Traf2 (Tnf receptor-associated factor 2) - Rat Genome Database

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Gene: Traf2 (Tnf receptor-associated factor 2) Rattus norvegicus
Analyze
Symbol: Traf2
Name: Tnf receptor-associated factor 2
RGD ID: 1310457
Description: Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Located in cell cortex and membrane raft. Part of protein-containing complex. Orthologous to human TRAF2 (TNF receptor associated factor 2); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311786
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,341,950 - 8,366,609 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,341,951 - 8,366,538 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,447,015 - 11,471,676 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,033,239 - 20,057,902 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,223,083 - 18,247,745 (-)NCBIRnor_WKY
Rnor_6.032,746,061 - 2,770,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,746,075 - 2,770,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,727,474 - 2,752,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,692,740 - 3,717,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,693,271 - 3,717,346 (-)NCBI
Celera33,167,057 - 3,191,598 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminopyridine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
bisphenol A  (EXP)
bleomycin A2  (EXP)
cadmium dichloride  (EXP,ISO)
Candesartan cilexetil  (EXP)
carbon nanotube  (ISO)
chloroethene  (ISO)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
D-glucose  (EXP)
DDT  (EXP)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibromoacetic acid  (ISO)
dicoumarol  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
etoposide  (ISO)
folic acid  (ISO)
furan  (ISO)
gentamycin  (EXP)
glucose  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibrutinib  (ISO)
indometacin  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
magnesium oxide  (ISO)
metformin  (ISO)
Mitotane  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
pentobarbital  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
Salidroside  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. Akama KT and Van Eldik LJ, J Biol Chem. 2000 Mar 17;275(11):7918-24.
2. Tumor necrosis factor. Chu WM, Cancer Lett. 2013 Jan 28;328(2):222-5. doi: 10.1016/j.canlet.2012.10.014. Epub 2012 Oct 22.
3. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Fernandes A, etal., Glia. 2011 Jan;59(1):14-25. doi: 10.1002/glia.21072. Epub 2010 Oct 21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
7. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Matsuzawa A, etal., Antioxid Redox Signal. 2002 Jun;4(3):415-25.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2. Natoli G, etal., J Biol Chem. 1998 Nov 20;273(47):31262-72.
10. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Nishitoh H, etal., Genes Dev. 2002 Jun 1;16(11):1345-55.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
17. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Urano F, etal., Science. 2000 Jan 28;287(5453):664-6.
18. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
19. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
Additional References at PubMed
PMID:8069916   PMID:9020361   PMID:11278723   PMID:11279055   PMID:11374864   PMID:11728344   PMID:11821416   PMID:11907583   PMID:12296995   PMID:12477932   PMID:12958312   PMID:14743216  
PMID:15121867   PMID:15125833   PMID:15258597   PMID:15696169   PMID:16189514   PMID:16636664   PMID:17314283   PMID:17626074   PMID:18007661   PMID:18281285   PMID:18952128   PMID:19910209  
PMID:20447407   PMID:20562859   PMID:20577214   PMID:20614026   PMID:21525013   PMID:23000344   PMID:23429285   PMID:24011916   PMID:25416956   PMID:26610752   PMID:26674878   PMID:26732833  
PMID:28843337   PMID:30561431   PMID:31515488   PMID:34089727  


Genomics

Comparative Map Data
Traf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,341,950 - 8,366,609 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,341,951 - 8,366,538 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,447,015 - 11,471,676 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,033,239 - 20,057,902 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,223,083 - 18,247,745 (-)NCBIRnor_WKY
Rnor_6.032,746,061 - 2,770,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,746,075 - 2,770,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,727,474 - 2,752,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,692,740 - 3,717,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,693,271 - 3,717,346 (-)NCBI
Celera33,167,057 - 3,191,598 (-)NCBICelera
Cytogenetic Map3p13NCBI
TRAF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,881,958 - 136,926,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9136,881,912 - 136,926,607 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,780,968 - 139,821,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,900,786 - 138,940,888 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,056,801 - 137,096,903NCBI
Celera9110,295,018 - 110,335,296 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,252,590 - 109,280,516 (+)NCBIHuRef
CHM1_19139,929,666 - 139,969,783 (+)NCBICHM1_1
T2T-CHM13v2.09149,120,690 - 149,160,997 (+)NCBIT2T-CHM13v2.0
Traf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,407,994 - 25,436,952 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,407,994 - 25,436,952 (-)EnsemblGRCm39 Ensembl
GRCm38225,517,982 - 25,546,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,517,982 - 25,546,940 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,373,502 - 25,402,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,339,991 - 25,368,903 (-)NCBIMGSCv36mm8
Celera225,245,480 - 25,274,398 (-)NCBICelera
Cytogenetic Map2A3NCBI
Traf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,967,984 - 4,983,987 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,964,692 - 4,984,359 (+)NCBIChiLan1.0ChiLan1.0
TRAF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,912,671 - 136,955,331 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,917,358 - 136,955,331 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09107,938,935 - 107,984,797 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TRAF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,688,071 - 48,713,936 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,689,331 - 48,703,633 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,901,455 - 47,927,699 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,565,899 - 49,592,130 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,562,621 - 49,590,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,342,106 - 48,368,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,640,817 - 48,667,045 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,687,986 - 48,714,231 (-)NCBIUU_Cfam_GSD_1.0
Traf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,339,938 - 202,370,164 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366691,004,891 - 1,034,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21313,771,819 - 313,789,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,263,688 - 1,309,626 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,263,274 - 1,290,907 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,989,592 - 4,034,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Traf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760952,574 - 965,661 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760952,574 - 973,511 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH131098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,341,975 - 8,342,163 (+)MAPPERmRatBN7.2
Rnor_6.032,746,095 - 2,746,282NCBIRnor6.0
Rnor_5.032,727,508 - 2,727,695UniSTSRnor5.0
RGSC_v3.433,692,760 - 3,692,947UniSTSRGSC3.4
Celera33,167,077 - 3,167,264UniSTS
Cytogenetic Map3p13UniSTS
UniSTS:224846  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,342,174 - 8,342,341 (+)MAPPERmRatBN7.2
Rnor_6.032,746,294 - 2,746,460NCBIRnor6.0
Rnor_5.032,727,707 - 2,727,873UniSTSRnor5.0
RGSC_v3.433,692,959 - 3,693,125UniSTSRGSC3.4
Celera33,167,276 - 3,167,442UniSTS
Cytogenetic Map3p13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:114
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000008253
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 50 34 19 34 8 11 41 35 41 11 8
Low 4 7 7 7 33
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008253   ⟹   ENSRNOP00000008253
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,341,951 - 8,366,538 (-)Ensembl
Rnor_6.0 Ensembl32,746,075 - 2,770,620 (-)Ensembl
RefSeq Acc Id: NM_001107815   ⟹   NP_001101285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,341,956 - 8,366,505 (-)NCBI
Rnor_6.032,746,075 - 2,770,620 (-)NCBI
Rnor_5.032,727,474 - 2,752,102 (-)NCBI
RGSC_v3.433,692,740 - 3,717,332 (-)RGD
Celera33,167,057 - 3,191,598 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233594   ⟹   XP_006233656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,341,950 - 8,366,573 (-)NCBI
Rnor_6.032,746,069 - 2,770,640 (-)NCBI
Rnor_5.032,727,474 - 2,752,102 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233596   ⟹   XP_006233658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,341,950 - 8,366,609 (-)NCBI
Rnor_6.032,746,069 - 2,770,690 (-)NCBI
Rnor_5.032,727,474 - 2,752,102 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761588   ⟹   XP_008759810
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,341,950 - 8,366,518 (-)NCBI
Rnor_6.032,746,061 - 2,770,599 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105182   ⟹   XP_038961110
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,341,950 - 8,366,396 (-)NCBI
RefSeq Acc Id: XM_039105183   ⟹   XP_038961111
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,341,950 - 8,366,305 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101285   ⟸   NM_001107815
- UniProtKB: B5DFH7 (UniProtKB/TrEMBL),   E9PSP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233656   ⟸   XM_006233594
- Peptide Label: isoform X1
- UniProtKB: B5DFH7 (UniProtKB/TrEMBL),   E9PSP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233658   ⟸   XM_006233596
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008759810   ⟸   XM_008761588
- Peptide Label: isoform X1
- UniProtKB: B5DFH7 (UniProtKB/TrEMBL),   E9PSP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008253   ⟸   ENSRNOT00000008253
RefSeq Acc Id: XP_038961110   ⟸   XM_039105182
- Peptide Label: isoform X1
- UniProtKB: E9PSP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961111   ⟸   XM_039105183
- Peptide Label: isoform X1
- UniProtKB: E9PSP4 (UniProtKB/TrEMBL)
Protein Domains
MATH   RING-type   TRAF-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFH7-F1-model_v2 AlphaFold B5DFH7 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691881
Promoter ID:EPDNEW_R2406
Type:multiple initiation site
Name:Traf2_1
Description:Tnf receptor-associated factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,770,642 - 2,770,702EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310457 AgrOrtholog
BioCyc Gene G2FUF-50442 BioCyc
Ensembl Genes ENSRNOG00000006238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008253 ENTREZGENE
  ENSRNOP00000008253.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008253 ENTREZGENE
  ENSRNOT00000008253.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.210.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro MATH UniProtKB/TrEMBL
  TNF_rcpt--assoc_TRAF UniProtKB/TrEMBL
  TNF_rcpt-assoc_TRAF UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  TRAF2 UniProtKB/TrEMBL
  TRAF2_MATH UniProtKB/TrEMBL
  TRAF_BIRC3-bd UniProtKB/TrEMBL
  Znf_C3HC4_RING-type UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
  Znf_TRAF UniProtKB/TrEMBL
KEGG Report rno:311786 UniProtKB/TrEMBL
NCBI Gene 311786 ENTREZGENE
PANTHER PTHR10131 UniProtKB/TrEMBL
  PTHR10131:SF21 UniProtKB/TrEMBL
Pfam TRAF_BIRC3_bd UniProtKB/TrEMBL
  zf-C3HC4 UniProtKB/TrEMBL
  zf-TRAF UniProtKB/TrEMBL
PhenoGen Traf2 PhenoGen
PIRSF TRAF UniProtKB/TrEMBL
PROSITE MATH UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
  ZF_TRAF UniProtKB/TrEMBL
SMART MATH UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
UniProt B5DFH7 ENTREZGENE, UniProtKB/TrEMBL
  E9PSP4 ENTREZGENE
UniProt Secondary E9PSP4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Traf2  Tnf receptor-associated factor 2   Traf2_predicted  Tnf receptor-associated factor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Traf2_predicted  Tnf receptor-associated factor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED