Am17 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Am17 (Aortic mass QTL 17) Rattus norvegicus

Symbol: Am17
Name: Aortic mass QTL 17
RGD ID: 12903981
Previously known as: BpcakmC17QTL
Trait: aorta mass   (VT:0002845)    
Measurement Type: aorta weight to aorta length to body weight ratio   (CMO:0002722)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81723,858,926 - 68,858,926RGD_MAPPER_PIPELINE
mRatBN7.21723,653,184 - 68,653,184RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01721,490,950 - 66,490,950RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01723,473,207 - 68,473,207RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41729,603,712 - 72,799,224RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.LEW-(D17Chm14-D17Rat181)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Am17Rathypertension  IAGP 1599557 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Am17Ratabnormal aortic weight  IAGP 1599557 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Am17Rataorta weight to aorta length to body weight ratio  IDA 1599557 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Am17Ratcontrolled sodium content diet  IDA 1599557 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Am17Ratpost excision weight measurement  IDA 1599557 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Am17RatSS.LEW-(D17Chm14-D17Rat181)/Ayd  IEA 1599557 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Am17Rataorta mass  IDA 1599557 RGD 


#
Reference Title
Reference Citation
1. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.


1 to 20 of 667 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1311127Gcm2glial cells missing transcription factor 2172365263723661754Rat
3036Makmale germ cell-associated kinase172368375323731125Rat
621692Tmem14ctransmembrane protein 14C172373376923739906Rat
1565353Pak1ip1PAK1 interacting protein 1172374221723753325Rat
1562963C17h6orf52similar to human chromosome 6 open reading frame 52172375335923776251Rat
9425447LOC103694058uncharacterized LOC103694058172378845923798379Rat
1303198Gcnt2glucosaminyl (N-acetyl) transferase 2172379685923901625Rat
40995008LOC120097872uncharacterized LOC120097872172380082223808093Rat
41295529LOC120097871uncharacterized LOC120097871172384817723852178Rat
126928215LOC121529648ribosomal protein L9-like172389887823899557Rat
41224811Gcnt2-ps1glucosaminyl (N-acetyl) transferase 2, pseudogene 1172390937423917596Rat
41119229Rpl29-ps4ribosomal protein L29, pseudogene 4172398021123980662Rat
2324472Rpl13a-ps4ribosomal protein L13A, pseudogene 4172398563923986287Rat
1310267Tfap2atranscription factor AP-2 alpha172402871624047507Rat
2324338Cks2l1CDC28 protein kinase regulatory subunit 2 like 1172427143124271897Rat
1589812Ofcc1orofacial cleft 1 candidate 1172450691924813225Rat
7684968LOC102555259uncharacterized LOC102555259172503663825038772Rat
40996526Rps3a-ps7ribosomal protein S3a, pseudogene 7172505761625058293Rat
41383133LOC120098031U4 spliceosomal RNA172506229225062377Rat
11490069LOC108348547uncharacterized LOC108348547172506851525073508Rat

1 to 20 of 667 rows
1 to 20 of 635 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10119D17Arb4244173422548134225727Ratregion
10119D17Arb4244173422548134225872Ratregion
10119D17Arb4244173422556634225727Ratregion
10348D17Mit4231176046341260463643Ratregion
10349D17Arb7237176046340560463642Ratregion
10350D17Wox12137176046350060463637Ratregion
10351D17Wox13150176046348360463633Ratregion
10709D17Mgh3112174142981541429923Ratregion
11150D17Wox11134173787123537871375Ratregion
11151D17Wox18232173787115737871389Ratregion
33790D17Mit3194175348176653481960Ratregion
33860D17Mit10231175523786855238103Ratregion
33882D17Mit2129173199078431990913Ratregion
34120D17Mgh597175090909950909196Ratregion
34122D17Mgh8157175090909650909253Ratregion
34391D17Mgh9148176811706768117215Ratregion
34645D17Pas1339175278466452785007Ratregion
35985D17Rat20163173852519738525360Ratregion
36011D17Rat17157173583708535837242Ratregion
36107D17Rat29178175336728153367459Ratregion
1 to 20 of 635 rows

Flank 1: (D17Rat84)
Rat AssemblyChrPosition (strand)Source
GRCr81723,858,926 - 23,859,062 (+)Marker Load Pipeline
mRatBN7.21723,653,184 - 23,653,323 (+)MAPPER
Rnor_6.01721,490,950 - 21,491,085NCBI
Rnor_5.01723,473,207 - 23,473,342UniSTS
RGSC_v3.41729,603,712 - 29,604,237RGD
RGSC_v3.41729,604,089 - 29,604,224UniSTS
RGSC_v3.11729,606,930 - 29,607,065RGD
Celera1723,324,112 - 23,324,238UniSTS
RH 3.4 Map17280.1RGD
RH 3.4 Map17280.1UniSTS
RH 2.0 Map17199.7RGD
SHRSP x BN Map1717.2899RGD
FHH x ACI Map1722.3299RGD
Cytogenetic Map17p12UniSTS
Flank 2: (D17Chm71)
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41772,798,986 - 72,799,224RGD


1 to 10 of 85 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat

1 to 10 of 85 rows


Note Type Note Reference
qtl_general number of animals used: 5 gender: male 1599557
qtl_general also affects heart mass, heart right and left ventricle mass, kidney mass, body mass and blood pressure 1599557
qtl_statistics_details software package used: ANOVA followed by Dunnett test in the SYSTAT 9 program 1599557
qtl_trait_method measurement method: selected males were weaned at 21 days of age then fed 2% NaCl diet starting from 35 days of age, at 14 weeks animals were decapitated, organs removed, blotted and weighed 1599557
qtl_trait_method aorta section was from the diaphragm to the first intercostal artery 1599557