Serpinb6a (serpin family B member 6A) - Rat Genome Database

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Gene: Serpinb6a (serpin family B member 6A) Rattus norvegicus
Analyze
Symbol: Serpinb6a
Name: serpin family B member 6A
RGD ID: 735108
Description: Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72983; serine (or cysteine) peptidase inhibitor, clade B, member 6; serine (or cysteine) peptidase inhibitor, clade B, member 6a; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; serpin B6; serpin family B member 6; serpin peptidase inhibitor, clade B (ovalbumin), member 6; Serpinb6
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,076,811 - 31,195,035 (+)NCBIGRCr8
mRatBN7.21730,871,468 - 30,989,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,871,468 - 31,014,427 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,685,617 - 30,804,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,289,360 - 32,407,916 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,681,350 - 30,799,899 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,154,747 - 32,209,598 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,190,801 - 32,209,590 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,084,076 - 34,102,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,316,389 - 37,335,124 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,319,229 - 37,337,965 (+)NCBI
Celera1730,535,108 - 30,553,843 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ampicillin  (EXP)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
neomycin  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
raloxifene  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Coughlin P, etal., Proc Natl Acad Sci U S A 1993 Oct 15;90(20):9417-21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:14670919   PMID:16175637   PMID:17761692   PMID:19056867   PMID:20451170   PMID:23376485   PMID:23533145   PMID:27068509  


Genomics

Comparative Map Data
Serpinb6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,076,811 - 31,195,035 (+)NCBIGRCr8
mRatBN7.21730,871,468 - 30,989,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,871,468 - 31,014,427 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,685,617 - 30,804,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,289,360 - 32,407,916 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,681,350 - 30,799,899 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,154,747 - 32,209,598 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,190,801 - 32,209,590 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,084,076 - 34,102,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,316,389 - 37,335,124 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,319,229 - 37,337,965 (+)NCBI
Celera1730,535,108 - 30,553,843 (+)NCBICelera
Cytogenetic Map17p12NCBI
SERPINB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,948,159 - 2,971,793 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl62,948,159 - 2,972,165 (-)EnsemblGRCh38hg38GRCh38
GRCh3762,948,393 - 2,972,027 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,893,392 - 2,917,089 (-)NCBINCBI36Build 36hg18NCBI36
Build 3462,893,391 - 2,917,089NCBI
Celera64,177,451 - 4,201,136 (-)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,821,595 - 2,845,591 (-)NCBIHuRef
CHM1_162,950,764 - 2,974,758 (-)NCBICHM1_1
T2T-CHM13v2.062,817,071 - 2,840,707 (-)NCBIT2T-CHM13v2.0
Serpinb6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391334,101,901 - 34,186,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1334,101,901 - 34,186,777 (-)EnsemblGRCm39 Ensembl
GRCm381333,917,918 - 34,002,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1333,917,918 - 34,002,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv371334,009,787 - 34,094,618 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361333,925,392 - 33,943,461 (-)NCBIMGSCv36mm8
Celera1335,047,258 - 35,132,241 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.0NCBI
HMSD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21781,458,498 - 81,466,877 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11867,145,099 - 67,159,622 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01857,306,835 - 57,315,231 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11860,613,877 - 60,624,559 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC106504299
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,752,689 - 1,776,087 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.171,755,252 - 1,776,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,832,151 - 1,836,133 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,204,019 - 69,219,020 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,207,684 - 69,219,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660442,881,786 - 2,896,484 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Serpinb6a
751 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:80
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000024161
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat

Markers in Region
RH129867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,989,458 - 30,989,648 (+)MAPPERmRatBN7.2
Rnor_6.01732,209,354 - 32,209,543NCBIRnor6.0
Rnor_5.01734,102,676 - 34,102,865UniSTSRnor5.0
RGSC_v3.41737,334,888 - 37,335,077UniSTSRGSC3.4
Celera1730,553,607 - 30,553,796UniSTS
RH 3.4 Map17326.02UniSTS
Cytogenetic Map17p12UniSTS
Serpinb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2831,874,506 - 31,875,418 (+)MAPPERmRatBN7.2
Rnor_6.0834,714,297 - 34,715,208NCBIRnor6.0
Rnor_5.0834,745,725 - 34,746,636UniSTSRnor5.0
RGSC_v3.4833,282,598 - 33,283,509UniSTSRGSC3.4
Celera833,306,736 - 33,307,646UniSTS
Cytogenetic Map8q21UniSTS
Cytogenetic Map17p12UniSTS
Serpinb6c  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,978,000 - 30,978,060 (+)MAPPERmRatBN7.2
Rnor_6.01732,197,843 - 32,197,902NCBIRnor6.0
Rnor_5.01734,091,165 - 34,091,224UniSTSRnor5.0
RGSC_v3.41737,323,431 - 37,323,490UniSTSRGSC3.4
RGSC_v3.41737,826,272 - 37,826,332UniSTSRGSC3.4
Celera1731,029,328 - 31,029,388UniSTS
Celera1730,542,150 - 30,542,209UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024161   ⟹   ENSRNOP00000024161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,970,957 - 30,989,694 (+)Ensembl
Rnor_6.0 Ensembl1732,190,801 - 32,209,590 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102782   ⟹   ENSRNOP00000089104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,970,845 - 31,014,427 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118879   ⟹   ENSRNOP00000090303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,871,468 - 30,989,694 (+)Ensembl
RefSeq Acc Id: NM_001395026   ⟹   NP_001381955
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,076,811 - 31,195,035 (+)NCBI
mRatBN7.21730,871,468 - 30,989,697 (+)NCBI
RefSeq Acc Id: NM_001395027   ⟹   NP_001381956
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,176,255 - 31,195,035 (+)NCBI
mRatBN7.21730,970,915 - 30,989,697 (+)NCBI
RefSeq Acc Id: NM_199085   ⟹   NP_954516
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,176,255 - 31,195,035 (+)NCBI
mRatBN7.21730,970,915 - 30,989,697 (+)NCBI
Rnor_6.01732,190,801 - 32,209,590 (+)NCBI
Rnor_5.01734,084,076 - 34,102,920 (+)NCBI
RGSC_v3.41737,316,389 - 37,335,124 (+)RGD
Celera1730,535,108 - 30,553,843 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253871   ⟹   XP_006253933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,176,550 - 31,195,035 (+)NCBI
mRatBN7.21730,971,210 - 30,989,703 (+)NCBI
Rnor_6.01732,190,911 - 32,209,598 (+)NCBI
Rnor_5.01734,084,076 - 34,102,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095492   ⟹   XP_038951420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,076,961 - 31,195,035 (+)NCBI
mRatBN7.21730,871,622 - 30,989,697 (+)NCBI
RefSeq Acc Id: NP_954516   ⟸   NM_199085
- UniProtKB: Q6P9U0 (UniProtKB/TrEMBL),   A6J7I2 (UniProtKB/TrEMBL),   F7EUC3 (UniProtKB/TrEMBL),   A0A8I6ABJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253933   ⟸   XM_006253871
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A6H8 (UniProtKB/TrEMBL),   F7EUC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024161   ⟸   ENSRNOT00000024161
RefSeq Acc Id: XP_038951420   ⟸   XM_039095492
- Peptide Label: isoform X1
- UniProtKB: Q6P9U0 (UniProtKB/TrEMBL),   A6J7I2 (UniProtKB/TrEMBL),   F7EUC3 (UniProtKB/TrEMBL),   A0A8I6ABJ3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089104   ⟸   ENSRNOT00000102782
Ensembl Acc Id: ENSRNOP00000090303   ⟸   ENSRNOT00000118879
RefSeq Acc Id: NP_001381955   ⟸   NM_001395026
- UniProtKB: Q6P9U0 (UniProtKB/TrEMBL),   A6J7I2 (UniProtKB/TrEMBL),   F7EUC3 (UniProtKB/TrEMBL),   A0A8I6ABJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381956   ⟸   NM_001395027
- UniProtKB: Q6P9U0 (UniProtKB/TrEMBL),   A6J7I2 (UniProtKB/TrEMBL),   F7EUC3 (UniProtKB/TrEMBL),   A0A8I6ABJ3 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P9U0-F1-model_v2 AlphaFold Q6P9U0 1-379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700417
Promoter ID:EPDNEW_R10941
Type:multiple initiation site
Name:Serpinb6a_1
Description:serpin family B member 6A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,190,802 - 32,190,862EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735108 AgrOrtholog
BioCyc Gene G2FUF-9597 BioCyc
Ensembl Genes ENSRNOG00000017962 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024161.6 UniProtKB/TrEMBL
  ENSRNOT00000102782.1 UniProtKB/TrEMBL
  ENSRNOT00000118879.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6887824 IMAGE-MGC_LOAD
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
MGC_CLONE MGC:72983 IMAGE-MGC_LOAD
NCBI Gene 291085 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  SERPIN B6 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb6a PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017962 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A8I6A6H8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6J7I2 ENTREZGENE, UniProtKB/TrEMBL
  F7EUC3 ENTREZGENE, UniProtKB/TrEMBL
  Q6P9U0 ENTREZGENE
UniProt Secondary Q6P9U0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-19 Serpinb6a  serpin family B member 6A  Serpinb6  serpin family B member 6  Name and Symbol changed 629549 APPROVED
2016-04-13 Serpinb6  serpin family B member 6  Serpinb6  serpin peptidase inhibitor, clade B (ovalbumin), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Serpinb6  serpin peptidase inhibitor, clade B (ovalbumin), member 6  Serpinb6a  serine (or cysteine) peptidase inhibitor, clade B, member 6a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Serpinb6a  serine (or cysteine) peptidase inhibitor, clade B, member 6a  Serpinb6  serine (or cysteine) peptidase inhibitor, clade B, member 6  Symbol and Name updated 1299863 APPROVED
2005-07-08 Serpinb6  serine (or cysteine) peptidase inhibitor, clade B, member 6    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6  Name updated 1299863 APPROVED