Traf2 (Tnf receptor-associated factor 2) - Rat Genome Database
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Gene: Traf2 (Tnf receptor-associated factor 2) Rattus norvegicus
Analyze
Symbol: Traf2
Name: Tnf receptor-associated factor 2
RGD ID: 1310457
Description: Exhibits mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Localizes to cell cortex; membrane raft; and protein-containing complex. Orthologous to human TRAF2 (TNF receptor associated factor 2); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC311786
Orthologs:
Homo sapiens (human) : TRAF2 (TNF receptor associated factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Traf2 (TNF receptor-associated factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Traf2 (TNF receptor associated factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TRAF2 (TNF receptor associated factor 2)
Canis lupus familiaris (dog) : TRAF2 (TNF receptor associated factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Traf2 (TNF receptor associated factor 2)
Sus scrofa (pig) : TRAF2 (TNF receptor associated factor 2)
Chlorocebus sabaeus (African green monkey) : TRAF2 (TNF receptor associated factor 2)
Heterocephalus glaber (naked mole-rat) : Traf2 (TNF receptor associated factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.032,746,061 - 2,770,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,746,075 - 2,770,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,727,474 - 2,752,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,692,740 - 3,717,332 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.133,693,271 - 3,717,346 (-)NCBI
Celera33,167,057 - 3,191,598 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4-aminopyridine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Anacardic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
bisphenol A  (EXP)
bleomycin A2  (EXP)
cadmium dichloride  (EXP,ISO)
Candesartan cilexetil  (EXP)
carbon nanotube  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibromoacetic acid  (ISO)
dicoumarol  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
etoposide  (ISO)
folic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibrutinib  (ISO)
indometacin  (ISO)
isoflurane  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
magnesium oxide  (ISO)
metformin  (ISO)
Mitotane  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
pentobarbital  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
T-2 Toxin  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)


References

Additional References at PubMed
PMID:8069916   PMID:9020361   PMID:11278723   PMID:11279055   PMID:11374864   PMID:11728344   PMID:11821416   PMID:11907583   PMID:12296995   PMID:12477932   PMID:12958312   PMID:14743216  
PMID:15121867   PMID:15125833   PMID:15258597   PMID:15696169   PMID:16189514   PMID:16636664   PMID:17314283   PMID:17626074   PMID:18007661   PMID:18281285   PMID:18952128   PMID:19910209  
PMID:20447407   PMID:20562859   PMID:20577214   PMID:20614026   PMID:21525013   PMID:23000344   PMID:23429285   PMID:24011916   PMID:25416956   PMID:26610752   PMID:26674878   PMID:26732833  
PMID:27494324   PMID:28843337   PMID:30561431   PMID:31515488  


Genomics

Comparative Map Data
Traf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.032,746,061 - 2,770,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,746,075 - 2,770,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,727,474 - 2,752,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,692,740 - 3,717,332 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.133,693,271 - 3,717,346 (-)NCBI
Celera33,167,057 - 3,191,598 (-)NCBICelera
Cytogenetic Map3p13NCBI
TRAF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9136,881,912 - 136,926,607 (+)EnsemblGRCh38hg38GRCh38
GRCh389136,881,933 - 136,926,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379139,776,341 - 139,821,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,900,786 - 138,940,888 (+)NCBINCBI36hg18NCBI36
Build 349137,056,801 - 137,096,903NCBI
Celera9110,295,018 - 110,335,296 (+)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,252,590 - 109,280,516 (+)NCBIHuRef
CHM1_19139,929,666 - 139,969,783 (+)NCBICHM1_1
Traf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,407,994 - 25,436,952 (-)NCBI
GRCm38225,517,982 - 25,546,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,517,982 - 25,546,940 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,373,502 - 25,402,414 (-)NCBIGRCm37mm9NCBIm37
MGSCv36225,339,991 - 25,368,903 (-)NCBImm8
Celera225,245,480 - 25,274,398 (-)NCBICelera
Cytogenetic Map2A3NCBI
Traf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,967,984 - 4,983,987 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,964,692 - 4,984,359 (+)NCBIChiLan1.0ChiLan1.0
TRAF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,912,671 - 136,955,331 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,917,358 - 136,955,331 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09107,938,935 - 107,984,797 (+)NCBI
TRAF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl948,689,331 - 48,703,633 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1948,688,071 - 48,713,936 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Traf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366691,004,891 - 1,034,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21313,771,819 - 313,789,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl121,263,274 - 1,290,907 (-)Ensembl
ChlSab1.1121,263,688 - 1,309,626 (-)NCBI
Traf2
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
RH131098  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.032,746,095 - 2,746,282NCBIRnor6.0
Rnor_5.032,727,508 - 2,727,695UniSTSRnor5.0
RGSC_v3.433,692,760 - 3,692,947UniSTSRGSC3.4
Celera33,167,077 - 3,167,264UniSTS
Cytogenetic Map3p13UniSTS
UniSTS:224846  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.032,746,294 - 2,746,460NCBIRnor6.0
Rnor_5.032,727,707 - 2,727,873UniSTSRnor5.0
RGSC_v3.433,692,959 - 3,693,125UniSTSRGSC3.4
Celera33,167,276 - 3,167,442UniSTS
Cytogenetic Map3p13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3125786001Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3128136884Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3128500807Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3132972944Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3137891710Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3139773425Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35711366000866Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35711366000866Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3263142133477544Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3263142148562146Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:114
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000008253
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 50 34 19 34 8 11 41 35 41 11 8
Low 4 7 7 7 33
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008253   ⟹   ENSRNOP00000008253
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl32,746,075 - 2,770,620 (-)Ensembl
RefSeq Acc Id: NM_001107815   ⟹   NP_001101285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,746,075 - 2,770,620 (-)NCBI
Rnor_5.032,727,474 - 2,752,102 (-)NCBI
RGSC_v3.433,692,740 - 3,717,332 (-)RGD
Celera33,167,057 - 3,191,598 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233594   ⟹   XP_006233656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,746,069 - 2,770,640 (-)NCBI
Rnor_5.032,727,474 - 2,752,102 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233596   ⟹   XP_006233658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,746,069 - 2,770,690 (-)NCBI
Rnor_5.032,727,474 - 2,752,102 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761588   ⟹   XP_008759810
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,746,061 - 2,770,599 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101285 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233656 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233658 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759810 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69064 (Get FASTA)   NCBI Sequence Viewer  
  EDL93568 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101285   ⟸   NM_001107815
- UniProtKB: B5DFH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233656   ⟸   XM_006233594
- Peptide Label: isoform X1
- UniProtKB: B5DFH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233658   ⟸   XM_006233596
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008759810   ⟸   XM_008761588
- Peptide Label: isoform X1
- UniProtKB: B5DFH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008253   ⟸   ENSRNOT00000008253
Protein Domains
MATH   RING-type   TRAF-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691881
Promoter ID:EPDNEW_R2406
Type:multiple initiation site
Name:Traf2_1
Description:Tnf receptor-associated factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,770,642 - 2,770,702EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310457 AgrOrtholog
Ensembl Genes ENSRNOG00000006238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008253 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008253 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.210.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro MATH UniProtKB/TrEMBL
  TNF_rcpt--assoc_TRAF UniProtKB/TrEMBL
  TNF_rcpt-assoc_TRAF UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  TRAF2 UniProtKB/TrEMBL
  TRAF2_MATH UniProtKB/TrEMBL
  TRAF_BIRC3-bd UniProtKB/TrEMBL
  Znf_C3HC4_RING-type UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
  Znf_TRAF UniProtKB/TrEMBL
KEGG Report rno:311786 UniProtKB/TrEMBL
NCBI Gene 311786 ENTREZGENE
PANTHER PTHR10131 UniProtKB/TrEMBL
  PTHR10131:SF21 UniProtKB/TrEMBL
Pfam TRAF_BIRC3_bd UniProtKB/TrEMBL
  zf-C3HC4 UniProtKB/TrEMBL
  zf-TRAF UniProtKB/TrEMBL
PhenoGen Traf2 PhenoGen
PIRSF TRAF UniProtKB/TrEMBL
PROSITE MATH UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
  ZF_TRAF UniProtKB/TrEMBL
SMART MATH UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP Traf_like UniProtKB/TrEMBL
UniGene Rn.105232 ENTREZGENE
UniProt B5DFH7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PSP4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Traf2  Tnf receptor-associated factor 2   Traf2_predicted  Tnf receptor-associated factor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Traf2_predicted  Tnf receptor-associated factor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.