Fas (Fas cell surface death receptor) - Rat Genome Database

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Gene: Fas (Fas cell surface death receptor) Rattus norvegicus
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Symbol: Fas
Name: Fas cell surface death receptor
RGD ID: 619831
Description: Exhibits protease binding activity and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to estrogen stimulus; and nervous system development. Localizes to several cellular components, including CD95 death-inducing signaling complex; apical dendrite; and sarcolemma. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; intrinsic apoptotic pathway; INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apo-1 antigen; apoptosis-mediating surface antigen FAS; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas antigen (ATP1); Fas receptor; FASLG receptor; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; Tumor necrosis factor receptor superfamily, member 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,798,963 - 231,832,591 (+)NCBI
Rnor_6.0 Ensembl1252,589,785 - 252,624,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01252,589,785 - 252,624,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01259,812,248 - 259,846,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,259,443 - 238,274,745 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11238,423,465 - 238,438,767 (+)NCBI
Celera1228,912,823 - 228,946,152 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (IEP)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adult T-cell leukemia  (ISO)
alcoholic hepatitis  (IEP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
asthma  (IEP)
atherosclerosis  (IEP)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type IA  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
brain glioma  (IDA)
Brain Injuries  (IEP,ISO)
brain ischemia  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
Chest Trauma  (IEP)
chorioamnionitis  (ISO)
chronic conjunctivitis  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (IEP)
Chronic Uveitis  (ISO)
clonorchiasis  (IEP)
Colonic Neoplasms  (IEP)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
cryptorchidism  (IEP)
cutaneous T cell lymphoma  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Disease Progression  (ISO)
endophthalmitis  (IEP)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (IEP)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (IEP,ISO)
hematopoietic system disease  (ISO)
hepatitis B  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
heroin dependence  (IEP)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperoxia  (IEP,ISO)
hypersplenism  (ISO)
Hypothermia  (IEP)
Hypoxia-Ischemia, Brain  (IEP)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (IDA)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (IEP)
intrahepatic cholangiocarcinoma  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (IEP)
limited scleroderma  (ISO)
liver disease  (IEP)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IEP,IMP)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
Lymphomatoid Papulosis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
male infertility  (IEP)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Metabolic Brain Diseases  (IEP)
mixed connective tissue disease  (ISO)
Moyamoya disease  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Multisystemic Smooth Muscle Dysfunction Syndrome  (ISO)
myasthenia gravis  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (IDA)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
non-alcoholic fatty liver disease  (ISO)
ocular hypertension  (IEP)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Parkinson's disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (IDA)
primary biliary cholangitis  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
Radiation Injuries, Experimental  (IEP)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA)
retinal detachment  (IEP,IMP)
retinoblastoma  (ISO)
rheumatoid arthritis  (ISO)
sciatic neuropathy  (IEP)
seminoma  (ISO)
Sepsis  (IEP)
Sjogren's syndrome  (ISO,ISS)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (IDA,IEP)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO,ISS)
Taste Disorders  (ISO)
Temporomandibular Joint Osteoarthritis  (IEP)
Testicular Injury  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (IDA,IEP,ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (IEP)
urinary bladder cancer  (ISO)
varicocele  (IEP)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
visual epilepsy  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-bromohexadecanoic acid  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-nitrotoluene  (EXP)
25-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (EXP)
4-tert-butylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
Actein  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
Aloe emodin  (ISO)
Aloperine  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpinumisoflavone  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
arjunolic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP)
Aurothioglucose  (ISO)
benazepril  (EXP)
bentonite  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromochloroacetic acid  (EXP)
bucladesine  (EXP)
bufalin  (ISO)
buta-1,3-diene  (ISO)
Cacalol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carnosic acid  (ISO)
carvedilol  (ISO)
casticin  (ISO)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cetrorelix  (EXP,ISO)
charcoal  (EXP)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
cidofovir anhydrous  (ISO)
Cinobufotalin  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofazimine  (EXP)
clofibrate  (ISO)
clorgyline  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
cytarabine  (EXP)
D-glucose  (ISO)
daunorubicin  (ISO)
DDE  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibromoacetic acid  (ISO)
dichlorine  (EXP)
dichlorvos  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroartemisinin  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
Echimidine  (ISO)
elemental selenium  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
ferrosoferric oxide  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fotemustine  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gibberellin A3  (EXP)
gingerol  (ISO)
ginsenoside Re  (ISO)
glucose  (ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (EXP)
GSK690693  (ISO)
guggulsterone  (EXP)
GW 4064  (EXP)
Heliotrine  (EXP,ISO)
heparin  (ISO)
heroin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxyurea  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
ICI D1694  (ISO)
idelalisib  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP,ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leukotriene D4  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
magnesium oxide  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
masoprocol  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (EXP)
mifepristone  (ISO)
miquelianin  (EXP)
mitogen  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (ISO)
myriocin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naproxen  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitrobenzene  (ISO)
nitroglycerin  (ISO)
Nodularin  (ISO)
notoginsenoside R1  (ISO)
Nutlin-3  (ISO)
nystatin  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
octreotide  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP)
olmesartan  (ISO)
osthole  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
pemetrexed  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perifosine  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
procyanidin B3  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propofol  (ISO)
propranolol  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
reactive oxygen species  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
risperidone  (ISO)
Roridin A  (ISO)
rotenone  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sucrose  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrazolium violet  (ISO)
thalidomide  (EXP,ISO)
thiazoles  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiosalicylic acid  (EXP)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topotecan  (ISO)
transplatin  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanillic acid  (EXP)
vincristine  (ISO)
vinorelbine  (ISO)
vismodegib  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (IBA,ISO)
aging  (IEP)
apoptotic process  (IEA,ISO,TAS)
apoptotic signaling pathway  (IMP,ISO)
B cell mediated immunity  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to cobalt ion  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to estrogen stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hydrostatic pressure  (IEP)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (IEP)
cellular response to interferon-gamma  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to phenylalanine  (IEP)
cellular response to tumor necrosis factor  (IEP)
chordate embryonic development  (IEP)
circadian rhythm  (ISO)
dendrite regeneration  (IMP)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
Fas signaling pathway  (ISO)
gene expression  (ISO)
hepatocyte apoptotic process  (ISO)
immune response  (IEA)
inflammatory cell apoptotic process  (ISO)
lipid localization  (IEP)
liver regeneration  (IEP)
lymphocyte apoptotic process  (ISO)
maternal process involved in female pregnancy  (IEP)
motor neuron apoptotic process  (IBA,ISO)
necroptotic signaling pathway  (IBA,ISO)
negative regulation of apoptotic process  (IBA,ISO)
negative regulation of B cell activation  (ISO)
negative regulation of Schwann cell migration  (IMP)
negative regulation of Schwann cell proliferation  (IMP)
negative thymic T cell selection  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle atresia  (IEP)
ovulation cycle  (IEP)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell death  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (IBA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
regulation of apoptotic process  (IMP)
regulation of cell population proliferation  (IMP)
regulation of gene expression  (IMP)
regulation of lipid storage  (IEP)
regulation of lymphocyte differentiation  (ISO)
regulation of myeloid cell differentiation  (ISO)
regulation of stress-activated MAPK cascade  (IBA,ISO)
response to cycloheximide  (IEP)
response to cytokine  (IEP)
response to drug  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to fluoride  (IEP)
response to glucocorticoid  (ISO)
response to growth factor  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to toxic substance  (IEP,ISO)
signal transduction  (IEA)
spermatogenesis  (IEP)
spleen development  (ISO)
T cell homeostasis  (ISO)
telencephalon development  (IEP)
tumor necrosis factor-mediated signaling pathway  (IEA)

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214. Zalewska R, etal., Med Sci Monit. 2008 Dec;14(12):BR274-8.
215. Zhang B, etal., Carcinogenesis. 2007 May;28(5):1067-73. Epub 2006 Dec 20.
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217. Zhang L, etal., Med Chem. 2006 Nov;2(6):611-6.
218. Zhang LJ, etal., World J Gastroenterol. 2006 Mar 28;12(12):1918-23.
219. Zhang X, etal., Parasitol Res. 2008 Jul;103(2):393-9. Epub 2008 Apr 22.
220. Zhi EL, etal., Zhonghua Nan Ke Xue. 2013 Feb;19(2):111-5.
221. Zhou M, etal., Int J Mol Med. 2010 Jun;25(6):929-35.
222. Zwolak A, etal., Hum Exp Toxicol. 2016 Aug;35(8):799-807. doi: 10.1177/0960327115607078. Epub 2015 Oct 1.
Additional References at PubMed
PMID:6610701   PMID:7511063   PMID:7536190   PMID:7538908   PMID:7595210   PMID:7602121   PMID:8524870   PMID:8557033   PMID:8640868   PMID:8666928   PMID:8700551   PMID:8788039  
PMID:9681877   PMID:9697835   PMID:10429671   PMID:10588860   PMID:10950869   PMID:11096076   PMID:11101870   PMID:12011074   PMID:12431371   PMID:12683940   PMID:12702495   PMID:12801066  
PMID:13679421   PMID:14679192   PMID:14699504   PMID:15039234   PMID:15039424   PMID:15254243   PMID:15309723   PMID:15487762   PMID:15632112   PMID:16000635   PMID:16365167   PMID:16493007  
PMID:16507998   PMID:17441510   PMID:17980593   PMID:18199416   PMID:18204739   PMID:18246871   PMID:18289516   PMID:18363966   PMID:18407603   PMID:18614532   PMID:19151726   PMID:19239001  
PMID:19267062   PMID:19399403   PMID:19407976   PMID:19415683   PMID:19593445   PMID:19642903   PMID:20436477   PMID:20448356   PMID:20458337   PMID:20530871   PMID:20935634   PMID:21052097  
PMID:21382479   PMID:21421874   PMID:21586345   PMID:21625644   PMID:21803845   PMID:21868309   PMID:22609371   PMID:22891283   PMID:23583643   PMID:23785138   PMID:23934924   PMID:23973665  
PMID:24307234   PMID:24324791   PMID:24914971   PMID:24938610   PMID:25294749   PMID:25310648   PMID:25439027   PMID:26316710   PMID:27189477   PMID:27561622   PMID:27606894   PMID:27919821  
PMID:28346613   PMID:28595623   PMID:28722192   PMID:29891925   PMID:31155748  


Genomics

Comparative Map Data
Fas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,798,963 - 231,832,591 (+)NCBI
Rnor_6.0 Ensembl1252,589,785 - 252,624,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01252,589,785 - 252,624,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01259,812,248 - 259,846,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,259,443 - 238,274,745 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11238,423,465 - 238,438,767 (+)NCBI
Celera1228,912,823 - 228,946,152 (+)NCBICelera
Cytogenetic Map1q52NCBI
FAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1088,990,531 - 89,017,059 (+)EnsemblGRCh38hg38GRCh38
GRCh381088,968,429 - 89,017,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371090,750,555 - 90,776,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,740,268 - 90,765,522 (+)NCBINCBI36hg18NCBI36
Build 341090,740,267 - 90,765,521NCBI
Celera1084,497,075 - 84,522,333 (+)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,384,755 - 84,410,009 (+)NCBIHuRef
CHM1_11091,032,376 - 91,058,878 (+)NCBICHM1_1
Fas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,267,926 - 34,305,175 (+)NCBIGRCm39mm39
GRCm39 Ensembl1934,268,066 - 34,305,172 (+)Ensembl
GRCm381934,290,647 - 34,327,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,290,666 - 34,327,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv371934,365,149 - 34,402,260 (+)NCBIGRCm37mm9NCBIm37
MGSCv361934,356,663 - 34,393,767 (+)NCBImm8
Celera1935,067,780 - 35,104,920 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.48NCBI
Fas
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,961,013 - 3,987,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554253,961,671 - 3,987,513 (-)NCBIChiLan1.0ChiLan1.0
FAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11089,199,070 - 89,244,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,217,949 - 89,243,612 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01085,707,457 - 85,741,539 (+)NCBIMhudiblu_PPA_v0panPan3
FAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,738,811 - 38,763,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,737,611 - 38,763,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,489,983 - 38,514,797 (+)NCBI
ROS_Cfam_1.02640,322,559 - 40,347,441 (+)NCBI
UMICH_Zoey_3.12638,193,452 - 38,217,927 (+)NCBI
UNSW_CanFamBas_1.02637,756,887 - 37,781,708 (+)NCBI
UU_Cfam_GSD_1.02639,027,502 - 39,052,301 (+)NCBI
Fas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721378,564,885 - 78,583,646 (+)NCBI
SpeTri2.0NW_004936735209,369 - 234,582 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114100,927,305 - 100,954,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214109,911,730 - 109,939,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Fas
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479115,290,022 - 15,315,848 (+)NCBI

Position Markers
D1Bda62  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01252,623,332 - 252,623,569NCBIRnor6.0
Rnor_5.01259,844,649 - 259,844,886UniSTSRnor5.0
RGSC_v3.41238,273,287 - 238,273,524UniSTSRGSC3.4
Celera1228,944,694 - 228,944,931UniSTS
Cytogenetic Map1q52UniSTS
BE108106  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01252,624,564 - 252,624,720NCBIRnor6.0
Rnor_5.01259,845,881 - 259,846,037UniSTSRnor5.0
RGSC_v3.41238,274,519 - 238,274,675UniSTSRGSC3.4
Celera1228,945,926 - 228,946,082UniSTS
RH 3.4 Map4490.22UniSTS
Cytogenetic Map1q52UniSTS
RH94405  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01252,624,340 - 252,624,503NCBIRnor6.0
Rnor_5.01259,845,657 - 259,845,820UniSTSRnor5.0
RGSC_v3.41238,274,295 - 238,274,458UniSTSRGSC3.4
Celera1228,945,702 - 228,945,865UniSTS
Cytogenetic Map1q52UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1233490105264802994Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1215711860260711860Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1236763415258766873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1238830534278228767Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1233663100273792054Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1215828102260828102Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1216324817261324817Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1241482188281795785Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1215711860258765521Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1238824734279986079Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1221901238266901238Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1221901238266901238Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1221901238266901238Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1221901238266901238Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1244401175264636028Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1244401175264636028Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1193968438261264776Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1215828102260828102Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1225689973270689973Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1225689973270689973Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1195598053265002735Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1215684498260684498Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1226706329271706329Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1249206242281795785Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1249607907266793958Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1210360774264802828Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700264802994Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1208517798266948272Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1230420627262031693Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1216324817261324817Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1215828102260828102Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238830408266793958Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1202571665264802994Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1227509470255131140Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1210652654255652654Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221901238266901238Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1202571665264802994Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1222492538267492538Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210990171255990171Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:85
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000025928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 10 2 14 2 1 11
Low 2 43 47 39 5 39 8 11 69 35 35 8
Below cutoff 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025928   ⟹   ENSRNOP00000025928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1252,589,785 - 252,624,790 (+)Ensembl
RefSeq Acc Id: NM_139194   ⟹   NP_631933
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21231,798,963 - 231,832,591 (+)NCBI
Rnor_6.01252,589,785 - 252,624,790 (+)NCBI
Rnor_5.01259,812,248 - 259,846,107 (+)NCBI
RGSC_v3.41238,259,443 - 238,274,745 (+)RGD
Celera1228,912,823 - 228,946,152 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_631933 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD20221 (Get FASTA)   NCBI Sequence Viewer  
  BAA05109 (Get FASTA)   NCBI Sequence Viewer  
  EDM13158 (Get FASTA)   NCBI Sequence Viewer  
  EDM13159 (Get FASTA)   NCBI Sequence Viewer  
  Q63199 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_631933   ⟸   NM_139194
- Peptide Label: precursor
- UniProtKB: Q63199 (UniProtKB/Swiss-Prot),   F1LWQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025928   ⟸   ENSRNOT00000025928
Protein Domains
Death   TNFR-Cys

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690863
Promoter ID:EPDNEW_R1387
Type:multiple initiation site
Name:Fas_1
Description:Fas cell surface death receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01252,589,835 - 252,589,895EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: