17beta-estradiol multiple interactions ISO RGD:731933 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MTR mRNA CTD PMID:20823114 17beta-estradiol increases expression ISO RGD:731933 6480464 Estradiol results in increased expression of MTR mRNA CTD PMID:31614463 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of MTR mRNA CTD PMID:33387578 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of MTR mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1552179 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of MTR mRNA CTD PMID:26251327 5,6,7,8-tetrahydrofolic acid multiple interactions ISO RGD:731933 6480464 5 more ... CTD PMID:16598758 5-methyltetrahydrofolic acid affects binding ISO RGD:731933 6480464 5-methyltetrahydrofolate binds to MTR protein CTD PMID:17477549 acetaldehyde decreases activity EXP 6480464 Acetaldehyde results in decreased activity of MTR protein CTD PMID:9590515 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of MTR mRNA CTD PMID:31881176 acrylamide decreases expression ISO RGD:731933 6480464 Acrylamide results in decreased expression of MTR mRNA CTD PMID:32763439 all-trans-retinoic acid decreases expression ISO RGD:731933 6480464 Tretinoin results in decreased expression of MTR mRNA CTD PMID:33167477 aluminium atom multiple interactions ISO RGD:731933 6480464 Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] more ... CTD PMID:14745455 , PMID:26989453 aluminium(0) multiple interactions ISO RGD:731933 6480464 Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] more ... CTD PMID:14745455 , PMID:26989453 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MTR mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of MTR mRNA CTD PMID:30779732 antirheumatic drug affects response to substance ISO RGD:731933 6480464 MTR gene polymorphism affects the susceptibility to Antirheumatic Agents, MTR protein affects the susceptibility to Antirheumatic Agents CTD PMID:18322994 aristolochic acid A decreases expression ISO RGD:731933 6480464 aristolochic acid I results in decreased expression of MTR mRNA CTD PMID:33212167 arsane multiple interactions ISO RGD:731933 6480464 [MTR gene SNP affects the susceptibility to Arsenic] which affects the abundance of Cacodylic Acid more ... CTD PMID:26989453 , PMID:28889078 arsane affects response to substance ISO RGD:731933 6480464 MTR gene SNP affects the susceptibility to Arsenic CTD PMID:28889078 arsenic atom multiple interactions ISO RGD:731933 6480464 [MTR gene SNP affects the susceptibility to Arsenic] which affects the abundance of Cacodylic Acid more ... CTD PMID:26989453 , PMID:28889078 arsenic atom affects response to substance ISO RGD:731933 6480464 MTR gene SNP affects the susceptibility to Arsenic CTD PMID:28889078 arsenite(3-) multiple interactions ISO RGD:731933 6480464 arsenite inhibits the reaction [G3BP1 protein binds to MTR mRNA] CTD PMID:32406909 arsenous acid decreases expression ISO RGD:731933 6480464 Arsenic Trioxide results in decreased expression of MTR protein CTD PMID:15894607 benazepril affects response to substance ISO RGD:731933 6480464 MTR gene SNP affects the susceptibility to benazepril, MTR protein polymorphism affects the susceptibility to benazepril CTD PMID:15148588 , PMID:20445573 benzimidazoles decreases activity EXP 6480464 Benzimidazoles results in decreased activity of MTR protein CTD PMID:17222188 benzo[a]pyrene increases mutagenesis ISO RGD:731933 6480464 Benzo(a)pyrene results in increased mutagenesis of MTR gene CTD PMID:25435355 benzo[a]pyrene increases methylation ISO RGD:731933 6480464 Benzo(a)pyrene results in increased methylation of MTR promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:731933 6480464 Benzo(a)pyrene results in decreased expression of MTR mRNA CTD PMID:20064835 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:731933 6480464 7 more ... CTD PMID:26238291 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MTR mRNA CTD PMID:34947998 bisphenol A decreases expression ISO RGD:731933 6480464 bisphenol A results in decreased expression of MTR protein CTD PMID:33376534 bucladesine multiple interactions ISO RGD:731933 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MTR mRNA CTD PMID:20823114 butanal decreases expression ISO RGD:731933 6480464 butyraldehyde results in decreased expression of MTR mRNA CTD PMID:26079696 CGP 52608 multiple interactions ISO RGD:731933 6480464 CGP 52608 promotes the reaction [RORA protein binds to MTR gene] CTD PMID:28238834 cisplatin multiple interactions ISO RGD:731933 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of MTR mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:731933 6480464 cobaltous chloride results in decreased expression of MTR mRNA CTD PMID:19320972 copper atom multiple interactions ISO RGD:731933 6480464 Copper affects the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 copper(0) multiple interactions ISO RGD:731933 6480464 Copper affects the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 copper(II) sulfate decreases expression ISO RGD:731933 6480464 Copper Sulfate results in decreased expression of MTR mRNA CTD PMID:19549813 cyanocob(III)alamin affects binding ISO RGD:731933 6480464 Vitamin B 12 binds to MTR protein CTD PMID:17477549 cyanocob(III)alamin multiple interactions EXP 6480464 [Fatty Acids more ... CTD PMID:25003120 cyanocob(III)alamin increases activity ISO RGD:731933 6480464 Vitamin B 12 results in increased activity of MTR protein CTD PMID:17982279 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of MTR mRNA CTD PMID:27281708 cyclosporin A decreases expression ISO RGD:731933 6480464 Cyclosporine results in decreased expression of MTR mRNA CTD PMID:25562108 D-penicillamine multiple interactions ISO RGD:731933 6480464 Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 diarsenic trioxide decreases expression ISO RGD:731933 6480464 Arsenic Trioxide results in decreased expression of MTR protein CTD PMID:15894607 dimethylarsinic acid multiple interactions ISO RGD:731933 6480464 [MTR gene SNP affects the susceptibility to Arsenic] which affects the abundance of Cacodylic Acid CTD PMID:28889078 dinitrogen oxide decreases activity ISO RGD:731933 6480464 Nitrous Oxide results in decreased activity of MTR protein CTD PMID:18472229 dopamine multiple interactions ISO RGD:731933 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein] more ... CTD PMID:14745455 dopamine increases activity ISO RGD:731933 6480464 Dopamine results in increased activity of MTR protein CTD PMID:14745455 doxorubicin decreases response to substance ISO RGD:731933 6480464 MTR mRNA results in decreased susceptibility to Doxorubicin CTD PMID:16322897 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of MTR mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:731933 6480464 Ethanol inhibits the reaction [IGF1 protein results in increased activity of MTR protein], Ethanol promotes the reaction [Dopamine results in increased activity of MTR protein] CTD PMID:14745455 folic acid affects expression ISO RGD:731933 6480464 Folic Acid affects the expression of MTR mRNA CTD PMID:17311948 folic acid increases activity EXP 6480464 Folic Acid results in increased activity of MTR protein CTD PMID:31721048 folic acid decreases expression ISO RGD:1552179 6480464 Folic Acid deficiency results in decreased expression of MTR mRNA CTD PMID:25384423 folic acid increases expression ISO RGD:1552179 6480464 Folic Acid deficiency results in increased expression of MTR protein CTD PMID:25384423 folic acid multiple interactions EXP 6480464 Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTR protein], Homocysteine inhibits the reaction [Folic Acid results in increased activity of MTR protein] CTD PMID:31721048 , PMID:33788065 formaldehyde decreases expression ISO RGD:731933 6480464 Formaldehyde results in decreased expression of MTR mRNA CTD PMID:23649840 glutathione multiple interactions ISO RGD:731933 6480464 Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]] more ... CTD PMID:26989453 glutathionylcobalamin multiple interactions ISO RGD:731933 6480464 [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form CTD PMID:26989453 homocysteine affects metabolic processing ISO RGD:731933 6480464 MTR gene polymorphism affects the metabolism of Homocysteine CTD PMID:20532609 homocysteine multiple interactions EXP 6480464 Homocysteine inhibits the reaction [Folic Acid results in increased activity of MTR protein] CTD PMID:31721048 homocysteine affects binding ISO RGD:731933 6480464 Homocysteine binds to MTR protein CTD PMID:17477549 hydroxocobalamin multiple interactions ISO RGD:731933 6480464 [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form more ... CTD PMID:26989453 hypoxanthine multiple interactions ISO RGD:731933 6480464 [Thymidine co-treated with Hypoxanthine co-treated with 5 more ... CTD PMID:16598758 ivermectin decreases expression ISO RGD:731933 6480464 Ivermectin results in decreased expression of MTR protein CTD PMID:32959892 lead(0) multiple interactions ISO RGD:731933 6480464 Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] more ... CTD PMID:14745455 , PMID:26989453 lead(2+) multiple interactions ISO RGD:731933 6480464 Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] more ... CTD PMID:14745455 , PMID:26989453 LY294002 multiple interactions ISO RGD:731933 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 medroxyprogesterone acetate multiple interactions ISO RGD:731933 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MTR mRNA CTD PMID:20823114 mercury atom multiple interactions ISO RGD:731933 6480464 Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] more ... CTD PMID:14745455 , PMID:26989453 mercury(0) multiple interactions ISO RGD:731933 6480464 Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] more ... CTD PMID:14745455 , PMID:26989453 methotrexate multiple interactions ISO RGD:731933 6480464 5 more ... CTD PMID:16598758 methotrexate affects localization ISO RGD:731933 6480464 Methotrexate affects the localization of MTR protein CTD PMID:22484375 methotrexate decreases response to substance ISO RGD:731933 6480464 MTR mRNA results in decreased susceptibility to Methotrexate CTD PMID:19426680 methotrexate affects metabolic processing ISO RGD:731933 6480464 MTR gene polymorphism affects the metabolism of Methotrexate CTD PMID:15753437 methotrexate decreases expression ISO RGD:731933 6480464 Methotrexate results in decreased expression of MTR protein CTD PMID:16598758 methylcobalamin increases activity ISO RGD:731933 6480464 mecobalamin results in increased activity of MTR protein alternative form CTD PMID:26989453 methylcobalamin multiple interactions ISO RGD:731933 6480464 Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] more ... CTD PMID:26989453 methylmercury chloride decreases expression ISO RGD:731933 6480464 methylmercuric chloride results in decreased expression of MTR mRNA CTD PMID:28001369 nitroprusside decreases activity EXP 6480464 Nitroprusside results in decreased activity of MTR protein CTD PMID:9108260 paracetamol decreases expression ISO RGD:731933 6480464 Acetaminophen results in decreased expression of MTR mRNA CTD PMID:21420995 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of MTR mRNA CTD PMID:33387578 phenylhydrazine decreases activity EXP 6480464 phenylhydrazine results in decreased activity of MTR protein CTD PMID:33788065 phenylhydrazine multiple interactions EXP 6480464 Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTR protein] CTD PMID:33788065 pirinixic acid multiple interactions ISO RGD:731933 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MTR mRNA CTD PMID:19710929 progesterone increases expression ISO RGD:731933 6480464 Progesterone results in increased expression of MTR mRNA CTD PMID:20864642 quercetin decreases expression ISO RGD:731933 6480464 Quercetin results in decreased expression of MTR mRNA CTD PMID:21632981 S-adenosyl-L-methioninate affects binding ISO RGD:731933 6480464 S-Adenosylmethionine binds to MTR protein CTD PMID:17477549 S-adenosyl-L-methioninate multiple interactions ISO RGD:731933 6480464 [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form more ... CTD PMID:26989453 S-adenosyl-L-methionine affects binding ISO RGD:731933 6480464 S-Adenosylmethionine binds to MTR protein CTD PMID:17477549 S-adenosyl-L-methionine multiple interactions ISO RGD:731933 6480464 [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form more ... CTD PMID:26989453 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:731933 6480464 Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] more ... CTD PMID:26989453 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of MTR mRNA CTD PMID:25697676 streptozocin decreases activity EXP 6480464 Streptozocin results in decreased activity of MTR protein CTD PMID:16835399 streptozocin multiple interactions ISO RGD:1552179 6480464 [Streptozocin co-treated with Dietary Fats] results in decreased expression of MTR mRNA CTD PMID:29127188 sulforaphane multiple interactions ISO RGD:1552179 6480464 [NFE2L2 protein affects the susceptibility to sulforaphane] which affects the expression of MTR mRNA CTD PMID:30529165 tert-butyl hydroperoxide decreases expression ISO RGD:731933 6480464 tert-Butylhydroperoxide results in decreased expression of MTR mRNA CTD PMID:27509014 thimerosal multiple interactions ISO RGD:731933 6480464 Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]] more ... CTD PMID:14745455 , PMID:26989453 thimerosal decreases expression ISO RGD:731933 6480464 Thimerosal results in decreased expression of MTR mRNA CTD PMID:27188386 thymidine multiple interactions ISO RGD:731933 6480464 [Thymidine co-treated with Hypoxanthine co-treated with 5 more ... CTD PMID:16598758 triazines multiple interactions ISO RGD:1552179 6480464 Triazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of MTR mRNA] CTD PMID:27469509 trichloroethene decreases activity EXP 6480464 Trichloroethylene metabolite results in decreased activity of MTR protein, Trichloroethylene results in decreased activity of MTR protein CTD PMID:24923549 trichostatin A increases expression ISO RGD:731933 6480464 trichostatin A results in increased expression of MTR mRNA CTD PMID:24935251 trimellitic anhydride increases expression ISO RGD:1552179 6480464 trimellitic anhydride results in increased expression of MTR mRNA CTD PMID:19042947 urethane decreases expression ISO RGD:731933 6480464 Urethane results in decreased expression of MTR mRNA CTD PMID:28818685 valproic acid increases expression ISO RGD:731933 6480464 Valproic Acid results in increased expression of MTR mRNA CTD PMID:24935251 valproic acid affects expression ISO RGD:731933 6480464 Valproic Acid affects the expression of MTR mRNA CTD PMID:25979313 wortmannin multiple interactions ISO RGD:731933 6480464 Wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein], Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455