Irf4 (interferon regulatory factor 4) - Rat Genome Database

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Gene: Irf4 (interferon regulatory factor 4) Rattus norvegicus
Analyze
Symbol: Irf4
Name: interferon regulatory factor 4
RGD ID: 1308050
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including T-helper 17 cell lineage commitment; positive regulation of cytokine production; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including histone acetylation; myeloid dendritic cell differentiation; and negative regulation of toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Orthologous to human IRF4 (interferon regulatory factor 4); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21733,721,800 - 33,742,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1733,721,811 - 33,740,070 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1733,560,168 - 33,578,389 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01735,164,039 - 35,182,262 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01733,555,976 - 33,574,191 (-)NCBIRnor_WKY
Rnor_6.01734,886,746 - 34,905,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1734,886,739 - 34,905,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01738,499,069 - 38,517,524 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,170,409 - 40,189,976 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,176,635 - 40,190,951 (-)NCBI
Celera1733,262,619 - 33,280,861 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-mevalonic acid  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
ethyl methanesulfonate  (ISO)
ferroheme b  (ISO)
flavonoids  (ISO)
fluvastatin  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
heme b  (ISO)
hexadecanoic acid  (ISO)
hydroxychloroquine  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
metam  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
mevastatin  (ISO)
nickel atom  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pomalidomide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cellular_component  (ND)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleosome  (ISO)
nucleus  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Implication of IRF4 aberrant gene expression in the acute leukemias of childhood. Adamaki M, etal., PLoS One. 2013 Aug 15;8(8):e72326. doi: 10.1371/journal.pone.0072326. eCollection 2013.
2. Variant IRF4/MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia. Allan JM, etal., Leukemia. 2010 Apr;24(4):877-81. doi: 10.1038/leu.2009.298. Epub 2010 Jan 21.
3. Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia. Chang CC, etal., Blood. 2002 Dec 15;100(13):4671-5. Epub 2002 Aug 1.
4. Fine-scale mapping of the 6p25.3 chronic lymphocytic leukaemia susceptibility locus. Crowther-Swanepoel D, etal., Hum Mol Genet. 2010 May 1;19(9):1840-5. doi: 10.1093/hmg/ddq044. Epub 2010 Feb 1.
5. An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males. Do TN, etal., Biochim Biophys Acta. 2010 Feb;1802(2):292-300. doi: 10.1016/j.bbadis.2009.10.015. Epub 2009 Nov 6.
6. Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas. Feldman AL, etal., Leukemia. 2009 Mar;23(3):574-80. doi: 10.1038/leu.2008.320. Epub 2008 Nov 6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. IRF4 mutations in chronic lymphocytic leukemia. Havelange V, etal., Blood. 2011 Sep 8;118(10):2827-9. doi: 10.1182/blood-2011-04-350579. Epub 2011 Jul 25.
10. Expression of MUM1/IRF4 mRNA as a prognostic marker in patients with multiple myeloma. Heintel D, etal., Leukemia. 2008 Feb;22(2):441-5. Epub 2007 Aug 9.
11. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. Iida S, etal., Nat Genet. 1997 Oct;17(2):226-30.
12. MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Ito M, etal., Jpn J Cancer Res. 2002 Jun;93(6):685-94.
13. Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy. Jiang DS, etal., Hypertension. 2013 Jun;61(6):1193-202. doi: 10.1161/HYPERTENSIONAHA.111.00614. Epub 2013 Apr 15.
14. Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Jo SH, etal., Blood. 2010 Oct 14;116(15):2759-67. doi: 10.1182/blood-2009-07-234559. Epub 2010 Jun 28.
15. IRF4 is a key thermogenic transcriptional partner of PGC-1alpha. Kong X, etal., Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049.
16. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. Lan Q, etal., Eur J Haematol. 2010 Dec;85(6):492-5. doi: 10.1111/j.1600-0609.2010.01518.x.
17. Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke. Lin Y, etal., Neurol Sci. 2015 Jun;36(6):913-20. doi: 10.1007/s10072-015-2096-2. Epub 2015 Feb 5.
18. Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response. Lopez-Girona A, etal., Br J Haematol. 2011 Aug;154(3):325-36. doi: 10.1111/j.1365-2141.2011.08689.x. Epub 2011 Jun 24.
19. Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4. Ma S, etal., J Biol Chem. 2013 Sep 13;288(37):26430-40. doi: 10.1074/jbc.M113.475913. Epub 2013 Jul 29.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. MUM1 expression dichotomises follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes. Naresh KN Haematologica. 2007 Feb;92(2):267-8.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. IRF4 is a suppressor of c-Myc induced B cell leukemia. Pathak S, etal., PLoS One. 2011;6(7):e22628. doi: 10.1371/journal.pone.0022628. Epub 2011 Jul 27.
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. Roberts MJ, etal., Am J Clin Pathol. 2013 Feb;139(2):210-9. doi: 10.1309/AJCP0YGM8BLFYHJY.
28. A role for IRF4 in the development of CLL. Shukla V, etal., Blood. 2013 Oct 17;122(16):2848-55. doi: 10.1182/blood-2013-03-492769. Epub 2013 Aug 7.
29. Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias. So AY, etal., Blood. 2014 Aug 28;124(9):1502-12. doi: 10.1182/blood-2014-02-553842. Epub 2014 Jul 8.
30. Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study. Sundram U, etal., J Cutan Pathol. 2005 Mar;32(3):227-34.
31. Detection of MUM1/IRF4-IgH fusion in multiple myeloma. Yoshida S, etal., Leukemia. 1999 Nov;13(11):1812-6.
Additional References at PubMed
PMID:12374808   PMID:15184678   PMID:15959530   PMID:16236719   PMID:16428437   PMID:19946888   PMID:22948820   PMID:22983707   PMID:22992523   PMID:22992524   PMID:24627105   PMID:28851732  
PMID:34628795  


Genomics

Comparative Map Data
Irf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21733,721,800 - 33,742,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1733,721,811 - 33,740,070 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1733,560,168 - 33,578,389 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01735,164,039 - 35,182,262 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01733,555,976 - 33,574,191 (-)NCBIRnor_WKY
Rnor_6.01734,886,746 - 34,905,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1734,886,739 - 34,905,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01738,499,069 - 38,517,524 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,170,409 - 40,189,976 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,176,635 - 40,190,951 (-)NCBI
Celera1733,262,619 - 33,280,861 (-)NCBICelera
Cytogenetic Map17p12NCBI
IRF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386391,752 - 411,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6391,739 - 411,443 (+)EnsemblGRCh38hg38GRCh38
GRCh376391,752 - 411,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366336,760 - 356,193 (+)NCBINCBI36Build 36hg18NCBI36
Build 346336,759 - 356,193NCBI
Celera61,620,599 - 1,639,926 (+)NCBICelera
Cytogenetic Map6p25.3NCBI
HuRef6264,308 - 284,078 (+)NCBIHuRef
CHM1_16393,650 - 413,301 (+)NCBICHM1_1
T2T-CHM13v2.06250,136 - 269,771 (+)NCBIT2T-CHM13v2.0
Irf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,933,191 - 30,950,965 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,933,209 - 30,950,959 (+)EnsemblGRCm39 Ensembl
GRCm381330,749,233 - 30,766,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,749,226 - 30,766,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,841,127 - 30,858,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,756,723 - 30,774,392 (+)NCBIMGSCv36mm8
Celera1330,963,334 - 30,981,003 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
Irf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546512,497,462 - 12,513,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546512,497,534 - 12,512,529 (-)NCBIChiLan1.0ChiLan1.0
IRF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16341,637 - 360,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6342,718 - 356,654 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06206,282 - 226,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IRF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.135760,367 - 782,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl35767,011 - 781,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha35777,727 - 796,599 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.035714,152 - 737,540 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl35714,202 - 738,113 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.135700,365 - 719,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.035718,232 - 734,827 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,054,228 - 2,070,812 (+)NCBIUU_Cfam_GSD_1.0
Irf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494625,039,805 - 25,055,378 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366331,564,637 - 1,580,859 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366331,565,293 - 1,580,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7133,371 - 149,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17133,358 - 149,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IRF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11771,739,920 - 71,758,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666044315,955 - 334,864 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475623,918,323 - 23,931,501 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475623,917,111 - 23,931,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irf4
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:491
Count of miRNA genes:248
Interacting mature miRNAs:322
Transcripts:ENSRNOT00000024494
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 15
Low 1 26 24 12 4 12 8 10 40 29 26 11 8
Below cutoff 17 27 27 27 1 32 6 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079332   ⟹   ENSRNOP00000070345
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1733,721,811 - 33,739,449 (-)Ensembl
Rnor_6.0 Ensembl1734,886,739 - 34,903,862 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088931   ⟹   ENSRNOP00000074106
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1733,721,811 - 33,740,070 (-)Ensembl
Rnor_6.0 Ensembl1734,886,746 - 34,905,117 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098421   ⟹   ENSRNOP00000086418
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1733,721,811 - 33,739,449 (-)Ensembl
RefSeq Acc Id: NM_001106108   ⟹   NP_001099578
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21733,721,811 - 33,740,070 (-)NCBI
Rnor_6.01734,886,746 - 34,905,117 (-)NCBI
Rnor_5.01738,499,069 - 38,517,524 (+)NCBI
RGSC_v3.41740,170,409 - 40,189,976 (-)RGD
Celera1733,262,619 - 33,280,861 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253899   ⟹   XP_006253961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21733,721,800 - 33,742,570 (-)NCBI
Rnor_6.01734,889,379 - 34,905,190 (-)NCBI
Rnor_5.01738,499,069 - 38,517,524 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253900   ⟹   XP_006253962
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21733,721,800 - 33,742,569 (-)NCBI
Rnor_6.01734,889,379 - 34,905,191 (-)NCBI
Rnor_5.01738,499,069 - 38,517,524 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099578 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253961 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253962 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98364 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099578   ⟸   NM_001106108
- UniProtKB: D3ZEX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253962   ⟸   XM_006253900
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006253961   ⟸   XM_006253899
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000070345   ⟸   ENSRNOT00000079332
RefSeq Acc Id: ENSRNOP00000074106   ⟸   ENSRNOT00000088931
RefSeq Acc Id: ENSRNOP00000086418   ⟸   ENSRNOT00000098421
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEX6-F1-model_v2 AlphaFold D3ZEX6 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700425
Promoter ID:EPDNEW_R10947
Type:single initiation site
Name:Irf4_1
Description:interferon regulatory factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01734,905,136 - 34,905,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308050 AgrOrtholog
BioCyc Gene G2FUF-9538 BioCyc
Ensembl Genes ENSRNOG00000061070 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070345.2 UniProtKB/TrEMBL
  ENSRNOP00000074106 ENTREZGENE
  ENSRNOP00000074106.1 UniProtKB/TrEMBL
  ENSRNOP00000086418 ENTREZGENE
  ENSRNOP00000086418.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079332.2 UniProtKB/TrEMBL
  ENSRNOT00000088931 ENTREZGENE
  ENSRNOT00000088931.2 UniProtKB/TrEMBL
  ENSRNOT00000098421 ENTREZGENE
  ENSRNOT00000098421.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/TrEMBL
InterPro Interferon_reg_fac_CS UniProtKB/TrEMBL
  Interferon_reg_factor UniProtKB/TrEMBL
  Interferon_reg_factor-3 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:291100 UniProtKB/TrEMBL
NCBI Gene 291100 ENTREZGENE
Pfam IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
PhenoGen Irf4 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF UniProtKB/TrEMBL
  IRF_2 UniProtKB/TrEMBL
SMART IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2JXN7_RAT UniProtKB/TrEMBL
  A0A8I6A257_RAT UniProtKB/TrEMBL
  D3ZEX6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irf4  interferon regulatory factor 4   Irf4_predicted  interferon regulatory factor 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Irf4_predicted  interferon regulatory factor 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED