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Gene: Mtr (5-methyltetrahydrofolate-homocysteine methyltransferase) Rattus norvegicus
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Symbol: Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Description: Exhibits amino acid binding activity; folic acid binding activity; and methionine synthase activity. Involved in several processes, including cellular amino acid metabolic process; cellular response to methionine; and cellular response to nitric oxide. Predicted to localize to the cytosol. Biomarker of type 2 diabetes mellitus and vitamin B12 deficiency. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autistic disorder; hematologic cancer (multiple); hyperhomocysteinemia; and methylmalonic aciduria and homocystinuria type cblG. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase); PARTICIPATES IN folate mediated one-carbon metabolic pathway; folate metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH (RS)-amphetamine; 2,6-dinitrotoluene; acetaldehyde.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-methyltetrahydrofolate--homocysteine methyltransferase; methionine synthase; methioninesynthase; MS; vitamin-B12 dependent methionine synthase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01766,210,444 - 66,295,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01767,954,893 - 68,041,488 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,782,708 - 68,867,101 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11768,793,540 - 68,877,930 (+)NCBI
Celera1762,230,512 - 62,313,601 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Mtr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621283
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.