Ppp1r3g (protein phosphatase 1, regulatory subunit 3G) - Rat Genome Database

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Gene: Ppp1r3g (protein phosphatase 1, regulatory subunit 3G) Rattus norvegicus
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Symbol: Ppp1r3g
Name: protein phosphatase 1, regulatory subunit 3G
RGD ID: 1308930
Description: Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glucose homeostasis; positive regulation of glycogen (starch) synthase activity; and positive regulation of glycogen biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 1 complex. Orthologous to human PPP1R3G (protein phosphatase 1 regulatory subunit 3G); INTERACTS WITH 17beta-estradiol; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC291069; protein phosphatase 1 regulatory subunit 3G; RGD1308930; similar to Protein phosphatase 1, regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1 binding subunit R6)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81729,080,407 - 29,083,739 (-)NCBIGRCr8
mRatBN7.21728,874,956 - 28,878,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1728,876,482 - 28,877,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1728,735,157 - 28,738,488 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01730,338,702 - 30,342,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010002114.19,551 - 12,881 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01729,566,032 - 29,570,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1729,567,404 - 29,568,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01731,462,778 - 31,467,037 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41735,177,316 - 35,178,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1728,477,350 - 28,481,612 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21471512  


Genomics

Comparative Map Data
Ppp1r3g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81729,080,407 - 29,083,739 (-)NCBIGRCr8
mRatBN7.21728,874,956 - 28,878,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1728,876,482 - 28,877,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1728,735,157 - 28,738,488 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01730,338,702 - 30,342,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010002114.19,551 - 12,881 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01729,566,032 - 29,570,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1729,567,404 - 29,568,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01731,462,778 - 31,467,037 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41735,177,316 - 35,178,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1728,477,350 - 28,481,612 (-)NCBICelera
Cytogenetic Map17p12NCBI
PPP1R3G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3865,085,341 - 5,089,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl65,085,341 - 5,089,487 (+)EnsemblGRCh38hg38GRCh38
GRCh3765,085,575 - 5,089,721 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3665,030,719 - 5,031,860 (+)NCBINCBI36Build 36hg18NCBI36
Celera66,312,541 - 6,314,276 (+)NCBICelera
Cytogenetic Map6p25.1NCBI
HuRef64,960,005 - 4,961,740 (+)NCBIHuRef
CHM1_165,087,834 - 5,089,569 (+)NCBICHM1_1
T2T-CHM13v2.064,954,549 - 4,958,695 (+)NCBIT2T-CHM13v2.0
Ppp1r3g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391336,142,816 - 36,154,371 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1336,142,822 - 36,154,371 (+)EnsemblGRCm39 Ensembl
GRCm381335,958,824 - 35,970,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1335,958,839 - 35,970,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv371336,059,775 - 36,062,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361335,975,371 - 35,977,853 (+)NCBIMGSCv36mm8
Celera1337,083,562 - 37,086,044 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.44NCBI
Ppp1r3g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554658,487,009 - 8,488,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554658,485,273 - 8,488,181 (-)NCBIChiLan1.0ChiLan1.0
PPP1R3G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2519,712,149 - 19,713,905 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1615,716,098 - 15,717,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v064,918,313 - 4,920,187 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.165,103,943 - 5,105,690 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl65,103,955 - 5,105,031 (+)Ensemblpanpan1.1panPan2
PPP1R3G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha355,213,922 - 5,214,785 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0355,277,465 - 5,278,338 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1355,144,013 - 5,144,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0355,169,454 - 5,170,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0356,501,670 - 6,502,533 (+)NCBIUU_Cfam_GSD_1.0
Ppp1r3g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494619,109,666 - 19,113,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365347,380,932 - 7,381,948 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365347,379,443 - 7,382,752 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl73,051,149 - 3,052,210 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.173,049,153 - 3,059,840 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.273,152,599 - 3,155,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11767,099,511 - 67,101,255 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1767,100,173 - 67,101,234 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660445,025,901 - 5,028,494 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475620,170,051 - 20,171,010 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475620,168,734 - 20,171,456 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r3g
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000021704
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 40 109 86 85 55 24 55 6 199 87 89 42 59 30

Sequence


Ensembl Acc Id: ENSRNOT00000021704   ⟹   ENSRNOP00000064180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1728,876,482 - 28,877,525 (-)Ensembl
Rnor_6.0 Ensembl1729,567,404 - 29,568,447 (-)Ensembl
RefSeq Acc Id: NM_001400600   ⟹   NP_001387529
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81729,080,407 - 29,083,739 (-)NCBI
mRatBN7.21728,874,956 - 28,878,288 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001387529 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98287 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064180.1
Ensembl Acc Id: ENSRNOP00000064180   ⟸   ENSRNOT00000021704
RefSeq Acc Id: NP_001387529   ⟸   NM_001400600
- UniProtKB: A6J7D7 (UniProtKB/TrEMBL),   M0R4A0 (UniProtKB/TrEMBL)
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4A0-F1-model_v2 AlphaFold M0R4A0 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308930 AgrOrtholog
BioCyc Gene G2FUF-9632 BioCyc
Ensembl Genes ENSRNOG00000016222 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021704.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2440 UniProtKB/TrEMBL
InterPro CBM21_dom_sf UniProtKB/TrEMBL
  CBM_21 UniProtKB/TrEMBL
  PP1_regulatory_subunit_3 UniProtKB/TrEMBL
NCBI Gene 291069 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3G UniProtKB/TrEMBL
Pfam CBM_21 UniProtKB/TrEMBL
PhenoGen Ppp1r3g PhenoGen
PROSITE CBM21 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016222 RatGTEx
UniProt A6J7D7 ENTREZGENE, UniProtKB/TrEMBL
  M0R4A0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Ppp1r3g  protein phosphatase 1, regulatory subunit 3G  RGD1308930  similar to Protein phosphatase 1, regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1 binding subunit R6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308930  similar to Protein phosphatase 1, regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1 binding subunit R6)   RGD1308930_predicted  similar to Protein phosphatase 1, regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1 binding subunit R6) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308930_predicted  similar to Protein phosphatase 1, regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1 binding subunit R6) (predicted)  LOC291069_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291069_predicted  similar to Protein phosphatase 1, regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1 binding subunit R6) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL