIPK1 protein] CTD PMID:19643600 WIN 55212-2 decreases expression ISO RGD:1320896 6480464 Win 55212-2 results in decreased expression of RIPK1 protein CTD PMID:30776504
Biological Process activation of JNKK activity IEA GO:0004706 1600115 GO_REF:0000108 GOC GO_REF:0000108 activation of JUN kinase activity IBA FB:FBgn0030018 more ... 13792537 PMID:21873635 GO_Central amyloid fibril formation ISO RGD:1320896 1624291 (PMID:22817896) RGD PMID:22817896 amyloid fibril formation ISS UniProtKB:Q13546 1600115 GO_REF:0000024 UniProt GO_REF:0000024 apoptotic process ISO RGD:1320896 1624291 (PMID:21737330), (PMID:22891283), (PMID:29440439) RGD PMID:21737330 more ... apoptotic process ISO RGD:1320897 1624291 (MGI:MGI:5926457 more ... RGD MGI:MGI:5926457 more ... apoptotic process ISS UniProtKB:Q13546 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell death ISO RGD:1320896 1624291 (PMID:30988283) RGD PMID:30988283 cell death ISO RGD:1320897 1624291 (MGI:MGI:6305600, PMID:30988283) RGD MGI:MGI:6305600 , PMID:30988283 cellular protein catabolic process ISO RGD:1320896 1624291 (PMID:17389591) RGD PMID:17389591 cellular response to growth factor stimulus ISO RGD:1320897 1624291 (MGI:MGI:5306563, PMID:20125124) RGD MGI:MGI:5306563 , PMID:20125124 cellular response to hydrogen peroxide ISO RGD:1320897 1624291 (MGI:MGI:6140989, PMID:27258785) RGD MGI:MGI:6140989 , PMID:27258785 cellular response to tumor necrosis factor ISO RGD:1320896 1624291 (PMID:17389591) RGD PMID:17389591 extrinsic apoptotic signaling pathway ISO RGD:1320896 1624291 (PMID:10521396), (PMID:7538908), (PMID:8612133) RGD PMID:10521396 more ... necroptotic process ISO RGD:1320896 1624291 (PMID:21737330), (PMID:22265414), (PMID:29440439) RGD PMID:21737330 more ... necroptotic process ISO RGD:1320897 1624291 MGI:MGI:104798 more ... RGD MGI:MGI:5306844 more ... necroptotic process ISS UniProtKB:Q13546 1600115 GO_REF:0000024 UniProt GO_REF:0000024 necroptotic signaling pathway ISS UniProtKB:Q60855 1600115 GO_REF:0000024 UniProt GO_REF:0000024 necroptotic signaling pathway ISO RGD:1320896 1624291 (PMID:11101870), (PMID:16507998), (PMID:22265413), (PMID:22817896), (PMID:31827280) RGD PMID:11101870 more ... necroptotic signaling pathway ISO RGD:1320897 1624291 (MGI:MGI:5291865 more ... RGD MGI:MGI:5291865 more ... negative regulation of apoptotic process ISO RGD:1320897 1624291 (MGI:MGI:6377951, PMID:30185824) RGD MGI:MGI:6377951 , PMID:30185824 negative regulation of cardiac muscle cell proliferation ISO RGD:1320897 1624291 (MGI:MGI:6271967, PMID:30321469) RGD MGI:MGI:6271967 , PMID:30321469 negative regulation of extrinsic apoptotic signaling pathway ISO RGD:1320896 1624291 (PMID:21525013) RGD PMID:21525013 negative regulation of extrinsic apoptotic signaling pathway ISO RGD:1320897 1624291 MGI:MGI:104798 more ... RGD MGI:MGI:5521568 , PMID:22089168 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO RGD:1320897 1624291 (MGI:MGI:5306563, PMID:20125124) RGD MGI:MGI:5306563 , PMID:20125124 negative regulation of G1/S transition of mitotic cell cycle ISO RGD:1320897 1624291 (MGI:MGI:6271967, PMID:30321469) RGD MGI:MGI:6271967 , PMID:30321469 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1320896 1624291 (PMID:17047155) RGD PMID:17047155 peptidyl-serine autophosphorylation ISO RGD:1320896 1624291 (PMID:23473668), (PMID:31827280) RGD PMID:23473668 , PMID:31827280 peptidyl-serine autophosphorylation ISO RGD:1320897 1624291 (MGI:MGI:6401044, PMID:31827281) RGD MGI:MGI:6401044 , PMID:31827281 positive regulation of apoptotic process ISO RGD:1320896 1624291 (PMID:17389591), (PMID:22173242), (PMID:8612133) RGD PMID:17389591 more ... positive regulation of cell death IMP 7777171 RGD positive regulation of extrinsic apoptotic signaling pathway ISO RGD:1320897 1624291 MGI:MGI:104798 (MGI:MGI:5510543 , PMID:19498109) RGD MGI:MGI:5510543 , PMID:19498109 positive regulation of extrinsic apoptotic signaling pathway ISO RGD:1320896 1624291 (PMID:21525013), (PMID:22274400) RGD PMID:21525013 , PMID:22274400 positive regulation of hydrogen peroxide-induced cell death ISO RGD:1320896 1624291 (PMID:20550618) RGD PMID:20550618 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1320897 1624291 (MGI:MGI:5521568, PMID:22089168) RGD MGI:MGI:5521568 , PMID:22089168 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1320896 1624291 (PMID:12761501), (PMID:17389591) RGD PMID:12761501 , PMID:17389591 positive regulation of inflammatory response ISO RGD:1320897 1624291 (MGI:MGI:6401044, PMID:31827281) RGD MGI:MGI:6401044 , PMID:31827281 positive regulation of inflammatory response ISO RGD:1320896 1624291 (PMID:31827280) RGD PMID:31827280 positive regulation of interleukin-6-mediated signaling pathway ISO RGD:1320896 1624291 (PMID:31827280) RGD PMID:31827280 positive regulation of interleukin-6-mediated signaling pathway ISO RGD:1320897 1624291 (MGI:MGI:6401044, PMID:31827281) RGD MGI:MGI:6401044 , PMID:31827281 positive regulation of interleukin-8 production ISO RGD:1320896 1624291 (PMID:16127453) RGD PMID:16127453 positive regulation of JNK cascade ISO RGD:1320896 1624291 (PMID:17389591) RGD PMID:17389591 positive regulation of JNK cascade ISO RGD:1320897 1624291 (MGI:MGI:5306563, PMID:20125124) RGD MGI:MGI:5306563 , PMID:20125124 positive regulation of macrophage differentiation ISO RGD:1320896 1624291 (PMID:17047155) RGD PMID:17047155 positive regulation of MAPK cascade ISO RGD:1320897 1624291 (MGI:MGI:5306563, PMID:20125124) RGD MGI:MGI:5306563 , PMID:20125124 positive regulation of necroptotic process IMP 7777172 RGD positive regulation of necroptotic process ISO RGD:1320896 1624291 (PMID:22028622), (PMID:22274400), (PMID:22817896) RGD PMID:22028622 more ... positive regulation of necrotic cell death ISO RGD:1320896 1624291 (PMID:20550618) RGD PMID:20550618 positive regulation of NF-kappaB transcription factor activity ISO RGD:1320896 1624291 (PMID:10521396), (PMID:21931591), (PMID:8612133) RGD PMID:10521396 more ... positive regulation of NF-kappaB transcription factor activity ISO RGD:1320897 1624291 (MGI:MGI:5306563 more ... RGD MGI:MGI:5306563 more ... positive regulation of phosphorylation ISO RGD:1320897 1624291 (MGI:MGI:5315337, PMID:21052097) RGD MGI:MGI:5315337 , PMID:21052097 positive regulation of production of miRNAs involved in gene silencing by miRNA ISO RGD:1320896 1624291 (PMID:26020802) RGD PMID:26020802 positive regulation of programmed cell death ISO RGD:1320896 1624291 (PMID:16611992) RGD PMID:16611992 positive regulation of protein phosphorylation ISO RGD:1320896 1624291 (PMID:17389591) RGD PMID:17389591 positive regulation of transcription by RNA polymerase II ISO RGD:1320896 1624291 (PMID:16127453), (PMID:17389591) RGD PMID:16127453 , PMID:17389591 positive regulation of tumor necrosis factor production ISO RGD:1320896 1624291 (PMID:16127453) RGD PMID:16127453 positive regulation of tumor necrosis factor-mediated signaling pathway ISO RGD:1320897 1624291 (MGI:MGI:6271183, PMID:30439713) RGD MGI:MGI:6271183 , PMID:30439713 programmed necrotic cell death ISO RGD:1320897 1624291 (MGI:MGI:6140989, PMID:27258785) RGD MGI:MGI:6140989 , PMID:27258785 protein autophosphorylation ISO RGD:1320896 1624291 (PMID:29440439), (PMID:8612133) RGD PMID:29440439 , PMID:8612133 protein autophosphorylation ISO RGD:1320897 1624291 (MGI:MGI:6120592 more ... RGD MGI:MGI:6120592 more ... regulation of ATP:ADP antiporter activity ISO RGD:1320896 1624291 (PMID:16507998) RGD PMID:16507998 regulation of reactive oxygen species metabolic process ISO RGD:1320897 1624291 (MGI:MGI:5315337, PMID:21052097) RGD MGI:MGI:5315337 , PMID:21052097 response to tumor necrosis factor ISO RGD:1320896 1624291 (PMID:10521396) RGD PMID:10521396 ripoptosome assembly ISO RGD:1320896 1624291 (PMID:21737330) RGD PMID:21737330 ripoptosome assembly ISS UniProtKB:Q13546 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ripoptosome assembly involved in necroptotic process ISO RGD:1320897 1624291 MGI:MGI:104798 more ... RGD MGI:MGI:5315337 , PMID:21052097 T cell apoptotic process ISO RGD:1320897 1624291 (MGI:MGI:5291865, PMID:21876153) RGD MGI:MGI:5291865 , PMID:21876153 T cell apoptotic process ISS UniProtKB:Q60855 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Cellular Component cytosol ISO RGD:1320896 1624291 RGD GO_REF:0000052 death-inducing signaling complex ISO RGD:1320896 1624291 (PMID:11101870) RGD PMID:11101870 membrane raft IDA 1624191 RGD mitochondrion ISO RGD:1320896 1624291 (PMID:16507998) RGD PMID:16507998 protein-containing complex IDA 1624191 ; 2298728 RGD protein-containing complex ISO RGD:1320896 1624291 (PMID:22817896) RGD PMID:22817896 receptor complex ISO RGD:1320896 1624291 (PMID:8612133) RGD PMID:8612133 ripoptosome ISO RGD:1320896 1624291 (PMID:21737330) RGD PMID:21737330 ripoptosome ISS UniProtKB:Q13546 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Molecular Function ATP binding IEA InterPro:IPR000719 1600115 GO_REF:0000002 InterPro GO_REF:0000002 death domain binding ISO RGD:1320896 1624291 UniProtKB:P78560 , UniProtKB:Q15628 (PMID:8612133), (PMID:9044836) RGD PMID:8612133 , PMID:9044836 death receptor binding IPI RGD:619831 8662865 RGD death receptor binding ISO RGD:1320896 1624291 UniProtKB:P25445 (PMID:7538908) RGD PMID:7538908 identical protein binding ISO RGD:1320896 1624291 UniProtKB:Q13546 (PMID:22817896), (PMID:23473668), (PMID:25416956) RGD PMID:22817896 more ... JUN kinase kinase kinase activity IBA FB:FBgn0030018 more ... 13792537 PMID:21873635 GO_Central protein binding IPI RGD:621313 2298728 following seizure RGD protein binding ISO RGD:1320897 1624291 PR:P25118 more ... RGD MGI:MGI:3766891 more ... protein binding ISO RGD:1320896 1624291 UniProtKB:B7UI21 more ... RGD PMID:10356400 more ... protein binding IPI RGD:1310457 2298728 following seizure RGD protein binding IPI RGD:628700 11341801 RGD protein homodimerization activity ISO RGD:1320896 1624291 (PMID:29440439) RGD PMID:29440439 protein homodimerization activity ISO RGD:1320897 1624291 (MGI:MGI:6120592, PMID:29440439) RGD MGI:MGI:6120592 , PMID:29440439 protein kinase activity ISO RGD:1320896 1624291 (PMID:15001576), (PMID:22265413), (PMID:22817896) RGD PMID:15001576 more ... protein kinase activity ISO RGD:1320897 1624291 (MGI:MGI:6120592, PMID:29440439) RGD MGI:MGI:6120592 , PMID:29440439 protein kinase activity ISS UniProtKB:Q13546 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein serine/threonine kinase activity ISO RGD:1320896 1624291 (PMID:23473668), (PMID:30988283), (PMID:31827280), (PMID:8612133) RGD PMID:23473668 more ... protein serine/threonine kinase activity ISO RGD:1320897 1624291 (MGI:MGI:5912943 more ... RGD MGI:MGI:5912943 more ... protein-containing complex binding IPI RGD:621237 more ... 1624191 heterooligomerization RGD protein-containing complex binding ISO RGD:1320896 1624291 (PMID:22265414) RGD PMID:22265414 ubiquitin protein ligase binding ISO RGD:1320896 1624291 UniProtKB:Q8WZ73 (PMID:18450452) RGD PMID:18450452
Gene-Chemical Interaction Annotations
