Gcm2 (glial cells missing transcription factor 2)

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Gene: Gcm2 (glial cells missing transcription factor 2) Rattus norvegicus

Analyze

Symbol:

Gcm2

Name:

glial cells missing transcription factor 2

RGD ID:

1311127

Description:

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including cellular ion homeostasis; parathyroid gland development; and transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); benzo[a]pyrene (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

chorion-specific transcription factor GCMb; glial cells missing homolog 2; glial cells missing homolog 2 (Drosophila); LOC291047

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	17	21,490,402 - 21,499,516 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	21,490,402 - 21,499,516 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	23,472,659 - 23,481,773 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	29,603,541 - 29,612,656 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	29,604,108 - 29,613,827 (+)	NCBI
Celera	17	23,323,562 - 23,332,669 (+)	NCBI		Celera
Cytogenetic Map	17	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial isolated hypoparathyroidism (ISO)

Familial Isolated Hypoparathyroidism 2 (ISO)

genetic disease (ISO)

Hyperparathyroidism 4 (ISO)

hypoparathyroidism (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

folic acid (ISO)

methylisothiazolinone (ISO)

N-ethyl-N-nitrosourea (ISO)

paracetamol (ISO)

sirolimus (ISO)

trichostatin A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell differentiation (ISO)

cellular calcium ion homeostasis (ISO)

cellular phosphate ion homeostasis (ISO)

cellular response to organic substance (ISO)

gene expression (ISO)

gliogenesis (IBA)

negative regulation of apoptotic process (ISO)

parathyroid gland development (ISO)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of transcription by RNA polymerase II (IBA)

transcription by RNA polymerase II (ISO)

Cellular Component

cellular_component (ND)

nucleus (IBA,ISO)

Molecular Function

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

molecular_function (ND)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated


1.	Ding C, etal., J Clin Invest. 2001 Oct;108(8):1215-20.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline
6.	RGD automated data pipeline
7.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	RGD automated import pipeline for gene-chemical interactions
9.	RGD comprehensive gene curation

Additional References at PubMed

PMID:9770492	PMID:14573516	PMID:15728199	PMID:15863676	PMID:17382312	PMID:19968565	PMID:20190276	PMID:20484821	PMID:22871113	PMID:27745835

Genomics

Comparative Map Data

Gcm2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	17	21,490,402 - 21,499,516 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	21,490,402 - 21,499,516 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	23,472,659 - 23,481,773 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	29,603,541 - 29,612,656 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	29,604,108 - 29,613,827 (+)	NCBI
Celera	17	23,323,562 - 23,332,669 (+)	NCBI		Celera
Cytogenetic Map	17	p13	NCBI

GCM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	6	10,873,223 - 10,882,041 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	6	10,873,223 - 10,881,941 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	6	10,873,223 - 10,882,041 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	6	10,873,456 - 10,882,098 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	10,981,450 - 10,990,084 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	10,981,449 - 10,990,084	NCBI
Celera	6	12,101,899 - 12,110,544 (-)	NCBI
Cytogenetic Map	6	p24.2	NCBI
HuRef	6	10,749,238 - 10,757,883 (-)	NCBI		HuRef
CHM1_1	6	10,875,550 - 10,884,190 (-)	NCBI		CHM1_1

Gcm2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	41,254,903 - 41,264,511 (-)	NCBI	GRCm39		mm39
GRCm38	13	41,101,427 - 41,111,035 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	41,101,427 - 41,111,035 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	41,196,796 - 41,205,357 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	13	41,112,402 - 41,121,157 (-)	NCBI			mm8
Celera	13	42,183,278 - 42,191,831 (-)	NCBI		Celera
Cytogenetic Map	13	A3.3	NCBI

Gcm2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	3,523,029 - 3,530,342 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955465	3,523,029 - 3,530,342 (+)	NCBI	ChiLan1.0	ChiLan1.0

GCM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	10,990,928 - 10,999,554 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	10,990,928 - 10,999,554 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	10,712,428 - 10,722,056 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

GCM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	35	10,561,514 - 10,568,106 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	35	10,561,245 - 10,568,351 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Gcm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936534	2,135,627 - 2,142,621 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	7,564,252 - 7,570,523 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	7,563,880 - 7,570,628 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	7,925,756 - 7,928,086 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GCM2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	17	61,256,611 - 61,264,390 (+)	Ensembl
ChlSab1.1	17	61,256,063 - 61,264,688 (+)	NCBI

Gcm2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624756	15,087,045 - 15,095,049 (+)	NCBI

Position Markers

D17Rat84

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	17	21,490,950 - 21,491,085	NCBI	Rnor6.0
Rnor_5.0	17	23,473,207 - 23,473,342	UniSTS	Rnor5.0
RGSC_v3.4	17	29,603,712 - 29,604,237	RGD	RGSC3.4
RGSC_v3.4	17	29,604,089 - 29,604,224	UniSTS	RGSC3.4
RGSC_v3.1	17	29,606,930 - 29,607,065	RGD
Celera	17	23,324,112 - 23,324,238	UniSTS
Cytogenetic Map	17	p12	UniSTS
RH 3.4 Map	17	280.1	UniSTS
RH 3.4 Map	17	280.1	RGD
RH 2.0 Map	17	199.7	RGD
SHRSP x BN Map	17	17.2899	RGD
FHH x ACI Map	17	22.3299	RGD

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	24787908	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	32230361	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	33303755	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38243814	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	63676140	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	73413148	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	73413148	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	519770	23422380	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	519770	36283402	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	17	3336972	24030841	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	3336972	24030841	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	3336972	37790462	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	3336972	63676140	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	3336972	73413148	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	3336972	73413148	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	3336972	73413148	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3414039	28073589	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4716067	27691136	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4716067	27691136	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	5191047	50191047	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	5191047	50191047	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9730263	21491085	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9730263	21491085	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9730263	21491085	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9730263	21491085	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9730263	21491085	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9730263	21491085	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9730263	21491085	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9730263	21491085	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	9827304	54827304	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	10529709	42542027	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	14009679	23316697	Rat
1331720	Rf43	Renal function QTL 43	2.881		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	17	15743755	22711729	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15743755	61036897	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	18676140	63676140	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	18676140	63676140	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	21490950	62195822	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	21490950	66490950	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	21490950	66490950	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	21490950	66490950	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	21490950	66490950	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	21490950	66490950	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	21490950	74823273	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	210
Count of miRNA genes:	146
Interacting mature miRNAs:	171
Transcripts:	ENSRNOT00000020244
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low	2	10	26	10	19	10	8	9	9	10	9	11	8
Below cutoff	1	1	1	1		1		2	2	1	18

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01090682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC119496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000020244 ⟹ ENSRNOP00000020244

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	21,490,402 - 21,499,516 (+)	Ensembl

RefSeq Acc Id:

NM_001106105 ⟹ NP_001099575

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	21,490,402 - 21,499,516 (+)	NCBI
Rnor_5.0	17	23,472,659 - 23,481,773 (+)	NCBI
RGSC_v3.4	17	29,603,541 - 29,612,656 (+)	RGD
Celera	17	23,323,562 - 23,332,669 (+)	RGD

Sequence:

show sequence

TGCATCTCTCTGTTTCTCTCTGTGTCTGTGTGTCTCTCTTTCTGTCTCCCTCTGTCTCTGTCTC
TGTCCCCTCCCTCCTCTTCCTCCTCCTCCTTTCACTCACCTCTCGCCCTACATCTCATTTGGGA
AAAAGTCACCCTGTGCGCTCCTTGCTTTTATTTCTCTTTCAGGCCCCTCCAGATGCCAGCAGAC
AGCATGCAGGACCCCGATCCTGTGCTTTCCTACGGGATGAAACTCACATGGGACATCAATGACC
CGCAGATGCCTCAGGAACCAGCTCACTTCGACCACTTCCGGGAGTGGCCTGATGGCTACGTGCG
CTTCATCTACAGCAGTCAGGAGAAGAAAGCTCAGCGCCACCTGAGCGGCTGGGCCATGCGCAAC
ACCAACAACCACAATGGCCACATCCTCAAAAAGTCCTGCCTGGGCGTGGTGGTGTGCGCACGCG
CCTGCGCCCTGAAGGATGGCTCGCACCTGCAGCTGAGGCCAGCCATCTGCGACAAGGCTCGTCT
GAAGCAACAAAAGAAAGCTTGCCCCAACTGTCATTCAGCTTTGGAGCTGGTCCCTTGCCGAGGA
CACAGTGGATACCCTGTCACCAACTTCTGGAGACTTGATGGCAATGCAATATTTTTTCAGGCCA
AAGGAGTTCATGATCATCCCAGACCAGAGAGCAAGTCAGAGACAGAAGGCAGAAGAAGTGCCCT
CAAGAGACAGATGGCCTCTTTCTACCAACCCCAGAAAAGGAGATCAGAGGAGCCTGAGGCAGGA
AGCACTCAGGACACCAGGGGACACTCCAATAGCACGCCTGTCCCAGAACCCTCAGAACTGTTTG
CTATGCCTGCTGACACCAGCTTCCCTATTTCAGGGCATTCTTCCCTTTCCTTCCCAAACTCTGA
TGTCCACAGAGTTACCTGTGACCTGCCCACCTTTCCAGGAGATGTAATACTTCCCTTTCAGAAA
TATTCAAATCCAAGCATTTATTTCCCTGGGCCACCTTGGAGCTATGAATTGGCAAGTCCTGGAG
TTACGGGTTCAAGTCCATATCCTACCCTGTATAAAGACCCCTCCATTGTCCCCGATGACCCTGA
CTGGATCCATCTAAACTCACTACAATATAATGTGAGTTCATACGGCAGCTATGAGAGAAGCTTG
GATCTCACAGCTAGATATCATGGCTGGAAACCTACACATGGGAAAGCTGGCCTTGAGGAGAAGG
TTGACTGTAGGCCATGCCAGGCTGTGCCCACATCGCCTTATTACAACCTAGAGCTGCCCTGCAG
GTACCTGCCAGTGGCCCCGGCAGGTACCCAGGCCCTGCAGACAGTGATCACCACCACAGTGGCT
TATCAGGCTTACCAGCACCCTGCTCTGAAACACGGCGACAGCGTGCAGGAGGTTAGCAGCCTTG
CCAGTTGCACCTACGCTTCTGAAAACCTCCCAATGCCCATCTATCCGCAAGCCTTAGACCCTCA
AGAGGGAGCCATCCAGGCAGCCTCCCCTTCAGGGAGAGCCCCTGGGATAGTCCCTGGAGATTGC
CAGGCAGCCAGACCTACTCTGGCTTTCCCTCAAGAAACAGATCCCTCCAGGACAGCTGGAGCAG
ATGTGTGGGATGTGTGTCTGTCTGGGGTGGGCTCTGTGATGGCTTACTTGGATAGGACAGGGCA
ACCCTTTAACCTCGACAATGAGGACTTTTAGGAGGGTCCCAGGATACACACACCATGACAATGA
AGTACATGCTAGATAACCCATGCCCAGGGGCAACGACTTGCTTGGGTGGTTCATACACATACAG
GACTGGAGTTGAGTGTAAAGGCACCTGGGGAGTTATAAGTTGGGAATGATAGGTGCTGGAAGTT
AGCACAGCACTTTGAAACCTGCCACACCGCATAGGCTAGTAGCAGTGCGAGCATCCCAGATGAA
CAAATAAAGGAGCGGGAGGGACCTGCAATGCCCTGGCCTGCCCTTCCTTAGCTTGCCTGCTAAG
GATGCTAGTTCCATTCTTAACCTTTGCCCTTTAGACTTTTAGAGAATTTCACACAGCTGTGAAT
AGCATCAAGAGGCTATGTAAGCAGCATGGGTGTGGAAGCCTGGAGAGAAACATATGAAACGTAT
GAAATGTAGCAAGTGTTTTATTGCCCTGCAGGCTTTTCCATTCATCAGCTGAAAATTCTGTAAG
CCAAGAGGAACCCTACATAACTTGGGGTGCTATGACATCTGTGAACTGAAGCTCCCCCCACCCT
GGGGGGGAGCCTCCTCTGTGTTAAAGATTCCTCAATGTGGACTGATTGGCAAGAATTTCTGTGA
TGTTGAGAGCTGGAATGTTGCAGGTCTGAGGCCAGATCTGTGACTTTAACCCTTTAATAGCCAT
GTCTCACCTATTAAGTGATTAAGTGGATCCCTTTGGGATGCACAAACAAACCCCAAGTTTCTAT
TTCCCCCAAAGGCTAAAAATGTCATCAAGTAGCATCTTAGGCTACTATATGGAAAAAGAAAATA
TATATATATATTTATATATATAATCCTGTCTTCCTGGTTTTACCACTAATGAATTTTTCACATA
CCTTGATTTATGAGTTCCTTTGTTCTATTACTATAAAAACGTTATGAACTTGCTCCCTCCATGT
TTGAACATGTTTTCAAATCTATGTTCCCTACTCCGTGATCAACTAATGTTCAGCTCCATAATAA
AATCTCTCGTTTCCTTTGAGGTAAGAGCTATGGTTCTTGTGTCCACACACCTCAGTAATCCCAG
CACTCTGAAGGCTAAGGCAGGAGGATTTGCCTATGGCACTTGCTGTAGATGGCTTTTCAAATAT
CAATTTCTACCAGACAGTTTCTGTGTCTCGTGAGTCACTGAGGACAGTTCAGGCCTGTTACTTG
CTGGTGAGACACAACTCAGTATATGAACACTTTAAAACTGTCACCAATTTAGACACAATTTAAC
TAACCTAGCCTTACTGGTTTCTATGCTGACAAAACTGAACTTAATCTATATTTTATGGCTTTTT
TTAAACTTTTTATTATATATTTCTTTACTTACATTTCAAAGGTTACTCCCCTTCCTGGTTTCCT
GTCCATAAGCCCCCATTCCCTCCCCTCCCTCTCCCCCATACAGGTATTCCCCCTATACATCTGC
CTTATTGCCCTCCCCCATATTCCCTTGCACTGGGGGTCCAACCTTGGCAAGACCAAGGGCTTTC
CCTTCCATTGGTGCCCAACAAGGCTATTCTCTGCTACATATCCAGTTGGAGCCCTGGGTCAGTC
CGTGTATAGTCTTTCGGTAGTGGTTTAGTCCCTGGAAGCTCTGATTGGTTGGCATTGTTGTTTT
CTATATTTTAATAAAAGACAATTGATATTGTTCTATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099575	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98221	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001099575 ⟸ NM_001106105

- UniProtKB:

D3ZXW4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPADSMQDPDPVLSYGMKLTWDINDPQMPQEPAHFDHFREWPDGYVRFIYSSQEKKAQRHLSGW
AMRNTNNHNGHILKKSCLGVVVCARACALKDGSHLQLRPAICDKARLKQQKKACPNCHSALELV
PCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEGRRSALKRQMASFYQPQKRRSEE
PEAGSTQDTRGHSNSTPVPEPSELFAMPADTSFPISGHSSLSFPNSDVHRVTCDLPTFPGDVIL
PFQKYSNPSIYFPGPPWSYELASPGVTGSSPYPTLYKDPSIVPDDPDWIHLNSLQYNVSSYGSY
ERSLDLTARYHGWKPTHGKAGLEEKVDCRPCQAVPTSPYYNLELPCRYLPVAPAGTQALQTVIT
TTVAYQAYQHPALKHGDSVQEVSSLASCTYASENLPMPIYPQALDPQEGAIQAASPSGRAPGIV
PGDCQAARPTLAFPQETDPSRTAGADVWDVCLSGVGSVMAYLDRTGQPFNLDNEDF

hide sequence

RefSeq Acc Id:

ENSRNOP00000020244 ⟸ ENSRNOT00000020244

Protein Domains

GCM

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
17	23479459	23479460	C	A	snv	COP/CrCrl (MCW & UW), ZFDM (KyushuU), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), WN/N (KNAW), SDLEF7/Barth (UDEL), HTX/Kyo (KyushuU), RCS/Kyo (KyushuU), HWY/Slc (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), SBH/Ygl (MCW)

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
17	21497202	21497203	C	A	snv	COP/CrCrl (MCW & UW), WAG/Rij (RGD), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDS, MR/N (MCW), WN/N (MCW), LH/MavRrrc (RGD), LN/MavRrrc (RGD), LL/MavRrrc (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), SBH/Ygl (MCW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
17	29610342	29610343	C	A	snv	SS/JrHsdMcwi (MDC), WAG/Rij (ICL), WN/N (KNAW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), COP/CrCrl (MCW & UW), LH/MavRrrc (ICL), LL/MavRrrc (ICL), LN/MavRrrc (ICL), SBH/Ygl (ICL), SBN/Ygl (ICL), SR/JrHsd (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), MR/N (KNAW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311127	AgrOrtholog
Ensembl Genes	ENSRNOG00000015008	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000020244	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020244	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.20.28.80	UniProtKB/TrEMBL
	3.30.1370.90	UniProtKB/TrEMBL
InterPro	GCM	UniProtKB/TrEMBL
	GCM_dom_sf	UniProtKB/TrEMBL
	GCM_large	UniProtKB/TrEMBL
	GCM_small	UniProtKB/TrEMBL
	Tscrpt_reg_GCM_motif	UniProtKB/TrEMBL
KEGG Report	rno:291047	UniProtKB/TrEMBL
NCBI Gene	291047	ENTREZGENE
PANTHER	PTHR12414	UniProtKB/TrEMBL
Pfam	GCM	UniProtKB/TrEMBL
PhenoGen	Gcm2	PhenoGen
PROSITE	GCM	UniProtKB/TrEMBL
Superfamily-SCOP	GCM_motif	UniProtKB/TrEMBL
UniGene	Rn.218554	ENTREZGENE
UniProt	D3ZXW4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-12-04	Gcm2	glial cells missing transcription factor 2	Gcm2	glial cells missing homolog 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-03	Gcm2	glial cells missing homolog 2	Gcm2	glial cells missing homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gcm2	glial cells missing homolog 2 (Drosophila)	Gcm2_predicted	glial cells missing homolog 2 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gcm2_predicted	glial cells missing homolog 2 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM