Il2ra (interleukin 2 receptor subunit alpha) - Rat Genome Database

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Gene: Il2ra (interleukin 2 receptor subunit alpha) Rattus norvegicus
Analyze
Symbol: Il2ra
Name: interleukin 2 receptor subunit alpha
RGD ID: 2895
Description: Exhibits interleukin-2 receptor activity. Involved in inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; and positive regulation of T cell proliferation. Localizes to cell surface. Used to study Korean hemorrhagic fever; asthma; and diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1-nitropropane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2RAC; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha chain; interleukin-2 receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21766,849,974 - 66,898,665 (-)NCBI
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01770,500,672 - 70,547,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01772,204,467 - 72,250,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,050,491 - 78,097,802 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11778,061,323 - 78,108,635 (-)NCBI
Celera1766,355,852 - 66,402,955 (-)NCBICelera
RH 3.4 Map17636.4RGD
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthaleneacetic acid  (ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-tert-butylhydroquinone  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
capsiate  (ISO)
carbon nanotube  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
fragrance  (ISO)
gentamycin  (EXP)
hexachlorobenzene  (EXP)
indole-3-acetic acid  (ISO)
ionomycin  (EXP,ISO)
isopentenyl diphosphate  (ISO)
lactacystin  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
methotrexate  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nonanoic acid  (ISO)
o-anisidine  (ISO)
ouabain  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
pimecrolimus  (ISO)
procyanidin B3  (ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (EXP)
prostratin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
theophylline  (ISO)
thiopental  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
WR-1065  (ISO)
zalcitabine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alcina A, etal., PLoS One. 2009;4(1):e4137. Epub 2009 Jan 6.
2. Aricha R, etal., J Immunol. 2008 Feb 15;180(4):2132-9.
3. Chen L, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):203-208. doi: 10.3760/cma.j.issn.1001-0939.2020.03.013.
4. Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11.
5. Easterbrook JD, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15502-7. Epub 2007 Sep 18.
6. Fernandez-Ruiz E, etal., J Immunol. 1989 Dec 15;143(12):4146-51.
7. Fulton RB, etal., J Immunol. 2010 Aug 15;185(4):2382-92. Epub 2010 Jul 16.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Honey CR and Shen H, J Neurosurg. 1999 Jul;91(1):109-13.
11. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
12. Imbert V and Renauld PR, Eur Cytokine Netw. 1999 Mar;10(1):71-8.
13. Kawasaki E, etal., J Clin Endocrinol Metab. 2009 Mar;94(3):947-52. Epub 2008 Dec 23.
14. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. Liu F, etal., PLoS One. 2010 Nov 3;5(11):e15404.
16. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
17. Ma J, etal., J Allergy Clin Immunol. 2011 Jun;127(6):1447-56.e6. Epub 2011 Mar 4.
18. Maier LM, etal., PLoS Genet. 2009 Jan;5(1):e1000322. Epub 2009 Jan 2.
19. MGD data from the GO Consortium
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Nolte-'t Hoen EN, etal., J Leukoc Biol. 2008 Jan;83(1):112-21. Epub 2007 Oct 10.
22. OMIM Disease Annotation Pipeline
23. Page TH and Dallman MJ, Eur J Immunol 1991 Sep;21(9):2133-8.
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Preston JA, etal., Eur Respir J. 2011 Jan;37(1):53-64. Epub 2010 Jun 4.
27. Rasmuson J, etal., Chest. 2011 Mar 24.
28. RGD automated data pipeline
29. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. RGD automated import pipeline for gene-chemical interactions
31. Sharfe N, etal., Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3168-71.
32. Skripuletz T, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1564-71. Epub 2007 Mar 9.
33. Thessen Hedreul M, etal., J Neuroimmunol. 2009 May 29;210(1-2):30-9. Epub 2009 Mar 9.
34. Ugrasbul F, etal., Pediatr Diabetes. 2008 Dec;9(6):596-601. Epub 2008 May 21.
35. Varas A, etal., Int Immunol. 1997 Oct;9(10):1589-99.
36. Wan L, etal., Appl Microbiol Biotechnol. 2008 Nov;81(1):33-41. Epub 2008 Aug 13.
Additional References at PubMed
PMID:2467293   PMID:7477352   PMID:7584142   PMID:7688139   PMID:8125140   PMID:8262055   PMID:8755570   PMID:8769481   PMID:10072077   PMID:10760791   PMID:12702495   PMID:12867038  
PMID:14990792   PMID:15240714   PMID:15294943   PMID:15368291   PMID:15728238   PMID:15843532   PMID:15909309   PMID:16227984   PMID:16301745   PMID:16973387   PMID:17082577   PMID:18628982  
PMID:18641307   PMID:18792410   PMID:18832572   PMID:18958875   PMID:19008373   PMID:19159826   PMID:19723499   PMID:19884905   PMID:19934022   PMID:21460847   PMID:21508411   PMID:22072979  
PMID:23416241   PMID:29772575  


Genomics

Comparative Map Data
Il2ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21766,849,974 - 66,898,665 (-)NCBI
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01770,500,672 - 70,547,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01772,204,467 - 72,250,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,050,491 - 78,097,802 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11778,061,323 - 78,108,635 (-)NCBI
Celera1766,355,852 - 66,402,955 (-)NCBICelera
RH 3.4 Map17636.4RGD
Cytogenetic Map17q12.2NCBI
IL2RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl106,010,689 - 6,062,370 (-)EnsemblGRCh38hg38GRCh38
GRCh38106,010,689 - 6,062,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37106,052,652 - 6,104,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,093,512 - 6,144,278 (-)NCBINCBI36hg18NCBI36
Build 34106,093,511 - 6,144,278NCBI
Celera105,982,579 - 6,033,743 (-)NCBI
Cytogenetic Map10p15.1NCBI
HuRef105,979,490 - 6,030,662 (-)NCBIHuRef
CHM1_1106,052,649 - 6,103,793 (-)NCBICHM1_1
Il2ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,647,603 - 11,698,005 (+)NCBIGRCm39mm39
GRCm39 Ensembl211,647,618 - 11,698,004 (+)Ensembl
GRCm38211,642,792 - 11,693,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,642,807 - 11,693,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv37211,564,419 - 11,614,821 (+)NCBIGRCm37mm9NCBIm37
MGSCv36211,560,703 - 11,611,044 (+)NCBImm8
Celera211,560,200 - 11,610,847 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.91NCBI
Il2ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542122,641,511 - 22,694,913 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542122,642,004 - 22,694,729 (-)NCBIChiLan1.0ChiLan1.0
IL2RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1106,037,664 - 6,086,018 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0106,053,549 - 6,103,863 (-)NCBIMhudiblu_PPA_v0panPan3
IL2RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,892,130 - 29,948,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,894,125 - 29,944,643 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha226,924,836 - 26,975,354 (+)NCBI
ROS_Cfam_1.0230,275,012 - 30,330,188 (+)NCBI
UMICH_Zoey_3.1227,372,288 - 27,422,786 (+)NCBI
UNSW_CanFamBas_1.0228,208,376 - 28,259,290 (+)NCBI
UU_Cfam_GSD_1.0228,928,272 - 28,977,130 (+)NCBI
Il2ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,349,142 - 32,390,487 (+)NCBI
SpeTri2.0NW_0049364848,514,333 - 8,555,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,948,552 - 65,001,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11064,948,149 - 65,001,320 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,153,916 - 71,162,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL2RA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,134,961 - 6,187,731 (-)NCBI
ChlSab1.1 Ensembl96,141,430 - 6,149,447 (-)Ensembl
Vero_WHO_p1.0NW_02366605111,438,032 - 11,490,878 (-)NCBI
Il2ra
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624775927,337 - 991,062 (-)NCBI

Position Markers
RH143008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,850,057 - 66,850,177 (+)MAPPER
Rnor_6.01770,499,236 - 70,499,355NCBIRnor6.0
Rnor_5.01772,203,031 - 72,203,150UniSTSRnor5.0
RGSC_v3.41778,049,055 - 78,049,174UniSTSRGSC3.4
Celera1766,354,416 - 66,354,535UniSTS
RH 3.4 Map17658.2UniSTS
Cytogenetic Map17q12.3UniSTS
RH94535  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map17636.4UniSTS
Cytogenetic Map17q12.3UniSTS
fb22g09.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,858,666 - 66,859,585 (+)MAPPER
Rnor_6.01770,507,845 - 70,508,763NCBIRnor6.0
Rnor_5.01772,211,640 - 72,212,558UniSTSRnor5.0
RGSC_v3.41778,057,664 - 78,058,574UniSTSRGSC3.4
Celera1766,363,025 - 66,363,943UniSTS
Cytogenetic Map17q12.3UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172149095074823273Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172841314873413148Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173097522875975228Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173097522875975228Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173205588277922655Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173330362778303627Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173330362785321557Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173628324577922655Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173779030673413148Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)174117605786176057Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)174117605786176057Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174173108086731080Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174254187285446768Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174435615789356157Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174866025273413148Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174866025273413148Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)175241095790843779Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)175241095790843779Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175347518090690466Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175387148890843779Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175399194790843779Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175622429686731080Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)176219570373981731Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)176219570374702206Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176219582286194199Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176549735982019219Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176700421277922655Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176751265790843779Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176933327285183543Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:709
Count of miRNA genes:295
Interacting mature miRNAs:395
Transcripts:ENSRNOT00000073144
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 7 7
Low 2 6 1 12 11 9 7 11
Below cutoff 23 34 26 26 3 6 33 25 27 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073144   ⟹   ENSRNOP00000066383
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)Ensembl
RefSeq Acc Id: NM_013163   ⟹   NP_037295
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21766,851,494 - 66,898,665 (-)NCBI
Rnor_6.01770,500,672 - 70,547,929 (-)NCBI
Rnor_5.01772,204,467 - 72,250,556 (-)NCBI
RGSC_v3.41778,050,491 - 78,097,802 (-)RGD
Celera1766,355,852 - 66,402,955 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095399   ⟹   XP_038951327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21766,849,974 - 66,864,084 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037295 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951327 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41428 (Get FASTA)   NCBI Sequence Viewer  
  EDL78597 (Get FASTA)   NCBI Sequence Viewer  
  P26897 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037295   ⟸   NM_013163
- Peptide Label: precursor
- UniProtKB: P26897 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066383   ⟸   ENSRNOT00000073144
RefSeq Acc Id: XP_038951327   ⟸   XM_039095399
- Peptide Label: isoform X1
Protein Domains
Sushi

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2895 AgrOrtholog
Ensembl Genes ENSRNOG00000047647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066383 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073144 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro IL-2_rcpt_alpha UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report rno:25704 UniProtKB/Swiss-Prot
NCBI Gene 25704 ENTREZGENE
PANTHER PTHR10573 UniProtKB/Swiss-Prot
PhenoGen Il2ra PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot
SMART CCP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot
UniProt IL2RA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il2ra  interleukin 2 receptor subunit alpha  Il2ra  interleukin 2 receptor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Il2ra  interleukin 2 receptor, alpha  Il2ra  interleukin 2 receptor, alpha chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Il2ra  Interleukin 2 receptor, alpha chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is upregulated following lymphocyte activation 728928