Il2ra (interleukin 2 receptor subunit alpha) - Rat Genome Database

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Gene: Il2ra (interleukin 2 receptor subunit alpha) Rattus norvegicus
Analyze
Symbol: Il2ra
Name: interleukin 2 receptor subunit alpha
RGD ID: 2895
Description: Enables interleukin-2 receptor activity. Involved in inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; and positive regulation of T cell proliferation. Located in cell surface. Used to study Korean hemorrhagic fever; asthma; and diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1-nitropropane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2RAC; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha chain; interleukin-2 receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21766,849,974 - 66,898,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,849,974 - 66,898,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1770,337,084 - 70,384,350 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01774,165,907 - 74,213,174 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01768,208,899 - 68,256,163 (-)NCBIRnor_WKY
Rnor_6.01770,500,672 - 70,547,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01772,204,467 - 72,250,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,050,491 - 78,097,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11778,061,323 - 78,108,635 (-)NCBI
Celera1766,355,852 - 66,402,955 (-)NCBICelera
RH 3.4 Map17636.4RGD
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthaleneacetic acid  (ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-tert-butylhydroquinone  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
capsiate  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
Didecyldimethylammonium  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
fragrance  (ISO)
gentamycin  (EXP)
hexachlorobenzene  (EXP)
indole-3-acetic acid  (ISO)
ionomycin  (EXP,ISO)
isopentenyl diphosphate  (ISO)
lactacystin  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
methotrexate  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nonanoic acid  (ISO)
o-anisidine  (ISO)
ouabain  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
pimecrolimus  (ISO)
procyanidin B3  (ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (EXP)
prostratin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiopental  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
WR-1065  (ISO)
zalcitabine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). Alcina A, etal., PLoS One. 2009;4(1):e4137. Epub 2009 Jan 6.
2. Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. Aricha R, etal., J Immunol. 2008 Feb 15;180(4):2132-9.
3. [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia]. Chen L, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):203-208. doi: 10.3760/cma.j.issn.1001-0939.2020.03.013.
4. Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis. Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11.
5. Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Easterbrook JD, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15502-7. Epub 2007 Sep 18.
6. IL-2 protects T cell hybrids from the cytolytic effect of glucocorticoids. Synergistic effect of IL-2 and dexamethasone in the induction of high-affinity IL-2 receptors. Fernandez-Ruiz E, etal., J Immunol. 1989 Dec 15;143(12):4146-51.
7. Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. Fulton RB, etal., J Immunol. 2010 Aug 15;185(4):2382-92. Epub 2010 Jul 16.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Immunosuppression for neural xenografts: a comparison of cyclosporin and anti-CD25 monoclonal antibody. Honey CR and Shen H, J Neurosurg. 1999 Jul;91(1):109-13.
11. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
12. Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines. Imbert V and Renauld PR, Eur Cytokine Netw. 1999 Mar;10(1):71-8.
13. Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. Kawasaki E, etal., J Clin Endocrinol Metab. 2009 Mar;94(3):947-52. Epub 2008 Dec 23.
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice. Liu F, etal., PLoS One. 2010 Nov 3;5(11):e15404.
16. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
17. Alleviating allergic airway diseases by means of short-term administration of IL-2 and dexamethasone. Ma J, etal., J Allergy Clin Immunol. 2011 Jun;127(6):1447-56.e6. Epub 2011 Mar 4.
18. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. Maier LM, etal., PLoS Genet. 2009 Jan;5(1):e1000322. Epub 2009 Jan 2.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134. Nolte-'t Hoen EN, etal., J Leukoc Biol. 2008 Jan;83(1):112-21. Epub 2007 Oct 10.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha and beta chain genes: differentially regulated gene activity in response to mitogenic stimulation. Page TH and Dallman MJ, Eur J Immunol 1991 Sep;21(9):2133-8.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. Preston JA, etal., Eur Respir J. 2011 Jan;37(1):53-64. Epub 2010 Jun 4.
27. Presence of Activated Airway T Lymphocytes in Human Puumala Hantavirus Disease. Rasmuson J, etal., Chest. 2011 Mar 24.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Sharfe N, etal., Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3168-71.
32. Dose-dependent recruitment of CD25+ and CD26+ T cells in a novel F344 rat model of asthma. Skripuletz T, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1564-71. Epub 2007 Mar 9.
33. Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. Thessen Hedreul M, etal., J Neuroimmunol. 2009 May 29;210(1-2):30-9. Epub 2009 Mar 9.
34. Prevention of diabetes: effect of mycophenolate mofetil and anti-CD25 on onset of diabetes in the DRBB rat. Ugrasbul F, etal., Pediatr Diabetes. 2008 Dec;9(6):596-601. Epub 2008 May 21.
35. Role of IL-2 in rat fetal thymocyte development. Varas A, etal., Int Immunol. 1997 Oct;9(10):1589-99.
36. High-level expression of a functional humanized single-chain variable fragment antibody against CD25 in Pichia pastoris. Wan L, etal., Appl Microbiol Biotechnol. 2008 Nov;81(1):33-41. Epub 2008 Aug 13.
Additional References at PubMed
PMID:2467293   PMID:7477352   PMID:7584142   PMID:7688139   PMID:8125140   PMID:8262055   PMID:8755570   PMID:8769481   PMID:10072077   PMID:10760791   PMID:12702495   PMID:12867038  
PMID:14990792   PMID:15240714   PMID:15294943   PMID:15368291   PMID:15728238   PMID:15843532   PMID:15909309   PMID:16227984   PMID:16301745   PMID:16973387   PMID:17082577   PMID:18628982  
PMID:18641307   PMID:18792410   PMID:18832572   PMID:18958875   PMID:19008373   PMID:19159826   PMID:19723499   PMID:19884905   PMID:19934022   PMID:21460847   PMID:21508411   PMID:22072979  
PMID:23416241   PMID:29772575  


Genomics

Comparative Map Data
Il2ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21766,849,974 - 66,898,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,849,974 - 66,898,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1770,337,084 - 70,384,350 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01774,165,907 - 74,213,174 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01768,208,899 - 68,256,163 (-)NCBIRnor_WKY
Rnor_6.01770,500,672 - 70,547,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01772,204,467 - 72,250,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,050,491 - 78,097,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11778,061,323 - 78,108,635 (-)NCBI
Celera1766,355,852 - 66,402,955 (-)NCBICelera
RH 3.4 Map17636.4RGD
Cytogenetic Map17q12.2NCBI
IL2RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38106,010,689 - 6,062,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl106,010,689 - 6,062,370 (-)EnsemblGRCh38hg38GRCh38
GRCh37106,052,652 - 6,104,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,093,512 - 6,144,278 (-)NCBINCBI36Build 36hg18NCBI36
Build 34106,093,511 - 6,144,278NCBI
Celera105,982,579 - 6,033,743 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,979,490 - 6,030,662 (-)NCBIHuRef
CHM1_1106,052,649 - 6,103,793 (-)NCBICHM1_1
T2T-CHM13v2.0106,011,401 - 6,062,560 (-)NCBIT2T-CHM13v2.0
Il2ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,647,603 - 11,698,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl211,647,618 - 11,698,004 (+)EnsemblGRCm39 Ensembl
GRCm38211,642,792 - 11,693,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,642,807 - 11,693,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv37211,564,419 - 11,614,821 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36211,560,703 - 11,611,044 (+)NCBIMGSCv36mm8
Celera211,560,200 - 11,610,847 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.91NCBI
Il2ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542122,641,511 - 22,694,913 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542122,642,004 - 22,694,729 (-)NCBIChiLan1.0ChiLan1.0
IL2RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1106,037,664 - 6,086,018 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0106,053,549 - 6,103,863 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL2RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,892,130 - 29,948,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,894,125 - 29,944,643 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha226,924,836 - 26,975,354 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0230,275,012 - 30,330,188 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl230,275,175 - 30,327,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1227,372,288 - 27,422,786 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,208,376 - 28,259,290 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0228,928,272 - 28,977,130 (+)NCBIUU_Cfam_GSD_1.0
Il2ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,349,142 - 32,390,487 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364848,544,062 - 8,555,332 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364848,514,333 - 8,555,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,948,563 - 65,001,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11064,948,149 - 65,001,320 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,153,916 - 71,162,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL2RA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,134,961 - 6,187,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl96,141,430 - 6,149,447 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605111,438,032 - 11,490,878 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2ra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624775924,648 - 942,354 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624775927,337 - 991,062 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il2ra
329 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:709
Count of miRNA genes:295
Interacting mature miRNAs:395
Transcripts:ENSRNOT00000073144
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat

Markers in Region
RH143008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,850,057 - 66,850,177 (+)MAPPERmRatBN7.2
Rnor_6.01770,499,236 - 70,499,355NCBIRnor6.0
Rnor_5.01772,203,031 - 72,203,150UniSTSRnor5.0
RGSC_v3.41778,049,055 - 78,049,174UniSTSRGSC3.4
Celera1766,354,416 - 66,354,535UniSTS
RH 3.4 Map17658.2UniSTS
Cytogenetic Map17q12.3UniSTS
RH94535  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map17636.4UniSTS
Cytogenetic Map17q12.3UniSTS
fb22g09.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,858,666 - 66,859,585 (+)MAPPERmRatBN7.2
Rnor_6.01770,507,845 - 70,508,763NCBIRnor6.0
Rnor_5.01772,211,640 - 72,212,558UniSTSRnor5.0
RGSC_v3.41778,057,664 - 78,058,574UniSTSRGSC3.4
Celera1766,363,025 - 66,363,943UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 7 7
Low 2 6 1 12 11 9 7 11
Below cutoff 23 34 26 26 3 6 33 25 27 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073144   ⟹   ENSRNOP00000066383
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1766,849,974 - 66,898,697 (-)Ensembl
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)Ensembl
RefSeq Acc Id: NM_013163   ⟹   NP_037295
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21766,851,494 - 66,898,665 (-)NCBI
Rnor_6.01770,500,672 - 70,547,929 (-)NCBI
Rnor_5.01772,204,467 - 72,250,556 (-)NCBI
RGSC_v3.41778,050,491 - 78,097,802 (-)RGD
Celera1766,355,852 - 66,402,955 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095399   ⟹   XP_038951327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21766,849,974 - 66,864,084 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037295 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951327 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41428 (Get FASTA)   NCBI Sequence Viewer  
  EDL78597 (Get FASTA)   NCBI Sequence Viewer  
  P26897 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037295   ⟸   NM_013163
- Peptide Label: precursor
- UniProtKB: P26897 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066383   ⟸   ENSRNOT00000073144
RefSeq Acc Id: XP_038951327   ⟸   XM_039095399
- Peptide Label: isoform X1
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26897-F1-model_v2 AlphaFold P26897 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2895 AgrOrtholog
BioCyc Gene G2FUF-8799 BioCyc
Ensembl Genes ENSRNOG00000047647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066383 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073144 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro IL-2_rcpt_alpha UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report rno:25704 UniProtKB/Swiss-Prot
NCBI Gene 25704 ENTREZGENE
PANTHER PTHR10573 UniProtKB/Swiss-Prot
Pfam Sushi UniProtKB/Swiss-Prot
PhenoGen Il2ra PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot
SMART CCP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot
UniProt IL2RA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il2ra  interleukin 2 receptor subunit alpha  Il2ra  interleukin 2 receptor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Il2ra  interleukin 2 receptor, alpha  Il2ra  interleukin 2 receptor, alpha chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Il2ra  Interleukin 2 receptor, alpha chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is upregulated following lymphocyte activation 728928