Traf2 (Tnf receptor-associated factor 2)

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Gene: Traf2 (Tnf receptor-associated factor 2) Rattus norvegicus

Analyze

Symbol:

Traf2

Name:

Tnf receptor-associated factor 2

RGD ID:

1310457

Description:

Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process and tumor necrosis factor-mediated signaling pathway. Located in cell cortex. Part of protein-containing complex. Orthologous to human TRAF2 (TNF receptor associated factor 2); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 1H-pyrazole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC311786

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	8,341,950 - 8,366,609 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,341,951 - 8,366,538 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,447,015 - 11,471,676 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,033,239 - 20,057,902 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,223,083 - 18,247,745 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,746,061 - 2,770,690 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,746,075 - 2,770,620 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,727,474 - 2,752,102 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,692,740 - 3,717,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,693,271 - 3,717,346 (-)	NCBI
Celera	3	3,167,057 - 3,191,598 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

Leigh disease (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

Transplant Rejection (IEP)

tuberous sclerosis 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-colchicine (ISO)

(S)-naringenin (ISO)

1'-acetoxychavicol acetate (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (EXP,ISO)

1H-pyrazole (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-aminopyridine (EXP)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acrylamide (ISO)

adenine (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (EXP,ISO)

atrazine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

berberine (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP,ISO)

cadmium dichloride (EXP,ISO)

Candesartan cilexetil (EXP)

carbon nanotube (ISO)

ceritinib (ISO)

chloroethene (ISO)

chlorogenic acid (EXP)

chlorpyrifos (ISO)

cinacalcet (ISO)

cisplatin (ISO)

clofibrate (ISO)

cocaine (ISO)

coenzyme Q10 (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

curcumin (ISO)

D-glucose (EXP)

DDT (EXP)

deoxycholic acid (ISO)

diarsenic trioxide (EXP,ISO)

diazinon (ISO)

dibromoacetic acid (ISO)

dicoumarol (ISO)

elemental selenium (ISO)

emodin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (EXP)

etoposide (ISO)

folic acid (ISO)

furan (ISO)

gentamycin (EXP)

glucose (EXP)

hydralazine (ISO)

hydrogen peroxide (ISO)

ibrutinib (ISO)

indometacin (ISO)

isoflurane (EXP)

ivermectin (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

magnesium oxide (ISO)

metformin (ISO)

Mitotane (EXP)

N-acetyl-L-cysteine (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

o-anisidine (ISO)

obeticholic acid (ISO)

p-menthan-3-ol (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

parthenolide (ISO)

pentobarbital (EXP)

perfluorooctane-1-sulfonic acid (ISO)

procymidone (ISO)

pyrethrins (ISO)

quercetin (ISO)

resveratrol (ISO)

Salidroside (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

simvastatin (ISO)

sodium arsenite (ISO)

T-2 toxin (EXP)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vorinostat (ISO)

zerumbone (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

cellular response to nitric oxide (ISO)

innate immune response (ISO)

interleukin-17-mediated signaling pathway (ISO)

mRNA stabilization (ISO)

negative regulation of glial cell apoptotic process (IMP)

non-canonical NF-kappaB signal transduction (ISO)

positive regulation of canonical NF-kappaB signal transduction (IBA,ISO)

positive regulation of extrinsic apoptotic signaling pathway (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of NF-kappaB transcription factor activity (IMP)

positive regulation of T cell cytokine production (ISO)

positive regulation of tumor necrosis factor-mediated signaling pathway (ISO)

programmed necrotic cell death (ISO)

protein autoubiquitination (IEA,ISO)

protein catabolic process (ISO)

protein K63-linked ubiquitination (IBA,ISO)

protein-containing complex assembly (ISO)

regulation of apoptotic process (ISO)

regulation of immunoglobulin production (ISO)

regulation of JNK cascade (ISO)

regulation of protein-containing complex assembly (ISO)

signal transduction (ISO)

signal transduction involved in regulation of gene expression (ISO)

tumor necrosis factor-mediated signaling pathway (IBA,IMP,ISO)

Cellular Component

CD40 receptor complex (ISO)

cell cortex (IDA)

cytoplasm (ISO)

cytoplasmic side of plasma membrane (IBA,ISO)

cytosol (ISO)

IRE1-TRAF2-ASK1 complex (ISO,ISS)

membrane raft (ISO)

protein-containing complex (IDA)

TRAF2-GSTP1 complex (ISO)

tumor necrosis factor receptor superfamily complex (ISO)

ubiquitin ligase complex (ISO)

vesicle membrane (ISO)

Molecular Function

CD40 receptor binding (ISO)

enzyme binding (ISO)

identical protein binding (ISO)

mitogen-activated protein kinase kinase kinase binding (IPI)

molecular adaptor activity (ISO)

protein binding (IPI,ISO)

protein kinase binding (IPI,ISO)

protein phosphatase binding (ISO)

protein-containing complex binding (IPI,ISO)

protein-macromolecule adaptor activity (ISO)

signaling adaptor activity (ISO)

sphingolipid binding (ISO)

thioesterase binding (ISO)

tumor necrosis factor binding (ISO)

tumor necrosis factor receptor binding (IBA,ISO)

ubiquitin protein ligase binding (IBA,ISO)

ubiquitin-protein transferase activity (IBA,ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

apoptotic cell death pathway (IEA)

c-Jun N-terminal kinases MAPK signaling pathway (ISO)

ceramide signaling pathway (ISO)

Endoplasmic Reticulum-associated degradation pathway (IEA)

hepatitis C pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway (IEA)

small cell lung carcinoma pathway (IEA)

Trail mediated signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (IMP,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism.	Akama KT and Van Eldik LJ, J Biol Chem. 2000 Mar 17;275(11):7918-24.
2.	Tumor necrosis factor.	Chu WM, Cancer Lett. 2013 Jan 28;328(2):222-5. doi: 10.1016/j.canlet.2012.10.014. Epub 2012 Oct 22.
3.	Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways.	Fernandes A, etal., Glia. 2011 Jan;59(1):14-25. doi: 10.1002/glia.21072. Epub 2010 Oct 21.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain.	Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
7.	Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.	Matsuzawa A, etal., Antioxid Redox Signal. 2002 Jun;4(3):415-25.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2.	Natoli G, etal., J Biol Chem. 1998 Nov 20;273(47):31262-72.
10.	ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.	Nishitoh H, etal., Genes Dev. 2002 Jun 1;16(11):1345-55.
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.	Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
17.	Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.	Urano F, etal., Science. 2000 Jan 28;287(5453):664-6.
18.	Tumor necrosis factor signaling.	Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
19.	Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts.	Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.

Additional References at PubMed

PMID:8069916	PMID:9020361	PMID:11278723	PMID:11279055	PMID:11374864	PMID:11728344	PMID:11821416	PMID:11907583	PMID:12296995	PMID:12477932	PMID:12958312	PMID:14743216
PMID:15121867	PMID:15125833	PMID:15258597	PMID:15696169	PMID:16189514	PMID:16636664	PMID:17314283	PMID:17626074	PMID:18007661	PMID:18281285	PMID:18952128	PMID:19910209
PMID:20447407	PMID:20562859	PMID:20577214	PMID:20614026	PMID:21525013	PMID:23000344	PMID:23429285	PMID:24011916	PMID:25416956	PMID:26610752	PMID:26674878	PMID:26732833
PMID:28843337	PMID:30561431	PMID:31515488

Genomics

Comparative Map Data

Traf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	8,341,950 - 8,366,609 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,341,951 - 8,366,538 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,447,015 - 11,471,676 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,033,239 - 20,057,902 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,223,083 - 18,247,745 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,746,061 - 2,770,690 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,746,075 - 2,770,620 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,727,474 - 2,752,102 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,692,740 - 3,717,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,693,271 - 3,717,346 (-)	NCBI
Celera	3	3,167,057 - 3,191,598 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

TRAF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,881,958 - 136,926,607 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	136,881,912 - 136,926,607 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,780,968 - 139,821,059 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,900,786 - 138,940,888 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	137,056,801 - 137,096,903	NCBI
Celera	9	110,295,018 - 110,335,296 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,252,590 - 109,280,516 (+)	NCBI		HuRef
CHM1_1	9	139,929,666 - 139,969,783 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,116,134 - 149,160,997 (+)	NCBI		T2T-CHM13v2.0

Traf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,407,994 - 25,436,952 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,407,994 - 25,436,952 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,517,982 - 25,546,940 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,517,982 - 25,546,940 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,373,502 - 25,402,414 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,339,991 - 25,368,903 (-)	NCBI		MGSCv36	mm8
Celera	2	25,245,480 - 25,274,398 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.32	NCBI

Traf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	4,967,984 - 4,983,987 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	4,964,692 - 4,984,359 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRAF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	2,477,075 - 2,518,371 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	107,938,935 - 107,984,797 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	136,912,671 - 136,955,331 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	136,917,358 - 136,955,331 (+)	Ensembl	panpan1.1		panPan2

TRAF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,688,071 - 48,713,936 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,689,331 - 48,703,633 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,901,455 - 47,927,699 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,565,899 - 49,592,130 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,562,621 - 49,590,227 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,342,106 - 48,368,330 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,640,817 - 48,667,045 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,687,986 - 48,714,231 (-)	NCBI		UU_Cfam_GSD_1.0

Traf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,339,938 - 202,370,164 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	1,003,528 - 1,029,249 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	1,004,891 - 1,034,913 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRAF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	1	313,771,819 - 313,789,938 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRAF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,263,688 - 1,309,626 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,263,274 - 1,290,907 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	3,989,592 - 4,034,330 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Traf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	952,574 - 965,661 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	952,574 - 973,511 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Traf2
49 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	114
Interacting mature miRNAs:	121
Transcripts:	ENSRNOT00000008253
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat

Markers in Region

RH131098

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	8,341,975 - 8,342,163 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	2,746,095 - 2,746,282	NCBI	Rnor6.0
Rnor_5.0	3	2,727,508 - 2,727,695	UniSTS	Rnor5.0
RGSC_v3.4	3	3,692,760 - 3,692,947	UniSTS	RGSC3.4
Celera	3	3,167,077 - 3,167,264	UniSTS
Cytogenetic Map	3	p13	UniSTS

UniSTS:224846

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	8,342,174 - 8,342,341 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	2,746,294 - 2,746,460	NCBI	Rnor6.0
Rnor_5.0	3	2,727,707 - 2,727,873	UniSTS	Rnor5.0
RGSC_v3.4	3	3,692,959 - 3,693,125	UniSTS	RGSC3.4
Celera	3	3,167,276 - 3,167,442	UniSTS
Cytogenetic Map	3	p13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	39	50	34	19	34	8	11	41	35	41	11	8
Low		4	7	7		7			33
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC169064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000008253 ⟹ ENSRNOP00000008253

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,341,951 - 8,366,538 (-)	Ensembl
Rnor_6.0 Ensembl	3	2,746,075 - 2,770,620 (-)	Ensembl

RefSeq Acc Id:

NM_001107815 ⟹ NP_001101285

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	8,341,956 - 8,366,505 (-)	NCBI
Rnor_6.0	3	2,746,075 - 2,770,620 (-)	NCBI
Rnor_5.0	3	2,727,474 - 2,752,102 (-)	NCBI
RGSC_v3.4	3	3,692,740 - 3,717,332 (-)	RGD
Celera	3	3,167,057 - 3,191,598 (-)	RGD

Sequence:

show sequence

CGCGAAGACCGTTGGGGCTTTGTGGTGCGTGGGTTATAACTCACATGGCTGCAGCCAGTGTGAC
TTCCCCTGGCTCCCTAGAACTGCTGCAGCCTGGCTTCTCCAAGACCCTTCTGGGGACAAGGTTA
GAAGCCAAGTACCTGTGTTCAGCCTGCAGAAACATCCTGCGGAGGCCATTCCAGGCCCAGTGTG
GGCACCGCTACTGCTCCTTCTGCCTGACCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGC
CTGTGTTCACGAAGGCCTGTATGAAGAAGGCATTTCTATTTTAGAGAGCAGTTCGGCCTTTCCA
GATAACGCTGCCCGCAGAGAGGTGGAGAGCCTGCCAGCCGTCTGTCCCAATGATGGATGCACCT
GGAAGGGGACCTTGAAAGAATACGAGAGCTGCCACGAAGGACTGTGCCCATTCCTGCTGACTGA
GTGCCCTGCGTGTAAAGGCCTGGTTCGCCTCAGCGAGAAGAAGCACCACACTGAGCAGGAATGC
CCCAAAAGGAGCCTGAGCTGCCAGCACTGCAGGGCACCCTGTAGCCATGCAGACCTGGAGCTAC
ACTACGAGGTCTGCCCCAAGTTTCCCTTAACCTGTGATGGCTGTGGCAAGAAGATCTCTCAGGA
GAAGCTTCAGGACCATGTCAGAACGTGCAGTAAGTGCCGGGTCCTCTGCAGGTTCCACGCCATC
GGCTGCTCGGAGCTGGTGGAGACTGAGGACCTGCAGGACCACGAGCTGCAGCGTCTACGGGAAC
ATCTGGCCCTACTGCTGAGCTCGTTCCTGGAGTCCCAAGCCTCACAGAACCAGGTGGGGCCAGA
GCTGTTACAGCGGTGCCAGATTTTGGAGCAGAAGATAGCCACCTTTGAGAACATTGTCTGCGTT
TTGAACCGGGAGGTAGAGAGGGTAGCAGTGACTGCAGAGGCTTGTAGCCGGCAGCACCGTCTGG
ACCAGGACAAGATTGAGGCCCTAAGCAACAAGGTGCAGCAGCTGGAGAGGAGCATCGGCCTCAA
GGACCTGGCCATGGCTGACCTGGAGCAGAAGGTCTCAGAGTTGGAGGTGTCCACCTATGATGGG
GTCTTCATCTGGAAGATCTCCGACTTCGCCAGAAAACGTCAGGAAGCCATCGCTGGCCGGACAC
CTGCTATCTTCTCCCCAGCCTTCTTCACAAGCAGATATGGCTACAAGATGTGTCTCCGGGTCTA
CTTGAATGGCGACGGCACTGGGCGGGGAACTCATCTGTCTCTCTTCTTCGTGGTGATGAAAGGT
CCCAATGATGCTCTCTTACAATGGCCTTTTAATCAGAAGGTGACTTTGATGTTGCTGGACCATA
ACAACCGAGAGCATGTGATCGACGCATTCAGGCCTGATGTAACTTCGTCCTCCTTCCAGAGGCC
TGTCAGTGACATGAATATCGCCAGTGGCTGCCCCCTCTTCTGCCCGGTGTCCAAGATAGAGGCC
AAGAATTCCTACGTGCGGGATGACGCCATCTTCATCAAAGCTATTGTGGACCTGACAGGACTCT
AGCCACCCTACTAAGAGCAGCAGCTCAGTGACGAGCTGTCACATTAGGCCAGCCAGGGCCTTCC
CACACGAGGGTGGGCAGGTTTGGTGTGAATGCCGAATGCCGGGGAGGACCTCAGCCTAAAGCCA
ATCACCATCACACAGACAGGCAGGAAGGAGCCTCCAGTTGGTCCTCAACTGGTAAACTGAGTTG
GAGGGTCAGCTGAGCTCAGGGTCCTGGGGGAACCAGCTGGGGATCTTCTCTTGCTGTATTTTCT
GTCTGGGGAAGGGAGACACCCTTTGGTGGGGTACTCAGAAAGGGCCTCTCAAGAGAGAGCCTCA
AGAGCTGCACCAGGAGCAAGAGTGATTGGCCTTCCCCAGCCCAGCCTTTGGGAAAGAGGCAGGG
GCTGCCCAGGAAAGGCATGCGCCTGCAGAGTGCAGCCCAGGAGAGAAGCGCTCTGGGACATAGG
CACGCACTGGAGCAGGGCCTGCCTGGGCTGCACAGCCCTGCCAGGTGGCCTGTATGGAGGAGAA
GTGATTAAACTATTCAGATGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006233594 ⟹ XP_006233656

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	8,341,950 - 8,366,573 (-)	NCBI
Rnor_6.0	3	2,746,069 - 2,770,640 (-)	NCBI
Rnor_5.0	3	2,727,474 - 2,752,102 (-)	NCBI

Sequence:

show sequence

CCGGCACTGAGTTCCGGGCGCGCGAAGACCGTTGGGTGAGGCGGCGCGGATCTAAGAGGGGGTC
GATTCTCAGCGGCGGCCGGGCCCGGGGCTTTGTGGTGCGTGGGTTATAACTCACATGGCTGCAG
CCAGTGTGACTTCCCCTGGCTCCCTAGAACTGCTGCAGCCTGGCTTCTCCAAGACCCTTCTGGG
GACAAGGTTAGAAGCCAAGTACCTGTGTTCAGCCTGCAGAAACATCCTGCGGAGGCCATTCCAG
GCCCAGTGTGGGCACCGCTACTGCTCCTTCTGCCTGACCAGCATCCTCAGCTCTGGGCCTCAGA
ACTGTGCTGCCTGTGTTCACGAAGGCCTGTATGAAGAAGGCATTTCTATTTTAGAGAGCAGTTC
GGCCTTTCCAGATAACGCTGCCCGCAGAGAGGTGGAGAGCCTGCCAGCCGTCTGTCCCAATGAT
GGATGCACCTGGAAGGGGACCTTGAAAGAATACGAGAGCTGCCACGAAGGACTGTGCCCATTCC
TGCTGACTGAGTGCCCTGCGTGTAAAGGCCTGGTTCGCCTCAGCGAGAAGAAGCACCACACTGA
GCAGGAATGCCCCAAAAGGAGCCTGAGCTGCCAGCACTGCAGGGCACCCTGTAGCCATGCAGAC
CTGGAGCTACACTACGAGGTCTGCCCCAAGTTTCCCTTAACCTGTGATGGCTGTGGCAAGAAGA
TCTCTCAGGAGAAGCTTCAGGACCATGTCAGAACGTGCAGTAAGTGCCGGGTCCTCTGCAGGTT
CCACGCCATCGGCTGCTCGGAGCTGGTGGAGACTGAGGACCTGCAGGACCACGAGCTGCAGCGT
CTACGGGAACATCTGGCCCTACTGCTGAGCTCGTTCCTGGAGTCCCAAGCCTCACAGAACCAGG
TGGGGCCAGAGCTGTTACAGCGGTGCCAGATTTTGGAGCAGAAGATAGCCACCTTTGAGAACAT
TGTCTGCGTTTTGAACCGGGAGGTAGAGAGGGTAGCAGTGACTGCAGAGGCTTGTAGCCGGCAG
CACCGTCTGGACCAGGACAAGATTGAGGCCCTAAGCAACAAGGTGCAGCAGCTGGAGAGGAGCA
TCGGCCTCAAGGACCTGGCCATGGCTGACCTGGAGCAGAAGGTCTCAGAGTTGGAGGTGTCCAC
CTATGATGGGGTCTTCATCTGGAAGATCTCCGACTTCGCCAGAAAACGTCAGGAAGCCATCGCT
GGCCGGACACCTGCTATCTTCTCCCCAGCCTTCTTCACAAGCAGATATGGCTACAAGATGTGTC
TCCGGGTCTACTTGAATGGCGACGGCACTGGGCGGGGAACTCATCTGTCTCTCTTCTTCGTGGT
GATGAAAGGTCCCAATGATGCTCTCTTACAATGGCCTTTTAATCAGAAGGTGACTTTGATGTTG
CTGGACCATAACAACCGAGAGCATGTGATCGACGCATTCAGGCCTGATGTAACTTCGTCCTCCT
TCCAGAGGCCTGTCAGTGACATGAATATCGCCAGTGGCTGCCCCCTCTTCTGCCCGGTGTCCAA
GATAGAGGCCAAGAATTCCTACGTGCGGGATGACGCCATCTTCATCAAAGCTATTGTGGACCTG
ACAGGACTCTAGCCACCCTACTAAGAGCAGCAGCTCAGTGACGAGCTGTCACATTAGGCCAGCC
AGGGCCTTCCCACACGAGGGTGGGCAGGTTTGGTGTGAATGCCGAATGCCGGGGAGGACCTCAG
CCTAAAGCCAATCACCATCACACAGACAGGCAGGAAGGAGCCTCCAGTTGGTCCTCAACTGGTA
AACTGAGTTGGAGGGTCAGCTGAGCTCAGGGTCCTGGGGGAACCAGCTGGGGATCTTCTCTTGC
TGTATTTTCTGTCTGGGGAAGGGAGACACCCTTTGGTGGGGTACTCAGAAAGGGCCTCTCAAGA
GAGAGCCTCAAGAGCTGCACCAGGAGCAAGAGTGATTGGCCTTCCCCAGCCCAGCCTTTGGGAA
AGAGGCAGGGGCTGCCCAGGAAAGGCATGCGCCTGCAGAGTGCAGCCCAGGAGAGAAGCGCTCT
GGGACATAGGCACGCACTGGAGCAGGGCCTGCCTGGGCTGCACAGCCCTGCCAGGTGGCCTGTA
TGGAGGAGAAGTGATTAAACTATTCAGATGTCTGCTGA

hide sequence

RefSeq Acc Id:

XM_006233596 ⟹ XP_006233658

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	8,341,950 - 8,366,609 (-)	NCBI
Rnor_6.0	3	2,746,069 - 2,770,690 (-)	NCBI
Rnor_5.0	3	2,727,474 - 2,752,102 (-)	NCBI

Sequence:

show sequence

GGCGTCTGTCCGTCAGACGGGGCGGGCCGCGACAGCGGGGGTGGTCCCAGCCGGCACTGAGTTC
CGGGCGCGCGAAGACCGTTGGGGCTTTGTGGTGCGTGGGTTATAACTCACATGGCTGCAGCCAG
TGTGACTTCCCCTGGCTCCCTAGAACTGCTGCAGCCTGGCTTCTCCAAGACCCTTCTGGGGACA
AGGTTAGAAGCCAAGTACCTGTGTTCAGCCTGCAGAAACATCCTGCGGAGGCCATTCCAGGCCC
AGTGTGGGCACCGCTACTGCTCCTTCTGCCTGACCAGCATCCTCAGCTCTGGGCCTCAGAACTG
TGCTGCCTGTGTTCACGAAGGCCTGTATGAAGAAGGCATTTCTATTTTAGAGAGCAGTTCGGCC
TTTCCAGATAACGCTGCCCGCAGAGAGGTGGAGAGCCTGCCAGCCGTCTGTCCCAATGATGGAT
GCACCTGGAAGGGGACCTTGAAAGAATACGAGCTACACTACGAGGTCTGCCCCAAGTTTCCCTT
AACCTGTGATGGCTGTGGCAAGAAGATCTCTCAGGAGAAGCTTCAGGACCATGTCAGAACGTGC
AGTAAGTGCCGGGTCCTCTGCAGGTTCCACGCCATCGGCTGCTCGGAGCTGGTGGAGACTGAGG
ACCTGCAGGACCACGAGCTGCAGCGTCTACGGGAACATCTGGCCCTACTGCTGAGCTCGTTCCT
GGAGTCCCAAGCCTCACAGAACCAGGTGGGGCCAGAGCTGTTACAGCGGTGCCAGATTTTGGAG
CAGAAGATAGCCACCTTTGAGAACATTGTCTGCGTTTTGAACCGGGAGGTAGAGAGGGTAGCAG
TGACTGCAGAGGCTTGTAGCCGGCAGCACCGTCTGGACCAGGACAAGATTGAGGCCCTAAGCAA
CAAGGTGCAGCAGCTGGAGAGGAGCATCGGCCTCAAGGACCTGGCCATGGCTGACCTGGAGCAG
AAGGTCTCAGAGTTGGAGGTGTCCACCTATGATGGGGTCTTCATCTGGAAGATCTCCGACTTCG
CCAGAAAACGTCAGGAAGCCATCGCTGGCCGGACACCTGCTATCTTCTCCCCAGCCTTCTTCAC
AAGCAGATATGGCTACAAGATGTGTCTCCGGGTCTACTTGAATGGCGACGGCACTGGGCGGGGA
ACTCATCTGTCTCTCTTCTTCGTGGTGATGAAAGGTCCCAATGATGCTCTCTTACAATGGCCTT
TTAATCAGAAGGTGACTTTGATGTTGCTGGACCATAACAACCGAGAGCATGTGATCGACGCATT
CAGGCCTGATGTAACTTCGTCCTCCTTCCAGAGGCCTGTCAGTGACATGAATATCGCCAGTGGC
TGCCCCCTCTTCTGCCCGGTGTCCAAGATAGAGGCCAAGAATTCCTACGTGCGGGATGACGCCA
TCTTCATCAAAGCTATTGTGGACCTGACAGGACTCTAGCCACCCTACTAAGAGCAGCAGCTCAG
TGACGAGCTGTCACATTAGGCCAGCCAGGGCCTTCCCACACGAGGGTGGGCAGGTTTGGTGTGA
ATGCCGAATGCCGGGGAGGACCTCAGCCTAAAGCCAATCACCATCACACAGACAGGCAGGAAGG
AGCCTCCAGTTGGTCCTCAACTGGTAAACTGAGTTGGAGGGTCAGCTGAGCTCAGGGTCCTGGG
GGAACCAGCTGGGGATCTTCTCTTGCTGTATTTTCTGTCTGGGGAAGGGAGACACCCTTTGGTG
GGGTACTCAGAAAGGGCCTCTCAAGAGAGAGCCTCAAGAGCTGCACCAGGAGCAAGAGTGATTG
GCCTTCCCCAGCCCAGCCTTTGGGAAAGAGGCAGGGGCTGCCCAGGAAAGGCATGCGCCTGCAG
AGTGCAGCCCAGGAGAGAAGCGCTCTGGGACATAGGCACGCACTGGAGCAGGGCCTGCCTGGGC
TGCACAGCCCTGCCAGGTGGCCTGTATGGAGGAGAAGTGATTAAACTATTCAGATGTCTGCTGA

hide sequence

RefSeq Acc Id:

XM_008761588 ⟹ XP_008759810

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	8,341,950 - 8,366,518 (-)	NCBI
Rnor_6.0	3	2,746,061 - 2,770,599 (-)	NCBI

Sequence:

show sequence

CGGCGCGGATCTAAGAGGGGGTCGATTCTCAGCGGCGGCCGGGCCCGGGTCAGGCACCGGGTGG
GAGTGGCGATTGGGGGCTTTGTGGTGCGTGGGTTATAACTCACATGGCTGCAGCCAGTGTGACT
TCCCCTGGCTCCCTAGAACTGCTGCAGCCTGGCTTCTCCAAGACCCTTCTGGGGACAAGGTTAG
AAGCCAAGTACCTGTGTTCAGCCTGCAGAAACATCCTGCGGAGGCCATTCCAGGCCCAGTGTGG
GCACCGCTACTGCTCCTTCTGCCTGACCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCC
TGTGTTCACGAAGGCCTGTATGAAGAAGGCATTTCTATTTTAGAGAGCAGTTCGGCCTTTCCAG
ATAACGCTGCCCGCAGAGAGGTGGAGAGCCTGCCAGCCGTCTGTCCCAATGATGGATGCACCTG
GAAGGGGACCTTGAAAGAATACGAGAGCTGCCACGAAGGACTGTGCCCATTCCTGCTGACTGAG
TGCCCTGCGTGTAAAGGCCTGGTTCGCCTCAGCGAGAAGAAGCACCACACTGAGCAGGAATGCC
CCAAAAGGAGCCTGAGCTGCCAGCACTGCAGGGCACCCTGTAGCCATGCAGACCTGGAGCTACA
CTACGAGGTCTGCCCCAAGTTTCCCTTAACCTGTGATGGCTGTGGCAAGAAGATCTCTCAGGAG
AAGCTTCAGGACCATGTCAGAACGTGCAGTAAGTGCCGGGTCCTCTGCAGGTTCCACGCCATCG
GCTGCTCGGAGCTGGTGGAGACTGAGGACCTGCAGGACCACGAGCTGCAGCGTCTACGGGAACA
TCTGGCCCTACTGCTGAGCTCGTTCCTGGAGTCCCAAGCCTCACAGAACCAGGTGGGGCCAGAG
CTGTTACAGCGGTGCCAGATTTTGGAGCAGAAGATAGCCACCTTTGAGAACATTGTCTGCGTTT
TGAACCGGGAGGTAGAGAGGGTAGCAGTGACTGCAGAGGCTTGTAGCCGGCAGCACCGTCTGGA
CCAGGACAAGATTGAGGCCCTAAGCAACAAGGTGCAGCAGCTGGAGAGGAGCATCGGCCTCAAG
GACCTGGCCATGGCTGACCTGGAGCAGAAGGTCTCAGAGTTGGAGGTGTCCACCTATGATGGGG
TCTTCATCTGGAAGATCTCCGACTTCGCCAGAAAACGTCAGGAAGCCATCGCTGGCCGGACACC
TGCTATCTTCTCCCCAGCCTTCTTCACAAGCAGATATGGCTACAAGATGTGTCTCCGGGTCTAC
TTGAATGGCGACGGCACTGGGCGGGGAACTCATCTGTCTCTCTTCTTCGTGGTGATGAAAGGTC
CCAATGATGCTCTCTTACAATGGCCTTTTAATCAGAAGGTGACTTTGATGTTGCTGGACCATAA
CAACCGAGAGCATGTGATCGACGCATTCAGGCCTGATGTAACTTCGTCCTCCTTCCAGAGGCCT
GTCAGTGACATGAATATCGCCAGTGGCTGCCCCCTCTTCTGCCCGGTGTCCAAGATAGAGGCCA
AGAATTCCTACGTGCGGGATGACGCCATCTTCATCAAAGCTATTGTGGACCTGACAGGACTCTA
GCCACCCTACTAAGAGCAGCAGCTCAGTGACGAGCTGTCACATTAGGCCAGCCAGGGCCTTCCC
ACACGAGGGTGGGCAGGTTTGGTGTGAATGCCGAATGCCGGGGAGGACCTCAGCCTAAAGCCAA
TCACCATCACACAGACAGGCAGGAAGGAGCCTCCAGTTGGTCCTCAACTGGTAAACTGAGTTGG
AGGGTCAGCTGAGCTCAGGGTCCTGGGGGAACCAGCTGGGGATCTTCTCTTGCTGTATTTTCTG
TCTGGGGAAGGGAGACACCCTTTGGTGGGGTACTCAGAAAGGGCCTCTCAAGAGAGAGCCTCAA
GAGCTGCACCAGGAGCAAGAGTGATTGGCCTTCCCCAGCCCAGCCTTTGGGAAAGAGGCAGGGG
CTGCCCAGGAAAGGCATGCGCCTGCAGAGTGCAGCCCAGGAGAGAAGCGCTCTGGGACATAGGC
ACGCACTGGAGCAGGGCCTGCCTGGGCTGCACAGCCCTGCCAGGTGGCCTGTATGGAGGAGAAG
TGATTAAACTATTCAGATGTCTGCTGAGTGGTGTT

hide sequence

RefSeq Acc Id:

XM_039105182 ⟹ XP_038961110

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	8,341,950 - 8,366,396 (-)	NCBI

RefSeq Acc Id:

XM_039105183 ⟹ XP_038961111

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	8,341,950 - 8,366,305 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101285	(Get FASTA)	NCBI Sequence Viewer
	XP_006233656	(Get FASTA)	NCBI Sequence Viewer
	XP_006233658	(Get FASTA)	NCBI Sequence Viewer
	XP_008759810	(Get FASTA)	NCBI Sequence Viewer
	XP_038961110	(Get FASTA)	NCBI Sequence Viewer
	XP_038961111	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI69064	(Get FASTA)	NCBI Sequence Viewer
	EDL93568	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008253
	ENSRNOP00000008253.6

RefSeq Acc Id:

NP_001101285 ⟸ NM_001107815

- UniProtKB:

B5DFH7 (UniProtKB/TrEMBL), E9PSP4 (UniProtKB/TrEMBL), A0A9K3Y7P7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACRNILRRPFQAQCGHRYCSFCLTSILSS
GPQNCAACVHEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGL
CPFLLTECPACKGLVRLSEKKHHTEQECPKRSLSCQHCRAPCSHADLELHYEVCPKFPLTCDGC
GKKISQEKLQDHVRTCSKCRVLCRFHAIGCSELVETEDLQDHELQRLREHLALLLSSFLESQAS
QNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQL
ERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFARKRQEAIAGRTPAIFSPAFFTSRYGY
KMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVT
SSSFQRPVSDMNIASGCPLFCPVSKIEAKNSYVRDDAIFIKAIVDLTGL

hide sequence

RefSeq Acc Id:	XP_006233656 ⟸ XM_006233594
- Peptide Label:	isoform X1
- UniProtKB:	B5DFH7 (UniProtKB/TrEMBL), E9PSP4 (UniProtKB/TrEMBL), A0A9K3Y7P7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACRNILRRPFQAQCGHRYCSFCLTSILSS GPQNCAACVHEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGL CPFLLTECPACKGLVRLSEKKHHTEQECPKRSLSCQHCRAPCSHADLELHYEVCPKFPLTCDGC GKKISQEKLQDHVRTCSKCRVLCRFHAIGCSELVETEDLQDHELQRLREHLALLLSSFLESQAS QNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQL ERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFARKRQEAIAGRTPAIFSPAFFTSRYGY KMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVT SSSFQRPVSDMNIASGCPLFCPVSKIEAKNSYVRDDAIFIKAIVDLTGL hide sequence

RefSeq Acc Id:

XP_006233658 ⟸ XM_006233596

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACRNILRRPFQAQCGHRYCSFCLTSILSS
GPQNCAACVHEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYELHYEVC
PKFPLTCDGCGKKISQEKLQDHVRTCSKCRVLCRFHAIGCSELVETEDLQDHELQRLREHLALL
LSSFLESQASQNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKI
EALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFARKRQEAIAGRTPAIFS
PAFFTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREH
VIDAFRPDVTSSSFQRPVSDMNIASGCPLFCPVSKIEAKNSYVRDDAIFIKAIVDLTGL

hide sequence

RefSeq Acc Id:	XP_008759810 ⟸ XM_008761588
- Peptide Label:	isoform X1
- UniProtKB:	B5DFH7 (UniProtKB/TrEMBL), E9PSP4 (UniProtKB/TrEMBL), A0A9K3Y7P7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACRNILRRPFQAQCGHRYCSFCLTSILSS GPQNCAACVHEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGL CPFLLTECPACKGLVRLSEKKHHTEQECPKRSLSCQHCRAPCSHADLELHYEVCPKFPLTCDGC GKKISQEKLQDHVRTCSKCRVLCRFHAIGCSELVETEDLQDHELQRLREHLALLLSSFLESQAS QNQVGPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQL ERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFARKRQEAIAGRTPAIFSPAFFTSRYGY KMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVT SSSFQRPVSDMNIASGCPLFCPVSKIEAKNSYVRDDAIFIKAIVDLTGL hide sequence

RefSeq Acc Id:

ENSRNOP00000008253 ⟸ ENSRNOT00000008253

RefSeq Acc Id:	XP_038961110 ⟸ XM_039105182
- Peptide Label:	isoform X1
- UniProtKB:	E9PSP4 (UniProtKB/TrEMBL), B5DFH7 (UniProtKB/TrEMBL), A0A9K3Y7P7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961111 ⟸ XM_039105183
- Peptide Label:	isoform X1
- UniProtKB:	E9PSP4 (UniProtKB/TrEMBL), B5DFH7 (UniProtKB/TrEMBL), A0A9K3Y7P7 (UniProtKB/TrEMBL)

Protein Domains

MATH RING-type TRAF-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DFH7-F1-model_v2	AlphaFold	B5DFH7	1-497	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691881

Promoter ID:

EPDNEW_R2406

Type:

multiple initiation site

Name:

Traf2_1

Description:

Tnf receptor-associated factor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	2,770,642 - 2,770,702	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310457	AgrOrtholog
BioCyc Gene	G2FUF-50442	BioCyc
Ensembl Genes	ENSRNOG00000006238	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008253	ENTREZGENE
	ENSRNOT00000008253.7	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	MATH	UniProtKB/TrEMBL
	TNF_rcpt--assoc_TRAF	UniProtKB/TrEMBL
	TRAF-like	UniProtKB/TrEMBL
	TRAF2	UniProtKB/TrEMBL
	TRAF2_MATH	UniProtKB/TrEMBL
	TRAF_BIRC3-bd	UniProtKB/TrEMBL
	Znf_C3HC4_RING-type	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
	Znf_TRAF	UniProtKB/TrEMBL
KEGG Report	rno:311786	UniProtKB/TrEMBL
NCBI Gene	311786	ENTREZGENE
PANTHER	PTHR10131	UniProtKB/TrEMBL
	PTHR10131:SF21	UniProtKB/TrEMBL
Pfam	TRAF_BIRC3_bd	UniProtKB/TrEMBL
	zf-C3HC4	UniProtKB/TrEMBL
	zf-TRAF	UniProtKB/TrEMBL
PhenoGen	Traf2	PhenoGen
PIRSF	TRAF	UniProtKB/TrEMBL
PROSITE	MATH	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
	ZF_TRAF	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006238	RatGTEx
SMART	MATH	UniProtKB/TrEMBL
	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	TRAF domain-like	UniProtKB/TrEMBL
	Trimerization domain of TRAF	UniProtKB/TrEMBL
UniProt	A0A9K3Y7P7	ENTREZGENE, UniProtKB/TrEMBL
	B5DFH7	ENTREZGENE, UniProtKB/TrEMBL
	E9PSP4	ENTREZGENE
UniProt Secondary	E9PSP4	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Traf2	Tnf receptor-associated factor 2	Traf2_predicted	Tnf receptor-associated factor 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Traf2_predicted	Tnf receptor-associated factor 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)