Nqo2 (N-ribosyldihydronicotinamide:quinone reductase 2) - Rat Genome Database

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Gene: Nqo2 (N-ribosyldihydronicotinamide:quinone reductase 2) Rattus norvegicus
Analyze
Symbol: Nqo2
Name: N-ribosyldihydronicotinamide:quinone reductase 2
RGD ID: 1303320
Description: Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94180; NAD(P)H dehydrogenase, quinone 2; NAD(P)H quinone dehydrogenase 2; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; QR2; quinone reductase 2; ribosyldihydronicotinamide dehydrogenase; ribosyldihydronicotinamide dehydrogenase [quinone]
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21730,909,482 - 30,938,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,723,881 - 30,752,881 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01732,327,627 - 32,356,626 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01730,719,617 - 30,748,617 (-)NCBIRnor_WKY
Rnor_6.01732,131,847 - 32,158,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,023,011 - 34,051,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,255,630 - 37,283,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,258,472 - 37,286,594 (-)NCBI
Celera1730,474,024 - 30,502,465 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amodiaquine  (ISO)
aristolochic acids  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
mefenamic acid  (ISO)
melatonin  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-nitrosodimethylamine  (EXP)
N-ribosylnicotinamide  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
primaquine  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
quinacrine  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
ubiquinone-1  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Loss of quinone reductase 2 function selectively facilitates learning behaviors. Benoit CE, etal., J Neurosci. 2010 Sep 22;30(38):12690-700. doi: 10.1523/JNEUROSCI.2808-10.2010.
2. Transthyretin: A key gene involved in the maintenance of memory capacities during aging. Brouillette J and Quirion R, Neurobiol Aging. 2007 May 16.
3. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Das A, etal., Free Radic Biol Med. 2006 May 15;40(10):1843-56. Epub 2006 Feb 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas. Hubackova M, etal., Int J Cancer. 2012 Jan 15;130(2):338-48. doi: 10.1002/ijc.26006. Epub 2011 Apr 20.
6. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. Long DJ 2nd, etal., J Biol Chem 2002 Nov 29;277(48):46131-9. Epub 2002 Sep 25.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. NQO2 gene is associated with clozapine-induced agranulocytosis. Ostrousky O, etal., Tissue Antigens. 2003 Dec;62(6):483-91.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. Wang W, etal., J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):127-34.
14. Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells. Zhang X, etal., J Biomed Res. 2012 Mar;26(2):103-9. doi: 10.1016/S1674-8301(12)60019-0.
15. Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery. Zhang XW, etal., Cell Physiol Biochem. 2012;29(3-4):453-62. doi: 10.1159/000338499. Epub 2012 Apr 3.
Additional References at PubMed
PMID:10945627   PMID:15489334   PMID:18254726   PMID:19056867   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Nqo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21730,909,482 - 30,938,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,723,881 - 30,752,881 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01732,327,627 - 32,356,626 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01730,719,617 - 30,748,617 (-)NCBIRnor_WKY
Rnor_6.01732,131,847 - 32,158,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,023,011 - 34,051,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,255,630 - 37,283,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,258,472 - 37,286,594 (-)NCBI
Celera1730,474,024 - 30,502,465 (-)NCBICelera
Cytogenetic Map17p12NCBI
NQO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,999,894 - 3,019,755 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl62,987,987 - 3,019,755 (+)EnsemblGRCh38hg38GRCh38
GRCh3763,000,128 - 3,019,989 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,945,066 - 2,964,993 (+)NCBINCBI36Build 36hg18NCBI36
Build 3462,945,229 - 2,964,993NCBI
Celera64,229,080 - 4,249,008 (+)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,873,204 - 2,893,131 (+)NCBIHuRef
CHM1_163,002,428 - 3,022,361 (+)NCBICHM1_1
T2T-CHM13v2.062,868,796 - 2,888,657 (+)NCBIT2T-CHM13v2.0
Nqo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391334,148,502 - 34,172,448 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1334,148,670 - 34,172,426 (+)EnsemblGRCm39 Ensembl
GRCm381333,964,655 - 33,988,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1333,964,687 - 33,988,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv371334,056,528 - 34,080,334 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361333,972,216 - 33,993,112 (+)NCBIMGSCv36mm8
Celera1335,093,939 - 35,117,741 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.01NCBI
Nqo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,186,928 - 10,200,237 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546510,186,928 - 10,200,098 (-)NCBIChiLan1.0ChiLan1.0
NQO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.162,928,021 - 2,947,304 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,928,021 - 2,947,304 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v062,819,422 - 2,844,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NQO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,294,776 - 3,315,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,294,850 - 3,312,836 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,301,901 - 3,322,549 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,350,127 - 3,370,739 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,350,161 - 3,370,710 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,225,857 - 3,246,468 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,248,146 - 3,268,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,580,552 - 4,601,200 (+)NCBIUU_Cfam_GSD_1.0
NQO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,792,876 - 1,806,301 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.171,792,745 - 1,805,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,825,528 - 1,829,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NQO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,149,197 - 69,168,476 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,147,937 - 69,161,045 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660442,937,996 - 2,957,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nqo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475621,857,721 - 21,867,727 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475621,857,048 - 21,869,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nqo2
117 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:135
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000024141
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 51 41 11 41 1 4 5 35 33 11 1
Low 6 8 7 7 69 8 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024141   ⟹   ENSRNOP00000024141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)Ensembl
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)Ensembl
RefSeq Acc Id: NM_001004214   ⟹   NP_001004214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21730,909,781 - 30,938,320 (-)NCBI
Rnor_6.01732,132,140 - 32,158,164 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
RGSC_v3.41737,255,630 - 37,283,753 (-)RGD
Celera1730,474,024 - 30,502,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253867   ⟹   XP_006253929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21730,909,482 - 30,938,723 (-)NCBI
Rnor_6.01732,131,847 - 32,158,559 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253868   ⟹   XP_006253930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21730,909,482 - 30,938,435 (-)NCBI
Rnor_6.01732,131,847 - 32,158,263 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095490   ⟹   XP_038951418
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21730,909,482 - 30,935,815 (-)NCBI
RefSeq Acc Id: XM_039095491   ⟹   XP_038951419
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21730,909,482 - 30,938,725 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001004214   ⟸   NM_001004214
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253929   ⟸   XM_006253867
- Peptide Label: isoform X1
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253930   ⟸   XM_006253868
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000024141   ⟸   ENSRNOT00000024141
RefSeq Acc Id: XP_038951419   ⟸   XM_039095491
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951418   ⟸   XM_039095490
- Peptide Label: isoform X1
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot)
Protein Domains
Flavodoxin_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY80-F1-model_v2 AlphaFold Q6AY80 1-231 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700415
Promoter ID:EPDNEW_R10939
Type:initiation region
Name:Nqo2_1
Description:N-ribosyldihydronicotinamide:quinone reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10940  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,158,204 - 32,158,264EPDNEW
RGD ID:13700416
Promoter ID:EPDNEW_R10940
Type:single initiation site
Name:Nqo2_2
Description:N-ribosyldihydronicotinamide:quinone reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10939  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,158,558 - 32,158,618EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303320 AgrOrtholog
BioCyc Gene G2FUF-9596 BioCyc
Ensembl Genes ENSRNOG00000017820 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024141 ENTREZGENE
  ENSRNOP00000024141.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024141 ENTREZGENE
  ENSRNOT00000024141.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128990 IMAGE-MGC_LOAD
InterPro Flavodoxin_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291084 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94180 IMAGE-MGC_LOAD
NCBI Gene 291084 ENTREZGENE
Pfam Flavodoxin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nqo2 PhenoGen
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QE49_RAT UniProtKB/TrEMBL
  NQO2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Nqo2  N-ribosyldihydronicotinamide:quinone reductase 2  Nqo2  NAD(P)H quinone dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-29 Nqo2  NAD(P)H quinone dehydrogenase 2  Nqo2  NAD(P)H dehydrogenase, quinone 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nqo2  NAD(P)H dehydrogenase, quinone 2      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Nqo2  NAD(P)H dehydrogenase, quinone 2      Symbol and Name status set to provisional 70820 PROVISIONAL